우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성

심세훈,황보영,권영준,정희연,이분희,김용구 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, Plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. Methods : The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). Results : There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. Conclusion : This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.

2-Amino-1-cyclopentene-1-dithiocarboxylate 유도체들의 전극 반응메카니즘

金映辰,金祐聖,沈允補,崔星洛 부산대학교 기초과학연구소 1990 부산대학교 기초과학연구소 연구논문집 Vol.10 No.-

N-methyl-2-amino-1-cyclopentene-1-dithiocarboxylic acid(N-CH₃acdc)와 2-amino-1-cyclopentene-1-dithiomethyl ester(S-Ch₃acdc)의 전기화학적 거동을 직류롤라로그래피, 순환전압전류법 및 조절전위 전기량법을 사용하여 dimethylformamide(DMF) 용매 중에서 조사하였다. N-CHacdc의 이합체는 +0.98V에서 2전자 산화반응을 거쳐 s가 한 원자 유리된 다섯원자 고리를 형성하는 전극반응이 일어남을 알았다. 그러나, S-CH₃acdc의 경우에 있어서는 N-CH₃acdc 화합물과는 달리 다섯원자 고리를 형성하지 않았으므로 N-CH₃acdc와는 다른 전극반응을 일으킴을 확인하였다. The electrochemical behavior of N-methyl-2-amino-1-cyclopotent-1-dithiocarboxylic acid (N-CH₃acdc) and 2-amino-1-cyclooptent-1-dithiomethyl ester (S-CH₃acdc) in DMF have been investigated by the use of polyargraphy, cyclic voltammetry and colometry. The dimer of N-CH₃acdc is further oxidized at +0.98 V via 2-electron process to produce free sulfur atom and cyclization product. The ring formation between two dithio group occurs along with the elimination of one sulfur atom. The elimination of sulfur atom occurs via two electron oxidation process at +0.98V vs. Ag/AgCl electrrode. However, the cyclization does not occur in the S-CH₃acdc.

확대관의 형상에 따른 원관내의 유속분포에 관한 연구

윤영환,심인보 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

An expanded pipe is an important device in designing energy system such as combustion chamber, heat exchanger and turbulence generator. In this study, mean velocity distribution and turbulent, fluctuation component of u' in the expanded pipe of which diffuser angles are ½θ=90。, 60。, 30。 and 15。 from 16㎜φ pipe to 32㎜φ pipe are measured by LDV system. Reynolds number of the experiments are from 8,000 to 60,000 approximately based on diameter and mean velocity of the large pipe. From the experiments, velocity profile at 150mm downstream from the diffuser become closer to fully developed velocity profile as Reynolds number becomes greater and the diffuser angle becomes smaller. However, turbulent fluctuation components of u' were almost uniform or homogeneous at the same location across cross section of the pipe for almost measuring condition. Therefore, these experimental data could be utilized in design of turbulence generator with parameters of velocity. angle of the diffuser and distance from the diffuser. Furthermore, velocity profiles and turbulent fluctuation components at 50㎜ upstream from the diffuser are also measured in order to use these data as inlet condition in numerical computation for comparison between experimental and computational data in an expanded pipe.

탄소섬유의 CVD-SiC 증착특성에 미치는 CH₃SiCl₃대 H₂의 비율의 영향

박병배,심환보,이보성,이영석,김종환 忠南大學校 産業技術硏究所 1994 산업기술연구논문집 Vol.9 No.2

Chemical vapor deposition of SiC on carbon fibers was investigated to improve oxidation resistance of carbon fibers, which was performed at the horizontal hot-wall reactor using the reactant mixtures of CH₃SiCl₃and H₂ with carrier gas Ar. The chemical composition, oxidation resistance, and tensile strength of SiC-coated carbon fiber were investigated as functions of CH₃SiCl₃/H₂ ratio, reaction temperature, coating thickness, and so on. The composition of deposited layer revealed C rich β-SiC at low hydrogen concentration and Si rich β-SiC at high hydrogen concentration. Because Si rich β-SiC layer is easy to be converted into SiO₂ favorable to oxidation resistance, high input value of H₂/CH₃SiCl₃ mole ratio resulted in good oxidation resistance in the SiC coating layer of carbon fibers.

