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      • KCI등재

        기제와 피부투과촉진제가 아포모르핀의 피부투과에 미치는 영향

        최영근,최옥,김건남,박은석,지상철 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

        In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), Transcutol^??, Labrasol^??, Labrafac hydro WL^??, Labrafil WL 2609 BS^?? and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low (0.08-0.36㎍/㎠/hr), the combination of PG and Labrafac^?? increased it significantly. The permeation rates of apomophine from PG/Labrafac^?? mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of 18㎍/㎠/hr was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the PG/Labrafac^?? (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, 117㎍/㎠/hr, was attained with myristic acid.

      • Zn₁-xFexSe의 고유결함에 관한 연구

        박남천,송재홍,채건식,오재근,김영국,손인호 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-

        We studied the native defects of dilute magnetic semiconductors Zn₁-xFexSe epilayer by using SAW device. The energy gap of Zn₁-xFexSe for each epilayer(x=0.0213, 0.0915) was 2.57eV, 2.74eV at room temperature (294K). The trap level for x=0.0213, 0.0915 were calculated by measuring Transverse Acoustoelectric Voltage(TAV). Also we can calculated cross section.

      • 컴퓨터 赤外線 全身體熱撮影과 FNT을 통해 살펴본 Bell's palsy에 대한 침치료의 臨床的 考察

        尹敏永,趙恩嬉,許泰永,趙南根,文炯喆 한국전통의학연구소 2001 한국전통의학지 Vol.11 No.1

        Object : This study is designed to evaluate the clinical therapy of acupuncture by the data of DITI(Digital Infrared Thermographic Imaging) and FNT(Facial Nerve stimulation Test) examination and the changes of clinical symptoms after the therapy of acupuncture in the patients with Bell's palsy. Contents : The conservative therapy with acupuncture was performed during 1-8weeks. The acupuncture points of S4, S6, G14, S2, BL2, SI18, TE23, LI4 and S36 were used. In the pre- and post therapy, DITI examinations was performed in patients who had Bell's palsy and were treated by acupuncture, and then tried to correlate the results of clinical symptoms with the difference of thermographic findings. And FNT examinations were performed in the same patients above, and then tried to correlate the results of clinical symptoms with the difference of nerve response findings. Setting : The standard routine thermographic examination with thermography (DITI) and nerve response with FNT(Facial Nerve Stimulation Test) were performed in the 16 patients with Bell's palsy at pre- and post acupuncture. Patients : Thermographic imaging of 16cases was analyzed. They had diagnosed Bell's palsy. They were treated by acupuncture and moxibustion therapy in Wonkwang Oriental Hospital from Jauary, 1999 to February, 2000. Results : 1) The results of treatment showes that 56.25% of patients achieved clinical excellent recovery and 31.25% achieved good recovery. After compairing the DITI results before and after treatment, we found 43.75% of patients achieved excellent recovery and 43.75% achieved good recovery. 2) After compairing the FNT results before and after treatment, we found 25% of patients achieved excellent recovery and 56.25% achieved good recovery. Conclusion : 1) Acupuncture showed good results over 87.5% in clinical evaluation and 87.5% in DITI. Thermographic examination showes terapeutic effect of acupuncture treatment. 2) Acupuncture showed good results over 87.5% in clinical evaluation and 81.25% in FNT. FNT showes nerve response recovery effect of acupuncture treatment.

