Gene Expression Analysis of the Bromobenzene Treated Liver with Non-hepatotoxic Doses in Mice

Lim, Jung-Sun,Jeong, Sun-Young,Hwang, Ji-Yoon,Park, Han-Jin,Cho, Jae-Woo,Song, Chang-Woo,Kim, Yang-Seok,Lee, Wan-Seon,Moon, Jin-Hee,Han, Sang-Seop,Yoon, Seok-Joo The Korean Society of Toxicogenomics and Toxicopro 2005 Molecular & cellular toxicology Vol.1 No.4

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.

관측자료 기반 격자 생성자료 생성 및 예측모형 연구

조창제(Chang Je Cho),곽경일(Gyeong Il Kwak),주현석(Hyun Seok Joo),김국진(Kuk Jin Kim) 전남대학교 수산과학연구소 2021 수산과학연구소논문집 Vol.30 No.1

Natural disasters are increasing due to recent climate change. Rainfall directly or indirectly affects aquaculture and agriculture. Therefore, it is important to anticipate and prepare for this. In this study, a study on the performance comparison between spatial interpolation techniques was conducted based on observed data, and predicted based on the data produced by the spatial interpolation techniques. The spatial interpolation methods compared the inverse distance weighting method, kriging and spatial random forest through MAE (Mean absolute error), RMSE (Root mean square error), correlation coefficient. The verification of predicted data was compared through MAE, CSI (Critical Success Index), FAR (False Alarm Ratio), POD (Probability of Detection) and ETS (Equitable Threat Score).

MgCl₂溶液內에서 STS 304 HP Stainless Steel 熔接部의 破壞擧動에 對한 硏究

金永奭,丁太權,朴昌彦,洪錫柱,梁仁榮,金基玉,朴煥奎,李茂錫,曺圭宰,鄭在康 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

This paper is based on an experiment analysing the stress corrosion cracking behaviour of welding specimens compared to that of non-welding specimens of STS 304 HP stainless steel in corrosion solution. As a corrosion condition, stainless steel has been known to be the most fragile in a solution of 42% MgCl₂heated to the boiling point, therefore the experiment was carried out in this condition. The experiment was carried out with argon gas TIG welding specimens and non-welding ones made of stainless steel plates, thickness 2mm, by tensile force. At this time, the tensile force was taken to be the value of the yield strength of the tensile test specimens divided by the safety factor of 3.0 to 3.5, 4.0, 4.5, and 5.0. In this paper, the relations between Time of Initial Crack, Time of Failure, Time of Final Fracture and Crack Propagation Length were investigated and then plotted. Furthermore, the relations between Stress Intensity Factor K proposed by Irwin and the Time of Initial Crack, the Time of Failure, the Time of Final Fracture were calculated and plotted. At the last, all the relations plotted were expressed to normal equations by computer, and the equations were used to analyse the data obtained in the experiment. The conclusions obtained in this study are as follows: 1. Welding materials, compared with non-welding ones, as the Time of Initial Crack, the Time of Failure, and the Time of Final Fracture were generally very fast, appeared to be a phenomenon of unstable brittleness fracture. 2. Non-welding materials, compared with welding ones, as the safety factor was larger or the working stress was smaller, appeared to be a phenomenon that the longer had had greater durability. Therefor, welding materials must be considered enough to be used in heate affected and stress corrosion atmosphere. 3. The normal equations of the Time of Initial Crack and the variation rate to the same Stress Intensity Factor K are as follows: (A) Non-welding T =259702.4-5451.2 K+28.386 K² T = -5451.2+28.386 K (B) Welding T= -332.693+28.043 K-0.211 K² T' =28.043-0.211 K here, T; Time of Initial Crack, T'; Variation Rate of Time of Initial Crack to Stress Intensity Factor K, K ; Stress Intensity Factor.

