2018년 조혈모세포이식 제제 등록시스템 결과 보고

강은숙,임채승,한규섭,김대원,강은숙 대한수혈학회 2020 大韓輸血學會誌 Vol.31 No.2

Background: Hematopoietic stem cell (HSC) transplantation is an important therapeutic option for many malignant and non-malignant diseases. The whole transplant process involves multiple areas and complex steps. The laboratory procedures include the collection, processing, and storage of HSC. The HSC registry aims to identify the current situation and draw improvement points by voluntarily registering the information of an HSC graft collected by each institute sharing the analyzed data. This study analyzed and shared the data for 2018. Methods: Data for 2018 registered at the HSC registry website (www.ksfa-registry.org) was downloaded and analyzed. The data were to enter the information of each collection and include the demography of the donors, transplant type, instrument, vascular access, mobilization modality, and the number of CD34+ cells. Results: Two thousand eight hundred eighty-eight collection datasets from 1,373 donors were registered from 19 institutes, which was slightly higher than that reported in 2017. The number of collections in one patient was in the range of 1∼17 times, and the average was two times. In allogeneic HSCT, the number of related donors was higher than that of unrelated donors. The frequency of collecting more than four times per donor was 25.2% for autologous donors, compared to 95.4% for allogeneic donors less than twice. Conclusion: The HSC registry is not limited to identifying the current situation and sharing the analyzed data, but is expected to contribute to the development of guidelines, education of human resources, and the standardization of laboratory procedures involved in hematopoietic stem cell transplantation. (Korean J Blood Transfus 2020; 31:109-118)

On O-Semimetrizability of Topological Spaces

강은숙,승병인 한국수학교육학회 1985 수학교육 Vol.23 No.2

공공정책의 합리성 제고를 위한 행동경제학의 적용: 부정부패연구를 중심으로

강은숙,김종석 한국정책학회 2014 한국정책학회 학술대회 Vol.2014 No.-

정부업무평가제도와 MBO의 연계방안

강은숙 한국행정연구원 2004 韓國行政硏究 Vol.13 No.2

이 연구는 1998년 이후 도입된 우리나라 공공부문의 여러 가지 성과관리제도 가운데 주요한 제도적 장치인 정부업무평가제도와 MBO 각각을 고찰 한 후, 두 제도의 연계방안을 모색하고 있다. 현재 도입되어 시행중인 각종 성과관리제도는 각 제도마다 주관부처와 법률적 근거가 상이하며 산출되는 정보가 중첩되는 가운데 체계적인 연계가 이루어지지 않고 있다. 이러한 현실은 성과관리의 대상이 되는 정부업무를 오히려 비효율적으로 수행하게 하는 요인으로 작용하여 공공부문개혁의 걸림돌로 작용할 우려가 있다. 따라서 이 논문은 현재 도입되어 운영되고 있는 정부업무평가제도와 목표관리제를 정책연계관점에 초점을 맞추어 제도간 연계방안을 모색하고 있다. 이를 위해서는 현행 정부업무평가제도 가운데 주요정책과제의 ‘추진전략 및 계획’이 목표관리제의 ‘개인업무 추진목표’와 일치될 수 있도록 4급 과장급 이상의 개인업무 재설계가 필요하고, 정부업무평가제도와 MBO를 비롯한 성과관리제도가 성과관리시스템이라는 틀 내에서 새롭게 재구축될 필요성이 있음을 역설하였다.

Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder

강은숙,민주홍,이광호,김병준 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.5

Background: The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder. We evaluated the performance of a cell-based indirect immunofluorescence assay (CIIFA) for detecting AQP4 antibodies using antigen prepared with a recombinant AQP4 peptide transfection technique and assessed the usefulness of CIIFA for diagnosis of NMOSD in routine clinical practice. Methods: Forty-six serum samples from 36 patients as a comparison set and another 101 patients enrolled consecutively from a neurology clinic were included. CIIFA and fluorescence immunoprecipitation assays (FIPA) were performed. CIIFA was performed at 2 different institutions for comparison purposes. Results: CIIFA and FIPA sensitivity in the comparison set was 86% and 79% in neuromyelitis optica (NMO) patients and 55% and 36% in high-risk NMO patients, respectively. The semiquantitative titer measured by CIIFA correlated well with the arbitrary unit (fluorescence units [FU]) derived from FIPA (r=0.66). Titers measured by CIIFA and FIPA were elevated in NMO patients compared to high-risk NMO patients (1:240 vs. 1:180 and 8,390 vs. 4,059FU, respectively). The frequency of AQP4 antibody detection by CIIFA in 101 consecutively enrolled patients was 100% in NMO and 23% in high-risk NMO patients, while only 4.6% in control patients, including those with multiple sclerosis. Conclusions: Detection of AQP4 antibodies by CIIFA provides sensitive and highly specific diagnostic information for NMO and high-risk NMO patients, which can be used to differentiate these conditions from other demyelinating CNS diseases.

