녹내장의 진단 경로

이관복(Kwan Bok Lee),김민경(Min Kyung Kim),김미진(Mi Jin Kim),안상일(Sang Il Ahn),황영훈(Young Hoon Hwang) 대한안과학회 2016 대한안과학회지 Vol.57 No.5

목적: 녹내장 환자들이 어떤 경로를 통해서 녹내장을 진단 받게 되는지 알아보고자 한다. 대상과 방법: 본원에서 녹내장을 처음 확진 받은 환자 484명(여 223명, 남 261명, 평균 나이 55.3세)을 대상으로 어떤 경로로 녹내장을 진단 받았는지 의무기록을 조사하였다. 진단 경로는 1) 녹내장 관련 증상 때문에 발견된 경우(안압 상승 관련 통증 또는 시각 증상이 녹내장 외에 다른 이상에 의해서 설명되지 않을 때), 2) 다른 증상 때문에 안과를 방문했다가 우연히 발견된 경우, 3) 건강검진에서 발견된 경우, 4) 녹내장 가족력 때문에 본인이 검사를 원한 경우로 나누었고, 안과진료와 건강검진에서 녹내장을 의심하게 된 이유는 1) 시신경유두 이상, 2) 높은 안압, 3) 두 가지 모두로 구분하였다. 결과: 녹내장 진단경로는 관련 증상 때문에 발견된 경우 11.8%, 안과에서 우연히 발견된 경우 74.2%, 건강검진에서 발견된 경우 12.4%, 본인이 원해서 발견된 경우 1.7%의 분포를 보였다. 안과진료와 건강검진에서 녹내장을 의심하게 된 이유는 시신경유두 이상 84.2%, 높은 안압 15.8%였고, 그중 7.4%는 시신경유두 이상과 높은 안압이 동반된 경우였다. 결론: 녹내장을 진단 받게 되는 가장 흔한 경로는 안과진료와 건강검진을 통한 시신경유두검사였다. 녹내장의 조기 진단을 위해서 정기적인 안과진료를 통한 시신경유두의 자세한 검사가 중요할 것으로 생각한다. Purpose: To evaluate the events leading to a diagnosis of glaucoma. Methods: Medical records of 484 subjects (223 women, 261 men, mean age, 55.3 years) who visited a glaucoma clinic without previous glaucoma diagnosis were reviewed. Events were classified into: 1) glaucoma-related symptoms, such as ocular pain accompanied by intraocular pressure elevation or visual disturbance without other ocular abnormalities except glaucoma, 2) ocular examination by an ophthalmologist for other symptoms, 3) routine health examination, or 4) patient request due to family history of glaucoma. Ocular findings that suggested glaucoma and led to detailed glaucoma assessment were classified as: 1) an optic disc abnormality, 2) high intraocular pressure, or 3) both. Results: Events that led to the diagnosis of glaucoma were glaucoma-related symptoms in 11.8%, examination by an ophthalmologist in 74.2%, routine health examination in 12.4%, and family history in 1.7% of subjects. Findings that suggested glaucoma in ocular and routine health examinations were an optic disc abnormality in 84.2% and high intraocular pressure in 15.8%, both of these findings were found in 7.4% of subjects. Conclusions: The most common path to glaucoma diagnosis was optic disc assessment by an ophthalmologist and routine health examination. To facilitate early detection of glaucoma, regular detailed optic disc evaluation by an ophthalmologist should be emphasized.

