폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

지리산국립공원 내 산림관리에 관한 전문가 인식 조사

김동현 ( Dong Hyeon Kim ),김의경 ( Eui Gyeong Kim ),박상병 ( Sang Byeong Park ),이정환 ( Jeong Hwan Lee ) 한국산림과학회 2010 한국산림과학회지 Vol.99 No.4

This study carried out the recognition of appropriate forest managements and directions in Jirisan National Park. For this purpose, we undertook interview survey about the recognition of forest management in Jirisan National Park from ecological and forest research fields` experts. From the statistical analysis results, it was founded that the difference among respondents` types was detected about recognition of forest management in National park. However, all the respondent types recognized that the forest management in National park is essential. So the forest management in national park by forest experts and relevant institutions are revealed needed.

Nanogenerators: Fully Rollable Transparent Nanogenerators Based on Graphene Electrodes (Adv. Mater. 19/2010)

Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19

<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>

간에서 보이는 직선연 징후의 CT 소견

박성태,이현경,김정혜,이성우 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

목적 : 전산화단층촬영(CT) 에서 조여증강 전, 후에 간 내에서 관찰되는 직선연 징후(straight border sign)의 그 원인에 따른 영상소견을 알아보고자 한다. 대상 및 방법 : 복부 CT에서 간내에서 직선연 징후를 보이는 9례를 후향적으로 분석하였다. 원인 질환은 간전이, 간세포암, 외상성 간손상이 각각 1례와 간농양, 재발성화농성담도염, 그리고 지방간 각각 2례였다. 결과 : 전이암과 간세포암 각각 1례에서는 종양의 문맥침범으로 인하여 그리고 간농양과 재발성화농성담도염 각각 2례에서는 염증이 있는 간엽으로의 스틸현상에 의해 직선연으로 경계되는 간 엽간의 조영증강의 차이가 있었다. 외상성 간손상 1례에서는 간문맥과 동맥의 손상에 의한 쐐기모양의 간경색이 관찰되었으며 2례의 지방간에는 간우엽에 갠틀리선을 경계로 하는 저음영이 관찰되었다. 결론 : CT 영상에서 간내 직선연 징후가 보일 때 음영의 분포 (해부학적 또는 비해부학학적), 감쇠도(고감쇠 또는 저감쇠), 그리고 조영증가 유무와 그 방법에 대한 지식을 모두 고려하여야 할 것으로 생각된다. Purpose : We demonstrate computed tomography (CT) appearances of straight border sign of liver and correlate with its causes. Material and Methods : We retrospectively reviewed nine cases of abdominal CT scan that showed the straight border sign. Underlying disease were liver metastasis (n=1), hepatocellular carcinoma (n=1), traumatic liver injury (n=1), liver abscess (n=2), recurrent pyogenic cholangitis (n=2), and fatty liver (n=2). Results : Attenuation differences of liver bordered by the straight line were depicted in various conditions. These conditions are the followings : portal vein invasion in case of liver metastasis and hepatocelluar carcinoma ; steel phenomenon in case of liver abscess and recurrent pyogenic cholangitis ; and hepatic artery and portal vein injury in case of traumatic liver injury. Lobar fatty liver lesions were also seen in right lobe bordered by straight line. Conclusion : To correctly interpret the straight border sign, we should consider the distribution (anatomic vs nonanatomic), the attenuation (low vs high), and the use and technique of contrast enhancement.

전주시 대중교통문제의 바람직한 개선방안 : 시내버스 노선체계를 중심으로

박기영,주상현 全北大學校 附設 都市및環境硏究所 1995 都市 및 環境硏究 Vol.10 No.1

Economic growth and rapid urbanization result in various urban problems. Above all these problems, urban traffic problem entails much more cost and time with the rapidly increasing traffic congestion in urban areas. In the case of Chonju city, the enlisted number of cars is increasing rapidly a year, while the increase rate of road is not more than the increase rate of it. Therefore, the focus of this study is to investigate the cause mass transportation problem and the effective methods to improve the problem. So the study on mass transportation problem must be synthesize. Accordingly it must be studied continually.

Pocine Adenovirus-3의 E1B Region의 鹽基序列 分析

朴鍾賢,宋載永,李重馥,玄芳勳,安東濬,車相昊,裵用泰,姜永源,Reddy, P S,全茂炯,安壽煥 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

