Colorectal Neoplasm in Asymptomatic Average-risk Koreans: The KASID Prospective Multicenter Colonoscopy Survey

( Hye Won Park ),( Jeong Sik Byeon ),( Suk Kyun Yang ),( Hyun Soo Kim ),( Won Ho Kim ),( Tae Il Kim ),( Dong Il Park ),( Young Ho Kim ),( Hyo Jong Kim ),( Moon Sung Lee ),( Il Kwon Chung ),( Sung Ae J 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.1

Background/Aims: The incidence of colorectal cancer is increasing in Korea, but the epidemiology of colorectal neoplasm is not clearly defined. We aimed to elucidate the prevalence of colorectal neoplasm in average-risk Koreans and explore the underlying risk factors. Methods: A large-scale, multicenter, prospective study was conducted. Of the 19,460 subjects who underwent colonoscopy at 11 university hospitals, we analyzed 3,951 consecutive asymptomatic adults with no risk factors for colorectal cancer. Results: The subjects were aged 52.1±11.6 years (mean±SD) and 60.1% of them were men. The prevalences of colorectal neoplasm and advanced neoplasm were 33.3% and 2.2%, respectively. The prevalence of a neoplasm increased with age (trend: p<0.001) and was higher in males (p<0.001). The prevalence of a proximal neoplasm was higher in subjects with a distal neoplasm than in those without a distal neoplasm (11.9% vs. 5.4%, p<0.001). However, 150 (52.1%) of the 288 subjects with a proximal neoplasm had no distal neoplasm. Conclusions: The overall prevalence of colorectal neoplasm in asymptomatic average-risk Koreans is comparable with that in Western countries. Being male and older are associated with a higher risk of colorectal neoplasm. Over half of proximal neoplasms are not associated with any distal sentinel lesions. (Gut and Liver 2009;3:35-40)

Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm

( Hyuk Yoon ),( Nayoung Kim ),( Cheol Min Shin ),( Hye Seung Lee ),( Bo Kyoung Kim ),( Gyeong Hoon Kang ),( Jung Mogg Kim ),( Joo Sung Kim ),( Dong Ho Lee ),( Hyun Chae Jung ) 대한소화기학회 2016 Gut and Liver Vol.10 No.2

Background/Aims: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. Methods: We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. Results: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 highgrade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sexmatched patients without metachronous gastric neoplasms (p=0.020). Conclusions: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms. (Gut Liver 2016;10:228-236)

췌장 점액낭성종양 41예의 임상 및 조직 소견

김종철 ( Jong Cheol Kim ),김명환 ( Myung Hwan Kim ),이태윤 ( Tae Yoon Lee ),김지영 ( Ji Young Kim ),한정혜 ( Jeung Hye Han ),박수정 ( Soo Jung Park ),이상수 ( Sang Soo Lee ),서동완 ( Dong Wan Seo ),장세진 ( Sei Jin Jang ),이성구 ( 대한소화기학회 2008 대한소화기학회지 Vol.51 No.1

