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Xu, Ting,Shen, Xiangfeng,Yu, Huali,Sun, Lili,Lin, Weihong,Zhang, Chunxiao The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.3
Background: Panax ginseng root is used in traditional oriental medicine for human health. Its main active components such as saponins and polysaccharides have been widely evaluated for treating diseases, but secondary active components such as oligosaccharides have been rarely studied. This study aimed to assess the impact of water-soluble ginseng oligosaccharides (WGOS), which were isolated from the warm-water extract of Panax ginseng root, on scopolamine-induced cognitive impairment in mice and its antineuroinflammatory mechanisms. Methods: We investigated the impact of WGOS on scopolamine-induced cognitive impairment in mice by using Morris water maze and novel object recognition task. We also analyzed the impact of WGOS on scopolamine-induced inflammatory response (e.g., the hyperexpression of proinflammatory cytokines IL-$1{\beta}$ and IL-6 and astrocyte activation) by quantitative real-time polymerase chain reaction and glial fibrillary acid protein (GFAP) immunohistochemical staining. Results: WGOS pretreatment protected against scopolamine-induced learning and memory deficits in the Morris water maze and in the novel object recognition task. Furthermore, WGOS pretreatment downregulated scopolamine-induced hyperexpression of proinflammatory cytokines interleukin (IL)-$1{\beta}$ and IL-6 mRNA and astrocyte activation in the hippocampus. These results indicate that WGOS can protect against scopolamine-induced alterations in learning and memory and inflammatory response. Conclusion: Our data suggest that WGOS may be beneficial as a medicine or functional food supplement to treat disorders with cognitive deficits and increased inflammation.
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Kedong Zhang,Xuhong Guo,Chengdong Wang,Xiangfeng Meng,Lining Sun,Youqiang Xing 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.5
During the dry post-machining processing of selective laser melting (SLM)-produced stainless steel with TiAlN coated tool, the elements of stainless steel chips can diff use and adhere into the coated tool surface, causing serious adhesive wear. In this study, to inhibit the adhesion problem at the tool-chip interface, surface textures with different scales (micro-, nano- and micro/nano-textures) are produced on tool rake face by laser processing before and after physical vapor deposition (PVD) TiAlN coatings deposition. To investigate the cutting performance of these developed coated tools, dry machining tests of the SLM-produced stainless steel are carried out. And, the mechanical properties of textured TiAlN coatings such as the hardness, elastic modulus and critical load are also studied to explain the results from the machining tests. It can be found that the anti-adhesive wear performance of TiAlN coated tool is improved by laser surface texturing. The texture dimension significantly affects the mechanical properties and dry cutting performance of the TiAlN coated tool, and the micro/nanotextures are found to be optimum. Meanwhile, the sequence of surface textures also has an effect on the wear performance of the developed TiAlN coated tools. In the experiment, laser surface texturing before coatings is effective in acting as a barrier against flaking of the TiAlN fi lm, providing a higher active surface for the subsequent TiAlN coatings and presenting a higher compressive residual stress. Thus, the developed cutting tool which is textured before TiAlN coatings deposition presents a milder wear compared to the developed one which is textured after TiAlN coatings deposition.
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Zhou Yufei,Li Dongdong,Wang Yingying,Hong Feng,He Xueru,Liu Shuai,Sun Xiangfeng 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4
The low coupling coeffi cient (CC) of loosely coupled transformer (LCT) can greatly aff ect the effi ciency of inductive power transfer (IPT) system. In order to improve the coupling coeffi cient and misaligned tolerance of LCT, this paper proposes a transformer structure with multiple independent small receiving coils. Respectively in ideal alignment and misalignment mode, the distribution of magnetic force lines and the variation law of CC of independent small receiving coils are analyzed. According to the relationship between the coupling coeffi cient matrix and the mutual inductance, the eff ective coupling coeffi cient (ECC) is deduced, and its variation with the misalignment distance is also analyzed. The ECC of the LCT with multi-receiver (MR) structure is almost unchanged. For the multiple loads' characteristics of receivers, by adopting S/P compensated topology, a 500 W outputs prototype of IPT system is established. The experimental results show that the ECC is improved and tolerance performance to lateral and rotational misalignment of proposed MR structure has good characteristics.
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