      • 영어 등위구조에서의 추출 현상

        이남근,정수영 조선대학교 인문학연구소 1998 外國文化硏究 Vol.21 No.1

        등위구문은 피접속요소가 서로 대등한 문법적 관계로 접속되는 구조로서 모든 언어에 산재하는 현상으로 많은 언어이론의 연구대상이 되어왔다. 그러나 등위구문을 분석함에 있어서 어떠한 시각에서 접근할 것인가에 대해 견해는 아주 다양하다. 현대 통사론에서 등위구문은 매우 중요한 문제로 다루어져 왔으며 가장 논란이 많은 문제 중의 하나일 것이다. 통사적인 제약이 가해져서 추출이 이루어진다고 판단하는 견해와 의미론적인 또는 화용론적인 관념들이 적용되어서 등위구문에서의 추출이 이루어진다는 견해등이 있다. Ross(1967)가 등위구조제약과 같은 조건을 제시한 이후로 지금껏 많은 학자들이 영어의 등위구조에서의 추출현상을 여러 각도에서 연구를 거듭하여 왔다. 그중에는 등위구조에서의 추출을 의미론적인 면과 화용론적인 면에서 접근하는 학자들이 많이 있다. 이 논문에서는 Lakoff(1986)나 Goldsmith(1985)와 같은 학자들의 의미론적인 입장과 Schmerling(1976)의 화용론적인 입장에서 영어에서의 등위구조의 추출현상을 다룬다. 영어의 등위구문에서의 추출 현상을 본석함에 있어서 이 세가지 측면에서의 분석을 논의하고 각각의 문제점을 제시하고자 한다. Coordinate structures consist of more than two conjuncts. Ross suggested that a conjunct cannot be moved and any element in a conjunct cannot be extracted from that conjunct. The first part of the Coordinate Structure Constraint, the Conjunct Constraint, prevents extraction of a whole conjunct, and the second part, the Element Constraint, prohibits extraction of any element in a conjunct. But not all languages follow that constraint. Ross admitted there is an exception : extraction out of conjuncts is possible only if the extraction is Across The Board. That is, the extraction out of coordinate structures is well-formed only if elements are extraction out of coordinate structures is well-formed only if elements are extracted out of all conjuncts. Violations of the Element Constraint are allowed just in case the ATB condition is met. But not all sentences follow the Coordinate Structure Constraint, the exception of that constraint being Ross's Across The Board. Thus, the fundamental problem is raised of whether the coordinate structure constraint really exists. On this, Goldsmith and Lakoff suggested that the extraction from the coordinate structure can be justified if coordinate sentences are related with some sort of semantic or pragmatic conditions instead of syntactic constraints. It is accepted that coordinate sentences have something to do with some semantic or pragmatic presuppositions like sequentiality.

      • KCI등재

        성장기 아동에서 전치부 개교의 치료증례 : A CASE FEPORT

        육근영,양규호,최남기,김선미 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

        전치부 개교는 중심 교합시 수직선상에서 상하악 전치간에 교합이 되지 않는 상태이며, 부정교합의 특성과 원인이 치료계획에 중요한 역할을 한다. 혼합 치열기에 전치부 개교의 치료 목적은 악습관을 조절하고 입 주위 근육의 비정상적인 기능을 제거하며, 악정형 장치를 통해 하악의 수직성장을 수평성장으로 전환하는 것이며, 치료 후의 안정성을 위해 계속적인 관찰이 필요하다. 본 증례에서는 혀내밀기 습관이 동반된 전치부 개교 환아의 치료를 위해 습관을 차단하는 tongue crib과 그 밖에 다양한 가철성 및 고정성 장치를 사용하여 양호한 결과를 얻었기에 보고하는 바이다. Anterior open bite is defined as the lack of contacts between the functional occluding teeth on vertical line at centric occlusion and classified into functional and skeletal anterior open bite based on its causes and characteristics. In mixed dentition, habit control and the elimination of abnormal perioral muscle function and moving the vertical direction development to the sagittal direction of the mandible by the functional appliance is a goal of treatment. This study presents the effective interception of oral habit by the tongue crib and functional-fixed treatment and treatment response of open bite related to tongue thrust habit.

