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      • SCOPUSKCI등재

        Synthesis of Ag/TiO<sub>2</sub> Core/Shell Nanoparticles with Antibacterial Properties

        Lin, Yue,Qiqiang, Wang,Xiaoming, Zhang,Zhouping, Wang,Wenshui, Xia,Yuming, Dong Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.8

        Monodispersed Ag/$TiO_2$ core/shell nanoparticles were synthesized in solution via colloid-seeded deposition process using Ag nanoparticles as colloid seeds and $Ti(SO_4)_2$ as Ti-source respectively. Silver nitrate was reduced to Ag nanoparticles with $N_2H_4{\cdot}H_2O$ in the presence of CTAB as stabilizing agent. The titania sols hydrolyzed by the $Ti(SO_4)_2$ solution deposited on the surface of Ag nanoparticles to form the Ag/$TiO_2$ core/shell nanoparticles. Inductively coupled plasma atomic emission spectrometry (ICP-AES) showed low amount of Ag ion leaching from the Ag/$TiO_2$ core/shell nanoparticles. The Ag/$TiO_2$ core/shell nanoparticles indicated excellent antibacterial effects against Escherichia coli and maintained long-term antibacterial property.

      • KCI등재

        Pulmonary Actinomycosis Imitating Lung Cancer on 18F-FDG PET/CT: A Case Report and Literature Review

        Lin Qiu,Lianjun Lan,Yue Feng,Zhanwen Huang,Yue Chen 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.6

        Here we report a case of 41-year-old man with a soft tissue density mass at right upper lung and palpable abscesses at right upper backside and right wrist. 18F-fluorodeoxyglucose positron emission tomography/computed tomography demonstrated a 7.8 x 5.0 cm mass with soft-tissue density in the upper lobe of the right lung with high metabolic activity. The infiltrative mass extended to adjacent chest wall soft tissue. Final diagnosis of pulmonary actinomycosis with multiple abscesses was made. The patient responded well to antibiotics treatment.

      • Investigation of ambient aerosol effective density with and without using a catalytic stripper

        Lin, Yue,Bahreini, Roya,Zimmerman, Stephen,Fofie, Emmanuel A.,Asa-Awuku, Akua,Park, Kihong,Lee, Seung-Bok,Bae, Gwi-Nam,Jung, Heejung S. Elsevier 2018 Atmospheric environment Vol.187 No.-

        <P><B>Abstract</B></P> <P>Size-resolved effective densities of ambient aerosols in Riverside, CA were determined over 4 periods during 2015–2016. A DMA-CPMA-CPC technique was used to measure effective density for particles with selected diameters of 50, 70, 101 and 152 nm. A catalytic stripper (CS) was used alternately to remove the volatile fraction of aerosol before density measurements. Aerosol non-refractory composition measurement was conducted in June 2016 campaign to understand the effect of chemical composition on particle density. The average densities for particles over all the measurement campaigns over BP mode (i.e. bypassing the CS) were 1.17 g/cm<SUP>3</SUP> at 50 nm and 1.25–1.28 g/cm<SUP>3</SUP> at 70, 101 and 152 nm. The average density after CS conditioning (CS mode) showed a decreasing trend from 1.22 g/cm<SUP>3</SUP> to 1.04 g/cm<SUP>3</SUP>, with increase in the selected size, and a mass fractal dimension (D<SUB>f</SUB>) of 2.85. Both the BP and CS mode particles showed the lowest effective density at 6–9 am and highest density at 11 a.m.-3 pm. The diurnal variation of density for both modes became more intensive as particle size increased. The variation was also more intense for the CS mode compared to the BP mode. Organic aerosol and ammonium nitrate mass in the size range of density measurements correlated well positively (R<SUP>2</SUP> = 0.78) and negatively (R<SUP>2</SUP> = 0.62), respectively with BP mode effective density. The study provides an update to the aerosol density profiles of a well-known receptor site (Riverside, CA) and investigates the transformation of particles in different seasons. The effective density profiles will be used in a follow-up study to better estimate the respiratory-deposited ambient aerosol mass.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Seasonal variation of ambient particle effective densities. </LI> <LI> Size dependent refractive particle effective densities. </LI> <LI> Influence of particle chemical composition on diurnal variation of particle effective density. </LI> </UL> </P>

      • KCI등재

        Patient and Care Delays of Breast Cancer in China

        Yue-Lin Li,Ya-Chao Qin,Lu-Ying Tang,Yu-Huang Liao,Wei Zhang,Xiao-Ming Xie,Qiang Liu,Ying Lin,Ze-Fang Ren 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