목적: 점액낭성종양은 최근 진단 예가 증가되고 있다. 이번 연구에서는 점액낭성종양의 임상 특징들을 알아보고, 또한 비침습 낭성종양과 침습 낭성종양의 임상 차이 및 수술 후 경과와 예후에 관해서 알아보고자 하였다. 대상 및 방법: 1995년 1월부터 2004년 12월까지 서울아산병원에서 췌장의 점액낭성종양으로 수술을 시행 받은 41예를 대상으로 환자의 증상, 수술방법, 병리, 검사실 소견, 장기생존율 등을 후향적인 방법으로 조사하였다. 결과: 병리 소견으로는 총 41예 중 선종이 33예, 경계 병변이 1예, carcinoma in situ가 1예, 침습 종양이 6예였다. 여자가 남자보다 약 4배 많았으며 평균연령은 49세였다. 우연히 발견된 경우가 가장 많았고 증상으로는 복통이 16예로 가장 많았다. 종양의 가장 흔한 위치는 미부였다. 침습 종양과 비침습 종양 간에 의미 있는 차이를 보인 인자는 복통, 종양의 크기와 벽재결절이었다. 치료성적은 비침습 종양은 수술 후 추적관찰 기간 동안 모두 생존하였고 침습 종양에서는 6예 중 2예에서 사망하였다. 결론: 점액낭성종양에서 침습 종양을 시사하는 임상 인자는 크기와 복통이다. 비침습 종양은 수술 후 예후가 매우 좋으므로 적극적인 치료가 요구되며 평균 42개월 추적 결과 재발예가 없었다. Background/Aims: Intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms are included in mucin-producing pancreatic tumors. The reports about IPMN are not uncommon but those about the mucinous cystic neoplasms are relatively few. The aims of this study were to define the natural history of resected mucinous cystic neoplasms of the pancreas and to identify the findings which suggest malignancy. Methods: The authors retrospectively evaluated the clinical outcomes of 41 patients with mucinous cystic neoplasms who were surgically resected at Asan Medical Center between 1995 and 2004. Results: Women (n=33) were more frequently affected than men (n=8). Thirty three patients (80.6%) had adenoma, 1 (2.4%) borderline malignancy, 1 (2.4%) carcinoma in situ, and 6 (14.6%) invasive mucinous cystadenocarcinoma. The most frequent symptom was abdominal pain (39%). About half of the enrolled patients were asymptomatic. Unilocular type (79%) was more frequent than the multilocular type (21%) on gross morphology. The tumor size of invasive mucinous cystic neopolasms was larger than that of non-invasive mucinous cystic neoplalsms (p=0.01). Abdominal pain was more frequent in invasive mucinous cystic neoplasms (p=0.026). On gross morphology, mural nodules were detected in 4 of 6 patients with invasive mucinous cystic neoplasms. However, they were not detected in any patients with non-invasive mucinous cystic neoplasms. Recurrence developed in none of the 35 patients with non-invasive mucinous cystic neoplasms, however 2 of the 6 patients with invasive mucinous cystic neoplasms died within 5 years. Conclusions: Clinical predictors of invasive mucinous cystic neoplasms are suggested to be tumor size and abdominal pain. The prognosis of the non-invasive mucinous cystic neoplasms is excellent when curative resection is performed. (Korean J Gastroenterol 2008;51:34-39)

Pathologic characteristics of histiocytic and dendritic cell neoplasms

Sun Och Yoon 대한혈액학회 2024 Blood Research Vol.59 No.2

Histiocytic and dendritic cell neoplasms comprise diverse tumors originating from the mononuclear phagocytic system, which includes monocytes, macrophages, and dendritic cells. The 5th edition of the World Health Organization (WHO) classification updating the categorization of these tumors, reflecting a deeper understanding of their pathogenesis. In this updated classification system, tumors are categorized as Langerhans cell and other dendritic cell neoplasms, histiocyte/macrophage neoplasms, and plasmacytoid dendritic cell neoplasms. Follicular dendritic cell neoplasms are classified as mesenchymal dendritic cell neoplasms within the stroma-derived neoplasms of lymphoid tissues. Each subtype of histiocytic and dendritic cell neoplasms exhibits distinct morphological characteristics. They also show a characteristic immunophenotypic profile marked by various markers such as CD1a, CD207/langerin, S100, CD68, CD163, CD4, CD123, CD21, CD23, CD35, and ALK, and hematolymphoid markers such as CD45 and CD43. In situ hybridization for EBV-encoded small RNA (EBER) identifies a particular subtype. Immunoprofiling plays a critical role in determining the cell of origin and identifying the specific subtype of tumors. There are frequent genomic alterations in these neoplasms, especially in the mitogen-activated protein kinase pathway, including BRAF (notably BRAF V600E), MAP2K1, KRAS, and NRAS mutations, and ALK gene translocation. This review aims to offer a comprehensive and updated overview of histiocytic and dendritic cell neoplasms, focusing on their ontogeny, morphological aspects, immunophenotypic profiles, and molecular genetics. This comprehensive approach is essential for accurately differentiating and classifying neoplasms according to the updated WHO classification.

