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완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과
박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2
The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.
하악골 결손부의 골형성에 미치는 Bioplant HTRⓡ의 영향
최도현,유선열,김옥준,허원실 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1
The present study was performed to investigate the effect of HTR□ (Hard Tissue Replacement) on osteogenesis in the mandibular bone defects. Eight adult male white rabbits weighing 2.5 to 3.0kg were used. Four bone defects (8mm in diameter and 4mm in depth) were made at the both mandibular body. In the control group, the right mesial bone defect was filled with blood clot and spontaneously healed, In the DFDB group, the right distal bone defect was filled with xenogenic demineralized freeze-dried bone. In the HTR□ group, the left mesial bone defect was filled with HTR□. In the HTR□-membrane group, the left dis- tal bone defect was filled with HTR□ and covered with BioMesh membrane. The rabbits were sacrified at 2,4,6 and 9 weeks after the operation and microscopic examination was performed. Results obtained were as follows: In the control and DFDB groups, inflammatory cells and the fibrous connective tissue existed and the bone growth was slower than HTR□ group by 6 week, and there was intervention of the soft tissue at 9 week. In the HTR□ group, bone trabeculi extended between the HTR□ particles without intervention of inflammatory cells and the connective tissue at 4 and 6 weeks. In addition, extensive osseous ingrowth into the HTR□ particles was observed at 9 week. Bone formation was more active in the HTR□ group than the control and DFDB groups. There was not obvious difference in the bone healing rate between the HTR□ and the HTR□-membrane group. These results suggest that the HTR□ promotes osteogenesis in the bone defects and the HTR□ group has no difference in comparison with the HTR□-BioMesh□ membrane group in bone healing.
구희정,서정길,김은희,허민도,정준기,박장수,강신원,박남규 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-
생리활성을 지닌 신경펩타이드의 구조와 활성간의 관계를 규명하기 위하여 고상법으로 합성한 세종류의 neuropeptide γ(mammalian-,trout- 그리고 goldfish-neuropeptide γ)를 사용하여 연구하였다. Circular dichroism spectra에 의하면 mammalian-,trout- 와 goldfish-neuropeptide γ는 완충액 조건하에 모두 random한 구조를 나타내었다. 중성 및 산성 지질 존재 하에서, mammalian-과 trout- neuropeptide γ는 여전히 random한 구조를 취하였다. 그러나, goldfish-neuropeptide γ는 중성 및 산성지질하에서 부분적으로 α-helix구조를 나타내었다. 장관 수축활성에 있어서는 carp 장관, guinea-pig 회장 그리고 rat십이지장에 대하여 비교하였다. Carp에 대해서는 goldfish-neuropeptide γ= trout- neuropeptide γ>mammalian-neuropeptide γ순으로 활서이 나타났다. 그러나, guinea-pig 회장과 rat십이지장에 대해서 mammalian-neuropeptide γ는 어류 유래성 neuropeptide g들 보다 높은 수축활성을 나타내었다. 이러한 결과들은 neuropeptide γ들이 종-특이적인 활성을 나타낸다는 것을 제시한다. The relationship between structure and biological activity was studied on the three neuropeptides(mammalian-,trout- and goldfish-neuropeptide γ)that were syntheized by the solid-phase method. Circular dichroism spectra showed that mammalian-,trout- and goldfish-neuropeptide γadopted an undered structure in buffer solution. In the presence od neutral and acidic liposomes, mammalian-and trout- neuropeptide γ also took a random structure. However, goldfish-neuropeptide γ took an α-helical structure in acidic liposomes. The intestinal motility response was investigated with carp interstines, guinea-pig ileums and rat duodenums. In case of carp intestine, contractine activity was as follows:goldfish-neuropeptide γ= trout- neuropeptide γ> mammalian-neuropeptide γ. On the other hand, the contracile activity of mammalian-neuropeptide γ was more potent than trout- and goldfish-neuropeptide γ in the guinea-pig ileums and rat duodenums. these results suggest that neuropeptide γs showed the species-specific activity.
