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Prognostic Significance of Hes-1, a Downstream Target of Notch Signaling in Hepatocellular Carcinoma
Zou, Jing-Huai,Xue, Tong-Chun,Sun, Chun,Li, Yan,Liu, Bin-Bin,Sun, Rui-Xia,Chen, Jie,Ren, Zheng-Gang,Ye, Sheng-Long Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Hairy and enhancer of split 1 (Hes-1) protein is a downstream target of Notch signaling and is a basic helix-loop-helix transcriptional repressor. However, definitive evidence for a role in hepatocellular carcinoma (HCC) cells has not been reported. Here, Hes-1 was revealed to an important component of the Notch signaling cascade in HCC cell lines possessing different potential for lung metastasis. Materials and Methods: RNAi mediated by plasmid constructs was used to analyze the role of Hes-1 in MHCC-97L HCC cells by assessing proliferation, apoptosis, cell migration and matrigel invasion following transfection. Hes-1 protein expression analysis in HCC tissue was also conducted by immunohistochemistry. Results: Our studies revealed that Hes-1 was decreased in HCC cell lines with higher lung metastasis potential at both the mRNA and protein levels. Down-regulation of the Hes-1 gene in MHCC-97L cells resulted in increased cell proliferation, reduced apoptosis and increased migration and invasion. Conclusions: Hes-1 has potential prognostic value in post-surgical HCC patients and may be an independent prognostic indicator for overall survival and tumor recurrence. These findings have important implications for understanding the mechanisms by which Hes-1 participates in tumor proliferation and invasion.
Skin Cancer: Clinico-Pathological Study of 204 Patients in Southern Governorates of Yemen
Al-Zou, Amer Bin,Thabit, Mazen Abood Bin,Al-Sakkaf, Khalid Abdulla,Basaleem, Huda Omer Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Skin cancer is a group of heterogeneous malignancies, in general classified into non-melanoma skin cancer (NMSC) and melanoma skin cancer (MSC). Incidences are high in many parts in the world with considerable geographical and racial variation. In the Yemen, there has been scarce information about skin cancer. The aim of this study was to evaluate the demographic characteristics and histological trend of skin cancer in Southern Governorates of Yemen. Materials and Methods: This retrospective study covered 204 cases of skin cancer at the Modern Histopathology Laboratory and Aden Cancer Registry and Research Center, Faculty of Medicine and Health Sciences, University of Aden, for the period 2006-2013. Data were classified regarding different demographic and tumor related variables and analyzed using CanReg-4 for cancer registry and SPSS (version 21). Results: The commonest encountered skin cancer was NMSC (93.1%). Generally, skin cancer appears slightly more frequently in females than males with a 1:1.06 male: female ratio, with a mean age of 62.9 years. Slightly higher than one-third (36.3%) were from Aden governorate. The head and neck proved to be the most common site in both males and females (58%). Basal cell carcinoma (BCC) is the most common histological type of skin cancer (50.5%). Conclusions: Skin cancer is a common cancer in patients living in southern governorates of Yemen. The pattern appears nearly similar to the international figures with a low incidence of MSC.
Metathetic Degradation of Styrene-Butadiene Rubber via Ru-Alkylidene Complex Catalyzed Reaction
Tingting Zou,Bin Jiang,Shaohui Lin,Qinmin Pan 한국고분자학회 2016 폴리머 Vol.40 No.5
Metathetic degradation and functionalization of styrene-butadiene rubber (SBR) were performed with allyl hexanoate, allyl chloroacetate, 5-hexenyl acetate and trifluoroethyl methacrylate as chain transfer agents (CTAs) using Grubbs 2<SUP>nd</SUP> generation catalyst. It has been demonstrated that the catalyst concentration, CTA concentration and reaction time were major factors influencing the molecular weights and polydispersity indices of targeted telechelic SBR oligomers. Well-defined oligomers with molecular weights ranging from 700 to 36600 g mol<SUP>-1</SUP> and polydispersity indices ranging from 1.17 to 4.79 were realized. The structures of the SBR oligomers were determined by FTIR and <SUP>1</SUP>H NMR analyses, which indicated that the functional groups of the CTAs were successfully attached onto the end of the polymer chains. To further investigate the performance of SBR oligomers, differential scanning calorimetry (DSC) analysis was performed, which indicated that the glass transition temperature (Tg) of the metathesis products decreased with longer reaction time.
