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Mutations of ARX and non-syndromic intellectual disability in Chinese population
Yufei Wu,Huan Zhang,Xiaofen Liu,Zhangyan Shi,Hongling Li,Zhibin Wang,Xiaoyong Jie,Shao-Ping Huang,Fu-Chang Zhang,Junlin Li,Ke-Jin Zhang,Xiao-Cai Gao 한국유전학회 2019 Genes & Genomics Vol.41 No.1
Mutations of Aristaless-related homeobox (ARX) gene were looked as the third cause of non-syndromic intellectual disability (NSID), while the boundary between true disease-causing mutations and non-disease-causing variants within this gene remains elusive. To investigate the relationship between ARX mutations and NSID, a panel comprising six reported causal mutations of the ARX was detected in 369 sporadic NSID patients and 550 random participants in Chinese. Two mutations, c.428_451 dup and p.G286S, may be disease-causing mutations for NSID, while p.Q163R and p.P353L showed a great predictive value in female NSID diagnosis with significant associations (X2 = 19.60, p = 9.54e−6 for p.Q163R; X2 = 25.70, p = 4.00e−07 for p.P353L), carriers of these mutations had an increased risk of NSID of more than fourfold. Detection of this panel also predicted significant associations between genetic variants of the ARX gene and NSID (p = 3.73e−4). The present study emphasized the higher genetic burden of the ARX gene on NSID in the Chinese population, molecular analysis of this gene should be considered for patients presenting NSID of unknown etiology.
Yufei Li,강지현,Yu Jin Lee,Jae-Yong Chung,Joo-Youn Cho 대한임상약리학회 2021 Translational and Clinical Pharmacology Vol.29 No.4
Trimethylamine N-oxide (TMAO) is a small molecular amine oxide generated from dietarycholine and carnitine through intestinal microbial metabolism. Recently, TMAO hasattracted much public attention as its role in disease progression has been proven in m
Jianning Li,Zhujian Li,Yufei Xu,Kaiyang Gu,Wendong Bao,Xiaobin Xu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5
This paper investigates the non-fragile state estimation problem for discrete nonlinear Markov jump neural networks(MJNNs) with sensor failures. Due to the limit communication resource, we adopt a kind of eventtriggered mechanism to determine whether the sensor sampling information is sent or not. By selecting suitable Lyapunov functions, a sufficient condition is obtained to guarantee the mean-square exponential stability of the augmented system. Finally, a numerical example is given to show the effectiveness of the proposed method.
Efficiency optimization of variable‑frequency controlled power factor correction converters
Yufei Zhou,Xueru He,Shuai Liu,Feng Hong,Jiaqi Ren,Dongdong Li 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.6
More attention is being paid to energy effi ciency and harmonic reduction. Thus, power factor correction (PFC) is widely used in power supplies. However, under the condition of light load, the single-stage LLC PFC converter has the problems of low effi ciency and output voltage misaligned, such as other PFC topologies. Aiming at the problems that occur under light load conditions, this paper proposes a least-pulse delta (Δ)–sigma (Σ) modulation (LPΔ–Σ modulation). Under diff erent loads, the system can automatically select the appropriate pulse density and reduce the energy transfer to the secondary side by uniformly turning off the driving signals, which stabilizes the output voltage and improves the system effi ciency. Meanwhile, LPΔ–Σ modulation is more benefi cial for improving the PF value when compared with the burst mode under light load conditions. Experimental results show that LPΔ–Σ modulation based on the traditional dual-loop control can eff ectively stabilize the output voltage and improve effi ciency. When compared with the existing burst control scheme, it reduces the output voltage ripple and eff ectively improves the PF.
Yufei Liu,Haibo Gao,Liang Ding,Guangjun Liu,Zongquan Deng,Nan Li 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.8
To control autonomous walking of a legged robot, it is essential to obtain the instantaneous velocity and posture of the robot. This paper presents a full body state estimation algorithm for a hexapod robot to estimate the velocity and posture of the trunk body without geometric knowledge of the environment. The velocity and posture estimates of the hexapod robot with passive compliant ankles are further processed by a data fusion method that is proposed based on the extended Kalman filter (EKF) technique, utilizing the leg kinematics model of the robot and the readouts from an on–board inertial measurement unit (IMU). The absolute footholds of the hexapod robot are estimated together with the velocity and posture of the trunk body, with consideration of intermittent ground contacts. Experiments have been conducted on both flat and uneven terrains, and the results have confirmed the effectiveness of the proposed approach.