무증상 한국인에서 대장 종양의 유병률 및 대장암 선별검사로서 대장내시경 검사의 역할

장혜숙 ( Hye Sook Chang ),최재원 ( Jae Won Choe ),양석균 ( Suk Kyun Yang ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),이진혁 ( Gin Hyug Lee ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( Young Il Min ) 대한장연구학회 2003 Intestinal Research Vol.1 No.2

목적: 최근 대장암의 선별검사로서 대장내시경 검사의 중요성이 강조되고 있으나, 이에 대한 국내 연구는 미비하다. 저자들은 무증상 한국인에서 대장 종양의 유병률을 알아보고, 대장암의 선별검사로서 대장내시경 검사의 역할에 대해 알아보고자 하였다. 대상 및 방법: 1998년 3월부터 2002년 7월까지 서울아산병원 건강증진센터에서 대장내시경 검사를 시행받은 3,325명의 검진자 중 직장 출혈, 최근 배변 습관의 변화, 대장암 또는 용종의 가족력이나 과거력, 염증성 장질환이나 대장 수술의 과거력 및 지난 10년 이내에 대장 내시경 검사나 대장조영술을 시행받은 적이 있는 환자 1,106명 및 대장내시경 검사가 불완전하게 시행된 11명을 제외한 2,208명을 대상으로 대장 종양의 빈도와 특성을 분석하였다. 결과: 대상군의 평균 나이는 49.2±10.1세였으며, 남자가 1,564명(70.8%)이었다. 대장 종양의 유병률은 선종 18.3%, 진행성 선종 2.0%, 대장암 0.3%이었으며, 50세 이상의 경우에는 각각 25.8%, 3.0%, 0.5%이었다. 남녀 모두 연령이 증가할수록 대장 선종, 진행성 선종 및 대장암의 빈도가 증가하였으며(p for trend<0.05), 여자보다 남자에서 대장 선종의 유병률이 유의하게 높았다(21.0% vs 12.0%, p<0.001). 한편 근위부 대장에서 종양이 발견될 확률은 원위부 대장에 종양이 있는 경우 26.0% (53/2004)로서 원위부 대장에 종양이 없는 경우의 10.3% (207/2004)보다 유의하게 높았다(p<0.001). 그러나 근위부 대장에서 관찰되는 진행성 종양의 69.2% (18/26)가 원위부 대장에 이상이 없이 고립성으로 존재한 경우였다. 결론: 무증상 한국인에서 대장 종양의 유병률은 서양에 비해 다소 낮은 경향이 있으며 또한 남녀 사이에 차이를 보인다. 따라서 한국에서의 대장암 선별검사의 지침을 마련하는데 있어 이러한 점들이 고려되어야 할 것이다. 한편 원위부 대장에 종양이 있는 경우에는 그렇지 않은 경우에 비해 근위부 대장에서 종양이 발견될 확률이 높아지지만, 원위부 대장에 종양이 있는 경우에만 대장내시경 검사를 할 경우 근위부 진행성 종양의 약 2/3를 놓치게 된다. 따라서 대장암 선별 검사로서 대장내시경 검사는 매우 유용한 것으로 생각된다. Background/Aims: Recent studies have reported the importance of screening colonoscopy for colorectal cancer. However, the prevalence of colorectal neoplasms in asymptomatic Korean population has not been determined until now. The purpose of this study was to evaluate the prevalence of colorectal neoplasms in asymptomatic Korean population and to assess the role of colonoscopy in colorectal cancer screening. Methods: We reviewed the endoscopic and pathologic reports of 3,325 patients who underwent colonoscopy at the Health Promotion Center, Asan Medical Center, from 1998 to 2002. Of them, 2,208 asymptomatic patients who underwent colonoscopy for the purpose of colorectal cancer screening were enrolled. Results: The mean age was 49.2 years and 70.8% were men. The overall prevalence of colorectal neoplasms was 18.6% and the prevalence among patients 50 years of age or older was 26.3%. The prevalence of neoplasms increased with age and was higher in the male. Patients with distal neoplasms were more likely to have proximal neoplasms than those without distal neoplasms. However, 69.2% of the patients with advanced proximal neolplasms had no synchronous distal neoplasms. Conclusions: The prevalence of colorectal neoplasms in asymptomatic average-risk Koreans seems to be lower than that in corresponding Westerns and shows a gender-difference. These results should be considered when establishing a guideline for colorectal cancer screening in Korea. Over half of the patients with advanced proximal neoplasms will not be detected if only those with distal neoplasms undergo colonoscopic screening. Therefore, colonoscopy may be useful as a screening test for colorectal cancer. (Intestinal Research 2003;2:179-185)

