Flutamide가 수컷 생쥐의 유해감각예민도에 미치는 영향

장세헌,김명정,박제민,양구범,한병득 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

Objectives : Previous findings on nociception modulatory effect of testosterone were controversial. In this study, androgen receptor antagonist flutamide was used to reveal testosterone effect on baseline nociceptive sensitivity and stress-induced antinociception in male mice. Methods : Experiments consist 3 Parts: 1) tail flick latency(TFL, sec, 52±1℃) was measured before and 30 minutes after intraperitoneal injection of flutamide 150, 100, 50mg/kg or vehicle(N=15 for each group); 2) TFL was measured before and after serial injection of LHRH antagonist antide(1mg/kg, ip), and 30 minutes after flutamide(100mg/kg, ip) or vehicle; 3) With pretreatment of flutamide(100mg/kg, ip) or vehicle(N=15 for each group), TFL was measured before and after 5 minutes of forced-swim in cold water(15±1℃). Results : 1.TFL was significantly elongated(hypoalgesic) in the flutamide 100 and 150mg/kg groups. TFL of flutamide 150mg/kg group was significantly longer than 50mg/kg group. 2.Though pretreatment with antide itself did not make any change in TFL, it blocked antinociceptive effect of flutamide. TFL was elongated by serial injections in both flutamide and control group. 3.TFL was elongated by FS in both flutamide and control group. FS-induced elongation of TFL was significantly more prominent in flutamide group. Conclusions : From these results, it is suggested flutamide has antinociceptive effect on baseline TFL and potentiates FS- induced antinociception.

장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향

서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin

Comparison of Psychological Characteristics of Lesch Types 2 (Anxiety Model) and 3 (Depressive Model) Alcoholism

Sae Heon Jang,Min Ho Chang,Young Myo Jae,Jin Hyuk Choi,Gyeong Hwan Lee 대한우울조울병학회 2019 우울조울병 Vol.17 No.2

Background: Lesch types 2 (L2, anxiety model) and 3 (L3, depressive model) of alcoholism exhibit different responses to anti-craving agents, and most treatment guidelines provide differential treatment strategies for bipolar depression (DEP) and unipolar DEP. We compare the psychological characteristics of L2 and L3 alcoholism and between the unipolar and bipolar subgroups. Methods: We reviewed medical records of patients who were diagnosed with alcohol use disorder using the DSM-5 diagnostic criteria and classified as L2 and L3 using Lesch Alcohol typology software. All patients completed self-report scales (Alcohol Use Disorders Identification Test [AUDIT], Beck Anxiety Inventory [BAI], Beck Depression Inventory-II [BDI-II], and Korean Symptom Checklist-95 [KSCL95]). The data were analyzed using descriptive statistics, the Wilcoxon Rank-Sum test, and ANOVA. Results: Of the 43 patients, 23 were assigned L2, and 20 were assigned L3. The scores for the KSCL95 subscales fell generally in the increasing order of the L2-unipolar (L2U, n=10), L2-bipolar (L2B, n=13), L3-unipolar (L3U, n=11), and L3-bipolar (L3B, n=9) types. The L3B scores were greater than the L3U scores for most KSCL95 subscales, by contrast with the DEP and BAI scores. Conclusion: We found psychological differences between L2 and L3 and identified the unique psychological characteristics for each subgroup by polarity. The psychological characteristics of these subgroups of alcohol use disorder may help improve the treatment success rates through individualized treatment strategies.

The Symptom Frequency Characteristics of the Hamilton Depression Rating Scale and Possible Symptom Clusters of Depressive Disorders in Korea: The CRESCEND Study

Sae-Heon Jang,Young-Nam Park,Young-Myo Jae,전태연,이민수,김재민,Seung Hee Jeong,Jung Bum Kim 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.4

Objective This study analyzed the symptom frequencies of 17-item Hamilton Depression Rating Scale (HDRS-17) to understand the characteristics of each item and to propose the possible symptoms clusters. Methods From psychiatric clinics of 18 Hospitals in Korea, 1,183 patients, diagnosed with major depressive disorder (psychotic or non-psychotic), dysthymia or depressive disorder not otherwise specified. according to DSM-IV criteria, participated in this study from January 2006 to August 2008. The frequencies of each item of HDRS-17 were analyzed according to sex and severity. In addition, we compared this study with a previous study performed in England by Hamilton and with two studies performed in Korea by Kim et al. Results The frequencies of HDRS-17 items varied widely in this study, ranging from 95.8% in work and activities to 37.4% in loss of weight. But, depressed mood, psychic anxiety and work and activities items exhibited constant and higher frequency or rank regardless of study, the severity of depression or sex. Insomnia early, somatic gastrointestinal, genital symptoms and insight showed relatively constant but lower frequency or rank in disregard of studies or the clinical variables. Other symptoms had variable frequencies or ranks according to the variable clinical situations (culture, time, sex, severity of depression). Conclusion We propose three clusters of symptoms in depressive disorders: core symptoms cluster, an associated symptoms, and a situation-specific symptoms. We can use these possible symptom clusters of depression in simplifying diagnosis of depression, increasing diagnostic specificity in special situation and indexing disease severity.