싸이버(Cyber) 문학의 현황과 전망 : Hypertext를 중심으로

안무승,심영보 대전대학교 인문과학연구소 2002 人文科學論文集 Vol.33 No.-

ПРЕЗЕНТАЦИЯ И КОММЕНТИРОВАНИЕ ФРАЗЕОЛОГИЧЕСКИХ ЕДИНИЦ РУССКОГО ЯЗЫКА В КОРЕЙСКОЙ АУДИТОРИИ

SHIM,YOUNG-BO 대구효성가톨릭대학교 1997 연구논문집 Vol.54 No.1

러시아의 언어학자 Б.Н.Головин은 "노어학입문서"에서 "노어학습에 있어 무엇보다 중요한 것은 정확한 어휘의 이해와 올바른 어휘의 사용이다. 그러므로 노어학습에 있어 중점을 두어야 할 부분은 정확한 이해와 많은 어휘의 비축을 돕는 일이다"라고 어휘의 중요성을 지적하고 있다. 현실적으로 노어학습 과정에 있어 문법적 지식과 함께 많은 어휘의 습득은 무엇보다도 중요한 역할을 하며, 특히 고급노어의 구사에 있어 러시아의 민속, 민족적특징을 내포하고 있는 문화어나 러시아의 역사 발전과정에서 생성된 속담, 관용구 등은 특별한 의미를 지닌다. 특히 한국과 러시아간의 오랜기간에 걸친 문화의 단절, 짧은 외교 역사등은 한국인의 러시아어 학습과정 및 학문적 접근에 있어 어려움을 주고있다. 문학예술작품의 분석이나 시사노어 학습에 있어 역사, 문화적인 내용을 함축하고 있는 어휘와 민족성원간의 활발한 삶 속에서 생성된 속담, 관용구 등은 특별한 해설이나 설명없이는 이해하기 힘들다. 이러한 관점에서 러시아의 속담이나 성구를 한국의 그것과 비교분석해 보고자 했다.

Analysis of the Structure of Correlations Between Yields and Some Qnantitative Traits in Sesame

Shim Kang-Bo,Kang Churl-Whan,Lee Yu-Young,Pae Suk-Bok,Jung Chan-Sik,Lee Myeong-Hee,Ahn Young-Sup,Suh Duck-Yong 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

Elevated Levels of Inflammatory and Vasoactive Factors in the Culprit Coronary Artery of Acute Myocardial Infarction

( Young Guk Ko ),( Jae Hun Jung ),( Sung Ha Park ),( Eui Young Choi ),( Bo Young Joung ),( Ki Chul Hwang ),( Dong Hoon Choi ),( Yang Soo Jang ),( Nam Sik Chung ),( Won Heum Shim ),( Seung Yun Cho ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3

Distal embolization of the thrombus and plaque debris, as well as the release of inflammatory and vasoactive factors are suggested as important factors that may jeopardize successful myocardial reperfusion during primary coronary intervention. However, there are currently few clinical data on the presence and the role of such factors. We performed in 18 acute myocardial infaction patients primary percutaneous coronary intervention(PCI) with the distal protection device of distal occlusive balloon type, PercuSurge GuideWire system. We collected blood samples from the femoral artery before PCI and from culprit coronary artery using Export aspiration catheter after predilation while inflating the distal protection balloon and after completing PCI with deflation of the distal protection balloon. We determined concentrations of C-reactive protein, soluble CD40 ligand, IL-6, serotonin, tissue factor, and factor VIIa inblood samples. The concentrations of soluble CD40 ligand(2.84±3.74 vs 0.98±0.63 ng/mL, p= 0.004), IL-6(33.67±32.63 vs 17.08±21.41 pg/mL, p<0.001), serotonin(2.05±0.76 vs 0.92±0.60 ng/mL, p<0.001), tissue factor (257.17±84.34 vs 154.60±87.99 pg/mL, p<0.001) and factor VIIa(34.30±27.30 vs 24.19±28.00 ng/mL, p=0.016) were significantly higher in the culprit coronary artery after the first predilation than those in the peripheral blood before PCI. However, the CRP concentrations in the samples from the culprit coronary artery and the femoral artery did not differ significantly(4.15±3.19 vs 4.60±3.68 mg/L, p=0.056). The blood samples from coronary artery after multiple aspirations showed reduced concentrations of soluble CD40 ligand(2.84±3.74 to 1.64±1.96 ng/mL, p=0.030), IL-6(33.67±32.63 to 22.44±21.87 ng/mL, p=0.010), serotonin(2.05±0.76 to 1.29±0.82 ng/mL, p<0.001), tissue factor(257.17±84.34 to 198.45±95.14 ng/mL, p=0.001) and factor VIIa(34.30±27.30 to 27.65±27.24 ng/mL, p=0.001) compared to those in the coronary aspirates obtained after first balloon dilation of the culprit lesions. We found increased levels of soluble inflammatory and vasoactive factors such as soluble CD40 ligand, IL-6, serotonin, tissue factor and factor VII in the aspirate from the culprit coronary artery compared to those in peripheral blood. The aspiration of blood from culprit lesion during PCI resulted in significantly reduced concentrations of inflammatory and vasoactive markers.