초음파유도 중심부바늘생검 결과 유두종양 환자에서의 유방암의 예측요소

이성훈(Sung Hoon Lee),우상욱(Sang Uk Woo),이혜정(Hye Jung Lee),김우영(Woo Young Kim),이재복(Jae Bok Lee) 대한종양외과학회 2012 Korean Journal of Clinical Oncology Vol.8 No.2

목적 : 유방의 유두상 병변은 양성 종양의 10%미만이며, 모든 악성종양의 0.5~0.2%를 차지한다. 중심부바늘생검에서 유방의 유두종양으로 진단된 경우 외과적 절제의 필요성에 있어서는 현재까지 논란이 있다. 이에 중심부바늘생검 결과 유두종양으로 진단되고 절제생검을 시행한 환자에서 유방암의 예측인자를 연구하였다. 대상과 방법 : 2009년 6월부터 2012년 6월까지 고려대학교 구로병원 외과에서 초음파유도하 중심부바늘생검 결과 유두종양과 비정형 유두종으로 진단되고 절제생검을 시행한 97예를 대상으로 하였다. 수술 전 중심부바늘생검과 수술 후 조직병리 소견에서 종양의 특성 및 크기를 분석하였다. 결과 : 97에 모두 여성이었으며 평균 연령은 45.1(16~68)세였다. 최종 조직검사결과 유두종양과 악성종양 환자의 평균 연령의 차이는 없었다. 중심부바늘생검에서 유두종양이였던 71예 중 절제생검의 최종조직검사 결과는 64(90.1%)예는 유두종양, 7(9.9%)예, 4(22.2%)예 및 7(38.9%)예로 유의한 차이가 있었다(P=0.001). 증상에서는 중심부바늘생검에서 유두종양인 경우에는 촉지성 종괴에서 유의하게 악성 종양이 많았다(P=0.03). 초음파 측정 종양의 크기가 1.5cm이상일 때 유의하게 악성 종양이 많았다(P=0.005). 중심부 바늘생검에서 유두종인 경우는 최종조직검사 결과 양성과 악성종양에서 초음파 측정 종양의 크기에서는 유의한 차이가 없었으나, 절제 후 최종조직 검사에서는 유의한 크기의 차이가 있었다(P=0.19, 0.002). 중심부바늘생검에서 비정형 유두종양인 경우에서는 초음파 측정 종양의 크기와 최종조직 크기에서 모두 유의한 차이가 있었다. (P=0.003, 0.019). 중심부바늘생검에서 유두종양인 경우 BIRAD 분류에 의한 분석결과 유의한 차이가 보였으나 (P=0.023), 비정형 유두종양에서는 유의한 차이가 없었다. 다변량 분석에서는 초음파 측정 종양크기가 1.5cm 을 초과한 경우에서만 유의한 결과를 보였으며 (P=0.45, OR=2.4 95% CI 0.16-0.95). 결론 : 중심부바늘생검 결과 비정형 유두종양의 절제생검의 필요성을 본 연구에서 다시 한번 확인할 수 있었다. 중심부바늘생검에서 조직병리 결과가 유두종양이라도 1.5cm이상이거나 촉지성 병변이거나, 영상의학적 소견과 중심부바늘생검의 결과에 불일치가 있는 경우에는 외과적 절제생검이 필요하다고 생각된다. Purpose : The breast papillary neoplasm was constituted approximately less than 10% of benign breast tumor and 0.5-20% of breast malignancy. The role of excisional biopsy for papillary neoplasm was diagnosed by core biopsy has been debated yet. The aims of this study were to evaluate the predictive factors of breast cancer after the pathologic result of core biopsy revealed papillary neoplasm. Materials and Methods : We analyzed the clinical and pathologic data of 97 patients who underwent breast excisional biopsy after the pathologic result of core biopsy revealed papillary neoplasm between June 2009 and June 2012 at the Guro Hospital of the Korea University Medical Center. Results : We found statistically significant differences of excisional biopsy results for malignancy between papillary neoplasm and atypical papillary neoplasm diagnosed by core biopsy (P=0.001). Malignancy was found to be significantly related to be palpable mass, Breast Imaging Reporting and Data System (BIRADs) when papillary neoplasm without atypia was present in the core biopsy (P=0.03, 0.023). There were no significant differences of tumor size between benign and malignancy which was measured by ultrasonogram in the papillary neoplasm without atypia. However, there were statistically significant differences of pathologic tumor size in the papillary neoplasm without atypia (P=002). All of pathologic and ultrasonogram tumor size were larger than in the malignancy with atypical papillary neoplasm diagnosed core biopsy. In the multivariate analysis, There was significantly higher in the case of ultrasonogram measured tumor size more than 1.5cm (P=0.45, OR+2.4 95% Cl 0.16~0.95). Conclusion : The excisional biopsy should be considered if the core biopsy had revealed atypical papillary neoplasm. We might suggest that excisional biopsy underwent in the papillary neoplasm without atypia with the case of the ultrasonogram measured tumor size more than 1.5cm and the existence of dis-concordance between radiologic findings and core biopsy pathologic result.

