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김택수 全北行政學會 2003 全北行政學報 Vol.17 No.1
분권화는 변화된 시대에 부응하여 자율과 다양성을 실현하는 거스를 수 없는 시대적 흐름이다. 본 논문은 지방분권화에 있어서 사무배분과, 인권·조직권 및 자주재정의 확립방안에 대해서 논의하였다. 개혁 방안은 첫째, 중앙정부와 지방정부간에 권한과 업무를 보충성의 원칙에 입각한 역할분담을 실현해야 한다. 이와 관련하여 많은 문제점을 나타내고 있는 기관위임사무의 폐지를 원칙으로 하되, 국가가 수행해야 할 역할과 관련된 사무이지만, 국가에 있어서 그에 대한 적정한 처리를 특별히 확보할 필요가 있는 것은 법령에 규정하여 이를 지방자치단체로 하여금 처리하게 하는 것이다. 둘째, 지방자치단체의 입법권을 강화하기 위해서는 조례제정권의 범위가 전향적으로 더욱 확대되어야 할 것이다. 셋째, 자치단체장의 인사전횡을 견제하면서 자치단체의 특성에 따른 자율성을 반영 할 수 있도록 인사권을 강화해야 한다. 인사권 강화를 위해서는 기구설치 기준의 폐지, 정원운영의 자율권확보, 인사교류의 활성화가 이루어져야 한다. 넷째, 자주재정권의 확립이다. 자주재정권의 확립은 중앙정부의 이전재원에 의존하지 않고, 세입에 관한 자기결정권과 자기책임을 갖는 것을 의미한다. 대안으로서 지방소득세와 지방소비세의 도입을 추진해야 한다. 다섯째, 시민사회 활성화를 통한 주민자치실현이다. 자치단체 차원의 시민참여 활성화를 위한 제도적 장치로 주민투표제에 관한 법률이 조속한 제정과 주민소환제의 도입이 필요하다.
베타1-아드레날린 수용체를 표적으로 하는 심근영상제로서 18F 표지된 nebivolol의 합성
김택수,박정훈,이준영,양승대,장동조 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.4
Selective β1-agonist and antagonists are used for the treatment of cardiac diseases including congestive heart failure, angina pectoris and arrhythmia. Selective β1-antagonists including nebivolol have high binding affinity on β1-adrenergic receptor, not β2-receptor mainly expressed in smooth muscle. Nebivolol is one of most selective β1-blockers in clinically used β1- blockers including atenolol and bisoprolol. We tried to develop clinically useful cardiac PET tracers using a selective β1-blocker. Nebivolol is C2-symmetric and has two chromane moiety with a secondary amino alcohol and aromatic fluorine. We adopted the general synthetic strategy using epoxide ring opening reaction. Unlike formal synthesis of nebivolol, we prepared two chromane building blocks with fluorine and iodine which was transformed to diaryliodonium salt for labelling of 18F. Two epoxide building blocks were readily prepared from commercially available chromene carboxylic acids (1, 8). Then, the amino alcohol building block (15) was prepared by ammonolysis of epoxide (14) followed by coupling reaction with the other building block, epoxide (7). Diaryliodonium salt, a precursor for 18F-aromatic substitution, was synthesized in moderate yield which was readily subjected to 18F-aromatic substitution to give 18F-labelled nebivolol.
김택수,이종윤,홍기호,박정수,김의종 대한진단검사의학회 2011 Annals of Laboratory Medicine Vol.31 No.1
Background: Various virulence factors and superantigens are encoded by mobile genetic elements. The relationship between clonal background and virulence factors differs in different geographic regions. We compared the distribution and relationship of spa types and virulence genes among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from a tertiary hospital in 2000-01 and 2007-08. Methods: In 2000-01 and 2007-08, 94 MRSA strains were collected from 3 intensive care units at a Korean tertiary hospital. We performed spa typing and multiplex PCR for 19 superantigen genes. Results: Relatively frequent spa types were t037 (40.5%), t002, t601, and t2138 in 2000-01, and t2460 (43.9%), t002, t037, t601, t324, and t2139 in 2007-08. We identified 4 novel spa types, 2 of which were designated as t5076 and t5079. Superantigen profiles were closely linked to spa types. For example, sea, sek, and seq superantigen genes were mainly detected in t037 strains. Conclusions: Major spa types differed depending on study periods, and the distribution of superantigen genes correlated with spa type. Background: Various virulence factors and superantigens are encoded by mobile genetic elements. The relationship between clonal background and virulence factors differs in different geographic regions. We compared the distribution and relationship of spa types and virulence genes among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from a tertiary hospital in 2000-01 and 2007-08. Methods: In 2000-01 and 2007-08, 94 MRSA strains were collected from 3 intensive care units at a Korean tertiary hospital. We performed spa typing and multiplex PCR for 19 superantigen genes. Results: Relatively frequent spa types were t037 (40.5%), t002, t601, and t2138 in 2000-01, and t2460 (43.9%), t002, t037, t601, t324, and t2139 in 2007-08. We identified 4 novel spa types, 2 of which were designated as t5076 and t5079. Superantigen profiles were closely linked to spa types. For example, sea, sek, and seq superantigen genes were mainly detected in t037 strains. Conclusions: Major spa types differed depending on study periods, and the distribution of superantigen genes correlated with spa type.