Case Report : Two Cases of Adrenal Abscesses Following Histoacryl(R) (N -butyl-2-cyanocrylate) Injection

( Bo Young Lee ),( Jae Young Jang ),( Soung Won Jeong ),( Gene Hyun Bok ),( Jeong Ho Ham ),( Joo Young Cho ),( Joon Seong Lee ),( Chan Sup Shim ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Gut and Liver Vol.5 No.2

We report two cases of adrenal abscesses that occurred following a Histoacryl(R) (N-butyl-2-cyanocrylate) injection for variceal bleeding. Patients had been diagnosed with alcoholic liver cirrhosis and gastric varices bleeding and received a Histoacryl(R) injection for the variceal bleeding. Patients had fever and abdominal tenderness and were diagnosed with an adrenal abscess at 2 months following the Histoacryl(R) injection. One patient received open drainage and the other underwent percutaneous drainage. When a patient has previously been injected with Histoacryl(R) for the treatment of variceal bleeding and presents with fever, an evaluation for an unusual complication such as adrenal abscess is recommended. (Gut Liver 2011;5:242-244)

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-036 : Mycobacterial Diseases ; Risk Factors for Recurrence of Successfully Treated Mycobacterium Avium Complex Lung Disease

( Bo Young Lee ),( Sun Young Kim ),( Sang Do Lee ),( Woo Sung Kim ),( Dong Soon Kim ),( Tae Sun Shim ),( Kyung Wook Jo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Many patients successfully treated for Mycobacterium avium complex(MAC) lung disease experience recurrence. This study analyzed the recurrence rate and risk factors for recurrence in patients successfully treated for MAC lung disease. Methods: The medical records of 158 patients successfully treated for MAC lung disease at a tertiary referral center in South Korea between March 2000 and December 2009 were retrospectively analyzed. Recurrence was recorded, and factors associated with recurrence were analyzed. Results: The mean age of the 158 patients was 60.7 ± 11.1 year; 75 (47.5%) were male. The etiologic agent was Mycobacterium avium in 77 patients (48.7%) and Mycobacterium intracellulare in 81 (51.3%). Forty-nine patients (31.0%) had the fi brocavitary form of the disease. Almost all patients had been previously treated with a macrolide-containing regimen, and 68 (43.0%) had received an aminoglycoside. During a median follow-up of 43.8 months, 50 (31.6%) patients experienced recurrence, at a median 11.9 months after treatment completion. Recurrence rate was higher in patients aged > 65 than in those = 65 years (p = 0.028) and those with the nodular bronchiectatic form than with other forms of the disease (p = 0.002). Multivariate analysis showed that only the nodular bronchiectatic form of the disease (odds ratio =3.22, 95% confi dence interval 1.42-7.27) was independently associated with increased risk of recurrence. Conclusions: Recurrence after successful treatment is frequent in patients with MAC lung disease. The recurrence rate was signifi cantly higher in patients with the nodular bronchiectatic form of the disease.