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( Shino Shimura ),( Norihisa Ishimura ),( Hironobu Mikami ),( Eiko Okimoto ),( Goichi Uno ),( Yuji Tamagawa ),( Masahito Aimi ),( Naoki Oshima ),( Shuichi Sato ),( Shunji Ishihara ),( Yoshikazu Kinosh 대한소화기기능성질환·운동학회 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.1
Background/Aims Small intestinal bacterial overgrowth (SIBO) is considered to be involved in the pathogenesis of functional gastrointestinal disorders (FGID). However, the prevalence and clinical conditions of SIBO in patients with FGID remain to be fully elucidated. Here, we examined the frequency of SIBO in patients with refractory FGID. Methods We prospectively enrolled patients with refractory FGID based on Rome III criteria. A glucose hydrogen breath test (GHBT) was performed using a gas analyzer after an overnight fast, with breath hydrogen concentration measured at baseline and every 15 minutes after administration of glucose for a total of 3 hours. A peak hydrogen value ≥ 10 ppm above the basal value between 60 and 120 minutes after administration of glucose was diagnosed as SIBO. Results A total of 38 FGID patients, including 11 with functional dyspepsia (FD), 10 with irritable bowel syndrome (IBS), and 17 with overlapping with FD and IBS, were enrolled. Of those, 2 (5.3%) were diagnosed with SIBO (one patient diagnosed with FD; the other with overlapping FD and IBS). Their symptoms were clearly improved and breath hydrogen levels decreased to normal following levofloxacin administration for 7 days. Conclusions Two patients initially diagnosed with FD and IBS were also diagnosed with SIBO as assessed by GHBT. Although the frequency of SIBO is low among patients with FGID, it may be important to be aware of SIBO as differential diagnosis when examining patients with refractory gastrointestinal symptoms, especially bloating, as a part of routine clinical care. (J Neurogastroenterol Motil 2016;22:60-68)
Kotaro Shimura,Seiji Mabuchi,Takeshi Yokoi,Tomoyuki Sasano,Kenjirou Sawada,Toshimitsu Hamasaki,Tadashi Kimura 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4
Objective: To investigate the utility of serum squamous cell carcinoma antigen (SCC-Ag) levels upon the diagnosis of recurrent cervical cancer for decision making in patient management. Methods: Clinical records from 167 cervical cancer patients who developed recurrence between April 1996 and September 2010 were reviewed. A Cox proportional hazards regression model was used to investigate the prognostic significance of serum SCC-Ag levels at the time of recurrence. The effects of various salvage treatments on survival outcomes of recurrent cervical cancer were examined with respect to serum SCC-Ag levels. Results: Serum SCC-Ag levels were elevated (>2.0 ng/mL) in 125 patients (75%) when recurrence was diagnosed. These patients exhibited significantly shorter postrecurrence survival than those with normal SCC-Ag levels (log-rank; p=0.033). Multivariate analyses revealed that an elevated serum SCC-Ag level was an independent prognostic factor for poor postrecurrence survival. In patients with SCC-Ag levels <14.0 ng/mL, radiotherapy or surgery resulted in improved survival compared with chemotherapy or supportive care. In contrast, in patients with SCC-Ag levels of ≥14.0 ng/mL, salvage treatment with radiotherapy had only a minimal impact on postrecurrence survival. Conclusion: The serum SCC-Ag level measured when cervical cancer recurrence is diagnosed can be useful for deciding upon the appropriate salvage treatment.
Magnetization Steps in Yb2Pt2Pb with the Shastry-Sutherland Lattice
Yasuyuki Shimura,Toshiro Sakakibara,Ken Iwakawa,Yoshichika Onuki,Kiyohiro Sugiyama 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We measured the DC magnetization of the antiferromagnet Yb2Pt2Pb (TN ~ 2.1 K) with theShastry-Sutherland lattice for two in-plane directions H k[100] and [110] down to 0.08 K. Multiplemetamagnetic transitions are found to develop in the field dependence of the magnetization M(H). Substantial anisotropy is observed in M(H) and is discussed on the basis of a two-sublattice modelwith strong Ising anisotropy along the orthogonal [110] ([1¯10]) directions recently proposed byOchiai et al.
