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Lee, Min-Hye,Lee, Seung-Hoon,Kim, Jihong,Lee, Sol Yi,Lim, Dae-Hee,Hwang, Kyoungtae,Hwang, Hansu,Jung, Yong Chae,Noh, Yong-Young,Kim, Dong-Yu Elsevier 2017 Carbon Vol.125 No.-
<P>The demand for high-purity semiconducting single-walled carbon nanotubes (sc-SWNTs) has increased considerably with the aim of utilizing their superior properties in a range of future applications. Among post-sorting methods, conjugated polymers have been regarded as one of the candidates to selectively isolate sc-SWNTs with uniform electrical properties. Herein, we demonstrate the ability to selectively sort two types of SWNTs by the two polymers PCTV18T and PC12TV18T, which have different alkyl side-chain densities. PC12TV18T, with a high alkyl chain density, shows great sorting ability for both high-pressure carbon monoxide and plasma-torch-grown SWNTs with a weight ratio of almost 1:1 in toluene solution. In addition, it is found that PC12TV18T selectively sorts sc-SWNTs with the high purity. The chirality and diameters of the enriched sc-SWNTs are further confirmed by Raman spectroscopy and photoluminescence excitation/emission mapping. Finally, we fabricate bottom gate/bottom contact thin-film transistors using the enriched sc-SWNTs as semiconductors to verify the electrical performance. Devices with well-percolated sc-SWNT networks displayed p-dominant properties with average charge-carrier mobilities of 2.05 cm(2) V-1 S-1 and 9.87 cm(2) V-1 S-1 and on/off current ratios of approximately 10(4) and 10(5) for high-pressure carbon monoxide and plasma-torch-grown SWNTs, respectively. (C) 2017 Elsevier Ltd. All rights reserved.</P>
Lee Eunyoung,Park Sehee,Choi Jae-Phil,Kim Min-Kyung,Yang Eunmi,Ham Sin Young,Lee Seungjae,Lee Bora,Yang Jeong-Sun,Park Byoung Kwon,Kim Da Sol,Lee So-Young,Lee Joo-Yeon,Jang Hee-Chang,Jeon Jaehyun,Park 대한의학회 2023 Journal of Korean medical science Vol.38 No.8
Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group with nirmatrelvir/ritonavir therapy versus a control group with supportive care. Serial viral load and culture from the upper respiratory tract were evaluated for seven days, and clinical responses and adverse reactions were evaluated for 28 days. Results: A total of 51 patients were analyzed including 40 in the treatment group and 11 in the control group. Faster symptom resolution during hospitalization (P = 0.048) was observed in the treatment group. Only minor adverse reactions were reported in 27.5% of patients. The viral load on Day 7 was lower in the treatment group (P = 0.002). The viral culture showed a positivity of 67.6% (25/37) vs. 100% (6/6) on Day 1, 0% (0/37) vs. 16.7 (1/6) on Day 5, and 0% (0/16) vs. 50.0% (2/4) on Day 7 in the treatment and control groups, respectively. Conclusions: Nirmatrelvir/ritonavir against the omicron was safe and resulted in negative viral culture conversion after Day 5 of treatment with better symptomatic resolution.
Physicochemical properties of sausage manufactured with carp (Carassius carassius) muscle and pork
Sol-Hee Lee,Sung-Duck Joe,Gye-Woong Kim,Hack-Youn Kim 한국축산학회 2020 한국축산학회지 Vol.62 No.6
The purpose of this study was to compare the physicochemical properties of sausage manufactured with carp (Carassius carassius) muscle and pork. Sausages were prepared using either 100% pork sausage (P10), a mixture of 50% pork and 50% carp muscle (P5C5), or 100% carp muscle (C10). The quality of the sausage emulsion was determined by analyzing approximate composition, pH, instrumental color, cooking yield, water holding capacity (WHC), viscosity, and texture profile analysis (TPA). Moisture content of cooked C10 was significantly higher than that of P10 or P5C5 (p < 0.05); however, protein content of cooked P10 was significantly higher than that of C10 (p < 0.05). The pH of uncooked and cooked C10 was significantly higher than that of P10 and P5C5 (p < 0.05). The cooking yield, WHC, and texture profile analysis of C10 were higher than those of P10 and P5C5 (p < 0.05). In addition, the viscosity of uncooked C10 was higher than that of P10 and P5C5. These results suggest that carp muscle can enhance sausage quality with respect to pH, WHC, cooking yield, viscosity, and TPA.
