http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Estimating population density of Nicrophorus quadripunctatus (Coleoptera: Silphidae) in Korea
Kim Do‐Sung,Cho Young‐Bok,Han Yong‐Gu 한국곤충학회 2020 Entomological Research Vol.50 No.11
Estimating the population density of organisms is of great concern to ecologists and much effort has been put into making accurate assessment of population levels in nature. We evaluated the trapping web (TW) method for the determination of the density of species of burying beetles. We found eight and six species of burying beetles at Beopjusa and Ssanggok‐ri areas, respectively. Most of the species population comprised Nicrophorus quadripunctatus, with densities of 65 and 195 per ha for Beopjusa and Ssanggok‐ri areas, respectively. Moreover, the flight intercept trap (FIT) method from 2003 to 2007 also revealed the same trend: Beopjusa temple (2928) to Ssanggok‐ri (5835). However, the differences in number of individuals were probably due to the differences in the methods and the length of the trapping period. The populations of N. quadripunctatus exist as metapopulations, making accurate assessment of the population densities extremely difficult. We hypothesized that the TW method could accurately estimate population densities extrapolated from patch population size per area.
최도영,이재동,백용현,이송실,유명철,한정수,양형인,박상도,유미현,박은경,박동석,Choi, Do-young,Lee, Jae-dong,Back, Yong-hyeon,Lee, Song-shil,Yoo, Myung-chul,Han, Chung-soo,Yang, Hyung-in,Park, Sang-do,Ryu, Mi-hyun,Park, Eun-kyung,Park, 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4
Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.
Sang Won Kim,Dongryul Oh,Hee Chul Park,Do Hoon Lim,Sung Wook Shin,Sung Ki Cho,Geum-Youn Gwak,Moon Seok Choi,Yong Han Paik,Seung Woon Paik 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.1
Purpose: To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) followed by radiotherapy (RT) in treatment-naïve patients with locally advanced hepatocellular carcinoma (HCC). Materials and Methods: Eligibility criteria were as follows: newly diagnosed with HCC, the Barcelona Clinic Liver Cancer stage C, Child-Pugh class A or B, and no prior treatment for HCC. Patients with extrahepatic spread were excluded. A total of 59 patients were retrospectively enrolled. All patients were treated with TACE followed by RT. The time interval between TACE and RT was 2 weeks as per protocol. A median RT dose was 47.25 Gy10 as the biologically effective dose using the α/β = 10 (range, 39 to 65.25 Gy10). Results: At 1 month, complete response was obtained in 3 patients (5%), partial response in 27 patients (46%), stable disease in 13 patients (22%), and progressive disease in 16 patients (27%). The actuarial one- and two-year OS rates were 60.1% and 47.2%, respectively. The median OS was 17 months (95% confidence interval, 5.6 to 28.4 months). The median time to progression was 4 months (range, 1 to 35 months). Grade 3 or greater liver enzyme elevation occurred in only two patients (3%) after RT. Grade 3 gastroduodenal toxicity developed in two patients (3%). Conclusion: The combination treatment of TACE followed by RT with two-week interval was safe and it showed favorable outcomes in treatment-naïve patients with locally advanced HCC. A prospective randomized trial is needed to validate these results.
Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
( Do Hyoung Kim ),( Young Youl Hyun ),( Jin Joo Cha ),( Sua Lee ),( Hyun Kyung Lee ),( Jong Wook Choi ),( Su-hyun Kim ),( Sang Youb Han ),( Cheol Whee Park ),( Eun Young Lee ),( Dae Ryong Cha ),( Sung 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.1
In response to the increase in the prevalence of chronic kidney disease (CKD) in Korea, the growth of patients requiring renal replacement therapy and the subsequent increase in medical costs, the rapid expansion of patients with end-stage kidney disease (ESKD), and the decrease in patients receiving home therapy, including peritoneal dialysis, the Korean Society of Nephrology has proclaimed the new policy, Kidney Health Plan 2033 (KHP 2033). KHP 2033 would serve as a milestone to bridge the current issues to a future solution by directing the prevention and progression of CKD and ESKD, particularly diabetic kidney disease, and increasing the proportion of home therapy, thereby reducing the socioeconomic burden of kidney disease and improving the quality of life. Here, we provide the background for the necessity of KHP 2033, as well as the contents of KHP 2033, and enlighten the Korean Society of Nephrology’s future goals. Together with patients, healthcare providers, academic societies, and national policymakers, we need to move forward with goal-oriented drive and leadership to achieve these goals.