      • KCI등재

        고대산 북서사면(경기도 연천군) 지역의 식물상 및 산림군락 분류에 관한 연구

        김남영,김흥식,김영설,김정유,박완근 江原大學校 森林科學硏究所 2004 Journal of Forest Science Vol.20 No.-

        2003년 3월부터 10월까지 고대산을 대상으로 식물상과 산림군락을 조사하였다. 관속식물은 94과 299속 481종 1아종 66변종 4품종 1교잡종으로 총 553종류인 것으로 나타났으며, 한국특산식물은 8과 11속 13종 총 13종류, 희귀 및 멸종위기식물은 12과 15속 15속 15종 총 15종류, 귀화식물은 9과 15속 17종 총 17종류로 나타났다. 산림군락은 신갈나무-철쭉군목, 신갈나무-생강나무군단, 갈참나무-신갈나무군락, 굴참나무-신갈나무군락, 당단풍-신갈나무군락으로 전체 1군목, 1군단, 3군락이 분포하는 것으로 나타났다. The study was carried out to investigate the flora and community classification of forest vegetation in Mt. Godae from March to October, 2003. As a result of that, the vascular plants were 94 families, 299 genera, 481 species, 1 subspecies, 66 varieties, 4 formae, 1 hybrid, 553 taxa in all; korean endemic plants were 8 families, 11 genera, 13 species, 13 taxa in all; rare or endangered plants were 12 families, 15 genera, 15 species, 15 taxa in all; naturalized plants were 9 families, 15 genera, 17 species, 17 taxa in all. forest vegetation was classified into 1 order, 1 alliance, 3 communities; Rhododendro - Quercetalia mongolicae (Kim 1990) Lindero - Quercion mongolicae (Kim 1990) A. Fraxinus rhynchophylla - Quercus mongolica Community B. Quercus variabilis - Quercus mongolica Community C. Acer pseudo-sieboldianum - Quercus mongolica Community

      • KCI등재

        생활치 미백제가 우치 법랑질의 투명도에 미치는 영향

        김동준,김영주,김학근,박은종,서은주,황윤찬,오원만,황인남 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.3

        본 연구에서는 현재 임상에서 home bleaching을 위해 사용되고 있는 표백 재료들이 치아 법랑질의 투명도에 어떠한 변화를 일으키는지 고찰해 보고자 시행하였다. 실험 대상으로는 하루 전 발거한 우치 (bovine tooth)를 사용하였다. 치아의 순면에 수직되게 다이아몬드 드릴을 이용해 수주 하에서 직경 6 mm의 원통형 치아 시편을 만들어 순면이 노출된 상태로 투명한 아크릭 레진에 포매한 후, low speed diamond saw (Isomat, Buehler Co., USA)를 사용하여 1.2 mm 두께로 절단하였다. 절단된 시편은 순면을 먼저 편평하게 연마하고,절단된 면을 연마하여 두께 1 mm의 시편을 완성하였다. 완성된 시편(우치 25개)을 무작위로 추출하여 3개의 그룹으로 나누고 나머지는 대조군으로 하였다. Opalescence (10% carbamide peroxide, Ultradent, Milford, USA), Rembrandt (10% carbamide peroxide, DenMat, USA) 및 Opalescence F(15% carbamide peroxide with fluoride, Ultradent)를 시편의 순면에 1주일 동안 적용 (표백제는 24시간마다 교체)하였고, 설측면은 증류수를 적신 거즈에 접촉된 상태로 보관하였다 표백제를 적용하기 전과 적용 3, 5, 7일째에 시편의 삼자극치 X, Y, Z 값을 색채색차계 (Color & Color Differencemeter, Model TC-6FX, Tokyo Denshoku Co., Japan)로 백색 배경판과 흑색 배경판 상에서 측정하였다 백색 배경판과 흑색 배경판 상에서 측정된 Y값의 평균값을 이용해 contrast ratio를 계산하였다 얻어진 값을 One Way Repeated Measured ANOVA를 이용하여 통계 처리한 결과 10% Opalescence처치군, 15% Opalescence-F처치군 및 대조군에서는 통계적으로 유의할만한 증감을 보이지 않았고, Rembrandt처치군에서는 Contrast ratio가 증가하였다 (p < 0.01) . This study was done to evaluate whether vital bleaching agents could influence on the translucency of the bovine enamel. The anterior bovine teeth that were extracted one day before and without any gross discoloration were obtained and then were preserved in physiologic saline. 6 mm cylindrical tooth specimens were fabricated with diamond puncher perpendicularly on labial surface of bovine tooth. After embedded in transparent acrylic resin with labial surface being exposed, they were cut to a thickness of 1.2 mm with low speed diamond saw (Isomat, Buehler Co., Lake Bluff, IL, USA). They were smoothly ground to 1 mm thickness of enamel with sandpaper. 24 specimens were randomly divided into 3 groups and control group respectively. Opalescence (10% carbamide peroxide, Ultradent, South Jordan, USA), Rembrandt (10% carbamide peroxide, DenMat, USA) and Opalescence F (15% carbamide peroxide with fluoride, Ultradent, USA) were applied on labial sides of the bovine enamel for 7 days (bleaching agents were reapplied every 24 hours) and the opposite surface was contacted to cotton that soaked in distilled water. The control group was soaked in distilled water. Three stimulus value X, Y and Z were evaluated with colorimeter (Color ' Color Differencerneter, Model TC-6FX, Tokyo Denshoku Co., Japan) on the labial surface of all specimen three times on white and black background plate before the bleaching agents were applied and on 3rd, 5th and 7th day after applied. The degree of translucency was normally assessed by measuring the inverse property, opacity (contrast ratio). 10% Opalescence, 15% Opalescence-F, and control group showed no significant variation in the translucency of bovine enamel, However Rembrandt decreased the translucency of it (p < 0.01).

