Carnosine Promotes Exhaustive Swimming Capacity in Mice

Jong-Soo Kim, Ki Nam Lee, Jin-Joo Hue, Jun-Hyeong Kim, Bong Soo Kang, Sang Yoon Nam, Young Won Yun, Jae-Hwang Jeong2, Beom Jun Lee 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1

To investigate the effect of carnosine on exhaustive exercise, swimming tests were conducted weekly with loads corresponding to 5% of body weight attached to the tails of mice, and the swimming time to exhaustion was measured. Eighty male ICR mice were divided into four groups, to which carnosine was administered at doses of 0 (control), 10, 50, and 250 mg/kg/day, respectively, for a period of four weeks. At the end of swimming exercise challenges, serum biochemistry, oxidative stress enzyme activity, and antioxidant enzyme activity in tissues were determined. Treatment with 250 mg/kg carnosine resulted in a significant increase in swimming times to exhaustion, compared to the control group in the first (P<0.01) and third week (P<0.05). Significantly lower serum lactate levels were observed after the swimming exercise in the carnosine-treated groups (10 and 250 mg/kg), compared with the control (P<0.01). Malondialdehyde levels in the liver (10 and 50 mg/kg carnosine treated groups) and skeletal muscle (250 mg/kg carnosine treated group) were significantly lower, compared with the control (P<0.05). Significantly lower protein carbonyl levels in skeletal muscle were observed in the 50 and 250 mg/kg carnosine treated groups, compared with the control (P<0.01). Superoxide dismutase and glutathione peroxidase activities in skeletal muscle did not differ significantly among the groups. These results indicate that carnosine may improve swimming exercise capacity by attenuating production of lactate and reducing oxidative stress in mice.

멕시코와 네팔도입 고추 유전자원의 두 가지 점무늬병에 대한 저항성

조은형,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

Pepper genetic resources consisting of introductions from Mexico and Nepal and susceptible and resistant controls were tested for resistance to gray leaf spot and to bacterial spot by serially inoculating the two disease pathogens, Stemphylium spp. first and Xanthomonas campestris pv. vesicatoria next, with application of fungicide after evaluation of resistance to gray leaf spot first. KC866, KC872, KC902, KC905 were resistant to gray leaf spot in addition to known resistance sources, KC43, KC47, KC220, KC319, KC320, KC380. KC897 was on the top of the resistance sources list, even better than KC177(163192), and was followed by KC889, KC896, KC898, all of which were introductions from Nepal.

충수염의 임상적 고찰과 초음파의 유용성

박정배,양혁준,김형수,황성연,박철완,이근 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Appendicitis is the most common acute abdomen in Emergency Medical Center & outpatient department. But sometimes, it is difficult for us to diagnose because of clinically variable symptoms. We reviewed the ultrasonographic findings and analyse 521 cases of appendectomy patients about its distribution of sex and age, seasonal prevalence, clinical symptom and signs, laboratory findings, duration from onset of symptom to arrival at hospital, duration from arrival at hospital to operation, vital signs, operative results, and associated diseases, which were treated at the department of General Surgery & Emergency Medical Center in Chung Ang Gil Hospital from July, 1994 to June, 1995. The results were as follows : 1. The most common age group was second decade. And male to female ratio was 1.43:1. Seasonal variation was not significant. 2. Of 521 cases, 141 cases(27.1%) visited the hospital within 24 hours from the onset of symptom, and 259 cases(49.7%) visited between 24 to 48 hours. 3. In duration from arrival to operation, the cases within 6 hours were 263 (50.5%), the cases between 6 and 12 hours were 131(25..1%). 4. In systolic blood pressure, cases below 90mmHg were 19(3.6%), cases above 160mmHg were 23(4.4%). Below 60mmHg diastolic pressure were 55 cases(10.6%), cases above 110mmHg were 9(1.7%). In pulse rate, above 90 rate/min were 171(32.8%). 5. On admission leukocytosis was found in 413 cases(79.3%) and 342 cases of them were pathologic appendicitis. 6. Ultrasoundgraphy was performed in the 87 cases, but 23 cases were suggested appendicitis. Among 23 cases, 22(95.7%) revealed pathologic appendicitis at ooperation and labortatory examination. Of the 64 cases which were normal on ultrasonography, only 2 cases(3.1%) were proved to be appendicitis. 7. The results of 496 operations without ultrasonography were appendicitis in 390 cases(78.6%), mesenteric lymphadenopathy 36(7.3%), pelvic inflammatory disease 28(5.6%), fecalith 15(3.0%), terminal ileitis 8(1.6%), diverticulitis 7(1.4%), urinary tract stones 5(1.0%), cecal cancer 2 cases, right ovarian tumor 2 cases, tubo-ovarian abscess 2 cases, grater omentum internal hernia 1 case. Our results showed that the sensitivity of ultrasonohraphy was 95.8% and the specificity 98.4% in the diagnosis of appendicitis, It suggests that the ultrasonography is very helpful in the diagnosis & differential diagnosis of acute appeendiditis.

