Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

트레드밀 운동시 흡기근 테이핑이 폐활량에 미치는 영향

김민지,신수영,송월섭,조수진,최동락,황미진,황진규,박진현,김경,Dennis W. Fell 대구대학교 특수교육재활과학연구소 2011 再活科學硏究 Vol.29 No.1

이 연구는 트레드밀 운동과 키네시오 테이핑의 효과에 따른 폐활량의 변화를 알아보기 위해 26명의 비흡연자가 참가하였으며 키네시오 테이핑을 적용하지 않은 그룹과 키네시오 테이핑을 적용한 두 그룹으로 무작위로 배정하고 각 군들을 주 3회 6주간의 트레드밀 훈련을 실시하였다. 실험 전과 후, 스파이로미터를 사용하여 키네시오 테이핑의 적용 따른 폐활량 변화 효과를 측정하였다. 이 연구의 결과를 종합해보면 키네시오 테이핑을 적용 그룹에서 적용하지 않은 그룹에 비해 FVC, FEV1에서 유의한 증가를 보였다. 이러한 결과는 건강한 성인에서 키네시오 테이핑을 적용한 경우 키네시오 테이핑을 적용하지 않고 트레드밀 운동을 한 경우보다 폐활량의 향상에 효과적이라고 생각되어진다. The purpose of this study was to investigate the variation of vital capacity(VC) according to the effects of kinesio taping with treadmill exercise. Twenty-six non-smokers were participated in this research and these subjects were randomly assigned into two groups. To measure the VC variation effects of kinesio taping, spirometer was used. The collected data were analyzed statistically by using a paired Mauchly test and repeated measure ANOVA. The results of this study were as follows; A group: treadmill with kinesio taping B group: treadmill without kinesio taping. Between A and B, there were significant differences. In the case of A group, there was 11.66% increase of VC, during 3 weeks experiment(p<.01). In the case of B group, there were significant differences, 3.35% increase of VC, during 3 weeks taping intervention(p<.01). After 6 weeks experiment, the improvement of VC shown a significant difference with intergroup (p<.05). From this result, it was revealed that treadmill exercise with kinesio taping was effective to improve VC to healthy adult than treadmill exercise without kinesio taping.

댄스스포츠 참여가 가족응집력 및 결혼만족에 미치는 영향

송채훈,박현서,박상규,정진영 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

Couples are happy everybody and desire that their married life is successful beginning married life, but conjugal love itself does not become sufficient condition of happy double harness. In different environment each character have and is thought in life bow as well as way that love grown-up man and woman and feel and because difference exists that act. This research drew specimen using Stratified Cluster Random Sampling after establish population to woman who get married between gwangju Chollanamdo area's dance sports program newcomers February, 2006. form the analysis of the date the following conclusion were abtaind abtaind : First, among low rank factor of family cohesive power according to incidental and age that analyze family cohesive power and marriage satisfaction according to general special quality sentimentalize relation leading person and a friend Difference that keep in mind as statistical in factor during time appeared. Second, family cohesive power by dance sports participation existence and nonexistence and result family cohesive power that analyze marriage satisfaction 4 Hawibyeons be that of that it is a car that sentimentalize relation, family support keeps in mind appear. Third, result family cohesive power that analyze dance sports participation degree and family cohesive power and relation of marriage satisfaction was expose that it is corelation that keep in mind with participation period and participation strength and Chamgibindo. Fourth, family cohesive power and low rank factor of family cohesive power that express marriage savage tribe and the strongest corelation as result that analyze relation with marriage satisfaction appeared by family economy and are since next sentimentalize relation, family, was expose by order of Chingu·time. Also, marriage satisfaction's low rank factor which display family cohesive power and the highest corelation appeared and was expose by next order of marriage, communication, authoritative marriage that is affection enemy by adaptation about married life.

