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Ai-min Ren,Yu Zhang,Weiwei Yu,Kai Zhao,Zhiru Hu,Zhiquan Zhang,Guodong Feng,Zhi-Guang Song 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
In this article, a series of coumarin derivativefluorescent probes have been synthesized, which can realizesimple, rapid and sensitive detection of Pd2+. We tested thefluorescence properties of threefluorescentprobes, (E)-N0-(((4-chloropyridin-2-yl) methylene)-7-(diethylamino)-2-oxo-2H-chromene-3-carbohy(CMDCC) has the betterfluorescence properties and anti-interference ability. Then, CMDCC as thefluorescence probe for detection of Pd2+ was systematic studied. Under optimized conditions, this probehas a wide pH range, a lower detection limit (4.4510 8 mol L-1), and a faster response speed (3 min). Inthe Pd2+ concentration range of 0.1 5 mmol L-1, thefluorescence intensity of this probe and concentrationof Pd2+ show a good linear response. In this work, Pd2+ content in organic waste liquid was successfullydetected and a standard addition test was also performed. The satisfactory recovery rate was obtained. Moreover, it can be observed with naked eyes that the palladium ion changes the solution color of CMDCCfrom green to red. This color change can easily be compared with other metal salts. It indicates thatCMDCC can also detect Pd2+ by colorimetric method. Therefore, CMDCC should be used to rapidly,conveniently detect Pd2+ in environmental samples.
( Ya-min Lai ),( Wei-yan Yao ),( Yao He ),( Xuan Jiang ),( Yu-bei Gu ),( Min-hu Chen ),( Yu-lan Liu ),( Yao-zong Yuan ),( Jia-ming Qian ) 대한소화기학회 2017 Gut and Liver Vol.11 No.2
Background/Aims: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective deple-tion of these leukocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation, promote remission and enhance drug efficacy. However, studies have reported contrasting efficacy out-comes based on patients` baseline demographic variables. This study was undertaken to understand the demographic features of GMA responders and nonresponders. Methods: This was a multicenter study in China involving four institutions and 34 patients with active UC. Baseline conventional medications were continued without changing the dosage. The treatment efficacy was evaluated based on the endo-scopic activity index and the Mayo score. Results: Thirty of the 34 patients completed all 10 GMA treatment sessions. The overall efficacy rate was 70.59%. The receiver operating characteristic analysis showed that the area under the curve was approximately 0.766 for a Mayo score of ≤5.5 with 0.273 specificity and 0.857 sensitivity (Youden index, 0.584) for GMA responders. No GMA-related serious adverse events were observed. Conclusions: The overall efficacy of GMA in patients with active UC who were taking first-line medications or were corticosteroid refractory was encouraging. Addition-ally, GMA was well tolerated and had a good safety profile. (Gut Liver 2017;11:216-225)
Telbivudine-Induced Myopathy: Clinical Features, Histopathological Characteristics, and Risk Factors
Min-Yu Lan,Hui-Chen Lin,Tsung-Hui Hu,Shu-Fang Chen,Chien-Hung Chen,Yung-Yee Chang,King-Wah Chiu,Tsu-Kung Lin,Shun-Sheng Chen 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.1
Background and Purpose Oral nucleos(t)ide analogs (NAs) are the mainstay treatment for chronic hepatitis B (CHB). Myotoxicity is an important extrahepatic effect related to NA treatment. Telbivudine is the NA for CHB that is frequently associated with muscle-related side effects. The risk factors for telbivudine-induced myopathy (TIM) are not yet clear. Methods This study characterized the clinical, magnetic resonance images (MRI), and pathological features of 12 TIM cases. A group of telbivudine-tolerant (TT) patients with CHB who received regular telbivudine treatment during the same period without the occurrence of myopathy was collected. Demographic and clinical factors were compared between the patients with TIM and the TT controls. Factors independently associated with TIM were identified using logistic regression analysis. Results The patients with TIM (males/females: 7/5, mean age: 57 years) developed myopathy after using telbivudine for a median period of 19.5 months. Muscle histopathology revealed abnormal proliferation, subsarcolemmal or sarcoplasmic accumulations, and ultrastructural defects of mitochondria. When compared with TT cases, patients with TIM had a lower estimated glomerular filtration rate and were more frequently positive for hepatitis B e antigen (HBeAg). Conclusions Mitochondrial abnormalities are characteristic histopathological features, and impaired renal function and HBeAg positivity are risk factors for TIM. Telbivudine-induced mitochondrial dysfunction and immune activation related to mitochondrial damage and HBeAg serostatus changes may underlie TIM. Constant clinical surveillance of myopathy during telbivudine treatment is needed due to the significant latency of its development. Dose adjustment for impaired renal function does not eliminate the risk of TIM occurrence.
Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma
Yu, Zu-Hu,Zhang, Qiang,Wang, Ya-Dong,Chen, Jing,Jiang, Zhi-Mao,Shi, Min,Guo, Xin,Qin, Jie,Cui, Guang-Hui,Cai, Zhi-Ming,Gui, Yao-Ting,Lai, Yong-Qing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognostic value. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative realtime polymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and 91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1 expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 in RCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemical assays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated high expression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p = 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients with high expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. This is the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affected patients.
Path Loss Exponent Estimation for Indoor Wireless Sensor Positioning
( Yu-sheng Lu ),( Chin-feng Lai ),( Chia-cheng Hu ),( Yueh-min Huang ),( Xiao-hu Ge ) 한국인터넷정보학회 2010 KSII Transactions on Internet and Information Syst Vol.4 No.3
Rapid developments in wireless sensor networks have extended many applications, hence, many studies have developed wireless sensor network positioning systems for indoor environments. Among those systems, the Global Position System (GPS) is unsuitable for indoor environments due to Line-Of-Sight (LOS) limitations, while the wireless sensor network is more suitable, given its advantages of low cost, easy installation, and low energy consumption. Due to the complex settings of indoor environments and the high demands for precision, the implementation of an indoor positioning system is difficult to construct. This study adopts a low-cost positioning method that does not require additional hardware, and uses the received signal strength (RSS) values from the receiver node to estimate the distance between the test objects. Since many objects in indoor environments would attenuate the radio signals and cause errors in estimation distances, knowing the path loss exponent (PLE) in an environment is crucial. However, most studies preset a fixed PLE, and then substitute it into a radio propagation loss model to estimate the distance between the test points; such method would lead to serious errors. To address this problem, this study proposes a Path Loss Exponent Estimation Algorithm, which uses only four beacon nodes to construct a radio propagation loss model for an indoor environment, and is able to provide enhanced positioning precision, accurate positioning services, low cost, and high efficiency.
An Optoelectronic Transimpedance Amplifier in 180-nm CMOS for Short-range LiDAR Sensors
Yu Hu,Ji-Eun Joo,Myung-Jae Lee,Sung Min Park 대한전자공학회 2022 Journal of semiconductor technology and science Vol.22 No.4
This paper presents an optoelectronic transimpedance amplifier (OTIA) implemented in a 180-nm CMOS technology, in which a P+/N-well avalanche photodiode (APD) is realized on-chip to reduce signal distortions occurring from bond-wire and I/O pad at the input node, a voltage-mode feedforward input configuration is exploited to boost the transimpedance gain, and a cross-coupled inverter-based post-amplifier (CI-PA) is added to reduce the mismatches from the previous stage. The proposed OTIA demonstrate 95.1-dBΩ transimpedance gain, 608-MHz bandwidth, 4.54-pA/√Hz noise current spectral density, 26.4-dB dynamic range that corresponds to the input currents of 2.38 μApp ~ 50 μApp, and 39.3-mW power dissipation from a single 1.8-V supply. The chip core occupies the area of 0.068 mm2.