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후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출
최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
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金煥起,梁奉龍,李正元 全北大學校 附設 都市및環境硏究所 1990 都市 및 環境硏究 Vol.5 No.-
This paper was the study on the change of the water quality an water quality management of reservior when Yong-dam dam constructed. The results obtained are as follows, water quality of river in surroundings area was BOD 1-2 ㎎/ℓ, TKN 1 ㎎/ℓ, T-P 0.03-0.013 ㎎/ℓ. Results from calculatin of the pollution loading of conteminations according to environmental factor, water quality was calculated to BOD 0.87 ㎎/ℓ, T-N 0.07 ㎎/ℓ. Because of increased of inlet nutrient, nutrient conditions in Yong-dam reservior will generated to eutrophication. Therefore, methods for control and management nutrition conditions are must be intercept and control to inflow of nutrient that included to water and wastewater.
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한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구
이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1
The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.
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金容完 제주대학교 1983 논문집 Vol.15 No.1
On account of the following reasons, the population of Southern Sung Hang-chou (杭州) increased continually. First, the people who had lived in the northern part moved to the south because of economic prosperity, Second, after Hang-chou changed to a political center, the number of the authority officials and soldiers increased. Third, by means of the Commercial development, many merchants gathered. According to these kind of reasons, the population of Hang-chou which were 0.8 million people only at the early year of Southern Sung exceeded 1.9 million people at the late year. Assuming there were 1.9 million people, the total annual consumption of rice would amount to somewhere between 6,800,000 shih (石) and 13,600,000 shill (provided we count 1 or 2 she^ng (升) of rice as a man's daily consumption) In reality, about 1,500,000 to 1,700,000 shih of official rice were consumed in Hang-chou each year at the early year of Southern Sung, About 800,000 of these were tax rice from Liang-che (兩浙) circuit and the remainder was bought from merchants by the government. By the late year of Dynasty tile purchases hall increased to 1 to 3 million shih. Besides these at least 3,000~4,000 shill Per day, or 1, 100,000 to 1, 400,000 shih annually were consumed by commoners. The places of importing were che^-bsi (浙西), ching-hsi(江西), Hu-nan(湖南) or Kuang-tung (廣東) area where a rice product had abound. Among these places, especially the area of che^-hsi was a largest to import and then the second area was kuang-tung. The transportation of rice was used to by channel or Sea-road rather than using land-road because of lowing expenses of transportation.
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金容完 제주대학교 1984 논문집 Vol.18 No.1
The administrators in Southern Sung feared that if proper measures were not carried out, the displaced people would revolt and disturb the peace. Therefore they enacted the policy to settle these displaced people. The policy can be described in two parts: one(Ⅰ) are temporary steps and the other (Ⅱ) long-term steps. Ⅰ. The first steps were the ones such as free distribution of food and clothing, medical services, and funeral articles, etc. Ⅱ. 1. Lending of arable land and bestowing of some favor: (e.g. exemption from taxes and public labor, endowments of seeds, farming tools, and cattle) 2. Employment as a soldier. 3. Appointment of Kue Cheng Kuan from the north to public offices This policy mentioned above was beneficial not only for the displaced persons but for Southern Sung government herself in that Southern Sung government could increase her financial power by letting them cultivate waste lands and could increase her military personnel.
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염소살균과 오존-염소살균 수도수의 사용과 관련한 가정 트리할로메탄 노출 비교평가
조완근,권기동,동종인,정용 한국환경과학회 2004 한국환경과학회지 Vol.13 No.7
Evaluated were household THMs exposure associated with the use of municipal tap water treated with chlorine and with ozone-chlorine. The current study measured the THMs concentrations in the tap water and indoor and outdoor air in the two types of household. along with an estimation of THMs exposure from water ingestion, showering, and the inhalation of indoor air. Chloroform was the most abundant THMs in all three media, yet no bromoform was detected in any sample. Contrary to previous findings, the fall water THMs concentrations exhibited no significant difference between the chlorine and ozone-chlorine treated water. However. the spring median chloroform concentration in the tap water treated with chlorine (17.6 ppb) was 1.3 times higher than that in the tap water treated with ozone-chlorine (13.4 ppb). It is suggested that the effects of the water parameters should be considered when evaluating the advantage of ozone-chlorine disinfection for THMs formation over chlorine disinfection. The indoor air THMs concentration trend was also consistent with the water concentration trend, yet the outdoor air THMs concentrations did not differ significantly between the two types of household. The indoor to outdoor air concentration ratios were comparable with previous studies. The THMs exposure estimates from water ingestion, showering, and the inhalation of indoor air suggested that, for the residents living in the surveyed households, their exposure to THMs in the home was mostly associated with their household water use, rather than the indoor air. The THMs exposure estimates from tap water ingestion were similar to those from showering.
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