관엽식물의 잎모양, 크기, 수형에 따른 시각적 인식이 뇌파변화 및 이미지 평가에 미치는 영향

송종은,엄수진,김수연,손기철,이종섭 충북대학교 첨단원예기술개발연구센터 1999 연구보고서 Vol.4 No.-

실내 환경내에서 관엽식물의 보다 효과적인 이용과 시각, 심리환경 스트레스 경감을 목적으로 관엽식물의 형태적 특성이 인간의 정신생리와 심리에 미치는 영향을 알아보고자 잎모양이 다른 아로우카리아(Araucaria excelsa)와 벤자민고무나무(Ficus benjamina), 잎크기가 다른 네프로네피스(Nephrolephis exaltata)와 스킨답서스(Scindapsus aureas), 그리고 수형이 다른 관음죽(Rhapis humilis)과 아레카야자(Chrysalidocarpus lutescens)를 선정하여 각 식물당 남녀 24명 총 72명을 대상으로 뇌파(Computerized EEG)검사, 혈압, 맥박, 시각이미지 평가를 시행하였다. 각 식물에 따른 뇌파를 비교한 결과 뚜렷한 차이를 보이지 않아 관엽식물의 관상에서 잎의 모양, 크기 및 수형이 있는 상태에서 모두 유의한 감소를 보여 스트레스 감소 효과와 안정 효과를 보인 것으로 나타났다. 그러나 각 식물간에는 유의한 차이는 없었다. 이러한 사실은 기존 연구에서 보여준 결과인 식물의 녹색에 대한 정신생리적 반응과 녹(綠)면적에 의한 뇌파변화는 인정되었지만 식물종류에 따른 반응은 중요하게 작용하지 않는 것으로 보여진다. 관엽식물에 대한 이미지는 평가는 4개의 요인 심미성, 청량감, 안정성, 질감성 인자로 구성되었다. 각 인자에 대한 식물종류간에 차이를 조사한 결과 서로 다른 특성을 보였으나 4인자인 질감성 차원에서는 차이가 없었다 이는 의식적으로 인식되는 시각적 이미지 평가요소에서 제 1인자인 심미성과 제 2인자인 청량성이 더 중요하게 작용되는 것으로 판단되었다. 앞으로 보다 명확한 효과를 검정하기 위해 녹시율(綠視率)과 여러 식물 종류를 조합한 좀 더 세밀한 비교와 함께 시간흐름에 따른 뇌파비교를 동시에 조사 분석하는 것이 필요한 것으로 판단된다.

경구면역을 통한 항원 특이적 IgA 항체 합성에 있어 Cholera Toxin과 Alginate-Microsphere의 효과

송민형,유진수,권명상,성승룡,김용희,권익찬,정서영,양재명,김평현 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

Secretory (S-IgA) isotype antibody (Ab) is known to play an essential role in the primary defense against various infectious agents in mucosal tissue. However, it has been mostly unsuccessful in the induction of antigen (Ag)-specific IgA Ab response in this site by peroral vaccination. In the present study, we investigated the effect of cholera toxin (CI) as a mucosal adjuvant and alginates-microspheres as a carrier on BSA-specific IgA Ab response in gut-associated lymphoid tissue`(GALT). Peroral immunization of BSA plus CT conferred a great BSA-specific IgA response but IgG response on intestinal fluid (IF). In contrast, intraperitoneal immunization of BSA with Freund's adjuvant readily induced BSA-specific IgG response but IgA response in IF. Further, number of CT specific IgA-secreting cells was substantially increased in mesenteric lymph node when CT-encapsulated-VI alginates-microspheres was administered perorally. Taken together, these results indicate that peroral immunization of soluble antigen in combination of CT or microspheres significantly enhances antigen-specific IgA response in GALT.

이동 애드 혹 네트워크에서의 환경적응형 QoS AODV 라우팅 프로토콜에 관한 연구

裵振勝,宋東勳,吳世德,鄭燦赫,金玄郁,李光培,文泰洙,郭承郁,河載承 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

