문화공간에 나타난 재생디자인 공간적 특성 연구 -서울시 박물관·미술관을 중심으로-

박세희 ( Park¸ Sehee ),윤재은 ( Yoon¸ Jaeeun ) 한국공간디자인학회 2021 한국공간디자인학회논문집 Vol.16 No.7

(연구배경 및 목적) 서울시는 ‘비전 2030, 문화시민도시 서울’을 목표로 시민의 행복한 삶과 삶을 위한 문화발전이라는 방향성을 가지고 사업을 추진하고 있다. 본 사업은 크게 개인, 공동체, 지역, 도시라는 범주로 나누어, 문화 주권, 문화 공생, 문화재생, 문화 창조를 목표로 한다. 특히 여러 정책의 추진과제 중 문화사업은 문화재생의 범위 안에 속해 문화를 새롭게 만들어내는 것이 아닌, 재생하는 것에 초점을 맞춘 문화예술 사업으로 진행했다. 이 중 ‘박물관·미술관 도시, 서울’은 서울시 곳곳에 방치된 유휴공간을 재생하여 문화공간으로 활용한다. 본 연구는 해당 문화공간을 파악하여, 각각의 사례들이 재생디자인의 범주에서 어떠한 방식으로 보존되며, 특성은 무엇인지 연구하였다. (연구방법) 본 연구는 우선 문화예술 및 관련 유사 공간의 공간재생 및 디자인에 관한 이론적 고찰을 수행하고, 서울특별시에서 ’17년~’23년까지 진행하는 ‘박물관·미술관 도시, 서울’ 프로젝트의 14개 문화시설 개관 사업 중 재생디자인에 해당하는 문화공간을 사례 연구의 대상으로 한다. 서울시가 진행하는 프로젝트의 사업은 연구자 본인이 직접 방문 또는 사업부서 문의를 통해 진행하였다. (결과) 연구 결과, 서울시 도시재생사업 중 문화공간 개관 사업의 특성을 분석하여 서울시 문화공간에 나타난 재생사업 체계적 유형을 도시 생활·문화 재생형, 콘텐츠 개발 및 특화형, 역사 보존형, 문화·예술 영유형 이렇게 네 가지로 분류하여 각 사례에 나타난 재생디자인 공간적 특성을 분석하였다. 재생공간의 공간적 특성을 살펴보면, 모두 유휴지에 새로운 용도를 부여하는 부활형 공간 활용을 하고 있으며, 되도록 원형보존을 목표로 하나, 안전도나 사업의 특성에 따라 구조적으로 원형보존 및 부분 개조하였다. 사업 규모에 따라 신관을 증축하여 신구건물을 연결한 사례도 있었으나, 대부분 건축물은 증축하지 않았다. 재생디자인의 특성은 보존성, 활용성이 기본으로 나타나되, 앞으로의 공간 활용성이나, 사업특징에 따라 역사성, 예술성, 사회·문화성, 장소성, 참여성, 연계성, 경관성 등이 다양하게 나타나고 있다. (결론) 이미 개관한 건축물뿐만 아니라, 앞으로 개관을 앞둔 건물 역시 서울시가 추구하는 도시재생의 목표에 따라 진행하되, 공간과 콘텐츠가 조화를 이룰 수 있는 방향성을 추구하여 지속 가능한 문화 재생공간으로 구현될 수 있기를 기대한다. (Background and Purpose) The Seoul Metropolitan Government is promoting a cultural development project for citizens’ lives and happiness levels under the "Vision 2030, Cultural Citizen City Seoul." This project is largely divided into categories of individuals, communities, regions, and cities, and aims to achieve cultural sovereignty, cultural symbiosis, cultural heritage, and cultural creation. In particular, this cultural and artistic project focused on regenerating culture, rather than creating a new culture within the context of the city’s cultural heritage. Among the project’s initiatives, "Museum, Art Museum City, Seoul" aimed to regenerate abandoned places across Seoul by transforming them into cultural spaces. This study identifies such cultural spaces and examines how each case is preserved under the banner of regenerative design. (Method) To this end, a theoretical review was conducted on the regeneration and design of cultural and artistic spaces, with a focus on the 14 cultural facility openings that happened in Seoul. The project was conducted by the Seoul Metropolitan Government and involved the researcher of this paper through inquiries from the relevant department. (Results) As a result of the study, the systematic types of regeneration projects in the cultural space of Seoul were classified into four categories: urban life and culture regeneration; content development and specialization; historical preservation; and culture and art. Following this, the spatial characteristics of reproduction design were analyzed for each case. All of them utilized resurrection-type spaces that gave new use to abandoned areas, while still preserving their original form as much as possible. In addition, they were structurally preserved and partially modified according to the safety level or the characteristics of each project. In some cases, new and old buildings were connected by expanding new buildings according to the size of the project. However, most of the buildings were not expanded. The characteristics of regenerative design are based on conservation and usability, but historical, artistic, social and cultural, place, participation, connection, and landscape appear in various ways depending on future space utilization and business characteristics. (Conclusions) In accordance with the goals of urban regeneration pursued by the Seoul Metropolitan Government, this research considered not only buildings that have already been opened, but also buildings that are about to be opened. In addition, this is expected to be implemented as a sustainable cultural reproduction space by harmonizing both the space itself and its content.

Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors

김원진,Yoon Jung Chung,Se Hwa Kim,Sehee Park1,Jae Hyun Bae,Gyuri Kim1,Su Jin Lee1,Jo Eun Kim1,박병우,임승길,이유미 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.1

Background: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. Methods: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 μg calcitriol (n=46), or placebo (n=44) for 6 months. Results: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8±13.6 pmol/L vs. 23.1±4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%±10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%±10.2% vs. 55.9%±9.13%, P>0.05). Conclusion: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.

Monolithic Hybridization of Diverse Carbon Nanotubes with Controlled Structures and Three Dimensional Graphene Foams for Supercapacitor Applications

Park, Sehee,Song, Wooseok,Kim, Seong Ku,Han, Jin Kyu,Chae, Heeyeop,Myung, Sung,Lee, Sun Sook,Lim, Jongsun,An, Ki-Seok American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.8

<P>Diverse carbon nanotubes (CNTs) with controlled structures and graphene hybrid nanostructures were synthesized for supercapacitor electrode applications. Three-dimensional multilayer graphene foams were synthesized via thermal chemical vapor deposition (TCVD). The diameter and density of the synthesized CNTs were controlled through the use of two different CVD systems in addition to adjusting the thickness of the Fe catalyst used in the production of these nanomaterials. We thereby fabricated single-walled CNTs/graphene, multi-walled CNTs/graphene, and vertically aligned CNTs/graphene hybrid nanostructures, which was confirmed via scanning electron microscopy and resonant Raman spectroscopy. Additionally, the electrochemical properties of the CNTs/graphene hybrid nanostructures were studied by cyclic voltammetry.</P>

Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice

Park, Sehee,Kim, Jin Il,Bae, Joon-Yong,Yoo, Kirim,Kim, Hyunung,Kim, In-Ho,Park, Man-Seong,Lee, Ilseob MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.2

The potential use of dietary measures to treat influenza can be an important alternative for those who lack access to influenza vaccines or antiviral drugs. Lactobacillus plantarum (Lp) is one of many lactic acid bacteria that grow in 'kimchi', an essential part of Korean meal, and several strains of Lp reportedly show protective effects against influenza. Using heat-killed Lp (nF1) isolated from kimchi, which is known for its immunomodulatory effects, we investigated whether regular oral intake of nF1 could influence the outcome of influenza virus infection in a mouse model. In a lethal challenge with influenza A (H1N1 and H3N2 subtypes) and influenza B (Yamagata lineage) viruses, daily oral administration of nF1 delayed the mean number of days to death of the infected mice and resulted in increased survival rates compared with those of the non-treated mice. Consistent with these observations, nF1 treatment also significantly reduced viral replication in the lungs of the infected mice. Taken together, our results might suggest the remedial potential of heat-killed Lactobacillus probiotics against influenza.