( Do Young Kim ),( Sook In Chung ),( Weon Sang Ro ),( Yong Han Paik ),( Young Nyun Park ),( Sang Hoon Ahn ),( Jung Gyu Park ),( Hee Dong Park ),( Kwan Sik Lee ),( Kwang Hyub Han ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: To see combined anti-fibrosis effect when lithospermate B (LAB), an anti-oxidant, and Nivocasan, a caspase inhibitor, were simultaneously administered in comparison with either compound. Methods: Hepatic fibrosis was induced in SD rats by thioacetamide (TAA). In fibrosis-preventive experiment, rats were injected with TAA and fed on LAB and Nivocasan at the same time. Grouping was; Normal control (N), Normal+ LAB+ Nivocasan (NLN), TAA control (T), TAA+LAB (TL), TAA+ Nivocasan (TN), TAA+LAB+Nivocasan (TLN). In fibrosisreversal experiment, rats were first treated with TAA, and then LAB and Nivocasan were fed. Grouping was; TAA control (F), TAA+LAB (FL), TAA+Nivocasan (FN), and TAA+LAB+ Nivocasan (FLN). Fibrotic area was evaluated quantitatively by computerized morphometry. Apoptosis was assessed using TUNEL assay, and immunohistochemical staining for malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4HNE) was performed to assess oxidative stress. Real-time quantitative PCR was used to determine expression of fibrosis-related genes. Results: The degree of hepatic fibrosis was significantly reduced in group TLN (4.9%) compared to TL (6.3%) or TN (6.7%) (p < 0.001). These results were similarly observed in fibrosisreversal experiment. Treatment with each compound significantly decreased fibrosis-related gene expression such as type I collagen α1 (col1α1), α-SMA, and TGF-β1 (p < 0.05). Co-treat ment with LAB and Nivocasan further reduced col1α1 expression compared with either compound in both fibrosispreventive and reversal experiment. TUNEL assay revealed that hepatocyte apoptosis significantly decreased in group TN and TLN compared to TL (p < 0.001). Similarly, apoptosis reduced significantly in group FN and FLN compared to FL (p < 0.001). Immunohistochemistry showed decrease of MDA and 4HNE, reflecting amelioration of oxidative stress in both fibrosispreventive and reversal experiment, when LAB or LAB+ Nivocasan was administered compared with Nivocasan alone (p < 0.05). Conclusion: Simultaneous administration of LAB and Nivocasan to suppress oxidative stress and apoptosis resulted in an enhanced effect on inhibition of hepatic fibrosis in rats.
A Piezoelectric Energy Harvester with High Efficiency and Low Circuit Complexity
Do, Xuan-Dien,Nguyen, Huy-Hieu,Han, Seok-Kyun,Ha, Dong Sam,Lee, Sang-Gug The Institute of Electronics and Information Engin 2015 Journal of semiconductor technology and science Vol.15 No.3
This paper presents an efficient vibration energy harvester with a piezoelectric (PE) cantilever. The proposed PE energy harvester increases the efficiency through minimization of hardware complexity and hence reduction of power dissipation of the circuit. Two key features of the proposed energy harvester are (i) incorporation synchronized switches with a simple control circuit, and (ii) a feed-forward buck converter with a simple control circuit. The chip was fabricated in $0.18{\mu}m$ CMOS processing technology, and the measured results indicate that the proposed rectifier achieves the efficiency of 77%. The core area of the chip is 0.2 mm2.
( Sang Hoon Lee ),( Sang Hun Lee ),( Seung Up Kim ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang Hyub Han ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/ Aims: Liver stiffness (LS) values measured using transient elastography (TE) can accurately assess the degree of liver fibrosis. The degree of liver fibrosis is significantly associated with the risk of hepatocellular carcinoma (HCC) development. Thus, this study investigated whether LS values at radiofrequency ablation (RFA) can predict HCC recurrence after RFA. Methods: Between May 2005 and April 2011, a total of 56 patients with HCC who underwent RFA and LS value measurement at the same day were analyzed in this retrospective study. All were followed up for monitoring the development of HCC recurrence until March 2013. Results: The mean age of the patients (40 men, 16 women) was 62.1 years, and the median LS value was 23.0 kPa. During the follow-up period (median 27.9 [range, 1.1-77.3] months), 33 (58.9%) patients experienced HCC recurrence and 18 (32.1%) were dead. Median time to recurrence was 17.1 (range, 2.5-67.8) months and median time to mortality was 27.9 (range, 1.1-77.3) months. Patients with recurrence showed significantly higher prevalence of liver cirrhosis, spleen size, multiple tumors, and LS values, whereas they had significantly lower platelet count than patients without recurrence (all P<0.05). On multivariate analysis, together with previous anti- HCC treatment history, patients with a higher LS value >13.0 kPa were at a significant greater risk for HCC recurrence after RFA with a hazard ratio of 6.981 (P<0.05; 95% confidence interval, 1.650-28.782) compared with those with LS value ≤13.0 kPa. However, LS values were not predictive for overall survival (P=0.237). Conclusions: Our data suggest that LS values measured using TE can be a useful predictor of HCC recurrence after RFA. Further studies with large sample size are warranted for the validation of our results.