시무라 쇼코(Shimura Shoko),정창미(번역자) 한국근현대미술사학회 2015 한국근현대미술사학 Vol.29 No.-
Japan put an end to their seclusion policy by concluding the Convention of Peace and Amity between the United States of America and the Empire of Japan in 1854. Accordingly, at the first year of Meiji era (1868), the five ports in Japan had been opened to the foreign countries; which were Yokohama, Hakodate, Kobe, Nagasaki and Niigata. This paper is focusing on “Yokohama Shashin”, the photographs that had brought back to the United States from Yokohama in the late 19th century. “Yokohama Shashin” refers to the commercial photographs shot as souvenirs for the tourist or the foreign residents of the Yokohama settlement in Japan. Its motif was “Old Japan”, the premodern images as well as the foreigners’ expected “authentic” Japanese sceneries. They bought “Yokohama Shashin” to confirm and memorize these images. It is said that Felice Beato and Shimooka Renjo have inaugurated this “Yokohama Shashin”. Charles Appleton Longfellow(1844-1893), son of the famous American poet, stayed in Japan from 1871 to 1873 and brought home over 350 photographs including his own and his mistresses’ portraits most probably shot by Beato. The poses of mistresses were mimicking Japanese women seen in “Yokohama Shashin”, and his portrait in kimono is identical to that of “Yokohama-e”, the portrait-paintings of foreigners visiting Yokohama depicted by Japanese painters in those days. The faces drawn in “Yokohama-e” had applied foreigners’ images from their own photographs; and at all times the figures were in kimono. “Yokohama-e” was a souvenir for foreigners in the same way as “Yokohama Shashin”. The Photographs Charles brought home from Japan present his idealized viewpoint toward Japanese women, and his selfconsciously created image of exotic “Good Old Japan”. John La Farge (1853-1910), an American painter, visited Japan with his historian friend, Henry Adams, in 1886. His essays with his own illustrations were appeared as “An Artist’s Letters from Japan” in Century Magazine from 1890 to 1893. Some of his illustrations were directly based on “Yokohama shashin”. La Farge worked on watercolor illustrations after returning to the United States with referring to the commercial photographs he brought back, as if he painted them from his own sketches drawn in Japan. Therefore, it is possible to say that his perspectives on Japan were depended heavily on from the images of “Old Japan”, which he believed to be “authentic”. This paper aims to reveal the Japanese images in the United States around the late 19th century by analyzing these examples.
Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease
Tsutsumi, Norito,Nishimata, Shigeo,Shimura, Masaru,Kashiwagi, Yasuyo,Kawashima, Hisashi The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.3
Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.
EFFECTS OF OZONATION AND CHLORINATION ON VIABILITY AND INFECTIVITY OF CRYPTOSPORIDIUM PARVUM OOCYSTS
Hirata, T.,Chikuma, D.,Shimura, A.,Hashimoto, A.,Motoyama, N.,Takahashi, K.,Moniwa,T.,Kaneko, M.,Saito, S.,Maede, S. 嶺南大學校 環境問題硏究所 1999 環境硏究 Vol.19 No.1
ABSTRACT Experimental studies on ozonation and chlorination were conducted to determine capacity for inactivating Cryptosporidium parvum oocysts in batch modes at pH 7, 20℃. In both experiments, the log reduction of animal infectivity was linear and clearly decreased as disinfectant CT product increased. However, the curve of reduction in viability determined by both in vitro excystation assay and DAPI/PI permeability assay exhibited a shoulder. The CT products of ozone per 1 log reduction in infectivity were 3 mg·min/L for 0.5 mg/L and 1.5mg·min/L for 0.3 mg/L, while viability determined by in vitro excystation was reduced by only 0.2 logs for the CT product of 3 mg·min/L. In the chlorination experiment, the reduction of animal infectiviry was up to 3 logs for the CT product of 2,700 mg·min/L, while reduction of viability was smaller at 0.16 logs in in vitro excystation and 0.04 logs in DAPI/PI permeability (in PI exclusion)for the same CT product. The CT product of free chlorine per 1 log reduction in infectivity was estimated to be in the range of 800 to 900 mg·min/L Experimental studies on ozonation and chlorination were conducted to determine capacity for inactivating Cryptosporidium parvum oocysts in batch modes at pH 7, 20℃. In both experiments, the log reduction of animal infectivity was linear and clearly decreased as disinfectant CT product increased. However, the curve of reduction in viability determined by both in vitro excystation assay and DAPI/PI permeability assay exhibited a shoulder. The CT products of ozone per 1 log reduction in infectivity were 3 mg·min/L for 0.5 mg/L and 1.5 mg·min/L for 0.3 mg/L, while viability determined by in vitro excystation was reduced by only 0.2 logs far the CT product of 3 mg·min/L. In the chlorination experiment, the reduction of animal infectivity was up to 3 logs for the CT product of 2,700 mg·min/L, while reduction of viability was smaller at 0.16 logs in in vitro excystation and 0.04 logs in DAPI/PI permeability (in PI exclusion) far the same CT product. The CT product of free chlorine per 1 log reduction in infectivity was estimated to be in the range of 800 to 900 mg·min/L.