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( Won Min Hwang ),( Se Hee Yoon ),( Dong Mee Lim ),( Kwang Sik Yoo ),( Seung Yun Han ),( Jae Ku Kang ),( Sung Ro Yun ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Acute kidney injury (AKI) is common clinical event and has high mortality rate despite advanced curative strategies. Several studies found that omega-3 polyunsaturated fatty acid (PUFA) diet reduces kidney dysfunction followed by ischemic injury. However oral appliance of omega-3 PUFA, in fact, can cause much variability arisen from diet procedure. Fat-1 transgenic mouse produce abundant omega-3 PUFA, result in balanced omega-6: omega-3 ratio than wild type mouse. The purpose of this study, therefore, is to see whether omega-3 PUFA has advantages in AKI caused by ischemic injury using fat-1 transgenic mice. Methods: Bilateral kidneys were subjected to 30 minutes of ischemia by clipping of both renal arteries, renal ischemia-reperfusion injury (IRI) was performed. Animals (fat-1 mice and C57BL/6 mice) are sacrificed 24 and 72 h of reperfusion. The effects of omega-3 PUFA on renal IRI were evaluated in terms of renal function, tubular necrosis, infi ammatory cell infi ltration. After that, renal function and severities of renal injury were estimated. Results: Fat-1 mice could reduce to increased BUN, serum creatinine and tissue Kim-1 levels(figure), and reduce neutrophil infi ltration in body after IRI, compared with Wild Type mice. Conclusions: Long-term and high dose of omega-3 supplement can protect renal function and facilitate renal recovery following IRI.
Effects of X-ray Irradiation on Six Insect Pests According to Their Positions in Export Flower Boxes
Seung-Hwan Yun,Hyun-Ah Kim,Min-Jun Kim,Jun-Won Park,Hyun Kyung Kim,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04
In this study, we investigated the effects of X-ray irradiation to control six important insect pests of floriculture crops: Liriomyza trifolii, Spodoptera litura, Myzus persicae, Tetranychus urticae, Bemisia tabaci, and Frankliniella intonsa. We irradiated on six insect pests that were placed in different positions (top, middle, and bottom) of export flower boxes after filling the boxes with roses and chrysanthemums, respectively. When irradiated with X-ray of 150 Gy, the eggs of T. urticae, B. tabaci, F. intonsa, L. trifolii, and S. litura were prevented from hatching at every position in the boxes. The pupation and emergence of L. trifolii larvae and S. litura larvae and B. tabaci nymphs and F. intonsa nymphs were inhibited at every position in the boxes. However, the emergence of T. urticae and M. persicae nymphs was not inhibited, even at the top position in the boxes. When pupae were irradiated, the emergence of L. trifolii was inhibited at every position in the boxes, while S. litura was not inhibited completely, even at the top position in the boxes. When adult T. urticae, S. litura, and L. trifolii were irradiated, the hatching rate of the F1 generation was not completely inhibited at every position. The insect pests that were not inhibited completely at the dose of 150 Gy showed much higher inhibitory effects at the dose of 250 Gy. Therefore, the dose of X-ray irradiation required to inhibit may vary according to the types of flowers and insect pests and according to their positions within the boxes.
( Seung Won Ra ),( Sun Young Kim ),( Yun Young Lim ),( Shin Jung Park ),( Chin Kook Rhee ),( Deog Kyeom Kim ),( Yong Bum Park ),( Chang Youl Lee ),( Hyoung Kyu Yoon ),( Jeong-woong Park ),( Kwang Ha Y 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Botanical medicines used as expectorants and antitussives have proven to be effective while also having excellent safety margins. We aimed at evaluating the efficacy and safety of a new botanical drug, CKD-497, in patients with acute upper respiratory tract infections and bronchitis. Methods In this phase 2 study, 225 patients were enrolled and randomly assigned to one of four treatment groups: placebo (n=55), Synatura® (n=49), CKD-497 200mg (n=68), or CKD-497 300mg (n=53). The study drugs were administered three times daily over the course of 7 days. Primary endpoint was the change in the bronchitis severity score (BSS) from baseline to day 7. Secondary endpoint was evaluated based on clinical response rates on days 4 and 7. A safety analysis was also performed. The Kruskal-Wallis test for intergroup differences and a Chi-square test were applied. Results Between baseline and day 7, the mean BSS scores decreased significantly in each group (P<0.001): 4.04±1.85, 4.31±1.47, 4.09±1.48, and 4.28±1.69. However, neither the CKD-497 nor Synatura® group showed any significant effect on the difference in BSS change (P=0.75). The rate of clinical response was higher in the CKD-497 300mg group as compared to the placebo only on day 4 (18% vs. 36%; P<0.05) and those having more severe bronchitis (phlegm score≥3) showed a significant reduction of total BSS in the Synatura® and CKD-497 groups (P=0.042). No significant adverse events were observed in either of the CKD-497 groups. Conclusion CKD-497 and even the positive control drug had no significant effect on BSS change in this phase 2 clinical trial. However, CKD- 497 300mg had a mild but significant clinical improvement in early bronchitis patients with more severe phlegm. Considering both efficacy and safety, a future study using 300mg of CKD-497 with a shorter-term endpoint is warranted in patients with more severe bronchitis symptoms.
Seung-Hwan Yun,Young-Uk Park,Sun-Ran Cho,Jin-Won Jeong,Youn-Ho Shin,Changmann Yoon,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.05
The American serpentine leafminer fly, Liriomyza trifolii (Burgess), is one of the most destructive polyphagous pests world wide. In this study, we determined electron beam doses for inhibition of normal development of the L. trifolii and investigated the effect of electron beam irradiation on DNA damage and p53 stability. Eggs, larvae, pupae and adults were irradiated with increasing doses of electron beam irradiation (six levels ranges from 30 to 200 Gy). At 150 Gy, the number of adults that developed from irradiated eggs, larvae and pupae was lower than those of untreated control. Fecundity and egg hatchability decreased depending on the doses applied. Reciprocal crosses between irradiated and unirradiated flies demonstrated that males were more radiotolerant than females. Adult longevity was not affected in all stages. The levels of DNA damage in L. trifolii adults were evaluated using the alkaline comet assay. Our results indicate that electron beam irradiation increased levels of DNA damage in a dose-dependent manner. Moreover, low doses of electron beam irradiation led to the rapid appearance of p53 protein with in 6 h; however, it decreased after exposure to high doses (150 Gy and 200 Gy). These results suggest that electron beam irradiation induced not only abnormal development and reproduction but also p53 stability caused by DNA damage in L. trifolii. We conclude that a minimum dose of 150 Gy should be sufficient for sterilization of L. trifolii.