Profiles and Clinical Characteristics of Newly Diagnosed Glaucoma in Urban Korea: A Multicenter Study

홍철,홍승우,박찬기,성경림,김창식,Korean Glaucoma Society 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.5

Purpose: To explore the clinical characteristics and profiles of newly diagnosed glaucoma subtypes in urban Korea. Methods: All newly diagnosed glaucoma patients enrolled in the participating ophthalmology outpatient clinics were included. A review of medical history including family history of glaucoma was conducted. The patients underwent completeophthalmologic examinations including visual field test. The diagnosis of glaucoma was based on the International Society ofGeographical and Epidemiological Ophthalmology criteria developed by glaucoma specialists. Results: A total of 198,671 patients visited the participating ophthalmology outpatient clinics during the study period (fromJanuary 1, 2001 to June 30, 2016), of which 5,530 (2.8%) were diagnosed with glaucoma. The mean age of the newly diagnosedglaucoma patients was 52.0 ± 17.3 years (range, 6 to 89) and 2,830 patients were male (51.2%). The mean untreated intraocularpressure and vertical cup-to-disc ratio of the optic nerve head of newly diagnosed glaucoma eyes were 22.1 ± 10.6mmHg and 0.66 ± 0.22, respectively. The most frequently observed subtypes of glaucoma were: normal tension glaucoma(33.0%) primary open-angle glaucoma (28.4%), ocular hypertension (11.1%), chronic angle-closure glaucoma (6.8%), neovascularglaucoma (5.2%), glaucoma associated with inflammation (3.8%), acute angle-closure glaucoma (3.3%), and glaucomaassociated with aphakia or pseudophakia (2.2%). Conclusions: Normal tension glaucoma was the most frequently observed glaucoma subtype in urban ophthalmology outpatientclinics in Korea.

Clinical Evaluation of Unilateral Open-Angle Glaucoma: A Two-Year Follow-Up Study

남정우,강연수,성미선,박상우 전남대학교 의과학연구소 2021 전남의대학술지 Vol.57 No.2

To evaluate the clinical characteristics of unilateral open-angle glaucoma, patients diagnosed with unilateral open-angle glaucoma from January 2017 to October 2018 were divided into primary open-angle glaucoma and normal-tension glaucoma groups according to the type of glaucoma diagnosed. The glaucoma and the contralateral eyes were compared, and the contralateral eye was analyzed for conversion to glaucoma and its risk factors were assessed during the 2-year follow-up period. Among 99 patients, 36 were diagnosed with primary open-angle glaucoma and 63 with normal-tension glaucoma. When comparing the glaucoma eye with the contralateral eye, the visual field mean deviation value (all p<0.001), peripapillary retinal nerve fiber layer thickness (all p<0.001), macular ganglion cell layer-inner plexiform layer thickness (p< 0.001, p=0.003), and optic nerve cup-disc ratio (p=0.005, p<0.001) were significantly different in both the primary open-angle glaucoma and normal-tension glaucoma groups. In normal-tension glaucoma, peripapillary retinal nerve fiber layer thickness was significantly thinner in the glaucoma conversion group than in the glaucoma non-conversion group (p=0.008). It was significantly associated with glaucoma conversion (odds ratio=0.97, p=0.023). In conclusion, in patients with unilateral open-angle glaucoma, the contralateral eye may develop glaucoma. In particular, if the peripapillary retinal nerve fiber layer thickness is decreased in normal-tension glaucoma, the possibility of glaucoma conversion is high; hence, careful examination is required.

녹내장 유형에 따른 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도의 비교

주병주,황영훈,이주화,김태진,Byung Ju Choo,Young Hoon Hwang,Joo Hwa Lee,Tai Jin Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To compare the levels of serum homocysteine, vitamin B12, vitamin B6 and folate in patients with normal-tension glaucoma, pseudoexfoliation glaucoma and high-tension glaucoma. Methods: Thirty-two healthy subjects, 35 patients with normal-tension glaucoma, 22 patients with pseudoexfoliation glaucoma and 31 patients with high-tension glaucoma were included in the present study. Fasting venous samples were collected from all the participants. The levels of serum homocysteine, vitamin B12, vitamin B6 and folate were measured. One-way analysis of variance was used for the comparison of homocysteine, vitamin B12, vitamin B6 and folate levels among the 4 groups. Results: The mean homocysteine levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.91 ± 5.11 and 17.60 ± 3.89 μmol/l, respectively, which were significantly higher than that of the control group (p = 0.014, p = 0.013, respectively). The mean vitamin B6 levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.67 ± 14.32 and 17.00 ± 10.58 nmol/l, respectively, which were significantly lower than that of the control group (p = 0.026, p = 0.008, respectively). Conclusions: Hyperhomocysteinemia may play a role as a risk factor in the development or progression of pseudoexfoliation glaucoma and high-tension glaucoma.