        Purpose This study differentiates patient and care delays of breast cancer and explores the related factors as well as the associations with the prognosis in Guangzhou, a southern city of China. Materials and Methods A cohort of female incident breast cancer patients (n=1,551) was recruited from October 2008 to March 2012 and followed up until January 1, 2016 (n=1,374) in the affiliated hospitals of Sun Yat-sen University. The factors associated with patient and care delays were analyzed with multivariable logistic models. Cox proportional hazards regression models were constructed to estimate the impacts of the delays on the prognosis. Results There were 40.4% patient delay (! 3 months) and 15.5% care delay (! 1 month). The patient delay, but not the care delay, was significantly related to the clinical stage and consequently worsened the prognosis of breast cancer (hazard ratio, 1.45; 95% confidence interval, 1.09 to 1.91 for progression-free survival). The factors related to an increased patient delay included premenopausal status, history of benign breast disease, and less physical examination. Conclusion Patient delay was the main type of delay in Guangzhou and resulted in higher clinical stage and poor prognosis of breast cancer. Screening for breast cancer among premenopausal women may be an effective way to reduce this delay.

      • KCI등재

        Enhanced electrochemical oxidation of dye wastewater with Fe2O3 supported catalyst

        Lin Yue,Jianbo Guo,Kaihong Wang,Jingliang Yang,Xiao Luo,Jing Lian,Li Wang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.2

        Electrochemical oxidation of Acid Red 3R was investigated in the presence of Fe2O3/γ-Al2O3 as Fenton-like catalyst in the reactor. The results showed that the catalyst had catalytic activity in theelectrochemical process. Under the optimal conditions, the decolorization efficiency reached 77.2% in100 min. UV–vis spectrum and LC–MS analysis revealed that the dye molecule was firstly decomposed toaromatic intermediates, further degraded to ring opening products and finally mineralized. The azo dyedegradation might be attributed to strong oxidant -OH that produced from the synergetic effect ofbetween Fe2O3/γ-Al2O3 catalyst and electrochemical system.

      • KCI등재

        Quantification of Ecosystem Carbon Exchange Characteristics in a Dominant Subtropical Evergreen Forest Ecosystem

        Yue-Lin Li,Guo-Yi Zhou,De-Qiang Zhang,Katherine Owen Wenigmann,Dennis Otieno,John Tenhunen,Qian-Mei Zhang,Jun-Hua Yan 한국기상학회 2012 Asia-Pacific Journal of Atmospheric Sciences Vol.48 No.1

        CO2 fluxes were measured continuously for three years (2003-2005) using the eddy covariance technique for the canopy layer with a height of 27 m above the ground in a dominant subtropical evergreen forest in Dinghushan, South China. By applying gapfilling methods, we quantified the different components of the carbon fluxes (net ecosystem exchange (NEE)), gross primary production (GPP) and ecosystem respiration (Reco) in order to assess the effects of meteorological variables on these fluxes and the atmospherecanopy interactions on the forest carbon cycle. Our results showed that monthly average daily maximum net CO2 exchange of the whole ecosystem varied from −3.79 to −14.24 μmol m−2 s−1 and was linearly related to photosynthetic active radiation. The Dinghushan forest acted as a net carbon sink of −488 g C m−2 y−1, with a GPP of 1448 g Cm−2 y−1, and a Reco of 961 g C m−2 y−1.Using a carboxylase-based model, we compared the predicted fluxes of CO2 with measurements. GPP was modelled as 1443 g C m−2 y−1, and the model inversion results helped to explain ca. 90% of temporal variability of the measured ecosystem fluxes. Contribution of CO2 fluxes in the subtropical forest in the dry season (October-March) was 62.2% of the annual total from the whole forest ecosystem. On average, 43.3%of the net annual carbon sink occurred between October and December, indicating that this time period is an important stage for uptake of CO2 by the forest ecosystem from the atmosphere. Carbon uptake in the evergreen forest ecosystem is an indicator of the interaction of between the atmosphere and the canopy, especially in terms of driving climate factors such as temperature and rainfall events. We found that the Dinghushan evergreen forest is acting as a carbon sink almost year-round. The study can improve the evaluation of the net carbon uptake of tropical monsoon evergreen forest ecosystem in south China region under climate change conditions.