배출권거래제 도입 및 운영, 제도의 안착 : 제도안착을 위한 몇 가지 의제 도출

강은숙,김종석 서울행정학회 2018 서울행정학회 학술대회 발표논문집 Vol.2018 No.11

공공재정에 대한 행동경제학적 접근

강은숙,김종석 서울행정학회 2015 서울행정학회 학술대회 발표논문집 Vol.2015 No.4

2002 년도 한국정책학회 춘계세미나 : 그린벨트에 대한 토지이용규제의 성격에 관한 연구 - 수도권지역을 중심으로

강은숙 한국정책학회 2002 한국정책학회 세미나 Vol.2002 No.1

Effect of solution temperature on the mechanical properties of dual-cure resin cements

강은숙,전영찬,정창모,허중보,윤미정,권용훈 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.2

PURPOSE. This study was to evaluate the effect of the solution temperature on the mechanical properties of dualcure resin cements. MATERIALS AND METHODS. For the study, five dual-cure resin cements were chosen and light cured. To evaluate the effect of temperature on the specimens, the light-cured specimens were immersed in deionized water at three different temperatures (4, 37 and 60℃) for 7 days. The control specimens were aged in a 37℃ dry and dark chamber for 24 hours. The mechanical properties of the light-cured specimens were evaluated using the Vickers hardness test, three-point bending test, and compression test, respectively. Both flexural and compressive properties were evaluated using a universal testing machine. The data were analyzed using a two way ANOVA with Tukey test to perform multiple comparisons (α=0.05). RESULTS. After immersion, the specimens showed significantly different microhardness, flexural, and compressive properties compared to the control case regardless of solution temperatures. Depending on the resin brand, the microhardness difference between the top and bottom surfaces ranged approximately 3.3-12.2%. Among the specimens, BisCem and Calibra showed the highest and lowest decrease of flexural strength, respectively. Also, Calibra and Multilink Automix showed the highest and lowest decrease of compressive strength, respectively compared to the control case. CONCLUSION. The examined dual-cure resin cements had compatible flexural and compressive properties with most methacrylate-based composite resins and the underlying dentin regardless of solution temperature. However, the effect of the solution temperature on the mechanical properties was not consistent and depended more on the resin brand.

언어네트워크 분석을 이용한 2010년과 2014년 교육감 선거공약과 취임사에 관한 연구

강은숙 한국교육정치학회 2019 敎育政治學硏究 Vol.26 No.1

이 연구는 전국동시 지방선거로 2010년 선출된 민선교육감과 2014년 선출된 민선교육감의 선거공약과 취임사를 분석하였다. 분석방법은 기존의 수사학이 분석할 때 발생하는 문제점을 보완한 언어 네트워크 분석을 실시하여 선거공약과 취임사에 출현한 단어의 빈도와 연결 중심성, 매개 중심성, 아이겐벡터 중심성 분석 결과와 네트워크 지도를 제시하고, 분석결과를 논의하였다. 이 연구를 통해 2010년 보수성향 민선교육감은 학력, 인성, 창의 등이 출현빈도와 중심성이 높은 단어였고, 진보성향 민선교육감은 혁신, 혁신학교로 파악되었다. 2014년에는 교육감의 가치지향과 관계없이 안전이 출현빈도와 중심성이 높은 단어였으며, 보수성향 민선교육감은 인재, 교육환경, 행복 등이고, 진보성향 민선교육감은 교육비, 교육복지, 무상급식, 무상교복 등이었다. 민선교육감들은 가치지향에 따라 선거공약과 취임사의 주요단어가 다르게 출현하였고, 선거공약과 취임사도 연관성을 나타냈으며, 시․도별 지방교육정책에도 반영된 것으로 파악되었다. This study analyzed the election pledge and inaugural address of the election on civilian superintendent elected in 2010 and 2014 of election nationwide. In this paper, we analyzed language network analysis method, and selected language network analysis to overcome the problem of analyzing existing rhetoric. In other words, the frequency, degree centrality, betweenness centrality, eigenvector centrality analysis results and network map of the words appearing in election pledge and inaugural address were presented and the analysis results were discussed in this paper. As a result of research, the conservative superintendent of ‘education’, ‘human resources’, ‘creativity’ were high frequency and centrality, on the hand progressive superintendent was identified as ‘innovation’ and ‘innovation school’ in 2010. In 2014, ‘safety’ was a high frequency and centrality regardless of the superintendent’s value orientation. The conservative superintendent used words of ‘human resources’, ‘educational environment’ and ‘happiness’, whereas the progressive superintendent was chosen words of ‘education expenses’, ‘education welfare’, ‘free lunch’ and ‘free school uniform’. The superintendents used the key words of election pledge and inaugural address differently according to their value orientation. The election pledge and inauguration were also correlated and were also reflected in the local education policy by city and provincial office of education.