개방각 녹내장 환자와 폐쇄각 녹내장 환자에서 녹내장 삼중수술의 효과

권계윤,배형원,이상엽,서상진,이윤하,홍사민,성공제,김찬윤 대한안과학회 2015 대한안과학회지 Vol.56 No.7

Purpose: To compare the surgical outcomes of triple procedure in patients with open-angle glaucoma and angle-closure glaucoma. Methods: The patients who underwent triple procedures for open-angle glaucoma and angle-closure glaucoma and were followed up for more than 1 year postoperatively were retrospectively reviewed. Preoperative and postoperative visual acuity, intraocular pressure (IOP), visual field mean deviation, refractive error, number of medications, and complications were analyzed. The effect of surgery on IOP reduction and refractive error correction was compared. Results: The IOP at 1 year postoperatively was 13.39 ± 2.25 mm Hg, 13.41 ± 2.79 mm Hg (p = 0.981) and IOP reduction was 4.51 ± 6.35 mm Hg, 9.11 ± 8.27 mm Hg (p = 0.042) in the open angle glaucoma group and angle closure glaucoma group,respectively. No patient in either group required reoperation due to uncontrolled IOP. The percentage of patients showing postoperative IOP reduction of at least 10% and 20% from baseline IOP was statistically higher in the angle-closure glaucoma group than in the open-angle glaucoma group. Prediction errors were -0.84 ± 0.88 D and -0.13 ± 0.65 D in the open-angle glaucoma group and angle-closure glaucoma group, respectively. Conclusions: Triple procedure was effective in reducing IOP in both open-angle glaucoma and angle-closure glaucoma patients. The patients with angle-closure glaucoma showed better results in IOP control and refractive error correction compared with patients with angle-closure glaucoma.