검색용 MeSH 필터와 단어인접탐색 기법을 활용한 KoreaMed 검색 효율성 향상 연구

정소나(So-Na Jeong),정지나(Ji-Na Jeong) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.5

의학학술문헌에는 해부학적 조직이나 기관명이 종양, 질환 또는 감염 용어들과 서로 조합하여 사용되는 언어적 특성을 가지고 있다. 의학학술문헌을 검색할 때 데이터베이스가 제공하는 통제어휘도구인 Medical Subject Headings (MeSH)를 활용하면 합성어, 동의어, 그리고 관련어를 추가로 검색할 수 있어 검색효율이 높다. 본 연구에서는 위암(Stomach Neoplasms) 어휘군을 검색용 필터로 추가하는 방법과 동시출현용어의 거리를 측정하여 단어인접탐색 기법으로 검색효율성을 향상시키는 연구를 수행하였다. 검색용 MeSH에 추가할 어휘군을 결정하기 위해 실험데이터로 PubMed에서 중심주제어가 “Stomach Neoplasms”인 2007년∼2016년 논문 8,625편을 내려 받아 논문제목으로부터 Stomach와 Neoplasms 관련 용어의 동시출현여부를 분석하였다. 검색효율성은 KoreaMed에서 검색되는 MEDLINE 학술지를 대상으로 “Stomach Neoplasms”가 MeSH로 색인되어 있는 277편으로 검증하였는데 MEDLINE MeSH, MeSH on Demand, 그리고 KoreaMed MeSH Indexer의 “Stomach Neoplasms” 색인어 추출여부와 검색용 필터로 어휘군을 적용했을 때, 그리고 동시출현 용어의 단어인접검색 기법을 적용했을 때 “Stomach Neoplasms”의 매칭여부를 비교하였다. 가장 출현빈도가 높은 용어는 “Gastric Cancer”로 2,780회 출현하였다. “Gastric Adenocarcinoma”, “Gastric MALT Lymphoma” 등과 같이 “Stomach” 용어와 “Neoplasms" 관련 조직학적 용어가 조합된 경우는 7,376개(88.51%)였다. 동시출현 거리가 2단어인 용어는 “Stomach”와 “Neoplasms”의 합성어로 5,234개(70.95%)였다. 연구 결과 MeSH용어를 제외하고 973개의 용어를 후보어휘군으로 선정하였다. MEDLINE MeSH와 KoreaMed MeSH Indexer의 MeSH 매칭률은 209편(75.5%)이었는데 검색필터를 적용한 결과 263편(94.9%)으로, 동시출현 용어의 13단어 단어인접탐색 기법을 적용한 경우 268편(96.7%)으로 매칭률이 향상되었다. 본 연구를 통해 자연어 검색에 있어서 검색효율을 향상시키는 수단으로 검색용 시소러스를 사용하면 색인비용에 대한 부담이 적고, 통제어의 망라적 장점과 자연어가 가지는 용어의 특정성을 유지할 수 있음을 증명하였다. 또한 불리안 검색보다는 단어인접탐색 기법을 활용하면 정확률을 높일 수 있어 검색 효율성이 향상됨을 알 수 있었다. This study examined the method for adding related to “stomach neoplasms” as filters to the Medical Subject Headings (MeSH) for search as well as a method for improving the search efficiency through a word-proximity search by measuring the distance of co-occurring terms. A total of 8,625 articles published between 2007 and 2016 with the major topic terms “stomach neoplasms” were downloaded from PubMed article titles. The vocabulary to be added to the MeSH for search were analyzed. The search efficiency was verified by 277 articles that had “Stomach Neoplasms” indexed as MEDLINE MeSH in KoreaMed. As a result, 973 terms were selected as the candidate vocabulary. “Gastric Cancer” (2,780 appearances) was the most frequent term and 7,376 compound words (88.51%) combined the histological terms of “stomach” and “neoplasm”, such as “gastric adenocarcinoma” and “gastric MALT lymphoma”. A total of 5,234 compounds words (70.95%), in which the co-occurring distance was two words, were found. The matching rate through the MEDLINE MeSH and KoreaMed MeSH Indexer was 209 articles (75.5%). The search efficiency improved to 263 articles (94.9%) when the search filters were added, and to 268 articles (96.7%) when the 13 word-proximity search technique of the co-occurring terms was applied. This study showed that the use of a thesaurus as a means of improving the search efficiency in a natural language search could maintain the advantages of controlled vocabulary. The search accuracy can be improved using the word-proximity search instead of a Boolean search.

