The Media Literacy of Residents in Southwestern China During the COVID-19 Epidemic

Shan He(Shan He),Lili Yao(Lili Yao),Xingyu Zhao(Xingyu Zhao),Weiwei Liu(Weiwei Liu) 아시아사회과학학회 2023 International Science Research Vol.3 No.2

Objective To measure residents’ abilities to acquire, analyze and evaluate information on media in southwestern China and to explore its predictive factors. Methods The convenience sampling method was used. A web-based questionnaire survey was conducted among 774 residents during the Spring Festival in 2020. Results Young, highly educated, unmarried, high-income, and urban residents preferred to seek and acquire information about COVID-19 epidemic through new media channels. Elderly residents tended to obtain information through television. Residents with low educational background and rural residents were more dependent on community information media. To analyze residents’ abilities in the judgement of 15 statements about COVID-19, residents with a master’s degree or above (OR = 2.755, [95% CI 1.160-6.542]) had better media literacy in identifying false health information released on social networking. Rural residents (OR = 0.609, [95% CI 0.433-0.855]) had lower media literacy. The total score decreased by 2.6% for every one-year increase of age. Conclusion Residents’ abilities to acquire, analyze and evaluate information were affected by their demographic characteristics in southwestern China. The authorities and local communities should develop different approaches of information dissemination, with the help of traditional and new media. It is important to improve the level of residents' media literacy, in order to achieve better effect in information dissemination and reception.

Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia

Weiwei Shan,Chao Wang,Zhenbo Zhang,Chao Gu,Chengcheng Ning,Xuezhen Luo,Qiongjie Zhou,Xiaojun Chen 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.3

Objective: To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). Methods: This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive metformin plus MA (MET group) or MA monotherapy (MA group). Each patient in the MA group received 160 mg of MA daily, whereas patients in the MET group received the same dose of MA plus 0.5 g of metformin thrice daily. Treatment response was assessed by histological examination of dilation and curettage specimens obtained after 12 weeks of therapy. Results: Each group had eight patients, and half of the patients in each group were diagnosed with MS. The complete response (CR) rate was 75% (6/8) in the MET group and 25% (2/8) in the MA group (p=0.105). Complications of MS did not affect the response rates in either group. In the MET group, 75% (3/4) of the patients had CR in the presence or absence of MS. In the MA group, 50% (2/4) of the patients with MS had CR, whereas no patient without MS had CR. No irreversible toxicities were observed. Conclusion: Metformin plus MA may be a potential alternative therapy for treating EAH, and the MS status of patients may have no effect on the efficacy of metformin plus MA therapy.

疫情防控常态化下医学院校康养专业人才培养的问题与策略研究

刘薇(Weiwei Liu),何姗(Shan He) 아시아사회과학학회 2022 International Science Research Vol.2 No.3

In order to further improve the public health emergency prevention and control mechanism and strengthen the construction of public health talent team, medical universities in China will gradually establish and improve the cultivation system of health care professionals, and provide health care professionals with more high-quality medical universities talent resources. Under the current situation, although most medical universities in China are actively preparing for the cultivation of high-quality talents for health care professionals, on the whole, there are still many problems in the cultivation mode of health care professionals in medical universities in China that need to be solved urgently. This paper elaborates on the training mode and system of health care professionals in the context of the normalization of epidemic prevention and control, aiming to clarify the system construction of health care professionals in medical universities, improve the specifications and levels of health care professionals, and further promote the healthy and orderly development of China's health care industry.

儿童友好型城市建设背景下意外伤害防控体系的构建策略

何姗(Shan He),严雪琴(Xueqin Yan),伍颖(Ying Wu),杨倩茹(Qianru Yang),刘薇薇(Weiwei Liu) 아시아사회과학학회 2023 International Science Research Vol.3 No.1

International researches on the relationship between children and cities, the impact of urban environment on children's body and mind, and how to build a child friendly city have reached a certain depth. At present, the construction of child friendly cities in China is still in its infancy. Among them, the urban spatial planning involving children has not been in-depth, and the disease burden caused by falls and road traffic injuries is still high. In view of the problems existing in the built environment of the city, we should carry out the construction of a child friendly city, pay attention to the safety guarantee of children's activity space, formulate targeted accidental injury prevention and control measures, and promote the inclusive sharing of children's medical and health service resources, high-quality and balanced development.

Prevention and control strategies for unintentional injuries of children in kindergartens/schools

He Shan(何姗,),Liu Weiwei(刘,薇薇) 아시아사회과학학회 2022 International Science Research Vol.2 No.1

教师是托幼机构/学校学龄前和学龄儿童生活环境的主要创造者。加强托幼机构/学校内儿童意外伤害的防控,是全社会开展儿童安全防护工作中的重要一环。托幼机构/学校开展儿童意外伤害防控工作的策略包括:加强托幼机构/学校伤害监测数据分析,创新培养方式、开展教师培训,对环境和产品设计进行技术革新,完善政策制度体系,加强校医人才队伍建设等。 Teachers are the main creators of the living environment of preschool and school-age children in kindergartens/schools. Strengthening the prevention and control of children s unintentional injuries in kindergartens/schools is an important part of the whole society s work of child safety protection. The strategies for childcare institutions/schools to carry out child unintentional injury prevention and control include: strengthening the analysis of injury monitoring data of childcare institutions/schools, innovating training methods, carrying out teacher training, carrying out technical innovation in environment and product design, improving policy and system, and strengthening the construction of school medical talents, etc.

