In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

양육시설 아동의 자아존중감 향상을 위한 미술치료 사례연구

장영숙,윤경아 조선대학교 학생지도연구소 2005 生活指導硏究 Vol.24 No.-

This case study aimed to improve low self-esteem and positive behavior development of a child who lives in a rehabilitation facility. The research questions included the following : 1. Do art therapy effective in improve self-esteem of the child who lives in rehabilitation facility? 2. Do art therapy effective in positive behavior development of the child who lives in rehabilitation facility? The subject of this study was six-years-old girl who lives in S-rehabilitation facility located in Gwangju. Art Therapy for the child has been progressed 16 sessions, twice a week, for 60 to 90 minutes. This case study used House-Tree-Person test supposed by Buck and Behavior Development Checklist reconstructed by the researcher as Measure apparatus. In conclusion, Art Therapy Program was effective in improving self-esteem and positive behavior development of the child who lives in rehabilitation facility.

학령전기 여아의 하반신 체형 유형분석 : 부산 및 경남지역을 중심으로

장정아,권영숙 服飾文化學會 2000 服飾文化硏究 Vol.8 No.6

This study was done to provide the fundamental data for scientific and rational children's clothing sizing system by investigating their somatometric characteristics and classifying somatotypes. The subjects were 269 elementary schoolgirls aged from 7 to 8 years old living in Pusan and Kyungsangnam-do. Data from each girl comprises 28 anthropometic measurments and 4 photographic measurments, related to the lower half of body. To analyze somatotypes of the lower half of body, factor analysis, cluster analysis, discriminant analysis were performed far statistical analysis of the data. As to the analysis to draw somatometric factors by this age group, five factors which explain 76.85% of the whole variances were extracted. The first and second factors which explain more than 60% of the whole variances represent 'horizontal size' and 'vertical size', which characterize most aspects of the body shape of the subjects. On the basis of the cluster analysis, three different lower half of body types were categorized. Type I has biggest horizontal size, average vertical size and most protruded belly. Type Ⅱ has average decree of horizontal size, quite big vertical size and most protruded hips. Type Ⅲ has smallest horizontal and vertical size. According to the analysis to discriminate somatotypes of the lower half of body of this age group, weight and waist circumference of discriminant function 1 and abdominal circumference of discriminant function 2 have coefficient values.

열공성 뇌경색과 뇌내출혈의 위험인자 비교

이장준,이현아,최종환,이형,임정근,이상도,박영춘 계명대학교 의과학연구소 2000 계명의대학술지 Vol.19 No.2

Cerebral small vessel disease is the most important cause of lacunar infarction (LI) and intracerebral hemorrhage (ICH). It is generally postulated that, in its early stages, the vascular lesion engenders vessel wall fragility and ICH. But if rupture dose not occur, segmental vessel occlusion evolves, producing LI. It may be a common aging phenomenon that is exacerbated by hypertension and diabetes mellitus. This study was performed to evaluate risk factors of LI and ICH. We reviewed retrospectively the medical records of 690 patients (254 LI, 436 ICH) with stroke who were admitted to Keimyung University Dongsan Medical Center from January 1995 to December 1998. The major risk factors including age, sex, hypertension, diabetes mellitus and several minor risk factors were analyzed in these patients. Older age (p<0.01), male sex(p<0.01), hypertension with treatment(p<0.01), hypertension with long duration(p<0.01) and hypertriglyceridemia(p<0.01), cigarette smoking(p<0.01) were significantly more frequent in LI. Younger age(p<0.01), female sex(p<0.01) and hypertension without treatment(p<0.01), hypertension with short duration(p<0.01) were more frequent in ICH. The prevalence, duration and treatment of diabetes mellitus were not different between these two groups. This study show that the age, sex, treatment of hypertension, duration of hypertension and cigarette smoking seem to be significant risk factors between LI and ICH.

기관지 방선균증의 임상 1례

이은영,장태원,정만홍,옥철호,이규원,손창배,이지숙,신은경,서정아,백종현,김영옥 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Actinomycosis is a chronic suppurative infection, whitch infiltrates mucosa-associated tissues. Thoracic, pelvic and cervicofacial infections of actinomyces are not uncommon, but endobronchial actinomycosis is rarely reported. We report a case of a 29 year old man who presented with a recurrent pneumonia and chronic cough. Fiberoptic bronchoscopy revealed occlusion of the right. lower medio-basal segment bronchus with exophytic endobronchial mass. The diagnosis was confirmed histologically by demonstration of sulfur granules in the bronchoscopic biopsy of the mass. Intravenous administration of amoxacillin and clindamycin followed by oral amoxacillin and clindamycin therapy resulted in complete recovery.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

Integrative molecular profiling identifies a novel cluster of estrogen receptor‐positive breast cancer in very young women

Park, Charny,Yoon, Kyong‐,Ah,Kim, Jihyun,Park, In Hae,Park, Soo Jin,Kim, Min Kyeong,Jang, Wooyeong,Cho, Soo Young,Park, Boyoung,Kong, Sun‐,Young,Lee, Eun Sook John Wiley and Sons Inc. 2019 Cancer Science Vol.110 No.5

