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이익수(Yk-Su Lee),박구원(Koo-Won Park),박진우(Jin-Woo Park) 한국콘텐츠학회 2008 한국콘텐츠학회논문지 Vol.8 No.2
재래시장은 경영환경의 변화에 따라 많은 어려움을 겪고 있다. 그동안 위기에 처한 재래시장을 활성화 시키기 위한 다양한 연구들이 진행되었다. 이에 따라 정부는 막대한 예산을 지원하여 재래시장의 현대화에 노력하였다. 그러나 외형적으로는 재래시장이 변화했으나 실제에 있어서는 아직 성과는 미미하다. 이러한 문제의식을 바탕으로 실시한 본 연구에서는 현재의 재래시장과 바람직한 재래시장에 대한 인식의 차이가 있음을 발견하였다. 이러한 인식차이를 바탕으로 재래시장 명소화의 방향 및 전략을 제시하였다. Depending on the changing business environment in the traditional markets are experiencing a lot of difficulties. In order to enable traditional markets has been to the brink of a variety of studies in progress. Accordingly, the government has a budget to support the massive effort to modernize its traditional markets. However, traditional market is changing, but the bottom line is the actual appearance of solving performance was still little. Based on these issues, awareness of the current research conducted in this desirable market and the traditional market for the traditional differences in the recognition of the discovery. Recognition of these differences based on the traditional attractions market direction and composition of the present strategy.
Jeon, YK,Park, CH,Kim, K-Y,Li, YC,Kim, J,Kim, YA,Paik, J-H,Park, B-K,Kim, C-W,Kim, Y-N John Wiley Sons, Ltd. 2007 The Journal of pathology Vol.213 No.2
<P>NK/T-cell lymphoma (NKTL) is strongly associated with latent Epstein–Barr virus (EBV) infection. Recently, latent membrane protein 1 (LMP1), an EBV oncoprotein, was reported to activate the phosphatidylinositol-3 kinase (PI3K)/Akt pathway for cell survival. Because geldanamycin (GA) and its derivative, 17-allylamino-17-demethoxygeldanamycin (17-AAG), exhibit anti-tumour activity by degrading HSP90 client proteins, including Akt, we investigated the effect of GA and 17-AAG on the survival of NKTL cell lines. EBV-positive NKTL cell lines, Hank-1 and NK-YS, and an EBV-negative NK leukaemia cell line, NK-L, were treated with PI3K and Akt inhibitors, GA, and 17-AAG, and were subjected to apoptosis and cell viability assays, and immunoblot analysis. EBV-positive B-lymphoblastoid cell lines IM9 and LMP1-transfected IM9 (IM9-LMP1) were also included. Hank-1 and NK-YS cell viability was compromised and apoptosis was induced by LY294002 (PI3K inhibitor) or Akt inhibitor II. GA or 17-AAG administration resulted in the apoptosis of NKTL cells, accompanied by Akt and pAkt down-regulation, caspase 3 activation, and mitochondrial membrane potential disruption. The intrinsic level of pAkt was higher in EBV-positive NKTL cells than in EBV-negative NK-L, and GA or 17-AAG decreased the viability of NKTL cells more efficiently than NK-L. Moreover, IM9-LMP1 was more sensitive to Akt inhibitor II or HSP90 inhibitors than IM9. Importantly, GA showed little effect on the viability of normal peripheral NK cells as non-neoplastic counterparts for comparison. In conclusion, this study suggests that the PI3K/Akt pathway is frequently activated in EBV-positive NKTL and that therapeutic modalities based on targeting the PI3K/Akt pathway with HSP90 inhibitors could be useful for achieving NKTL control. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>
Estrogen 과 Progesterone이 대장균의 백서질 및 방광점막 상피세포 점착에 미치는 영향
이영기(YK Lee),박정옥(JO Park),김정욱(JW Kim),박완석(WS Park),이승호(SH Lee) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.1
난소적출술을 시행한 암컷 흰주에 난소호르몬을 투여했을 때와 수컷 흰쥐에 estrogen을 투 여했을 때 각각의 대조군과 비교해서 어느정도의 대장균 점착이 방광 및 질상피세포에 일어 나는가 하는 연구결과 다음과 같은 결론은 얻었다. 1. 양측난소적출술을 시행한 암컷 흰쥐에 난소호르몬을 투여했을 때 대조군보다 유의한 대 장균 점착의 증가가 있었다. 2. 암컷과 수컷사이의 대장균 점착은 암컷의 경우 유의하게 많이 점착되었으며 암컷 방광상 피의 경우 약제를 투여한 주수에 따라 유의한 증가가 있었으나 질상피의 경우 주수에 따른 유의한 차이는 없었다. 수컷 흰쥐에 있어서 estrogen을 투여한 경우 대조군보다 유의한 증 가가 있었으나 투여 주수에 따른 유의한 차이는 없었다. 3. 임신중 증가된 비뇨기계 감염의 원인으로서 난소호르몬이 중요한 영향을 끼친다고 볼 수 있으며 progestereone을 단독 투여한 경우에서 보다 많은 대장균 점착을 보인것과 질상피세 포보다 방광상피세포에서 더 많은 대장균 점착을 보인 점에 대해서는 앞으로 더 연구가 되 어야 할 과제라 사료된다. The effect of exogenous ovarian hormones administered to male and oophorectomized female rats was investigated with regard to in vitro adherence of escherichia coli to exfoliated bladder and vaginal epithelial cells. The results were summarized as follows; 1. In female rats tendency of E. coli adhencrence to vaginal and bladder epithelial cells was significantly greater in ovarian hormone administered rats than in control group . 2. In ovarian hormone administered female rats, E.coli attached in significantly greater number to the bladder epithelial cells, E.coli adherence was oberved in greatest number in progesterone administered rats followed by estrogen administered group , and combined progesteren and estrogen administered group in descending order. 4. Duration of hormone administration correlated with the degree of E.coli adherence in female bladder epithelial cells however on influence was noted in female vaginal epithelial cells, neither in other hormone administraion. 5. In male rats, E.coli adherence was observed in significantly greater number in Estrogen administered rats, but the duration of administrtion gave no significantly effects. 6. Enhanced E.coli adherence was significantly greater in female rats than in male rats.
박송훈(SH Park),박윤기(YK Park),김종욱(JW Kim),이태형(TH Lee),이승호(SH Lee) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.11
The Endodermal sinus tumor of the ovary is a rare and highly lethal germ cell tumor The patient who came under our observation, died after 14 months despite debulking surgery and extensive chemotherapy We present a case of Endodermal sinus tumor with brief review of literatures.