Enhanced Photoelectrochemical Water Splitting and Photocatalytic Water Oxidation of Cu2O Nanocube-Loaded BiVO4 Nanocrystal Heterostructures

Wenzhong Wang,Weiwei Zhang,Shan Meng,Lujie Jia,Miao Tan,Chenchun Hao,Yujie Liang,JUN WANG,Bin Zou 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.6

Reducing the fast recombination of photogenerated electron-hole pairsof semiconductor photocatalyst is very important to improve itsphotocatalysis. In this paper we fabricate Cu2O nanocube-decoratedBiVO4 nanocrystal (denoted as BiVO4@Cu2O nanocrystal@nanocube)heterostructure photocatalyst by coupling n-type BiVO4 with p-type Cu2O. The BiVO4@Cu2O nanocrystal@nanocube photocatalysts show superiorphotocatalytic activities in photoelectrochemical (PEC) activity andphotocatalytic water oxidation to BiVO4 photocatalysts under visible lightillumination. The BiVO4@Cu2O nanocrystal@nanocube heterostructureelectrode achieves the highest photocurrent density of ~ 10 μA cm−2 at 0 Vversus Ag/AgCl, 5 times higher than that of BiVO4 nanocrystal electrode (~ 2 μA cm−2). The light induced evolution rate of O2generation for BiVO4@Cu2O nanocrystal@nanocube heterostructures is as high as 150 μmol h−1100 mg cat−1, more than 3times higher than that (48 μmol h−1100 mg cat−1) of BiVO4 nanocrystals. The enhanced photocatalysis activities of theBiVO4@Cu2O nanocrystal@nanocube photocatalysts are attributed to the efficient separation of the photoexcited electron-holepairs caused by inner electronic field (IEF) of p-n junction. This study opens up new opportunities in designing photoactivematerials with highly enhanced performance for solar energy conversion.

fects of Dietary Soy Intake on Maternal Thyroid Functions and Serum Anti-Thyroperoxidase Antibody Level During Early Pregnancy

Jing Li,Xiaochun Teng,Weiwei Wang,Yanyan Chen,Xiaohui Yu,Shen Wang,Jianxin Li,Lin Zhu,Chenyan Li,Chenling Fan,Hong Wang,Hongmei Zhang,Weiping Teng,Zhongyan Shan 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5

Soy and its isoflavones have been suggested to suppress thyroperoxidase (TPO), induce goiter, inhibit deiodinase, and modulate immune functions. This study initially investigated the effects of dietary soy consumption on maternal thyroid functions and anti-TPO antibody (TPOAb) production during early pregnancy. Data were collected through questionnaire from 505 women enrolled during early pregnancy by random sampling in Shenyang, China. Based on soy intake frequency, the subjects were divided into three groups (frequent [three or more times per week], conventional [more than twice per month but less than three times per week], and occasional [two or fewer times per month]). Serum thyrotropin (TSH), free thyroxine (FT_4), and TPOAb were measured by chemiluminescence immunoassay. Additionally, the concentrations of two primary isoflavones (daidzein and genistein) and creatinine were assessed in the spot urine samples from representative subjects (about 20%) randomly selected from the three groups. The percentages of frequent, conventional, and occasional consumers were 18.6%, 62.6%, and 18.8%, respectively. No difference was found in age, medical records, family history of thyroid diseases, serum FT_4, TSH, and TPOAb levels, TPOAb-positive percentages, or prevalence of thyroid dysfunctions among the groups. Both urinary daidzein and genistein levels were significantly higher in the frequent consumers compared with the other two groups. No correlations were found between urinary isoflavone levels and serum FT_4 or TSH. Urinary isoflavone levels were not significantly different between TPOAb-positive and -negative women among the randomly selected representative subjects. On the whole, our findings suggest dietary soy consumption during early pregnancy is not associated with the development of thyroid dysfunction or autoimmunity.

Comparison of the effect of oral megestrol acetate with or without levonorgestrel-intrauterine system on fertility-preserving treatment in patients with early-stage endometrial cancer: a prospective, open-label, randomized controlled phase II trial (Clin

Zhiying Xu,Bingyi Yang,Jun Guan,Weiwei Shan,Jiongbo Liao,Wenyu Shao,Xiaojun Chen 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1