Antiviral Agents Against Influenza Viruses

Sehee Park,Jin Il Kim,Man-Seong Park 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4

Antiviral Agents Against Influenza Viruses

Park, Sehee,Kim, Jin Il,Park, Man-Seong 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4

In annual epidemics and occasional pandemics, influenza viruses cause acute respiratory illnesses in infected humans. Vaccines and antiviral drugs are two main arsenals available for a fight against influenza viruses. However, vaccines often exhibit a limited efficacy in high risk populations, and antiviral drugs are always concerned for mutations, which confer viral resistance. Here we review current advances and knowledge in relation to the usage of antiviral drugs as a prophylactic or therapeutic and the mechanism of resistant variants mainly against the neuraminidase inhibitors. Comprehensive understanding of the resistant mechanism will pave a road for developing new antivirals and/or finding medical or natural alternatives inducing less frequent resistance, and application of combination therapy using two or three different kinds of antivirals can suggest a useful medical intervention against both of seasonal and highly pathogenic influenza viruses including resistant variants. In this review, we provide insights of antiviral drugs for the control and prevention of influenza viruses.

MicroRNA clustering on the biogenesis of suboptimal microRNAs

Park Sehee,Kang Igojo,Shin Chanseok 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.S

Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons.

Towards the Application of Human Defensins as Antivirals

Park, Mee Sook,Kim, Jin Il,Lee, Ilseob,Park, Sehee,Bae, Joon-Yong,Park, Man-Seong The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3

Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express ${\alpha}$- and ${\beta}$-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the 'defensin vaccine' concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

미술관의 작가참여 교육프로그램 실태와 개발에 관한 연구

박세희(Park Sehee) 한국예술경영학회 2006 예술경영연구 Vol.10 No.-

As more people want cultural life with the introduction of the high quality of life, humanity education is now taking up significant part of human life. Given this, education is required to foster humanity and emotion for emotional exchange and to display creativity through firsthand experience. Currently, many museums and art galleries offer various cultural activities to meet such demands. Although more education activities at an art museum can be seen in recent years, they are lacking in consistency without qualified manpower or staff to raise the quality of education programs. Regarding today’s growing demands for art education, this study is to look at how vitalize art museum education programs with artists, and that is three-folds: developing education programs like entertainment industry and involving community, integrating art museum education divided into art theory and practical skill, and offering the public more opportunities to appreciate modern art works more frequently. By concentrating on the programs involving artists, this study attempts to make a suggestion to expand the education programs. It will lend a helping hand so that an art museum can serve as a window to stimulate exchange with community by bringing new marketing promotion effect, artists can promote their works and reap economic profits, and audience can understand complicated modern arts easily with a help from artists and cultivate creativity.

