비호지킨 림프종의 임상적 고찰

김태원,조은택,조기섭,정재용,허재봉,장영,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

A retrospective clinical and histologic study of 30 non-Hodgkin's lymphomas diagnosed at the Department of Hemato-oncology of the Chosun University from January 1989 to December 1993 is presented. Among total 30 cases whose sexes were mentioned, male were 18 and female were 12 and the ratio is 1.5:1. The peak incidence of non-Hodgkin's lymphoma was found in the third decade. The case distributions by Working formulation were summarized in table 3. The most common histopathologic type of non-Hodgkin's lymphoma was the diffuse large cell type of intermediate grade. The presenting symptoms at the time of first visit to the hospital were summarized in table 4. The most common symptoms were palpable mass. Lymph node enlargements were found in 87 %, and most frequently on cervical area(35%). The incidence of primary nodal lymphoma is more frequent than extranodal lymphoma, 1.2:1. The most common primary site of extranodal lymphoma is the gastrointestinal tract. In the laboratory findings, the data of hemoglobin and hematocrit were summarized in table 8, 9, Values of hemoglobin and hematocrit of female patients greater than those of male patients. The results of the immunophenotypings of nodal and extranodal lymphoma indicates that the B-cell lymphoma are predominant(B:T=1.4:1). The clinical stage was Ⅱ in 9 cases(30%) Ⅲ in 9 cases(30%), Ⅳ in 8 cases(26.7%), Ⅰin 4 cases(13.3%), 28 cases were treated with CHOP regimen. Among them, 17 cases(60.8%) achieved a complete remission. 5 cases had a partial response. The most frequent toxicities were toxic hepatitis.

텅스텐 중합금 복합관통자 제조

송흥섭,김은표,박경진,류주하,Song Heung Sub,Kim Eun Pyo,Park Kyung Jin,You Joo Ha 한국분말야금학회 2004 한국분말재료학회지 (KPMI) Vol.11 No.5

A new concept of tungsten heavy alloy composite was suggested and manufactured in this study for the kinetic energy penetrator. The composite heavy alloy was composed of two parts, the center was molybdenum added heavy alloy compositions which were designed to promote the self-sharpening effect and outside was conventional heavy alloy in order to sustain the severe stress condition in the muzzle during the firing. The center part showed an intergranular and brittle mode at tungsten/tungsten interfaces by which self-sharpening effect could be activated. On the other hand, that of outside showed conventional ductile fracture mode under high strain rate condition. From the sub-scale penetration test, the depth of penetration in heavy alloy composites showed greater values than those of conventional tungsten heavy alloys. It is suggested that the heavy alloy composite could be considered as one of the future penetrator materials.

Bias voltage dependence of magnetic tunnel junctions comprising double barriers and CoFe/NiFeSiB/CoFe free layer

Kim, You Song,Chun, Byong Sun,Kim, Deok-kee,Hwang, Jae Yeon,Kim, Soon Sub,Rhee, J.R.,Kim, Keewon,Kim, Taewan,Kim, Young Keun IEEE 2006 IEEE transactions on magnetics Vol.42 No.10

The typical double-barrier magnetic tunnel junction (DMTJ) structure examined in this paper consists of a Ta 45/Ru 9.5/IrMn 10/CoFe 7/AlO<SUB>x</SUB>/free layer/AlO<SUB>x</SUB>/CoFe 7/IrMn 10/Ru 60 (nm). The free layer consists of an Ni<SUB>16</SUB>Fe<SUB>62</SUB>Si<SUB>8</SUB>B<SUB>14</SUB> 7 nm, Co<SUB>90</SUB>Fe<SUB>10</SUB> (fcc) 7 nm, or CoFe t<SUB>1</SUB>/NiFeSiB t<SUB>2</SUB>/CoFe t<SUB>1</SUB> layer in which the thicknesses t<SUB>1</SUB> and t<SUB>2</SUB> are varied. The DMTJ with an NiFeSiB-free layer had a tunneling magnetoresistance (TMR) of 28%, an area-resistance product (RA) of 86 k Ω μm<SUP>2</SUP>, a coercivity (H<SUB>c</SUB>) of 11 Oe, and an interlayer coupling field (H<SUB>i</SUB>) of 20 Oe. To improve the TMR ratio and RA, a DMTJ comprising an amorphous NiFeSiB layer that could partially substitute for the CoFe free layer was investigated. This hybrid DMTJ had a TMR of 30%, an RA of 68 k Ωμ m<SUP>2</SUP>, and a H<SUB>c</SUB> of 11 Oe, but an increased H<SUB>i</SUB> of 37 Oe. We confirmed by atomic force microscopy and transmission electron microscopy that H<SUB>i</SUB> increased as the thickness of NiFeSiB decreased. When the amorphous NiFeSiB layer was thick, it was effective in retarding the columnar growth which usually induces a wavy interface. However, if the NiFeSiB layer was thin, the roughness was increased and H<SUB>i</SUB> became large because of the magnetostatic Ne´el coupling.