Objective: To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) plus oral megestrol acetate (MA) as fertility-preserving treatment in patients with early-stage endometrial cancer (EEC). Methods: In this single-center, phase II study with open-label, randomized and controlled design, young patients (18–45 years) diagnosed with primary EEC were screened, who strongly required fertility-preserving treatment. Patients were randomly assigned (1:1) into MA group (160 mg oral daily) or MA (160 mg oral daily) plus LNG-IUS group. Pathologic evaluation on endometrium retrieved by hysteroscopy was performed every 3 months. The primary endpoint was complete response (CR) rate within 16 weeks of treatment. The secondary endpoints were CR rate within 32 weeks of treatment, adverse events, recurrent and pregnancy rate. Results: Between July 2017 and June 2020, 63 patients were enrolled and randomly assigned. Totally 56 patients (26 in MA group; 28 in MA + LNG-IUS group) were included into primary-endpoint analyses. The median follow-up was 31.6 months (range, 3.1–94.0). No significant difference in 16-week CR rate were found between MA and MA + LNG-IUS groups (19.2% vs. 25.0%, p=0.610; odds ratio=1.40; 95% confidence interval=0.38–5.12), while the 32-week CR rates were also similar (57.1% and 61.5%, p=0.743), accordingly. More women in MA + LNG-IUS group experienced vaginal hemorrhage (46.4% vs. 16.1%; p=0.012) compared with MA group. No intergroup difference was found regarding recurrence or pregnancy rate. Conclusion: Compared with MA alone, the addition of LNG-IUS may not improve the early CR rate for EEC, and may produce more adverse events instead.

Characteristics of progestin- insensitive early stage endometrial cancer and atypical hyperplasia patients receiving second-line fertility-sparing treatment

Shuang Zhou,Zhiying Xu,Bingyi Yang,Jun Guan,Weiwei Shan,Yue Shi,Xiaojun Chen 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4

Objective: This study investigated the characteristics of progestin-insensitive endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH) patients receiving fertility-sparing treatments and assessed the therapeutic effects of second-line fertility- preserving treatments. Methods: Three hundred and thirty-eight patients with EEC (n=75) or AEH (n=263) receiving fertility-preserving treatment were retrospectively analyzed. ‘Progestin-insensitive’ was defined as meeting one of the following criteria: 1) presented with progressed disease at any time during conservative treatment, 2) remained with stable disease after 7 months of treatment, and/or 3) did not achieve complete response (CR) after 10 months of treatment. Clinical characteristics and treatment results of progestin-insensitive patients receiving second-line treatment and those of progestin-sensitive patients were compared. Results: Eight-two patients (59 AEH and 23 EEC) were defined as progestin-insensitive and 256 as progestin-sensitive. In multivariate analysis, body mass index ≥28.0 kg/m2 (odds ratio [OR]=1.898) and lesion size >2 cm (OR=2.077) were independent predictors of progestin- insensitive status. Compared to AEH patients, progestin-insensitive EEC patients had poorer second-line treatment responses (28-week cumulative CR rate after changing second-line treatment, 56.3% vs. 85.4%, p=0.011). No statistical difference was found in CR rate among different second-line treatments. Conclusion: Obesity and larger lesion size were independent risk factors associatedwith progestin-insensitive status. In progestin-insensitive patients receiving second-line treatment, EEC patients had lower CR rate comparing with AEH patients. Further study with larger sample size is needed to evaluate efficacy of different second-line treatments for progestin insensitive patients.

PTEN mutation predicts unfavorable fertility preserving treatment outcome in the young patients with endometrioid endometrial cancer and atypical hyperplasia

Yu Xue,Youting Dong,Yaochen Lou,Qiaoying Lv,Weiwei Shan,Chao Wang,Xiaojun Chen 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4

Objective: This study aimed to investigate the impact of molecular classification and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment in the patients with endometrioid endometrial cancer (EEC) and endometrial atypical hyperplasia (EAH). Methods: This is a single-center retrospective study. A total of 135 patients with EEC and EAH receiving fertility-preserving treatment and molecular classification were reviewed. The distribution of the four types of molecular classification was described. The impact of non-specific molecular profile (NSMP), mismatch repair-deficiency (MMRd), and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment was analyzed. Results: Of the patients analyzed, 86.7% (117/136) were classified as having NSMP; 14 (10.4%), MMRd; 1 (0.7%), POLEmut EAH; and 3 (2.2%), p53abn EEC. The patients having NSMP and MMRd achieved similar 16-, 32-, and 48-week complete response rates. The patients harboring tier I and tier II PTEN mutations (PTENmut-Clin) achieved lower cumulative 32-week CR rates than those with PTEN-others (without PTENmut-Clin) (22/47, 46.8% vs. 50/74, 67.6%; p=0.023; odds ratio=0.422; 95% confidence interval [CI]=0.199–0.896). Insulin-resistance (hazard ratio [HR]=0.435; 95% CI=0.269–0.702; p=0.001) and PTENmut-Clin (HR=0.535; 95% CI=0.324–0.885; p=0.015) were independent negative predictors for lower 32-week CR rates. Conclusion: PTENmut-Clin is an independent risk factor for unfavorable fertility-preserving treatment outcomes in the patients with EEC and EAH. The patients with MMRd receiving fertility-preserving treatment achieved outcomes similar to those of the patients with NSMP. The molecular profiles might guide fertility-preserving treatment in the prognosis and clinical decisions.