The accuracy of ultrasonography on the location of lipomas in the forehead
( Joon Won Huh ),( Min Soo Kim ),( Kwang Hyun Choi ),( Hyang Joon Park ),( Mihn Sook Jue ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Preoperative recognition of tumor plane is important to avoid surgical complications in surgeries involving the scalp. Ultrasonography is a useful diagnostic tool to detect the depth of tumor noninvasively. However,some findings are not always in accordance with the actual locations of lipomas, especially in the forehead. Objectives: To evaluate the accuracy of preoperative ultrasonographic findings for the location of lipomas in the forehead. Methods: The study included 14 patients with lipomas in the forehead who all underwent preoperative ultrasonography and surgical excision of the lesions. We compared the diagnostic location of tumors by ultrasonography with the actual location in the surgical field. Results: On ultrasonography, 10 of 14 cases were diagnosed as frontalis-associated lipomas. However, 13 cases were confirmed as frontalis-associated lipomas intraoperatively, and only 1 case as superficial lipoma, which didn’t correspond with the ultrasonographic finding. The ultrasonographic findings were accurate in 9 of 14 cases (64.3%). Conclusion: The accuracy of ultrasonography on the location of lipomas in the forehead is not as high as expected. Therefore, the surgeon must consider the possibility of deep lipoma even if a forehead lipoma is superficial in location on ultrasonography.
Unusual case of desmoplastic fibroblastoma (collagenous fibroma) on the toe
( Joon Won Huh ),( Ji Sook Yoo ),( Young In Jeong ),( Min Soo Kim ),( Kwang Hyun Choi ),( Hyang Joon Park ),( Mihn Sook Jue ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Desmoplastic fibroblastoma is a rare benign soft tissue tumor of fibroblast origin that presents a slowly growing, painless, fibroproliferative mass located in the subcutaneous tissue or just deep to skeletal muscle. It occurs commonly in the upper extremity such as shoulder and upper arm, and lower extremity, followed by head and neck region. However, the occurrence on the toe was rarely reported. A 70-year-old man presented a painless, slow growing, soft tumor on the left fifth toe. On physical examination, a 1 cm flesh colored, pedunculated mass was located on the left fifth toe. Histopathologic examination showed well-circumscribed mass that consisted of scattered stellate or spindle fibroblasts in collagenous matrix without atypia, which was consistent with desmoplastic fibroblastoma. Desmoplastic fibroblastoma was rarely reported in the dermatologic field and unfamiliar to dermatologist. In Korea, only 2 cases of desmoplastic fibroblastoma have been reported so far. We here report a rare case of desmoplastic fibroblastoma with unusual appearance on the toe.
FCT 11 : Treatment for a refractory pruritus using oral aprepitant
( Joon Won Huh ),( Young In Jeong ),( Geon Kim ),( Eun Jung Kim ),( Hyang Joon Park ),( Mihn Sook Jue ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Aprepitant, approved in 2003 for chemotherapy-induced nausea and vomiting, is an oral neurokinin-1 receptor antagonist, which acts by inhibiting binding of the neurokinin-1 receptor with the substance P ligand in the skin and central nervous system. Substance P is an important mediator in the induction and maintenance of pruritus and therefore represents an interesting target for antipruritic treatment. A 79-year-old man presented with a refractory pruritus of unknown etiology. He previously failed to respond to topical steroid, oral anti-histamine, tricyclic antidepressant, gabapentin, cyclosporine and phototherapy. After stopping antipruritic therapy for 3 weeks, we administered 125mg of aprepitant on day 1 and 80mg on day 2,3 and 4 with an aim to relieve pruritus. Before treatment, visual analogue scale (VAS) score was 8 and the Dermatologic Life Quality Index (DLQI) score was 24. On day 4, they reduced to 4 and 16, respectively. After 6 weeks, VAS and DLQI score were 1 and 8, and the patient was completely satisfied with a deep sleep. We herein report a case of refractory pruritus responded dramatically to oral aprepitant. To our knowledge, this is the first documented case of refractory pruritus showing marked improvement with oral aprepitant in Korea.