Hydrodeoxygenation of oleic acid over Ce<SUB>(1-x)</SUB>Zr<SUB>(x)</SUB>O<SUB>2</SUB> solid solution

Jae-Oh Shim,Dae-Woon Jeong,Won-Jun Jang,Kyung-Won Jeon,Won-Bi Han,Hyun-Suk Na,Hak-Min Kim,Hyun-Seog Roh,Jeong-Geol Na,You-Kwan Oh,Chang Hyun Ko,Sang Sub Han 한국신재생에너지학회 2013 한국신재생에너지학회 학술대회논문집 Vol.2013 No.05

Role of Craniofacial Resection for Malignant Tumors Involving the Anterior Skull Base: Surgical Experience in a Single Institution

( You-sub Kim ),( Kyung-sub Moon ),( Gun-woo Kim ),( Sang Chul Lim ),( Kyung-hwa Lee ),( Woo-youl Jang ),( Tae-young Jung ),( In-young Kim ),( Shin Jung ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2015 Brain Tumor Research and Treatment Vol.3 No.2

Background Craniofacial resection (CFR) has been regarded as a standard treatment for various tumors involving the anterior skull base. The purpose of this study was to evaluate the results of CFR for the patients with anterior skull base malignancies in our hospital. Methods We retrospectively analyzed 17 patients with anterior skull base malignancies treated with CFR between 2001 and 2012. Mean follow-up duration was 41 months (range, 2-103 months). Results Intracranial involvement was found in 11 patients (65%) and orbital extension in 6 patients (35%). Classical bifrontal craniotomy was combined with endoscopic endonasal approach in 14 patients and external approach in 3 patients. Vascularized flap was used for reconstruction of the anterior fossa floor in 16 patients (94%). The most common pathological type was squamous cell carcinoma (6 patients). Gross total resection was achieved in all cases. Postoperative complications developed in 4 patients (24%) and included local wound problem and brain abscess. One patient with liver cirrhosis died from unexpected varix bleeding after the operation. Although postoperative treatment, such as radiotherapy or chemotherapy, was performed in 14 patients, local recurrence was seen in 6 patients. The mean overall survival time after the operation was 69.0 months (95% confidence interval: 47.5-90.5 months) with a 1-, 2-, and 5-year survival rate of 82.3%, 76.5%, and 64.7%, respectively. Postoperative radiotherapy was found to be the powerful prognostic factor for favorable survival. Conclusion Considering the higher local control rate and acceptable complication or mortality rate, CFR with adjuvant radiotherapy is a gold standard treatment option for malignant tumors involving anterior skull base, especially with extensive intracranial involvement.

Spinal Burkitt’s Lymphoma Mimicking Dumbbell Shape Neurogenic Tumor: A Case Report and Review of the Literature

You-Sub Kim,이정길,Ki-Young Choi,Jae-Won Jang 대한척추신경외과학회 2015 Neurospine Vol.12 No.3

Non-Hodgkin's lymphoma (NHL), a disease which may involve the spine, is frequently associated with advanced disease. Radiculopathy caused by spinal root compression as the initial presentation in patients with NHL is very rare and thought to occur in less than 5% of cases. A 69-year-old woman complained of a history of low back pain with right sciatica for 1 month prior to admission. Computed tomography and magnetic resonance imaging of the lumbar spine showed a dumbbellshape epidural mass lesion extending from L2 to L3, which was suggestive of a neurogenic tumor. After paraspinal approach and L2 lower half partial hemilaminectomy, total excision of the tumor was achieved, followed by rapid improvement of back pain and radiating pain. The lesion was confirmed to be Burkitt’s lymphoma by histopathological examination. We then checked whole-body PET-CT, which showed multifocal malignant lesions in the intestine, liver, bone and left supraclavicular lymph node. Although a rare situation, Burkitt’s lymphoma should be considered in the differential diagnosis for patients presenting with back and lumbar radicular pain without a prior history of malignancy. Burkitt’s lymphoma could be the cause of dumbbell-shape spinal tumor.

Role of Craniofacial Resection for Malignant Tumors Involving the Anterior Skull Base: Surgical Experience in a Single Institution

You-Sub Kim,Kyung-Sub Moon,Gun-Woo Kim,Sang Chul Lim,Kyung-Hwa Lee,Woo-Youl Jang,Tae-Young Jung,In-Young Kim,Shin Jung 대한뇌종양학회 2015 Brain Tumor Research and Treatment Vol.3 No.2