Zhou Yufei,Li Dongdong,Wang Yingying,Hong Feng,He Xueru,Liu Shuai,Sun Xiangfeng 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4
The low coupling coeffi cient (CC) of loosely coupled transformer (LCT) can greatly aff ect the effi ciency of inductive power transfer (IPT) system. In order to improve the coupling coeffi cient and misaligned tolerance of LCT, this paper proposes a transformer structure with multiple independent small receiving coils. Respectively in ideal alignment and misalignment mode, the distribution of magnetic force lines and the variation law of CC of independent small receiving coils are analyzed. According to the relationship between the coupling coeffi cient matrix and the mutual inductance, the eff ective coupling coeffi cient (ECC) is deduced, and its variation with the misalignment distance is also analyzed. The ECC of the LCT with multi-receiver (MR) structure is almost unchanged. For the multiple loads' characteristics of receivers, by adopting S/P compensated topology, a 500 W outputs prototype of IPT system is established. The experimental results show that the ECC is improved and tolerance performance to lateral and rotational misalignment of proposed MR structure has good characteristics.
Fangqing Li,Lin Chen,Yufei Wei,Zhiwei Yin,Keying Que 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Membrane distillation (MD) is considered an emerging desalination technology. However, the presenceof surfactants allows liquid to penetrate the membrane, resulting in membrane wetting, which hindersthe commercialization of MD. In this study, we use very few modified materials to prepare novel Janusthin membranes that immobilize modified materials (graphene oxide (GO) and UiO-66-NH2) on polytetrafluoroethylene(PTFE) hydrophobic base membranes via crosslinkers. The composite thin membraneproperties with eight different ratios and contents of GO and UiO-66-NH2 were fabricated and testedby a feed solution of sodium chloride containing a high concentration of sodium dodecyl sulfate. An optimalratio of Janus membrane with high flux without affecting the effluent water quality was obtained. The Janus membrane exhibited excellent anti-wetting properties compared to the original PTFE membrane. A desalination rate of up to 99.9% was still available even under 48 h of long-term operating conditionsby maintaining a flux of approximately 21.2 L/(m2h). The anti-wetting mechanism of thismembrane was further confirmed by the modified XDLVO model. It suggested that the novel Janus membranecould be a highly promising substitute to the MD process for the resource-based treatment ofsurfactant-containing wastewater, which played an important role in promoting its application.
Hongbo Li,Yufei Tong,Jianguang Yin,Hubiao Zhang,Changyu Yan 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1
Multi-cavity concrete-fi lled steel tube special shaped column (CFSTSSC) combines the excellent characteristics of multicavity steel tube and core concrete. CFSTSSC has the advantages of high bearing capacity, good ductility, and strong energy dissipation capacity. At present, accurate calculation methods for these kinds of structures are limited and research into crossshaped and L-shaped multi-cavity CFSTSSCs is not available. Therefore, the axial compression behavior of cross-shaped and L-shaped multi-cavity CFSTSSCs has been investigated, though experimental research and numerical simulation, in this study. First, axial compression tests were carried out on three cross-shaped and three L-shaped multi-cavity CFSTSSCs to analyze their failure modes, axial load-strain curve, ductility index, and ultimate bearing capacity. Then, fi nite element (FE) calculation models of cross-shaped and L-shaped multi-cavity CFSTSSCs were established. The FE models are in good agreement with the experimental results, which provides a foundation for further parameter analysis and failure mechanism study of special shaped columns. Finally, combining parameter analysis and limit equilibrium theory, equations for calculating the ultimate bearing capacity of cross-shaped and L-shaped multi-cavity CFSTSSCs were proposed. The results show that the error between the simplifi ed equation and the FE result is less than 15%, indicating that the equations can provide reference for practical engineering applications.
Enhanced NOx Gas Sensing Performance Based on Indium-Doped Co(OH)2 Nanowire-Graphene Nanohybrids
Jiabao Song,Yufei Lin,Kan Kan,Jingchao Wang,Songying Liu,Li Li,Keying Shi 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.6
"In this paper, the In(OH)3/Co(OH)2/rGO (ICG) nanohybrids have been synthesized via a simple reflux method. It was found that the nanostructures were actually composed of thin nanosheets or nanowires. The addition of indium in Co(OH)2 on rGO results in increase in the specific area of nanohybrids (105.7 m2 g-1 ). That enhanced the gas sensing responses to NOx compared with Co(OH)2/rGO significantly. The ICG nanohybrids with the mass ratio of 5:1 (ICG-5) exhibited excellent gas-sensing properties with low detection limit of 0.97 ppm and high sensitivity of 75.32% to 97 ppm NOx at room temperature (RT). The gas sensor also showed excellent selectivity to NOx when other common gases such as NH3, CO, C2H2 and H2 were present. The sensing mechanism could be attributed to the charge carrier concentration of Co(OH)2 greatly increased by indium doping, which at last encourages the electron transfer during the interaction with gases."