녹내장 환자에서 백내장 수술 후의 빛간섭단층촬영 지표에 영향을 미치는 인자

박문영,조윤혜 대한검안학회 2023 Annals of optometry and contact lens Vol.22 No.4

목적: 녹내장 환자에서 백내장 수술 후 시신경 및 황반 주위의 RNFL 및 BMO-MRW의 두께 변화와 녹내장의 타입에 따라 백내장 수술에 의한 차이가 있는지, 여기에 미치는 요인은 무엇인지에 대해 알아보고자 하였다. 대상과 방법: 68명의 녹내장 환자들이 포함되었으며 백내장 수술 전후 SD-OCT로 RNFL 및 BMO-MRW 두께 변화를 측정하였다. 폐쇄각과 개방각 녹내장 군으로 나누어 백내장 수술 전후 수치들을 비교하여 분석하였다. 결과: 피험자의 평균 나이는 71.72세였고, 남성 26명, 여성 42명, 개방각 녹내장은 35안, 폐쇄각 녹내장은 33안이었다. 백내장 수술 후 RNFL과 BMO-MRW 두께가 유의미하게 증가하였으며, 폐쇄각 녹내장군에서 백내장 수술 전의 시력이 유의미하게 좋았고, RNFL의 image Q값이 유의미하게 높았다. 다변량 선형 회귀 분석 상 RNFL의 두께 증가에 영향을 미치는 인자는 전체 녹내장 군과 개방각 녹내장 군에서 수술 전의 RNFL 두께였다. 즉, 백내장 수술 전에 RNFL 두께가 얇은 환자일수록 백내장 수술 후 RNFL의 두께가 증가하였다. 폐쇄각 녹내장 군에서는 수술 전 시력이 나쁠수록 수술 후 RNFL의 두께가 증가하였다. 반면 BMO-MRW 두께에 영향을 미치는 인자는 확인되지 않았다. 결론: 백내장 수술 후 RNFL 두께의 증가에 영향을 미치는 인자는 개방각 녹내장 군의 경우 수술 전의 RNFL 두께였으며, 폐쇄각 녹내장 군의 경우 수술 전 시력이었다. Purpose: The aim of this study was to investigate whether there are differences in the effects of cataract surgery based on the type of glaucoma and changes in the retinal nerve fiber layer (RNFL) thickness and Bruch's membrane opening-minimum rim width (BMO-MRW) thickness around the optic nerve and macula in patients with glaucoma. Furthermore, the factors influencing these effects were explored. Methods: 68 patients with glaucoma were enrolled, and changes in RNFL thickness and BMO-MRW before and after cataract surgery were measured using SD-OCT. The patients were divided into angle-closure and open-angle glaucoma groups and values before and after cataract surgery were analyzed. Results: The male-female ratio was 26:42, with an average age of 71.72 years at the time of surgery. There were 35 eyes with open-angle glaucoma and 33 eyes with angle-closure glaucoma. After cataract surgery, both RNFL and BMO-MRW values significantly increased. In the angle-closure glaucoma group, preoperative visual acuity was significantly better and RNFL image Q was significantly higher before cataract surgery. In a multivariate linear regression analysis, the factor influencing the increase in RNFL thickness was found to be the preoperative RNFL thickness in both the overall open angle glaucoma group and the angle closure glaucoma group. In other words, patients with thinner RNFL thickness before cataract surgery showed an increase in RNFL thickness after the surgery. In the angle closure glaucoma group, it was observed that worse preoperative visual acuity was associated with an increase in RNFL thickness after surgery. Conversely, no factors affecting BMO-MRW thickness were identified. Conclusions: The factors influencing the increase in RNFL thickness after cataract surgery were the preoperative RNFL thickness in open angle glaucoma group and the preoperative visual acuity in the angle closure glaucoma group.

한 눈 안면화염혈관종 녹내장 환아에서 무증상 반대 눈 안압과 유두함몰비에 대한 고찰

신영인(Young In Shin),김영국(Young Kook Kim),최수연(Sooyeon Choe),이윤정(Yun Jeong Lee),장미리내(Mirinae Jang),위서영(Seoyoung Wy),정진욱(Jin Wook Jeoung),박기호(Ki Ho Park) 대한안과학회 2021 대한안과학회지 Vol.62 No.12