아파트단지내 조경시설물 평가에 관한 연구 : 수원 매탄5단지를 사례로 A Case Study of Maetan Apartment Complex in Suwon, Korea

김학범,김정태,임형준 안성산업대학교 2002 論文集 Vol.34 No.-

This study aims to provide useful data for designing the outdoor space or planning landscape architecture facilities in apartment housing complex. Primary data were collected by questionnaire survey in Maetan Apartment Complex in Suwon. The questionnaires contain three sets of variables : outdoor environment, landscape architecture facilities, and the respondents' demographic variables. The results are as follows. 1) The apartment residents are using bench or pergola most frequently among the landscape architecture related facilities. 2) The residents are dissatisfied with shortage of parking lots, therefore, more parking area is needed in the apartment complex. 3) The residents expressed considerable concern for trees, however, they pointed out to change some species of trees and need some professional management for them. 4) The variables related landscape architecture facilities were reduced to 6 factors; 'trees', 'bench/pergola', 'excercise/playground', 'pavement', 'lighting facility', 'parking lots'. And 'trees' is perceived the most important factor by the residents. 5) Finally, 'landscape architecture facilities', is most important factor among variables consist of apartment exterior environment.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Case Report : Concomitant Glomus Tumor with CRPS in the Hand

( Hyeong Jun Jeong ),( Chan Mi Kim ),( Duck Mi Yoon ),( Kyung Bong Yoon ) 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.3

Glomus tumors are benign tumors that account for 1% to 5% of all soft tissue tumors of the hand and are characterized by a triad of sensitivity to cold, localized tenderness and severe paroxysmal pain. Paroxysmal pain is a symptom common not only in glomus tumors but also in CRPS, and the hand is one of the commonly affected sites in patients with both glomus tumors and CRPS. Therefore, it is not easy to clinically diagnose glomus tumors superimposed on already affected region of CRPS patients. We report a case of glomus tumor concomitantly originating with CRPS at the hand. (Korean J Pain 2013; 26: 295-298)

High-speed 3-D measurement with a large field of view based on direct-view confocal microscope with an electrically tunable lens

Jeong, Hyeong-jun,Yoo, Hongki,Gweon, DaeGab The Optical Society 2016 Optics express Vol.24 No.4

Dietary Selenium Supplement Prevents Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in ICR Mice

Jun-hyeong Kim,Jin-Joo Hue,Bong Su Kang,Hyunji Park,Sang Yoon Nam,Young Won Yun,Jong Soo Kim,Jae-Hwang Jeong,Beom Jun Lee 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.3

The role of selenium (Se) in modulating colon carcinogenesis induced by azoxymethane (AOM) followed by dextran sodium sulfate (DSS) was investigated in mice. Five-week old ICR mice were fed on diets containing different concentrations (0.02, 0.1 or 0.5 ppm) of Se for 24 weeks. Animals received three (0-2nd weeks) intraperitoneal injections of AOM (10 ㎎/㎏ body weight), followed by 2% DSS with drinking water for additional 1 week. There were 4 experimental groups including vehicle control group, positive control group given AOM/DSS with AIN-93G normal diet containing 0.1% Se (NSe), a low (0.02 ppm)-Se diet group (LSe) and a high (0.5 ppm)-Se diet group (HSe). Hematology was analyzed with a blood cell differential counter. Liver Se was analyzed by inductively coupled plasma-mass spectroscopy. Cell proliferation and apoptosis were determined by using proliferating cell nuclear antigen (PCNA) for proliferative activity and apoptotic index by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL), respectively. HSe group showed a low incidence of colonic tumor (64.7%), compared with the NSe positive control (75%) and LSe (77.8%) groups. In contrast, HSe group exhibited lower rate of PCNA-positive cells (39.3±6.9%) than positive control (64.3±0.3%) and LSe (57.3±2.9%) groups. In addition, apoptotic index of HSe group was higher than those of positive control and LSe groups. These results indicate that Se is a chemopreventive agent for colon carcinogenesis induced by AOM+DSS in male ICR mice.

