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Xu Li,Shian Shen,Junlin Deng,Tian Li,Chun-Bang Ding 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6
Antioxidant activities and functional propertiesof tea seed protein hydrolysates (TSPH) prepared usingalcalase with different (10, 20, 30 and 40%) values of thedegree of hydrolysis (DH) were investigated. The effect ofhydrolysis time on antioxidant activity was also investigated. As the hydrolysis time was extended, the DPPH radicalscavenging activity increased and finally reached a plateau,the copper chelating capacity decreased, and the superoxideradical scavenging and iron chelating activities increasedinitially, then subsequently slowed. The solubility, foamingproperties, and emulsification properties of TSPH wereaffected by pH and DH. As the DH value increased, theDPPH radical scavenging activity and the reducing powerincreased and the copper chelating capacity decreased. TSPH at 20 and 30% DH values exhibited higher superoxideradical scavenging and stronger iron chelating activitiesrespectively, than TSPH at other DH values. The DH valueof TSPH affected the antioxidant activity and functionalproperties.
Caineng Cao,Jingwei Luo,Li Gao,Junlin Yi,Xiaodong Huang,Suyan Li,Jianping Xiao,Zhong Zhang,Guozhen Xu 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose This study was conducted is to identify the prognostic value and staging categories of magnetic resonance imaging (MRI)–detected intracranial extension in nasopharyngeal carcinoma (NPC) with intensity-modulated radiotherapy (IMRT) to determine whether it is necessary to subclassify the T4 classification NPC. Materials and Methods A total of 335 nonmetastatic T4 classification NPC patients with MRI treated between March 2004 and June 2011 by radical IMRT were included. The T4 classification patients were subclassified into two grades (T4a, without intracranial extension vs. T4b, with intracranial extension) according to the site of invasion. Results The frequency of intracranial extension was 40.9% (137 of 335 patients). Multivariate analysis identified subclassification (T4a vs. T4b) as an independent prognostic factor for local failure-free survival (p=0.049; hazard ratio [HR], 0.498) and overall survival (p=0.004; HR, 0.572); however, it had no effect on regional failure-free survival or distant failure-free survival (p > 0.050). Conclusion For patients with T4 classification NPC, those with MRI-detected intracranial extension are more likely to experience local failure and death after IMRT than patients without intracranial extension. According to the site of invasion, subclassification of T4 patients as T4a or T4b has prognostic value in NPC.
Mutations of ARX and non-syndromic intellectual disability in Chinese population
Yufei Wu,Huan Zhang,Xiaofen Liu,Zhangyan Shi,Hongling Li,Zhibin Wang,Xiaoyong Jie,Shao-Ping Huang,Fu-Chang Zhang,Junlin Li,Ke-Jin Zhang,Xiao-Cai Gao 한국유전학회 2019 Genes & Genomics Vol.41 No.1
Mutations of Aristaless-related homeobox (ARX) gene were looked as the third cause of non-syndromic intellectual disability (NSID), while the boundary between true disease-causing mutations and non-disease-causing variants within this gene remains elusive. To investigate the relationship between ARX mutations and NSID, a panel comprising six reported causal mutations of the ARX was detected in 369 sporadic NSID patients and 550 random participants in Chinese. Two mutations, c.428_451 dup and p.G286S, may be disease-causing mutations for NSID, while p.Q163R and p.P353L showed a great predictive value in female NSID diagnosis with significant associations (X2 = 19.60, p = 9.54e−6 for p.Q163R; X2 = 25.70, p = 4.00e−07 for p.P353L), carriers of these mutations had an increased risk of NSID of more than fourfold. Detection of this panel also predicted significant associations between genetic variants of the ARX gene and NSID (p = 3.73e−4). The present study emphasized the higher genetic burden of the ARX gene on NSID in the Chinese population, molecular analysis of this gene should be considered for patients presenting NSID of unknown etiology.