박물관 건립에 나타난 문화정책 프로세스 특성 연구 -서울시 박물관 문화정책을 중심으로-

박세희 ( Park Sehee ),윤재은 ( Yoon Jaeeun ) 한국공간디자인학회 2021 한국공간디자인학회논문집 Vol.16 No.8

(연구배경 및 목적) 4차 산업혁명 시대 디지털 기술의 발달 및 최근 코로나 19(COVID-19)로 빚어진 팬데믹으로 물리적 공간을 중심으로 하던 기존 박물관은 변화하는 시대에 맞춰 역할과 기능을 개선할 시대에 직면했다. 최근 몇 년간 개관한 박물관들은 개관 이후 지속적인 운영을 목표로 하는 경우가 많아졌다. 따라서 문화정책 및 박물관 정책의 방향성이 달라지는 추세이며, 이러한 정책 변화가 박물관 건립정책에도 큰 영향을 미치고 있다. 본 연구는 문화정책과 국내 박물관 정책의 이론적 고찰을 통해 서울시 박물관 건립정책 현황과 실태를 분석하며, 박물관 문화정책 프로세스의 특성을 연구하는 데 목적이 있다. (연구방법) 연구의 대상은 서울시가 최근 '16년부터 개관을 목표로 했던 14개의 기관 중 개관을 완료한 박물관인 우리소리박물관, 서울생활사 박물관, 서울공예박물관으로 한다. 연구 방법은 우선, 선행연구를 분석하여 문화정책의 개념 및 박물관 건립에 관한 연구를 진행하고, 서울시 내부 문서 및 연구 및 발표 자료 등을 토대로 서울시 문화정책에 따른 박물관 건립에 나타난 정책 프로세스의 특성을 분석한다. (결과) 본 연구는 서울시 문화정책과 박물관 정책의 정책 범주 및 체계를 분석하여 서울시의 최근 박물관 건립 사례를 토대로 박물관 건립에 나타난 문화정책 프로세스 특성을 도출하였다. 지역’과 ‘도시’,‘공동체’, ‘개인’의 범주가 지역의 특성이나 박물관 콘텐츠의 성격에 따라 높거나 중간의 비율로 나타났고, 행정 범주는 모두 낮게 나타났다. 미래상인 ‘문화재생’, ‘문화창조’, ‘문화주권’, ‘문화공생’이 모든 사례에서 나타났으며, 박물관 건립과정을 단계별 세부 추진 업무나 사업 규모에 따라 확대·축소되나, 분석 결과 크게 기획단계, 구성 및 설계단계, 시공단계, 개관 및 평가단계라는 4단계로 나눌 수 있다. (결론) 모든 단계를 거쳐 박물관이 개관하게 되면 다 끝난 것이 아니라 또 다른 시작이다. 문화정책과 박물관 정책이 시대에 따라 변화하고 이를 직·간접적으로 적용·반영하며 상호작용하는 박물관 건립정책을 미루어 보면, 그 미래는 긍정적이다. 국공립 기관들이 내세우는 정책이 탁상공론에 그치지 않고 시민들 개개인을 우선시하고, 공동체성을 가지며, 지역과 도시를 고려할 뿐 아니라, 구시대적 행정절차를 고수하는 것이 아닌, 협치를 추구한다면, 앞으로 더욱 시대성에 맞는 보편타당한 박물관 문화정책이 완성될 것이다. 더불어 콘텐츠 성격이나 지역성 등 도시적 맥락에 맞는 다양한 박물관이 자리하기를 기대한다. (Background and Purpose) With the development of digital technology in the era of the Fourth Industrial Revolution and the recent COVID-19 pandemic, existing museums, which focused on the physical space, are improving roles and functions, in line with the changes. The museums that have been opened in recent years have often aimed at continuous operation. Therefore, the direction of cultural policy and museum policy is changing, which have a significant influence on the museum construction policy. The purpose of this study is to analyze the current status and the condition of museum construction policies in Seoul through theoretical considerations of cultural policy and domestic museum policy, and to study the characteristics of the museum's cultural policy process. (Method) The subjects of the study are the Seoul Museum of Korean Folk Music, the Seoul Urban Life Museum, and the Seoul Museum of Craft Art, which were recently opened, as part of the 14 institutions that the Seoul Metropolitan Government had aimed to open since 2016. First, research on the concept of cultural policy and the construction of a museum is conducted by analyzing previous studies. In addition, it analyzes the characteristics of the policy process that appeared in the construction of the museum according to the Seoul Metropolitan Government's cultural policy by referring to internal documents, research, and presentation materials. (Results) This study analyzed the policy categories and the systems of Seoul's cultural policy and the museum policy to derive the characteristics of the cultural policy process that appeared in the construction of the museum based on the recent case of museum construction in Seoul. The categories of region, city, community, and individual were high or medium depending on the characteristics of the region or museum content, and all administrative categories were low. Four visions: "Culture Regeneration," "Culture Creation," "Cultural Sovereignty," and "Cultural Symbiosis" were apparent in all cases, and the museum construction process has expanded and reduced according to detailed projects or project size, although the analysis can be largely categorized into four stages. (Conclusions) If the policies put forth by national and public institutions not only inform, but also prioritize individual citizens, take care of regions and cities, pursue cooperation without being bound by outdated administrative procedures, the museum's cultural policy is expected to be completed in the future. In addition, various museums suitable for the urban context such as content characteristics and locality are expected to be located.