AOM/DSS 유발 대장암에 대한 楡根皮와 白花蛇舌草 단일 및 배합 추출물의 항암 및 항염 효과

이선아,백동기,문구 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.6

Objectives: The aim of this experimental study was to evaluate the anti-neoplastic and anti-inflammatory effects of single and mixed extracts of Ulmus davidiana (UD) and Oldenlandia diffusa (OD) on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colonic neoplasms in mice. Methods: AOM/DSS induces colitis-associated colonic neoplasms in mice. Mice were divided into seven groups: normal-no inducement and no treatment; control-colonic neoplasms with no treatment; UD-colonic neoplasms and treatment with UD; OD-colonic neoplasms and treatment with OD; UD1+OD1-colonic neoplasms and treatment with UD1 and OD1. UD1+OD2-colonic neoplasms and treatment with UD1 and OD2; UD2+OD1-colonic neoplasms and treatment with UD2 and OD1. Single and mixed preparations of UD and OD were applied to mice for six weeks. The colon length and weight and histopathologic changes of colon tissue were observed. Serum pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), were determined by enzyme-linked immunosorbent assay. The mRNA expression levels of Bax, Bcl-2, and interferon-gamma (INF-γ) were measured by RT-PCR. Results: The colon length was significantly increased in OD, UD1+OD2, and UD2+OD1 mice, and the colon weight was significantly decreased in OD and UD1+OD2 mice. The morphological change of colon epithelial cells was more suppressed in complex-treatment groups than in single-treatment groups. The inhibitory effect on inflammatory cell invasion was especially shown in UD1+OD2 mice. The serum level of the pro-inflammatory TNF-α was decreased in all complex-treatment groups, and the IL-6 level was decreased in UD1+OD1 mice. Single-treatment groups had an increase in the mRNA expression of the pro-apoptosis regulator Bax, and UD2+OD1 decreased the mRNA expression of the anti-apoptosis regulator Bcl-2. The mRNA expression of INF-γ associated with inflammation was decreased in OD and UD1+OD2 mice. Conclusions: This study suggests that single and mixed extracts of Ulmus davidiana and Oldenlandia diffusa have anti-neoplastic and anti-inflammatory effects on AOM/DSS-induced colonic neoplasms in mice. Therefore, we conclude that UD, OD, and a mixture of UD and OD are potential therapeutic agents for colitis-associated colonic neoplasms.