      • CA 125치가 증가된 난소종괴 환자에서 악성 감별을 위한 CA 15-3과 TAG 72의 효용성

        이수미,김영탁,정동근,남주현,목정은 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

        The purpose of our study was to evaluate whether the combined use of serum tumor markers, CA 15-3 and TAG 72 could improve the efficacy for discriminating malignant from benign ovarian masses in patients with elevated serum CA 125 levels. Serum CA 15-3 and TAG 72 were preoperatively measured by immunoradiometric assay in 78 patients with pelvic masses who had elevated serum CA 125 levels above 35 U/ml. In 32 patients with epithelial ovarian cancers, serum CA 125 levels were elevated above 65 U/ml in 97% and serum CA 15-3(>30U/ml) and TAG 72(>10 u/ml) levels were elevated in 59% and 50%, respectively, suggesting relatively low sensitivity of CA 15-3 and TAG 72. However, in 41 patients with benign ovarian tumors, elevations of these two markers were detected only in 7% and 5%, respectively, and particularly, both markers were not elevated among all the aptients over 50 years of age. Coordinate elevations of CA 125(>35U/ml) and CA 15-3(>30U/ml) or TAG 72(>10 U/ml) could discriminate epithelial ovarian cancers from benign masses with a sensitivity of 72% and specificity of 90%. Among patients over 50 years of age, sensitivity and specificity were increased to 79% and 100%, respectively. It is concluded that the combined use of CA 15-3 and TAG 72 with CA 125 could obtain an improved efficacy for discrimination of epithelial ovarian cancer, especially among patients over 50 years of age.

      • 선형유도전자펌프내의 자기유체 유동에 관한 수치적 연구

        최훈기,유근종,박태봉,은재정,장남영 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

        Numerical analysis is performed for magnetic and MHD flow fields in Electro-Magnetic(EM) pump. A finite volume method is applied to solve magnetic field governing equations and the Navier-Stokes equations. Vector and scalar potential methods are adopted to obtain the electric and magnetic fields and the resulting Lorentz force in solving Maxwell equations. The magnetic field and velocity distributions are found to be influenced by the magnitude of the Reynolds number and the phase of applied electric current. Computational results indicate that the magnetic flux distribution with changing phase of electric current is characterized by a pair of counter-rotating closed loops. The velocity distribution of the flow field is influenced on the intensity of Lorentz force.

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