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- 저자 : Yanling Xie (검색결과 5 건)
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( Yanling Quan ),( Lin Wang ),( Yisheng Liu ),( Jingxiang Cong ),( Shengquan Xie ),( Xiuhong Wu ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.3
Plackett-Burman (PB) and Box-Behnken (BB) experimental designs were used to optimize fermentation variables for the biotransformation of glycyrrhizin (GL) to monoglucuronyl-glycyrrhetinic acid (MGGA). The PB design was first used to screen the important factors among the medium variables. The steepest ascent method was used to approach the optimum range for each of these factors. The BB design was finally used to analyze the response surfaces of the screened factors for further optimization. The optimized conditions for this system were 0.7 g/L MgSO4·7H2O, 1.19 g/L GL, and cultivation for six days. The biotransformation of GL to MGGA could reach up to 35.72%, which is a good result for this kind of transformation.
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Complete noncompact submanifolds of manifolds with negative curvature
Ya Gao,Yanling Gao,Jing Mao,Zhiqi Xie 대한수학회 2024 대한수학회지 Vol.61 No.1
In this paper, for an $m$-dimensional ($m\geq5$) complete noncompact submanifold $M$ immersed in an $n$-dimensional ($n\geq6$) simply connected Riemannian manifold $N$ with negative sectional curvature, under suitable constraints on the squared norm of the second fundamental form of $M$, the norm of its weighted mean curvature vector $|\textbf{\emph{H}}_{f}|$ and the weighted real-valued function $f$, we can obtain: \begin{itemize} \item several one-end theorems for $M$; \item two Liouville theorems for harmonic maps from $M$ to complete Riemannian manifolds with nonpositive sectional curvature. \end{itemize}
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Interpenetration Enhancing of Chitosan-PEGLM Double Network (DN) Hydrogel and Its Properties
Yiting Xu,Jianjie Xie,Hui Gao,Ying Cao,Min Chen,Yanling Liu,Birong Zeng,Feng-Chih Chang,Lizong Dai 한국고분자학회 2015 Macromolecular Research Vol.23 No.1
A series of polylactic acid-polyethylene glycol-polylactic acid diacrylate macromers (PEGLM) were synthesized,and a novel chitosan-PEGLM double network (DN) hydrogel was further successfully fabricated by thesequential interpenetrating technology with highly cross-linked chitosan as the rigid component and PEGLM as theflexible component. Their structures and components were characterized by 1H NMR, FTIR, and XRD. Their fracturemorphology was investigated by SEM. It was interesting to found that the compressive strength of hydrogel woundreach its maximum value when the chitosan content was 10%, no matter what the molecular weight of PEGLM componentwas. What’s more, we found that the compressive strength of 6KL7 could reach 1.07 MPa at gel state, whosePEG segment molecular weight was 6,000, and polymerization degree of PLA was 7. The effects of glutaraldehyderatio, polymerization degree of PLA, and molecular weight of PEG segment on the mechanical strength of DNhydrogels were also discussed in this article. To further strengthen DN hydrogels, the double network-linear (DNL)hydrogels were fabricated by introducing linear poly(vinyl alcohol) (PVA) into the DN hydrogels. The DN-Lhydrogels exhibited better mechanical properties, with the compressive strength up to 1.45 MPa. These hydrogelsmay have prospective applications in the fields of wound dressing, artificial cartilage and tissue engineering scaffoldmaterials which require high mechanical properties.
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Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
Dongliang Yang,Meng Ding,Yanni Song,Yanling Hu,Weijun Xiu,Lihui Yuwen,Yannan Xie,Yingnan Song,Jinjun Shao,Xuejiao Song,Heng Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot betreated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the body’s immune systemto eliminate pathogenic bacteria has confrmed promising therapeutic strategies in controlling bacterial infections. Subsequent studies found that antimicrobial immunotherapy has its own benefts and limitations, such as avoidingrecurrence of infection and autoimmunity-induced side efects. Current studies indicate that the various antibacterialtherapeutic strategies inducing immune regulation can achieve superior therapeutic efcacy compared with mono therapy alone. Therefore, summarizing the recent advances in nanomedicine with immunomodulatory functionsfor combating bacterial infections is necessary. Herein, we briefy introduce the crisis caused by drug-resistantbacteria and the opportunity for antibacterial immunotherapy. Then, immune-involved multimodal antibacterialtherapy for the treatment of infectious diseases was systematically summarized. Finally, the prospects and challengesof immune-involved combinational therapy are discussed.
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Juan Feng,Xiang Li,Xiaolan Yang,Chun Zhang,Yonghua Yuan,Jun Pu,Yunsheng Zhao,Yanling Xie,Huidong Yuan,Youquan Bu,Fei Liao 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
The use of uricase-deficient mammals to screen formulations of engineered uricases as potential drugs for hyperuricemia involves heavy costs and presents a technical bottleneck. Herein, a new practical system was investigated to evaluate the pharmacological significance of a bacterial uricase based on its ability to eliminate uric acid in plasma in vitro, its pharmacokinetics in vivo in healthy rats, and the modeled pharmacodynamics in vivo. This uricase, before and after modification with the monomethyl ether of poly(ethylene glycol)-5000, effectively eliminated uric acid in vitro in rabbit plasma, but its action was susceptible to xanthine inhibition. After intravenous injection of the modified uricase without purification, a bi-exponential model fit well to uricase activities in vivo in the plasma of healthy rats; the half-life of the modified uricase was estimated without interference from the unmodified uricase leftover in the sample and was nearly 100-fold longer than that of the unmodified uricase. Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Hence,this practical system is desirable for doing preliminary screening of formulations of engineered uricases as potential drugs for hyperuricemia.
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