In this paper, we propose a bidirectional mobile Ad Hoc routing protocol based on AODV(ad-hoc on-demand distance vector routing) with QoS(quality of service) support. At presence, wireless mobile communication focuses on how to efficiently support mobility of users more than QoS guarantee. However, in order to satisfy requirement of various applications which have been or will be served, QoS guarantee between end points is a very important issue. The existing AODV routing protocol is implemented to use only BE (Best Effort) service. However, actual wireless mobile environment requires to reduce a waste of communication resources and meet with the real-time change of data paths by setting up routes with QoS support, considering available communication resources at each node in advance. Therefore, in this thesis, we propose an adaptive QoS support method using hello message in order to rapidly meet with the change of available communication resources and to smoothly perform route maintenance. For performance evaluation, we analyzed the average data reception rate. At that time, we used evaluation parameters such as node's mobility-stop time, hello message period, and packet priority, considering the node's mobility and the number of best effort/QoS data flows. As results, we found that with our proposed method the average data reception rate was increased 16.293%, 15.914%, 17.238% for 300 mobility-stop second case and 4.809%, 4.264%, 2.956% for 300 mobility-stop second case.

일 농촌지역에서 발기부전의 유병률 및 상관 요인

홍진표,송해철,이무송,이창화,안준호,한오수,안태영,김성윤 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The purpose of this study was to investigate the prevalence of erectile dysfunction (ED) in a rural area of Korea and to examine the relationship between the prevalence and correlates of subjects. Method : This study was done as a part of the chronic disease survey of rural area by the Asan Foundation. Among 30 years or older population from Jung Eup, a rural area of Korea, 711 male subjects were sampled using a cluster probability sampling method. Trained interviewers visited and interviewed subjects aged 30 years or older with a structured interview. ED was categorized as 'none', 'mild', 'moderate', or 'severe' according to the ability to 'attain and/or maintain an erection satisfactory for sexual intercourse'. Response rate was 54.3% (N=386). Results : The age weighted prevalence of ED was 27.2% (minimal 14.1%, moderate 7.6%, severe 5.5%). Prevalence and severity increased with age. Liver disease and underweight were significantly (p<0.05) associated with ED. Smoking seemed to be correlated with ED, but did not reach statistically significant level. Conclusion : ED was highly prevalent in the rural community of Korea. Medical, sociodemographic, and lifestyle variables associated with ED may alert physicians to patients at risk for ED and offer insight to its etiology.

全北地方의 藥用 資源植物 分布

郭晙洙,金昌洙,宋英恩,金柱,朴珍華,韓宗鉉,宋昊俊 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

국민 소득이 늘어나고 건강에 대한 관심이 높아지면서 한약재에 대한 수요가 증가하게 되고 WTO체제의 출범과 함께 선진각국의 유전자원 확보전이 치열해지면서 국내에서도 약용자원식물의 분포상황 및 이들 유전자원 식물의 보전이 중요한 과제로 대두되고 있다. 따라서 전북지방의 약초자원식물의 분포상황 및 이들 유전자원식물의 보전이 중요한 과제로 대두되고 있다. 따라서 전북지방의 약초자원식물의 분포현황을 조사하여 그에 대한 보전대책 수립 및 연구의 기초자료를 얻고자 수행한 본연구의 주요결과는 다음과 같다. 1. 전북지방에 분포하는 약용 자원식물의 목록을 작성한 결과 총 40목 129과에 걸쳐 762종류의 식물이 정리되었다. 2. 이들 분포식물중 항암효과가 보고된 약용식물은 36과 74종류였다. 3. 지역적으로는 덕유산지역에 가장 다양한 식물이 반포하고 다음으로는 남원, 변산반도, 모악산, 무주군, 완주고산, 내장산, 장안산, 선운산, 비안도, 적상산 등의 순으로 나타났다. 4. 식물군별로는 쌍자엽식물강의 이판화군과 합판화군이 가장 다양하였고, 각 목별 과(科) 수는 통화식물목이 10개 과로서 가장 많았으며, 각 목별 종류 수에 있어서는 장미목이 99종으로 가장 많았고, 초롱꽃목(77종), 통화식물목(67종), 백합목(53종), 미나리아재비목(43종), 산형화목(39종) 등이 비교적 많은 종들을 포함하는 것으로 분석되었다. 5. 각 과별 종수 분석에서는 국화과가 70종으로 가장 많았고, 장미과(46종), 콩과(40종), 백합과(40종)등으로 나타나 이들 4개과의 합계 종수가 196종류로서 전체의 25.72%를 차지하였다. 그 다음으로 산형과(27종), 미나리아재비과(26종), 꿀풀과(25종), 벼과(22종), 마디풀과(19종), 현삼과(15종), 석죽과(12종), 제비꽃과(11종), 난초과(11종) 등이 비교적 많은 종수를 가지는 과(科)들이었다. With the improving of the people's standard of life and the heightening of the concerns of health, the demands of medicinal plants are more rapidly increase. Also, with the inauguration of World Trade Organization, and acceleration of openness in domestic markets, the procurement competitions of gene pools in medicinal plants are more intense among the countries. With these trends of the world, an acute subjects are coming up for us such as distribution status quo and preservation of medicinal plants in domestic area. Therefore this paper surveyed the distribution status quo of medicinal plants in Chonbuk province, arranged the catalogue and analyzed the data by plants and regions. The major results are as follows; 1. The total amounts of 762 species, 129 families, 40 orders of medicinal plants distributed in Chonbuk province. 2. The number of medicinal plants which are assumed to contain antineoplastic agents totals 36 families and 74 species. 3. In distribution of medicinal plants by region, the most diverse flora showed in Mt. Dukyoo followed by circumferences of Namwon, Byun-san, Mt. Moak, Muju, Dosan, Mt. Naejang, Mt. Jangan, Mt. Seon-woon, Beeando island and Mt. Juksang etc. in Chonbuk province.