      • KCI등재

        Magnesium isoglycyrrhizinate inhibits L-type Ca2+ channels, Ca2+ transients, and contractility but not hERG K+ channels

        Yue Lin,Yuanyuan Zhang,Qiongtao Song,Tao Song,Xue Han,Ying Zhang,Xuan Zhang,Xi Chu,Fenghua Zhang,Li Chu,Jianping Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10

        To explore the cardiovascular protective effectsof Magnesium isoglycyrrhizinate (MI), especially theunderlying cellular mechanisms related to L-type calciumchannels and myocardial contractility, and to examine theeffects of MI on hERG K? current expressed in HEK293cells. We used the whole-cell patch clamp technique,video-based edge detection and dual excitation fluorescencephotomultiplier systems to explore the effect of MIon L-type Ca2? currents (ICa-L) and cell contraction in ratcardiomyocytes. We also examined the rapidly activatingdelayed rectifier potassium current (IKr) expressed inHEK293 cells using a perforated patch clamp. MI inhibitedICa-L in a dose-dependent manner, with a half-maximalinhibitory concentration (IC50) of 0.22 mg/ml, and themaximal inhibitory effect was 61.10 ± 0.59%. MI at aconcentration of 0.3 mg/ml reduced cell shortening by24.12 ± 3.97% and the peak value of the Ca2? transient by36.54 ± 4.96%. MI had no significant influence on hERGK? channels expressed in HEK293 cells at all testpotentials. MI exerts protective effects on the heart via theinhibition of ICa-L and cell shortening in rat cardiomyocytes. However, MI had no significant influence on IKr;thus, MI may exert cardioprotective effects without causingdrug-induced long QT syndrome.

      • Scutellaria Extract Decreases the Proportion of Side Population Cells in a Myeloma Cell Line by Down-regulating the Expression of ABCG2 Protein

        Lin, Mei-Gui,Liu, Li-Ping,Li, Chen-Yin,Zhang, Meng,Chen, Yuling,Qin, Jian,Gu, Yue-Yu,Li, Zhi,Wu, Xin-Lin,Mo, Sui-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        Background and Aims: Scutellaria is one of the most popular traditional Chinese herbal remedies against various human diseases, including cancer. In this study, we examined the active effects of Scutellaria extract and its main flavonoid constituents on the proportion of side population cells within human multiple myeloma cell line RPMI8226 in vitro and explored the potential molecular mechanisms involved. Materials and Methods: The contents of flavonoids in ethanolic extract of Scutellaria baicalensis Georgi were determined using high performance liquid chromatography. The antiproliferative effect of the ethanolic extract on RPMI-8226 was determined by CCK assay. Apoptosis was measured by annexin combining with propidium iodide in a flow cytometer. Cell cycle analysis was performed by propidium iodide staining in combination with flow cytometry analysis. Hoechst 33342 exclusion assay was used for the identification of side population within RPMI8226 cells. The expression of ABCG2 protein was assessed by Western blotting assay. Results: The content of major flavonoids constitutents of Scutellaria extract was baicalin (10.2%), wogonoside (2.50%), baicalein (2.29%), and wogonin (0.99%), respectively. The crude Scutellaria extract did not show significant anti-proliferative effect, apoptosis induction and cell cycle arrest in RPMI-8226 within the concentrations of $1-75{\mu}g/mL$. However, the ethanolic extract, baicalein, wogonin and baicalin reduced the side population cells in RPMI-8226, and data showed that baicalein and wogonin had stronger inhibitory effects. Correspondingly, they also exhibited significant effects on decreasing the expression level of ABCG2 protein in RPMI-8226 in vitro. Conclusions: Our results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein. This study provides an insight for new therapeutic strategies targeting cancer stem cells of multiple myeloma.

      • KCI등재

        Studies on the electrochemical degradation of Acid Orange II wastewater with cathodes modified by quinones

        Lin Yue,Jianbo Guo,Jingliang Yang,Jing Lian,Xiao Luo,Xiangning Wang,Kaihong Wang,Li Wang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3

        The electrochemical oxidation of dye wastewater with the cathode modified by quinones has beeninvestigated. Under the optimal conditions, the decolorization efficiency can reach 96.0% after 120 min. The addition of tert-butanol significantly decreased the decolorization efficiency, suggesting theinvolvement of -OH radicals in the decomposition of H2O2. A potential difference may result in a quinoneradical on the cathode which can catalyze the reduction of O2 to H2O2. UV–vis spectrum and GC/MSanalysis revealed that the dye molecule was firstly initiated by the cleavage of –N55N–, and decomposedto aromatic intermediates, further degraded to ring opening products and finally mineralized.

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