Oncocytic Type Intraductal Papillary Mucinous Neoplasm Mimicking Mucinous Cystic Neoplasm of the Pancreas - A Case Report -

장태정,이종임 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.3

Oncocytic type intraductal papillary mucinous neoplasm is a newly defined subgroup of intraductal papillary mucinous neoplasms. A 35-year-old woman presented complaining of epigastric pain for one month. Enhanced computed tomography revealed a multilocular cystic mass in the distal body and tail of the pancreas. Endoscopic retrograde cholangiopancreatography showed no communication between the mass and the main pancreatic duct. The patient underwent a distal pancreatectomy and splenectomy. Microscopical examination showed a fibrous cyst wall; polypoid tumors exhibiting thin stalks, with extensive arborizing papillary growths from these stalks; and a focally cribriform pattern, lined by plump cells with abundant eosinophilic and granular cytoplasm. Red granules were detected in the cytoplasm of tumor cells on modified Gomori trichrome stain. Ultrastructurally, the tumor cells contained abundant cytoplasm packed with numerous mitochondria and intracellular and intercellular lumina. We describe an oncocytic type intraductal papillary mucinous neoplasm having the clinical characteristics of a mucinous cystic neoplasm. Oncocytic type intraductal papillary mucinous neoplasm is a newly defined subgroup of intraductal papillary mucinous neoplasms. A 35-year-old woman presented complaining of epigastric pain for one month. Enhanced computed tomography revealed a multilocular cystic mass in the distal body and tail of the pancreas. Endoscopic retrograde cholangiopancreatography showed no communication between the mass and the main pancreatic duct. The patient underwent a distal pancreatectomy and splenectomy. Microscopical examination showed a fibrous cyst wall; polypoid tumors exhibiting thin stalks, with extensive arborizing papillary growths from these stalks; and a focally cribriform pattern, lined by plump cells with abundant eosinophilic and granular cytoplasm. Red granules were detected in the cytoplasm of tumor cells on modified Gomori trichrome stain. Ultrastructurally, the tumor cells contained abundant cytoplasm packed with numerous mitochondria and intracellular and intercellular lumina. We describe an oncocytic type intraductal papillary mucinous neoplasm having the clinical characteristics of a mucinous cystic neoplasm.

Pancreatic serous cystic neoplasms accompanying other pancreatic tumors

Kim, So-Woon,Song, In Hye,An, Soyeon,Kim, So Yeon,Kim, Hyoung Jung,Song, Ki-Byung,Hwang, Dae Wook,Lee, Sang Soo,Byun, Jae Ho,Seo, Dong-Wan,Kim, Song Cheol,Yu, Eunsil,Hong, Seung-Mo Elsevier 2017 Human pathology Vol.60 No.-

<P>Serous cystic neoplasms (SCNs) are benign cystic neoplasms that predominantly occur in the tail of the pancreas in elderly women. It is well known that patients with von Hippel - Lindau syndrome can develop SCNs and neuroendocrine tumors in the pancreas. However, our understanding on SCNs accompanying other pancreatic tumors (SCNAOPTs) is limited. We compared the clinicopathological features of 15 surgically resected SCNAOPTs with 259 conventional SCNs. The prevalence of SCNAOPT was 5%. The SCNAOPTs were significantly smaller than conventional solitary SCNs, and they were more commonly observed in the head of the pancreas, whereas conventional solitary SCNs were more frequently noted in the body and tail. However, no differences were found in terms of sex, patient age, or the gross patterns of the SCNs. Accompanying neoplasms included 7 intraductal papillary mucinous neoplasms, 1 colloid carcinoma arising from intraductal papillary mucinous neoplasm, 6 neuroendocrine tumors, and 1 solid pseudo papillary neoplasm. Four neuroendocrine tumors associated with von Hippel Lindau syndrome occurred as multiples, whereas 2 neuroendocrine tumors without von Hippel Lindau syndrome were solitary. In summary, SCNAOPTs comprise 5% of all SCNs and tend to be smaller and located in the head of the pancreas. Common accompanying tumors include intraductal papillary mucinous neoplasms, neuroendocrine tumors, and other neoplasms such as colloid carcinoma and solid pseudopapillary neoplasm. (C) 2016 Elsevier Inc. All rights reserved.</P>