Concomitant Glomus Tumor with CRPS in the Hand

Jeong, Hyeong Jun,Kim, Chan Mi,Yoon, Duck Mi,Yoon, Kyung Bong The Korean Pain Society 2013 The Korean Journal of Pain Vol.26 No.3

Glomus tumors are benign tumors that account for 1% to 5% of all soft tissue tumors of the hand and are characterized by a triad of sensitivity to cold, localized tenderness and severe paroxysmal pain. Paroxysmal pain is a symptom common not only in glomus tumors but also in CRPS, and the hand is one of the commonly affected sites in patients with both glomus tumors and CRPS. Therefore, it is not easy to clinically diagnose glomus tumors superimposed on already affected region of CRPS patients. We report a case of glomus tumor concomitantly originating with CRPS at the hand.

CNG 혼소율 변화에 따른 디젤엔진의 성능 및 연소 특성에 관한 연구

장형준(Hyeong-Jun Jang),이선엽(Sun-Youp Lee),김창기(Chang-Gi Kim),조정권(Jeong-Kwon Cho),임종한(Jong-Han Lim),윤준규(Jun-Kyu Yoon) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.5

전 세계적으로 천연가스 시장에서는 천연가스의 저열량화 추세로 뚜렷하게 변화되고 있다. 이러한 추세는 국내의 천연가스 열량기준에 변화를 가져왔으며, 낮은 열량의 천연가스 도입으로 인해 현재 사용되고 있는 가스기기의 성능에도 변화가 있을 것으로 예측된다. 따라서 본 연구에서는 혼소엔진의 연소특성을 파악하기 위해 CNG 혼소율 변화를 이용하여 열효율, 도시평균유효압력 변동계수 및 열방출 특성을 고찰하였다. CNG 혼소율은 투입되는 연료의 총합 대비 공급되는 천연가스연료의 에너지로 계산하여 천연가스연료가 디젤연료를 대체하는 비율로 정의하였다. 엔진 실험조건으로는 공급되는 천연가스의 발열량은 10,400 ㎉/N㎥이며, 1800 rpm/500 N·m의 엔진 운전조건에서 디젤연료의 분사시기는 BTDC 16°CA, 분사압력은 85 ㎫로 설정하여 엔진의 성능 및 연소 실험을 진행하였다. 엔진 실험결과로 CNG 혼소율이 변화함에 따라 공급되는 디젤 연료량 역시 변화하고, CNG 혼소율이 증가할수록 디젤 연료량이 감소함으로써 점화에너지가 줄어들어 점화지연기간이 길어지는 연소특성을 나타내며, 이로 인해 엔진의 열효율과 출력도 감소하는 경향을 보였다. 그러나 연소안정성은 5% 미만으로 안정적인 엔진의 연소상태를 보여 실험의 신뢰성을 확보할 수 있었다. In the international natural gas market, natural gas has markedly low calories. The domestic calories standard of natural gas was changed and the performance and efficiency of many industrial machines using natural gas were affected because of low caloric natural gas. Therefore, in this study, a dual fuel engine fueled with natural gas and diesel was tested to examine the effects of the CNG substitution rate on the combustion characteristics, such as thermal efficiency, COVimep and heat release rate. The CNG substitution rate was defined as the ratio of CNG instead of diesel, which was calculated as the total energy. The conditions of the tested engine were fixed 1800 rpm/500 N·m. In addition, diesel fuel was injected at 16°CA BTDC and the fuel pressure was fixed at 85 ㎫; the lower heating value of CNG was 10,400 ㎉/N㎥. The results of the engine test showed that the amount of diesel fuel was changed according to the CNG substitution rate. Therefore, when the substitution rate was increased, the amount of diesel fuel was decreased, which affected the energy for ignition. In addition, the ignition delay duration was increased, which affected the thermal efficiency and torque. On the other hand, the COVimep was less than 5% and a stable combustion state of the engine was shown.