돼지 아데노바이러스(PAV-3). 6618주의 EIB region이 包含되어 있는 map unit 4.0에서 9.7까지의 유전자에 대한 1,984 bp의 염기서열을 決定하였으며, 이 結果를 알려진 여러 아데노바이러스 유전자와 비교하여 다음과 같은 결과를 얻었다. 1. PAV-3의 EIB유전자는 10개의 ORF로 구성되어 있으며, 그 중 아데노바이러스의 단백질과 유사성이 있는 것은 ORF1, ORF2 및 ORF3이었다. ORF1은 Ad41의 19kd 와 BAV-2에서의 EIB ORF2에서의 아미노산의 一致率은 각각 32%와 31%이었다. 2. ORF2는 Ad2 55kd protein과 tupaia adenovirus 44kd protein가 각각 34%로 아미노산 一致率이 가장 높았으며, Ad41의 52kd protein. BAV-3의 EIB ORF3에서도 33%의 一致率을 보였다. 3. ORF1은 61-666 uncleotide (606 bp), ORF 2에서는 429-1,850 uncleotide (1,422 bp)의 부위로 각각 202, 474 a.a로 構成되었으며, 예상되는 분자량은 20 kd와 52 kd이었다. 4. ORF3는 hexon-associated pIX유전자로 추정되며 내부에 1개의 polyadenylation signal(ATAAA)이 1938-1942 uncleotide에 위치하였으며, 이 부위는 TATA box (1937-1942 uncleotide)와 중복되어 존재하였다. Porcine adenovirus type 3 (PAV-3) does not cause severe infection in pigs. Adenovirus has been suggestive of live vaccine vector carrying foreign gene. One of insertion regions is delayed early (EIB) region. However, EIB region of PAV-3 has not been molecularly characterized to date. Nucleotide sequence of EIB of PAV-3 was determined. The EIB region was composed of 1,984 bp and located between 4.0 and 9.7 map units. Three potential open reading frames(ORFs) with low level of homology to other adenoviruses and a polyadenylation signal were identified in the rightward direction of genome. The nucleotide and the predicted amino acid sequences of EIB were compared to those of human and animal adenoviruses. One of the three potential ORFs. ORF1 encoded a polypeptide homologous to bovine adenovirus type 2(BAV-2) ORF2 and human adenovirus type 41(Ad41) 19 kd protein. ORF2 encoded a polypeptide homologous to human adenovirus type 2(Ad2) 55 kd protein, bovine adenovirus type 3(BAV-3) ORF3 and porcine adenovirus type 4(PAV-4) ORF2. The predicted protein of ORF1 had homology to those of Ad41 and BAV-2 with 32 and 31% respectively, whereas the deduced protein of ORF2 had homology to those of Ad2. BAV-3 and PAV-4 with 34, 33 and 29%, respectively.

Benzotriazole계 유도체의 제초활성과 분자 설계

성낙도,박현주,박승희,변종영 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Benzotriazole 유도체들의 정량적인 구조와 발아후 벼(Oryzae sativa L) 및 피(Echinochloa crus-galli)에 대한 생장저해 활성값(pI_50)사이의 관계들이 QSAR 방법으로 연구되었다. QSAR 분석에 의하면, 자유 라디칼 파라미터(E_R)가 매우 중요한 요소이었으며 pI_50 값은 파라치환기(X)의 E_R 파라미터에 대하여 포물선형의 관계를 나타내었다. (3)의 생장저해 활성은 (4)보다 우세하였으며 생장저해 활성이 가장 큰 화합물은 (3b)이었고 피의 생장저해 활성에 대한 E_R 파라미터의 적정값은 각각 E_R(3)=0.52와 E_R(4)=0.15이었다. 분자설계 결과, 치환기(X)가 전자 끌게이고 적정값 (0.52)와 E_R 파라미터를 가지는 분자가 가장 활성이 클 것으로 기대되었으며 Benzotriazole 유도체들의 생장저해 활성은 광합성반응(PS-II)에서 전자전달을 효과적으로 차단하는 결과로 믿어진다(1991년 9월 15일 접수, 1991년 9월 31일 수리). The relationships between the quantitative structure of benzotriazoles and their post-emergence growth inhibiting activity(pI_50) against Oryzae sativa L. and Echinochloa crus-galli were investigated using a generalized quantitative structure activity relationships(QSAR). According to the QSAR analysis, the free radical parameter (E_R) is a very important factor and the growth inhibiting activity values showed parabolic relation to E_R parameter of para-substituents(X). The activity of (3) was superior to those of (4) and (3b) is selected as the most highly effective compound. The optimal values of E_R parameter of the growth inhibiting activity aganist E. crus-galli are E_R(3)=0.52 and E_R(4)=0.15, respectively. From the result of molecular design, the substituents(X) of electron withdrawing properties and E_R parameter of optimal value(0.52) were most desirable for high activity of the benzotriazoles. And in view of this, benzotriazoles may also be effective in blocking the photosynthetic electron transfer.

발화기구의 정량적 해석을 위한 재현 실험 : 1차년도 전기화재 재현 Reconstruction for Electrical Fire

박남규,김상현,김진표,김윤희,문병선,조영진 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

Evaluation of Hot Deformation and Dynamic Recrystallization Behaviors of Advanced Reduced-Activated Alloy (ARAA)

Sang‑Wook Kim,Hyeon‑Woo Son,Taek‑Kyun Jung,Young‑Bum Chun,Yi‑Hyun Park,Ji‑Woon Lee,Soong‑Keun Hyun 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The hot deformation behavior of advanced reduced-activation alloy (ARAA) was investigated using hot torsion tests. Thefl ow stress decreased as deformation temperature increased and as strain rate decreased. The fl ow behavior demonstratedthe typical dynamic recrystallization (DRX). Based on the constitutive analysis of peak stress, the activation energy for hotdeformation was found to be 330.3 kJ mol −1 . Peak stress was analyzed as a function of the Zener–Hollomon parameter, andcalculated and experimental values were in good agreement. A DRX kinetic model for ARAA was derived with deformationconditions based on the Avrami-type model. It was confi rmed that the volume fraction of dynamically recrystallized grainsincreased as deformation temperature increased and as strain rate decreased. The necklace structure and grain boundarybulging were observed in the deformed microstructure of ARAA. The suggested DRX mechanism for ARAA during hotworking is discontinuous DRX.

비첨 성형술에서 비중격 연골 지주 이식 : 비순각 증가

박상현,유원민,박 철,박병윤 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.2