Background Craniofacial resection (CFR) has been regarded as a standard treatment for various tumors involving the anterior skull base. The purpose of this study was to evaluate the results of CFR for the patients with anterior skull base malignancies in our hospital. Methods We retrospectively analyzed 17 patients with anterior skull base malignancies treated with CFR between 2001 and 2012. Mean follow-up duration was 41 months (range, 2–103 months). Results Intracranial involvement was found in 11 patients (65%) and orbital extension in 6 patients (35%). Classical bifrontal craniotomy was combined with endoscopic endonasal approach in 14 patients and external approach in 3 patients. Vascularized flap was used for reconstruction of the anterior fossa floor in 16 patients (94%). The most common pathological type was squamous cell carcinoma (6 patients). Gross total resection was achieved in all cases. Postoperative complications developed in 4 patients (24%) and included local wound problem and brain abscess. One patient with liver cirrhosis died from unexpected varix bleeding after the operation. Although postoperative treatment, such as radiotherapy or chemotherapy, was performed in 14 patients, local recurrence was seen in 6 patients. The mean overall survival time after the operation was 69.0 months (95% confidence interval: 47.5–90.5 months) with a 1-, 2-, and 5-year survival rate of 82.3%, 76.5%, and 64.7%, respectively. Postoperative radiotherapy was found to be the powerful prognostic factor for favorable survival. Conclusion Considering the higher local control rate and acceptable complication or mortality rate, CFR with adjuvant radiotherapy is a gold standard treatment option for malignant tumors involving anterior skull base, especially with extensive intracranial involvement.

Microsurgical Management of Ruptured Blood Blister Aneurysms of the Internal Carotid Artery without Bypass: A Retrospective Single-Center Study of 36 Patients over 20 Years

Kim, You-Sub,Joo, Sung-Pil,Kim, Tae-Sun Elsevier 2019 World neurosurgery Vol.128 No.-

<P><B>Background</B></P> <P>Microsurgical management of blood blister aneurysms of the internal carotid artery is challenging because of the special characteristics of these aneurysms. We reviewed our diverse surgical methods with long-term clinical and radiologic follow-up.</P> <P><B>Methods</B></P> <P>We retrospectively reviewed all patients with blood blister aneurysms presenting with subarachnoid hemorrhage that were treated with microsurgical obliteration between 1993 and 2017. Baseline characteristics of patients and aneurysms, surgical methods, and clinical and radiologic outcomes were analyzed.</P> <P><B>Results</B></P> <P>This study included 36 patients. The patients were treated using microsurgery with direct clipping (2 patients; 5.6%), cotton-assisted clipping (24 patients; 66.7%), wrapping-clipping (5 patients; 13.9%), or wrapping-clipping with suturing (5 patients; 13.9%). Complete occlusion of aneurysm was achieved in 34 of 36 patients (94.4%). Severe vasospasm developed in 18 of 36 patients (50%). Ischemic events occurred in 8 patients (22.2%), 2 of whom remained with severe disability. Regrowth or recurrence occurred in 1 patient (0.28%), which required additional stent-assisted coil embolization. Mean modified Rankin Scale score was 2.0 (median, 1.0; range, 0–4) at discharge and 1.3 (median, 1.0; range, 0–4) at the last follow-up.</P> <P><B>Conclusions</B></P> <P>Direct clipping is ideal if possible; however, direct clipping is challenging in most blood blister aneurysms. Assisted clipping with cotton is mainly used and could be an effective technique for reinforcement of the friable wall, with good clinical outcomes in our series. Moreover, suturing followed by wrapping-clipping is also useful for managing intraoperative rupture.</P>

간의 점액표피양암종 1 예

김호정,김정한,최대섭,김택수,김재명,성상규,천대철,강유미,추길연,원종현,박석오,안장훈 대한내과학회 1994 대한내과학회지 Vol.47 No.4

Mucoepidermoid carcinoma arising in the liver is a rare malignant tumor which reported only about 10 cases to date, Several terms, such as adenosquamous carcinoma, adenoacanthoma, and mucoepidermoid carcinoma, have been used for carcinomas containing both adenomatous and squamous elements. Most of mucoepidermoid carcinoma have been reported in the salivary gland of primary site, but this tumor can also arise in many other regions of the body, such as lung, esophagus, pancreas, uterus, bladder, anus and etc. Mucoepidermoid carcinoma of the liver morphologically resembles that of the salivary gland. Histologically, this tumor consists of mixture of squamous cells, mucus-producing cells, and intermediate cells. Intercellular bridges and keratinization are also present in the epidermoid area of the tumor. We experienced a case of mueoepidermoid carcinoma arising in the liver of 68-year-old man. The tumor, measuring about 10×10 cm sized, was noted in left lobe of the liver with invasion to adjacent organs. The exploratory laparotomy was done and we obtained tissue from the tumor nodule protruding to the liver surface. Microscopically, this tumor revealed squamous element and intermingled mucoid element. And intercellular bridges and keratinization were noted in the epidermoid area. So we report this case of mucoepidermoid carcinoma of the liver with a literature review.

Direct Removal of Fourth Ventricle Hematoma in Massive Intraventricular Hemorrhage

You-Sub Kim,Han-Seung Ryu,Tae-Sun Kim,Sung-Pil Joo 대한신경외과학회 2022 Journal of Korean neurosurgical society Vol.65 No.2

Various grading systems and surgical techniques have been developed for the treatment of intraventricular hemorrhage (IVH); however, little attention has been paid to the fourth ventricle hematoma. Nonetheless, hemorrhagic dilation of the fourth ventricle may lead to catastrophic consequences for patients with massive IVH. We present two cases of massive IVH accompanied by massive fourth ventricle hematoma which was successfully removed with combination of suboccipital craniotomy for fourth ventricle hematoma and intraventricular fibrinolysis for supratentorial hematoma.