목적: 편측 안면화염혈관종과 동측 녹내장이 있는 환아에서 무증상 반대 눈의 안압과 유두함몰비에 대해 고찰하고자 한다. 대상과 방법: 1996년 9월부터 2020년 5월까지 본원 소아안과에서 한쪽 눈 안면화염혈관종 녹내장을 진단받은 35명의 의무기록을 후향적으로 분석하였다. 무증상 반대 눈의 임상특성(즉, 안압과 유두함몰비)을 안면화염혈관종과 녹내장이 모두 없는 대조군(35명 35안)과 비교하였다. 결과: 한쪽 눈 안면화염혈관종 녹내장군의 녹내장 진단 시 평균 연령은 0.56 ± 0.99세(범위, 0.08-4세)였다. 녹내장 진단 시 반대 눈의 평균 안압은 16.68 ± 5.73 mmHg (범위, 9-22.9)였고, 유두함몰비는 0.37 ± 0.14 (범위, 0.15-0.80)였다. 마지막 진료 시(평균 연령, 11.2 ± 7.5세) 평균 안압은 14.14 ± 6.29 mmHg (범위, 8.1-26.7)였고, 유두함몰비는 0.37 ± 0.12 (범위, 0.26-0.82)였다. 대조군(평균 연령, 11.2 ± 7.4세)과 비교했을 때 평균 안압에는 유의한 차이가 없었으나(14.14 ± 6.29 mmHg vs. 14.57 ± 2.49 mmHg, p=0.712) 유두함몰비는 대조군에 비해 유의하게 컸다(0.37 ± 0.12 vs. 0.30 ± 0.08, p=0.014). 결론: 한쪽 눈 안면화염혈관종 녹내장을 진단받은 환아에서 무증상 반대 눈의 유두함몰비가 대조군에 비해 증가되어 있었다. 안면화염혈관종 녹내장이 한쪽 눈에서 진단된 경우 반대 눈에 녹내장 발생 위험이 증가하는지에 대한 후속 연구가 필요하다. Purpose: To investigate the clinical features of non-affected fellow eyes in patients with unilateral facial port-wine stain (PWS) and ipsilateral secondary glaucoma. Methods: We performed a retrospective analysis of the medical records of 35 patients with unilateral facial PWS glaucoma and those of controls (35 subjects without both facial PWS and glaucoma) between September 1996 and May 2020. We noted patients’ age at the glaucoma diagnosis (for unilateral facial PWS glaucoma patients) or at the initial examination (for controls), cup-to-disc ratio (CDR), and intraocular pressure (IOP). We compared the clinical features between the glaucoma-free eyes in patients with unilateral facial PWS glaucoma and the controls. Results: The mean age at the glaucoma diagnosis for unilateral facial PWS glaucoma patients was 0.56 ± 0.99 years (range, 0.08-4). The mean IOP of the glaucoma-free eyes was 16.68 ± 5.73 mmHg (range, 9-22.9), and the mean CDR was 0.37 ± 0.14 (range, 0.15-0.80) at glaucoma diagnosis. The mean IOP of the glaucoma-free eyes was 14.14 ± 6.29 mmHg (range, 8.1-26.7), and the mean CDR was 0.37 ± 0.12 (range, 0.26-0.82) at final examination. When comparing glaucoma-free eyes of the unilateral facial PWS glaucoma patients with the control group (mean age, 11.2 ± 7.4 years), the mean CDR was significantly greater (0.37 ± 0.12 vs. 0.30 ± 0.08; p = 0.014) but there was no significant difference in the mean IOP (14.14 ± 6.29 mmHg vs. 14.57 ± 2.49 mmHg; p = 0.712). Conclusions: The glaucoma-free eyes of unilateral facial PWS glaucoma patients showed greater CDR compared to the non-facial PWS and non-glaucoma controls. Additional longitudinal studies are needed to investigate the clinical course of those eyes, whether the risk of developing glaucoma is increased.

일차의료 영역에서의 녹내장 검진

조지현,이혜원,송호연,조동영,유병연 大韓家庭醫學會 1994 Korean Journal of Family Medicine Vol.15 No.9-10

안면화염혈관종 환자에서의 녹내장 발생양상 및 치료

김미진(Mi Jin Kim),이원준(Won June Lee),박기호(Ki Ho Park),김태우(Tae-Woo Kim),이은지(Eun Ji Lee),유영석(Young Suk Yu),정진욱(Jin Wook Jeoung) 대한안과학회 2017 대한안과학회지 Vol.58 No.11