Li, Bin,Zhou, Zheng,Zou, Weixia,Gao, Wanxin Hindawi Publishing Corporation 2011 EURASIP journal on advances in signal processing Vol.2011 No.1
<P>Given the dense multipath propagation in typical ultra-wideband channels, traditional coherent receivers may become computationally complex and impractical. Recently, noncoherent UWB architectures have been motivated with simple implementations. Nevertheless, the rudimentary statistical assumption and practical information uncertainty inevitably results in a hardly optimistic receiving performance. Inspired by the nature processes, in this paper we suggest a noncoherent UWB demodulator based on the particle swarm intelligence which can be realized in two steps. Firstly, a characteristic spectrum is developed from the received samples. From a novel pattern recognition perspective, four distinguishing features are extracted from this characteristic waveform to thoroughly reveal the discriminant properties of UWB multipath signals and channel noise. Subsequently, this established multidimensional feature space is compressed to a two-dimension plane by the optimal features combination technique, and UWB signal detection is consequently formulated to assign these pattern points into two classes at the minimum errors criterion. The optimal combination coefficients and the decision bound are then numerically derived by using the particle swarm optimization. Our biological noncoherent UWB receiver is independent of any explicit channel parameters, and hence is essentially robust to noise uncertainty. Numerical simulations further validate the advantages of our algorithm over the other noncoherent techniques.</P>
An Efficient Spatial Data Index Based On Gossip for Overlay Networks
Zhiqiang Zou,Yue Wang,Kai Cao,Shu Shen,Bin Zhang 한국산학기술학회 2013 SmartCR Vol.3 No.3
In large and highly dynamic distributed environments, the retrieval of spatial data entails some challenges such as network topology, indexing efficiency, and mapping methods for multidimensional spatial data. Conventional methods may not allow for the complex retrieval of multidimensional spatial data in an efficient manner. This paper proposes an overlay network for indexing spatial data based on gossip. The proposed network, referred to as the 2D-Ring, has a ring-like topology with a spatial data index. First, the paper introduces a protocol for constructing an overlay network for indexing spatial data and then presents a method for mapping the data onto the 2D-Ring by using a distributed quadtree and control points. The results of a comprehensive experiment for an evaluation of the performance of the 2D-Ring with respect to various features indicate that the 2D-Ring converges logarithmically to network size, has desirable small-world properties, and is robust across dynamic scenarios. The proposed solution can be applied not only to overlay networks but also to other types of networks requiring the sharing of distributed data sets.
Wei Luo,Bin Zhang,Huawei Zou,Mei Liang,Yang Chen 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.51 No.-
In order to improve the interfacial properties in polypropylene/carbonfiber (PP/CF) composites,graphene oxide and brached polyethyleneimine were coated onto the surface of carbonfiber by layer-by-layer assembly in this work. Compared with the origin PP/CF composite, the composites reinforced by PP/CF–GO showed significant enhancement not only in tensile strength but also in elongation at break. Theimprovedfiber–matrix adhesion was proved by fracture morphology observation of scanning electronmicroscopy and almost unaffected mechanical properties of thefiber itself during the coating process. The optimal assembly time was found to be 10 for enhancing the overall composite mechanicalperformance.
Zhang Wanying,Zou Guiling,Li Bin,Du Xuefei,Sun Zhe,Sun Yu,Jiang Xiaofeng 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8
Inflammatory bowel disease (IBD) is an increasing global burden and a predisposing factor to colorectal cancer. Although a number of treatment options are available, the side effects could be considerable. Studies on fecal microbiota transplantation (FMT) as an IBD intervention protocol require further validation as the underlying mechanisms for its attenuating effects remain unclear. This study aims to demonstrate the ameliorative role of FMT in an ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) and elucidate its relative mechanisms in a mouse model. It was shown that FMT intervention decreased disease activity index (DAI) levels and increased the body weight, colon weight and colon length of experimental animals. It also alleviated histopathological changes, reduced key cytokine expression and oxidative status in the colon. A down-regulated expression level of genes associated with NF-κB signaling pathway was also observed. The results of 16S rRNA gene sequencing showed that FMT intervention restored the gut microbiota to the pattern of the control group by increasing the relative abundance of Firmicutes and decreasing the abundances of Bacteroidetes and Proteobacteria. The relative abundances of the genera Lactobacillus, Butyricicoccus, Lachnoclostridium, Olsenella and Odoribacter were upregulated but Helicobacter, Bacteroides and Clostridium were reduced after FMT administration. Furthermore, FMT administration elevated the concentrations of SCFAs in the colon. In conclusion, FMT intervention could be suitable for UC control, but further validations via clinical trials are recommended.