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광선각화증, 보웬병, 편평상피세포암에서 Ki-67, Cyclin A, p53, p16의 발현 양상
이효진 ( Hyo Jin Lee ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),김기홍 ( Ki Hong Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4
Background: Actinic keratosis (AK) and bowen`s disease (BD) are pre-cancerous diseases, and are regarded as an early squamous cell carcinoma (SCC). AK and BD can be progressed into SCC. In this process, tumor suppressor and cell proliferative proteins may play important roles. Objective: To investigate the differences of expression patterns of the immunohistochemical (IHC) staining and useful markers for differential diagnosis in AK, BD and SCC. Methods: Biopsy had proven 17 cases of AK, 20 cases of BD and 17 cases of SCC, which were all selected. IHC staining for Ki-67 and cyclin-A, as cell proliferative markers, p53 and p16 as tumor suppressor markers, were performed. Labeling index (LI) and distribution pattern of IHC expressions were measured. Results: LI of Ki-67 in AK, BD and SCC were 30.6%, 60.2% and 54.8%, respectively. LI of cyclin-A in AK, BD and SCC were 9.2%, 24.4% and 24.1%, respectively. LI of p53 in AK, BD and SCC were 20.7%, 37.9%, and 39.9%, respectively. LI of p16 in AK, BD and SCC were 10.6%, 38.3% and 39.9%, respectively. Lower 1/3 was the most frequent distribution pattern in AK in all IHC stains, full thickness lower 2/3 were the most frequent distribution pattern in BD and SCC in all IHC stains. Conclusion: LI and distribution pattern of Ki-67, cyclin-A, and p16, as well as the distribution pattern of p53 may be useful markers to differentiate AK from BD and SCC. Higher degree and full-thickness distribution pattern IHC expressions in all stains may be helpful in the diagnosis of BD, rather than AK. (Korean J Dermatol 2012;50(4):290∼298)
한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
순수 Ti 용접재의 기계적 특성 및 피로크랙 성장특성에 관한 연구
최병희,이종범,정장만,장경천,최병기 朝鮮大學校 機械技術硏究所 2007 機械技術硏究 Vol.10 No.2
In this study, fatigue fracture often occurs due to the fatigue crack in the machine and welding structure and this is the result of severe operational environment, operational condition, and design condition caused by the large scaled and light weighted machine and structure in recent days. Therefore, safety and reliability should be secured to prevent the fatigue fracture of machine and structure, and the use of titanium has been increased in the metal material for the safety and reliability. The purpose of this thesis was to investigate the welding characteristics and fatigue crack growth characteristics of titanium, commonly using power station, aircraft and ship. The experimented material was TIG welded in order to look over the characteristics according to the notch position and compare with other material. The results, at the same welding condition, 4 pass specimen which had the smallest number of welding pass had the highest tensile strength with 51kgf/㎟ and the tensile strength of 4 pass specimen was 10% higher than the one of 7 pass specimen, and its elongation reduced about 30%. The initial fatigue crack growth characteristic is slower in this order, boundary zone < welding zone < HAZ < base metal. Especially boundary zone's growth speed is slower about 30 times than base metals.
추적조사를 중심으로 한 腰椎間板脫出症에 대한 蜈蚣藥鍼의 臨床的 硏究
최회강,소기숙,고강훈,박소영,김성남,이종덕,원경숙,문형철,김성철 大韓鍼灸學會 2003 대한침구의학회지 Vol.20 No.3
Objective : This study is performed for the purpose of examining the efficacy of the scolopendrid(Scolopendra morsitans L) which has been to low back pain as a folk remedy. Methods & Results : Seventy patints with H.I.V.D. treated with the scolopendrid aquacupuncture and examined 4 tests; D.I.T.I., physical test, Oswestry disability index, and self-conscious pain rate were studied. And we follow up after discharge, we evaluated the present state and recovery period. Or we evaluated by herniated type and duration of onset. There was 58~97% of efficacy rate in each tests. Moreover, statistically valuable change in all 7D.I.T.I. points and in disability index and in self-conscious pain rate was showed. Conclusion : The scolopendrid aquacupuncture is possible to be effective terating the H.I.V.D patients. so we suggest the possibility using this new remedy to the H.I.V.D. patients.
정보기술수용모델(TAM)을 적용한 신용평가시스템의 실증적 연구 : On the Basis of TAM
최현호,박기남,이경구,김종원 대한경영학회 2003 大韓經營學會誌 Vol.16 No.5
Since International Monetary Fund (IMF), many Korean banks are using the Credit Risk Ratio System (CRRS) to systematically evaluate the borrower's credits. However, there are few research focusing on the key antecedents of successful CRRS utilization. Therefore, the purpose of this paper is to investigate the factors influencing individual intention to use and actual use of CRRS, and to analyze the relationships among those factors. Doing so, this study employs TAM (Technology Acceptance Model) proposed by Davis (1989) as a main framework. The results show that industry competition, diversity of customers' needs, organizational support, organizational experience, technical interchangeability, users' participation, and social norms make direct and/or indirect impacts on behavioral intention and actual use through perceived ease of use and perceived usefulness. The empirical findings from this study may prove useful for both IS researchers and practitioners.
흰쥐 내후야의 아미노산 함량에 대한 복측 또는 배측 뇌 해마 제거 영향
최석형,김종규,양훈모,민영기 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
This study was planned to analyze amino acids in the entorhinal cortex of dorsal and ventral hippocampectomized rats by high performance liquid chromatography (HPLC). Male albino rats were used. Under chloral hydrate anesthesia (20%, 2 ㎖/㎏ body weight), a hole was made in each parietal bone about 4 mm lateral to the sagittal suture, and 4 mm rostral to the lambda suture. The cortical tissue on each side was removed and, through this opening, the hippocampal tissue anterodorsal and posteroventral to the hippocampal flexures on both sides was removed by aspiration. This preparation served as the dorsal and the ventral hippocampal animals, respectively. The cortical control animal received the same surgery short of hippocampectomy. The normal rats served as normal control animal. One week later, the animals were sacrificed by decapitation in the cold room. Two to three milligrams of tissue was obtained from the entorhinal cortex in one side of the brain. The tissue samples were homogenized and centrifuged. Then content of each amino acid was measured by HPLC from the brain tissue. 1) The contents of aspartate were decreased significantly more in the dorsal and ventral hippocampal groups than in the normal and the cortical control groups, while there were no significant differences between the 2 hippocampal and 2 control groups. 2) The contents of glutamate were decreased significantly more in the dorsal hippocampal group than in the normal and the cortical control groups. The contents of glutamate were increased significantly more in the ventral hippocampal group than in the dorsal hippocampal, the normal control, and cortical control groups. while there was no significant difference between the 2 control groups. It is inferred from the above mentioned results that glutamate and aspartate of many amino acids may he used as a excitatory transmitter in entorhinal cortex, and that the dorsal hippocampus may be facilitatory to the entorhinal cortex, but the ventral hippocampus would be inhibitory/facilitatory to the cortex.