목적: 안면화염혈관종 환자의 녹내장 발생여부 및 시기, 치료방법에 대해 알아보고자 하였다. 대상과 방법: 2000년 1월부터 2016년 8월까지 안면화염혈관종 환자 58명 116안을 대상으로 후향적으로 의무기록을 분석하였다. 환자 들의 초진 시 연령, 시신경유두함몰 비율, 각막 직경 및 안압 상승여부, 녹내장의 발생여부와 시기, 치료 방법 등을 조사하였다. 녹내장이 발생한 눈과 녹내장이 발생하지 않은 눈의 임상적 특징을 비교하였으며, 추가적으로 녹내장이 발생한 눈 중에서 수술을 받은 눈과 그렇지 않은 눈으로 나누어 그 차이를 비교하였다. 결과: 안면화염혈관종 환자 58명 116안 중에서 녹내장을 진단 받은 것은 38명 46안(39.66%)이었고, 이 중에서 녹내장 수술을 시행한 경우는 26명 27안(58.69%)이었다. 대상환자 58명 중 19명(32.76%)에서 경련, 발달지연, 정신지체, 편마비 등의 신경학적 증상을 동반 하고, 32명(55.17%)에서 스터지-웨버증후군을 진단 받았다. 안면화염혈관종과 연관된 녹내장은 2세 이전에 대부분 발병하였고 (85.61%), 모든 환자에서 녹내장이 발생한 눈과 같은 방향에서 안면화염혈관종을 보였다. 녹내장 수술의 평균 횟수는 1.55 ± 0.93회로 첫 수술로 섬유주절개술 7안(25.93%), 섬유주절제술 5안(18.52%), 섬유주절개술 및 섬유주절제술의 병합 13안(48.15%), 방수유출 장치삽입술 2안(7.41%)을 시행하였다. 첫 수술나이는 평균 35.14 ± 50.91개월이었고, 27안 중에서 18안(66.67%)은 수술 후 안압이 21 mmHg 미만으로 조절되었으나 9안(33.33%)은 안압 상승으로 추가적인 녹내장 수술을 시행하였다. 결론: 안면화염혈관종 환자에서는 안압이 상승하거나 녹내장이 동반될 수 있으므로 정기적인 안과검진이 필요하다. 또한 발생하는 녹내장은 약물치료에도 안압을 조절하기 어려운 경우가 있으며, 이 경우 적절한 녹내장 수술 시행이 필요하다. Purpose: To characterize the development of glaucoma, age of glaucoma onset, and treatments for patients with a facial port-wine stain (PWS). Methods: We performed a retrospective analysis of the medical records of 58 patients (116 eyes) with facial PWS between January 2000 and August 2016. We noted patients’ age at the initial examination, cup-to-disc ratio, corneal diameter, occurrence of ocular hypertension, development of glaucoma, age of glaucoma onset, and treatments. We compared the clinical features of eyes that developed glaucoma with those that did not develop glaucoma. Among those eyes with glaucoma, we investigated the differences between eyes that underwent surgery and those that did not undergo surgery. Results: Among the 58 patients with a facial PWS (116 eyes), glaucoma was diagnosed in 38 patients (46 eyes; 39.66%). Of these, 26 patients (27 eyes; 58.69%) underwent glaucoma surgery. PWS-associated glaucoma usually developed by the age of 2 years (85.61%). In all patients, glaucoma developed on the same side of the face as the PWS. Of the 58 patients, 19 (32.76%) showed neurological symptoms, including seizures, developmental delays, intellectual disabilities, or hemiplegia, and 32 (55.17%) were diagnosed with Sturge-Weber syndrome. The mean number of glaucoma surgeries was 1.55 ± 0.93. The initial surgery included trabeculectomy (7 eyes), trabeculotomy (5 eyes), combined trabeculotomy/trabeculectomy (13 eyes), and aqueous drainage device insertion (2 eyes). The mean age at the first surgery was 35.14 ± 50.91 months. In 18 of 27 eyes (66.67%), the postoperative intraocular pressure (IOP) was controlled to below 21 mmHg, but 9 eyes (33.33%) showed elevated IOP and required a reoperation. Conclusions: PWS can be accompanied by ocular hypertension or glaucoma, so patients require regular ophthalmic examinations. When glaucoma occurs, it often does not respond to medication, making it difficult in some cases to control the IOP, so appropriate glaucoma surgery is necessary. J Korean Ophthalmol Soc 2017;58(11):1234-1241