양극산화와 절연파괴로 형성한 Ti-6Al-7Nb 합금의 산화피막 특성 평가

윤수연,이호진,배태성,송광엽 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.3

This study was performed to investigate the surface properties of electrochemically oxidized Ti-6Al-7Nb by anodic spark deposition technique. Discs of titanium alloy Ti-6Al-lNb of 20 mm in diameter and 2 mm in thickness were polished sequentially from #300 to #1,000 emery paper. They were ultrasonically washed in ethyl alcohol and acetone for 5 min and dried in a desiccator. Ti-6Al-7Nb was anodized in an electrolytic solution that was dissolved calcium and phosphate in water. The electrolytic voltage was set in the range of 170-320 V and the current density was 30 mA/cm^2. The surface oxide film was characterized by X-ray diffractometer, scanning electron microscope (SEM) and X-ray photoemission spectroscopy (XPS). The results obtained were summarized as follows; The main crystal structure of the titanium oxide was anatase type as analyzed with thin-film X-ray diffractometery. The coatings were porous with Pore diameter of 1~4 ㎛. The diameter of micropores increased with increasing the spark forming voltage. The porous coatings showed the growth of cell structure and more compact texture with increasing the voltage. Ca/P ratio in coatings was increased with increasing the voltage.

브랜드‘더마앤모어’를 위한 스페셜 프로모션 부스 디자인 연구 - ‘프레쉬 캐주얼 스타일링’을 활용하여 -

김수안,박수빈,송혜진,이종화,이진민,장미정,이성애 숙명여자대학교 디자인연구소 2018 숙명디자인학 연구 Vol.25 No.-

본 연구는 (주)애경과 S여대와 산학연계하여 진행한 브랜딩 스타일링 마케팅 기획 프로세스를 체계적으로 정리하는데 목적이 있다. 이에 본 연구는 2017년 9월~12월까지 환경디자인학과 ‘브랜딩·스타일링·마케팅’ 교과목에서 진행한 내용을 대상으로 하며 국내 샴푸브랜드 ‘더마앤모어’를 분석하여 디자인 개념을 결합하고 부스 디자인을 제시하는 과정들을 밝힌다. 이를 통해 본 연구는 향후 생활용품 브랜드의 디자인 개발에 있어서 창의적인 부스디자인의 방향성을 제시한다. 본 연구의 방법은 공간 브랜딩에 대한 이론적 고찰을 통해 브랜딩 스타일링 마케팅 프로세스의 스타일 분석, 디자인 개발, 공간 디스플레이 연출로 구성하여 그 과정을 밝힌다. 끝으로 본 연구는 대학과 산업체간의 연계를 통한 교과목 개발에 활용되는데 의의가 있다.