<P>Very young breast cancer patients are more common in Asian countries than Western countries and are thought to have worse prognosis than older patients. The aim of the current study was to identify molecular characteristics of young patients with estrogen receptor (ER)‐positive breast cancer by analyzing mutations and copy number variants (CNV), and by applying expression profiling. The whole exome and transcriptome of 47 Korean young breast cancer (KYBR) patients (age <35) were analyzed. Genomic profiles were constructed using mutations, CNV and differential gene expression from sequencing data. Pathway analyses were also performed using gene sets to identify biological processes. Our data were compared with young ER+ breast cancer patients in The Cancer Genome Atlas (TCGA) dataset. <I>TP53</I>,<I>PIK3CA</I> and <I>GATA3</I> were highly recurrent somatic mutation genes. APOBEC‐associated mutation signature was more frequent in KYBR compared with young TCGA patients. Integrative profiling was used to classify our patients into 3 subgroups based on molecular characteristics. Group A showed luminal A‐like subtype and IGF1R signal dysregulation. Luminal B patients were classified into groups B and C, which showed chromosomal instability and enrichment for APOBEC3A/B deletions, respectively. Group B was characterized by 11q13 (CCND1) amplification and activation of the ubiquitin‐mediated proteolysis pathway. Group C showed 17q12 (ERBB2) amplification and lower ER and progesterone receptor expression. Group C was also distinguished by immune activation and lower epithelial‐mesenchyme transition (EMT) degree compared with group B. This study showed that integrative genomic profiling could classify very young patients with breast cancer into molecular subgroups that are potentially linked to different clinical characteristics.</P>

산책을 통한 조형요소 탐색활동이 유아의 창의적 그림표현력과 그림감상능력에 미치는 영향

신경아 ( Kyung Ah Shin ),장영숙 ( Young Sook Jang ) 미래유아교육학회 2012 미래유아교육학회지 Vol.19 No.2

본 연구의 목적은 산책활동을 통한 주변의 조형요소 탐색활동이 유아의 창의적 그림표현력과 그림 감상능력에 미치는 영향을 살펴보고자 하는 것이다. 이를 위해 52명의 유아(실험집단의 유아 26명과통제집단의 유아 26명)를 연구대상으로 하여 12주간의 실험을 실시하였다. 실험집단은 산책활동을 통해 그림주제와 관련된 조형요소를 탐색한 후 그림 그리기 활동을 실시하였으며 통제집단은 교실에 서 그림주제와 관련된 사진자료를 활용하여 조형요소를 탐색한 후 그림 그리기 활동을 실시하였다. 그 결과, 산책을 통해 조형요소 탐색활동을 한 유아들이 교실에서 조형요소를 탐색한 유아들보다 창의적 그림표현력과 그림감상능력을 증진시키는데 효과적이었다. 이와 같은 연구 결과는 산책활동이 사물을 자세히 관찰하는 탐구력과 조형요소에 대한 미적 안목을 길러주어 창의적 그림표현력과 그림감상능력을 기르기 위한 효과적인 교육 방법이라는 것을 알 수 있다. The purpose of this study was to find out the effect of figurative element exploration activities through nature walks on young children`s creative drawing and picture appreciation ability. The subjects of this study were 52 young children who attended two kindergartens in Kyeonggi province. Among them, 26 children were assigned in an experimental group, and the rest 26 children were assigned in a control group. Young children in the experimental group were asked to draw pictures after experiencing figurative elements through nature walks once a week for twelve weeks. On the other hand, children in the control group drew pictures after experiencing the figurative elements by using photo materials during the same period. The collected data were statistically analyzed by t-test using SPSS 12.0 program. The results of the study were as follows. First, the statistically meaningful differences between experimental group and control group in creative drawing ability were shown. Second, there were statistically meaningful differences between experimental group and control group in picture appreciation ability. The results of this study show that the experience of figurative elements through nature walks should be offered to improve creative drawing and picture appreciation ability for young children.

Pitx2 induces the differentiation of epidermal keratinocyte

( Ah Young Cho ),( Ge Shi ),( Kyung Cheol Sohn ),( Dae Kyoung Choi ),( Tae Young Choi ),( Chang Deok Kim ),( Young Joon Seo ),( Jang Kyu Park ),( Jeung Hoon Lee ) 대한피부과학회 2008 초록집 Vol.46 No.20

Construction and Characterization of Shuttle Vectors for Succinic Acid-Producing Rumen Bacteria

Jang, Yu-Sin,Jung, Young Ryul,Lee, Sang Yup,Kim, Ji Mahn,Lee, Jeong Wook,Oh, Doo-Byoung,Kang, Hyun Ah,Kwon, Ohsuk,Jang, Seh Hee,Song, Hyohak,Lee, Sang Jun,Kang, Kyu Young American Society for Microbiology 2007 Applied and environmental microbiology Vol.73 No.17

<B>ABSTRACT</B><P>Shuttle vectors carrying the origins of replication that function in <I>Escherichia coli</I> and two capnophilic rumen bacteria, <I>Mannheimia succiniciproducens</I> and <I>Actinobacillus succinogenes</I>, were constructed. These vectors were found to be present at ca. 10 copies per cell. They were found to be stably maintained in rumen bacteria during the serial subcultures in the absence of antibiotic pressure for 216 generations. By optimizing the electroporation condition, the transformation efficiencies of 3.0 × 10<SUP>6</SUP> and 7.1 × 10<SUP>6</SUP> transformants/μg DNA were obtained with <I>M. succiniciproducens</I> and <I>A. succinogenes</I>, respectively. A 1.7-kb minimal replicon was identified that consists of the <I>rep</I> gene, four iterons, A+T-rich regions, and a <I>dnaA</I> box. It was found that the shuttle vector replicates via the theta mode, which was confirmed by sequence analysis and Southern hybridization. These shuttle vectors were found to be suitable as expression vectors as the homologous <I>fumC</I> gene encoding fumarase and the heterologous genes encoding green fluorescence protein and red fluorescence protein could be expressed successfully. Thus, the shuttle vectors developed in this study should be useful for genetic and metabolic engineering of succinic acid-producing rumen bacteria.</P>