자기 배양 골모세포를 이용한 임상적용례 : 증례보고 Case Report

김석중,옥인영,장정호,김용식,장재덕,박원종,이주형 대한골절학회 2004 대한골절학회지 Vol.17 No.2

광원의 종류에 따른 복합레진의 중합거동 및 중합률에 관한 연구

류주희,이인복,유현미,김미자,석창인,권혁춘 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.4

Objectives: The purpose of this study was to observe the reaction kinetics and the degree of polymerization of composite resins when cured by different light sources and to evaluate the effectiveness of the blue Light Emitting Diode Light Curing Units (LED LCUs) compared with conventional halogen LGUs. Materials and Methods: First, thermal analysis was performed by a differential scanning calorimeter(DSC). The LED LCU (Elipar Freelight, 320㎽/㎠) and the conventional halogen LCU (XL3000, 400㎽/㎠) were used in this study for curing three composite resins (SureFil, Z-250 and AEliteFLO). Second, the degree of conversion was obtained in the composite resins cured according to the above curing mode with a FTIR. Third, the measurements of depth of cure were carried out in accordance with ISO 4049 standards. Statistical analysis was performed by two-way ANOVA test at 95% levels of confidence and Duncan's procedure for multiple comparisons. Results: The heat of cure was not statistically different among the LCUs (p > 0.05). The composites cured by the LED (Exp) LCUs were statistically more slowly polymerized than by the halogen LCU and the LED (Std) LCU (p< 0.05). The composite resin groups cured by the LED (Exp) LGUs had significantly greater degree of conversion value than by the halogen LCU and the LED (Std) LCU (p = 0.0002). The composite resin groups cured by the LED (Std) LGUs showed significantly greater depth of cure value than by the halogen LCU and the LED (Exp) LGU (p < 0.05).

재요청을 고려한 버스중재프로토콜의 효율성 분석

박준석,이원주,전창호 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

Efficiency of bus arbitration scheme is modeled to analyze and compare five known arbitration protocols for single-bus multiprocessor system. The analytical model describes average access time as a measure of efficiency and takes resubmitted requests into account, amending contradiction of previous assumption that bus requests in each cycle are independent of those of previous cycles. The analytical results obtained from our model show that the efficiency of the equal priority protocol is as good as that of the rotating priority protocol.

염색슬러지 탄화물 재활용 및 자원화 순환망 구축 타당성에 관한 연구

임창호,김주청,이동석 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

The dyeing sludge is the major waste generated in Banwol & Sihwa Industrial Complex. The Purpose of this study is to develop BAT (Best available technique) for the treatment and recycling of dyeing sludge. The dyeing sludge was carbonized and the product was tested physical properties and chemical chracterizations and also analyzed chemical compositions. From the test results we expect that the products can be used as adsorbent for the removal of order in the poultry farm and cattle shed. The feasibility of other methods such as manufature of RDF and cement etc. were also studied.

평면굽힘하중을 받는 Al 2024-T3 합금의 미소균열 분포특성에 관한 연구

조석수,주원식,장득열,장백선,안원기 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

Machine structures, aircraft and pressure vessel etc. are designed by fail-safe or safe-fail concept but on the basis of existance of internal defect or crack initiation in early stage of fatigue life. Failure or fracture of machine structures is mainly occured by fatigue and relation between stress intensity factor range and crack growth rate can predict remaining life in components containing through-the-thickness crack but fatigue life of smooth specimen is dependent of initiation, growth and coalescene of micro-crack. Therefore, this paper presents relation between statistical properties of micro crack and fatigue life ratio in age-hardened Al 2024-T3 tested in-plane bending.

백터 DT(diffraction tomography)에 관한 기초연구

정주수,강석규,주창복 경남대학교 신소재연구소 1993 論文集 Vol.3 No.-

원통 유전체주의 비유전율분포에 관한 영상방법으로 Born 근사를 이용한 푸리에 변환방식에 관한 벡터 회절단층영상 알고리즘을 제시하고 여러 환경하에서 컴퓨터 시뮬레이션방법으로 재현된 상의 특성과 열화특성이 비교 검토되었다. 여러 환경하에서 조사된 회절파의 특성에 따라 재생상의 열화특성을 알 수 있으며 Born 근사하의 푸리에 변환방식에서도 회절파의 특성에서 재생상의 질적 향상을 기할 수 있는 공통효소를 갖고 있음을 제시하였다. This research presents a vector diffraction tomography algorithm on the image reconstruction process for the distribution dielectric permittivity in the fourier domain diffraction method using the Born approximation on the assumed circular dielectric cylinder model in air and the reconstructed image characteristics, degrading reconstructed image due to the Born approximation are discussed under the various situations by computer simulation method. It was shown that the degrading reconstructed images have common factors in the diffraction field characteristics to improve the reconstruction image quality.

DEN Tip에서의 피로균열 발생 및 진전거동에 대한 파괴역학적 해석

최용식,석창성,조용근,임창현,박종주 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

In order to predict the behaviour of a crack growth with accuracy, the SIF K values for the double edge notched specimen have been determined by finite element method. With considering the root radius of notch and the crack length which increase step by step, the availability of the modified K values have been evaluated by comparing with the experimental results from fatigue test.