안압상승으로 의뢰된 환자들의 원인 질환 및 치료 경과

홍현규(Hyunkyu Hong),김성진(Sungjin Kim),김고은(Ko Eun Kim) 대한안과학회 2018 대한안과학회지 Vol.59 No.10

목적: 1차 병원에서 안압상승으로 의뢰된 환자들의 원인 질환 및 임상 양상에 대해 알아보았다. 대상과 방법: 2016년 7월부터 2017년 7월까지 안압상승으로 본원에 의뢰된 환자들의 의무기록을 후향적으로 조사하였다. 골드만압평안압계로 측정한 치료 전 안압이 22 mmHg 이상이면서 본원에서 치료 후 6개월까지 경과관찰한 환자들을 대상으로 하였다. 안압상승을 유발한 기저 질환별 유병률 분석 및 일차녹내장과 이차녹내장군의 특징을 비교 분석하였다. 결과: 총 127명의 환자들의 평균 나이는 59.3 ± 16.8세였고, 치료 전 평균 안압은 31.7 ± 10.5 mmHg였다. 안압상승의 원인으로 고안압증이 22.0%, 일차녹내장이 31.5%, 이차녹내장이 46.5%를 차지하였고, 일차녹내장 중 원발개방각녹내장(20.5%)이, 이차녹내장 중 안염증에 의한 녹내장(12.6%)이 가장 높은 비율을 보였다. 양 군 비교 시 치료 후 6개월까지의 안압하강률은 비슷하였으나(52.1% vs. 53.9%, p=0.603), 이차녹내장군은 안압하강제 이외의 약물 및 수술을 시행한 비율이 일차녹내장군에 비해 유의하게 높았다(p<0.05). 치료 후 시력 호전 정도는 이차녹내장군에서 유의하게 더 컸으나(p=0.004), 6개월째 안전수지 이하의 시력을 보인 환자의 비율은 이차녹내장군에서 유의하게 더 높았다(p=0.027). 결론: 안압상승의 원인은 다양하며, 기저 질환에 따라 치료 방법 및 예후에 차이가 있으므로, 초진 시 안압상승의 원인 감별에 주의를 기울여야 할 것으로 사료된다. Purpose: To investigate the underlying causes and clinical characteristics of patients referred with intraocular pressure (IOP) elevation. Methods: We retrospectively reviewed the medical records of patients who were referred with IOP elevation from July 2016 to July 2017. Patients with baseline IOP ≥ 22 mmHg and those who were treated and followed up for 6 months were included. The prevalence rates of the underlying diseases that caused IOP elevation were evaluated and the clinical characteristics were compared between patients with primary and secondary glaucoma. Results: A total of 127 patients were included (mean age, 59.3 ± 16.8 years; baseline IOP, 31.7 ± 10.5 mmHg). Among the study participants, 22.0%, 31.5%, and 46.5% had been diagnosed with ocular hypertension, primary glaucoma, and secondary glaucoma, respectively. Among the causes of IOP elevation, open-angle glaucoma (20.5%) had the highest prevalence rate among those with primary glaucoma and inflammation-related glaucoma (12.6%) was the most prevalent cause among those with secondary glaucoma. In a comparison between patients with primary and secondary glaucoma, the percentage of IOP reduction was not significantly different at 6 months after treatment (52.1% vs. 53.9%, p = 0.603). However, the rate of patients treated with drugs other than IOP lowering agents or who underwent surgery was significantly higher in the secondary glaucoma group compared with the primary glaucoma group (all p < 0.05). At 6-month follow-up, the secondary glaucoma group showed significantly higher improvement rates of visual acuity (p = 0.004), but had a larger proportion of patients with a visual acuity of less than or equal to finger count (p = 0.027). Conclusions: Treatment and visual outcome can vary depending on the underlying cause of IOP elevation. Therefore, a thorough examination for determining the cause of IOP elevation is recommended at the initial stage.