Sol Hyun Lee,Ju-Hee Nho,Hye Young Kim,Eun Jee Lee 한국여성건강간호학회 2023 여성건강간호학회지 Vol.29 No.4
Purpose: This study aimed to identify factors influencing the health-related quality of life (HRQoL) of older adult women with sarcopenia.Methods: The study was secondary data analysis using data from the 2019 Korea National Health and Nutrition Examination Survey. The final sample consisted of 142 women aged 60 years and older with sarcopenia and were selected from 8,110 women. The participants was analyzed using complex descriptive statistics, independent t-test, and regression.Results: In terms of HRQoL, three general characteristics were found to be influential, with an explanatory power of 56.0%: difficulty climbing stairs, difficulty working, and perceived health status. Having no or mild difficulty when climbing stairs (B=.20, p=.001; B=.21, p<.001) and no or mild difficulty when working (B=.25, p=. 002; B=.208, p=.013) had a significant effect on HRQoL compared to severe difficulty. Having good or ordinary perceived health status had a significant effect on the HRQoL (B=.11, p<.001; B=.09, p<.001).Conclusion: Based on study findings that the HRQoL of older adult women with sarcopenia were influenced by difficulty climbing stairs and working, as well as good perceived health status, healthcare providers should assist elderly women to maintain physical activities in their daily lives.
Homo-succinic acid production by metabolically engineered <i>Mannheimia succiniciproducens</i>
Lee, Jeong Wook,Yi, Jongho,Kim, Tae Yong,Choi, Sol,Ahn, Jung Ho,Song, Hyohak,Lee, Moon-Hee,Lee, Sang Yup Elsevier 2016 Metabolic engineering Vol.38 No.-
<P><B>Abstract</B></P> <P>Succinic acid (SA) is a four carbon dicarboxylic acid of great industrial interest that can be produced by microbial fermentation. Here we report development of a high-yield homo-SA producing <I>Mannheimia succiniciproducens</I> strain by metabolic engineering. The PALFK strain (<I>ldhA</I> <SUP> <I>-</I> </SUP>, <I>pta</I> <SUP> <I>-</I> </SUP>, <I>ackA</I> <SUP> <I>-</I> </SUP> <I>, fruA</I> <SUP> <I>-</I> </SUP>) was developed based on optimization of carbon flux towards SA production while minimizing byproducts formation through the integrated application of <I>in silico</I> genome-scale metabolic flux analysis, omics analyses, and reconstruction of central carbon metabolism. Based on <I>in silico</I> simulation, utilization of sucrose would enhance the SA production and cell growth rates, while consumption of glycerol would reduce the byproduct formation rates. Thus, sucrose and glycerol were selected as dual carbon sources to improve the SA yield and productivity, while deregulation of catabolite-repression was also performed in engineered <I>M. succiniciproducens</I>. Fed-batch fermentations of PALFK with low- and medium-density (OD<SUB>600</SUB> of 0.4 and 9.0, respectively) inocula produced 69.2 and 78.4g/L of homo-SA with yields of 1.56 and 1.64mol/mol glucose equivalent and overall volumetric SA productivities of 2.50 and 6.02g/L/h, respectively, using sucrose and glycerol as dual carbon sources. The SA productivity could be further increased to 38.6g/L/h by employing a membrane cell recycle bioreactor system. The systems metabolic engineering strategies employed here for achieving homo-SA production with the highest overall performance indices reported to date will be generally applicable for developing superior industrial microorganisms and competitive processes for the bio-based production of other chemicals as well.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Mannheimia succiniciproducens</I> was engineered to produce homo-succinic acid. </LI> <LI> Different carbon sources were examined for optimal succinic acid production. </LI> <LI> Catabolic repression deregulation allowed co-fermentation of sucrose and glycerol. </LI> <LI> High productivity and yield of homo-succinic acid were achieved. </LI> <LI> Membrane cell recycling fermentation resulted in productivity of 38.6g/L/h. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>