초분광 영상을 이용한 가지과 묘의 수분함량 추정

전새롬 ( Sae-rom Jun ),유찬석 ( Chan-seok Ryu ),강예성 ( Ye-seong Kang ),김성헌 ( Seong-heon Kim ),장시형 ( Si-hyeong Jang ),박준우 ( Jun-wo Park ),타파스쿠마 ( Tapash Kumar Sarkar ),강동현 ( Dong-hyeon Kang ) 한국농업기계학회 2017 한국농업기계학회 학술발표논문집 Vol.22 No.2

본 연구는 초분광 영상을 이용하여 박과 모종의 수분함량을 비파괴적으로 추정하기 위해 수행되었다. 단계적으로 수분 스트레스를 받은 고추(n=45), 토마토(n=45) 모종을 초분광 영상시스템으로 촬영하여 모종 영역의 반사율을 추출하였고, 매 촬영 후 모종의 생체중과 건물중을 측정하여 수분함량을 계산하였다. 모종의 반사율과 계측된 수분함량을 변수로 하여 Partial Least Square Regression (PLSR) 분석을 이용하여 수분 추정모델을 구축하였다. 수분 추정모델을 작성한 결과 고추 모종의 Calibration (Cal.) 정확도(R²)는 0.68, 정밀도(RMSE 및 RE)는 각각 1.43%, 1.61%로 나타났고. 토마토 모종의 Calibration (Cal.) 정확도(R²)는 0.74, 정밀도(RMSE 및 RE)는 각각 2.77%, 3.09%로 나타났다. 두 모델을 이용하여 가지과 모델(n=90)을 작성한 결과 Calibration (Cal.) 정확도(R²)는 0.67, 정밀도(RMSE 및 RE)는 각각 2.53%, 1.61%로 나타났다. 본 연구를 통해 초분광 영상을 이용하여 박과 모종의 수분함량 추정가능성을 시사하였고, 모델의 정확도를 개선하기 위해 샘플 수 및 수분함량의 변이를 증가시키는 것이 필요하다고 판단된다.

6개월간의 주요우울장애 환자에서 Venlafaxine 단독요법 및 Olanzapine 병합요법의 치료 중단율

박현우(Hyun-Woo Park),장세헌(Sae-Heon Jang),제영묘(Young-Myo Jae),이대수(Dae-Su Lee),최진혁(Chin-Hyuk Choi) 대한사회정신의학회 2010 사회정신의학 Vol.15 No.1

본 연구에서 나타난 결과들은 항정신병 약물 병합군에서 더 높은 약물 순응도와 치료 효과를 나타내었다. 이는 우울증 환자들 에게서 항정신병 약물을 같이 처방함으로써 항우울제 단독으로 사용하는 것보다 환자의 약물 순응도를 높이고 치료 기간을 유지시켜 줌으로써 더 나은 치료효과를 나타낼 수 있을 것으로 보인다. Objectives:Antipsychotics augmentation is suggested as one of the strategies to improve the effectiveness of antidepressants in the treatment of major depressive disorder. This study calculated time to discontinuation of ven-lafaxine monotherapy group and olanzapine augmentation group with major depressive disorder during 6 months and discussed the effectiveness of olanzapine augmentation. Methods:We collected the data from medical records of patients who visited psychiatric outpatient clinic of Bongseng memorial hospital and were prescribed by venlafaxine XR alone, or combination of venlafaxine XR and olanzapine on first visit from Aug. 2006 to Aug. 2007. We measured time to discontinuation (no more visit), the degree of adherence by medication possession ratio (MPR) from first visit until 6 months. The degree of CGI-I, CGIS scores and dosages of each medication were also assessed by monthly for 6 months. We used chi-square test and ttest, Kaplan Meier method to analyze group differences in demographic data and clinical characteristics, treatment efficacy and survival analysis. Results:The mean survival time of augmentation group was longer than monotherapy group (129.55 days vs 99.86 days, log rank test p=0.0342). The difference of CGI-S between two groups was not different significantly (4.4 vs 4.3, p=0.743) at baseline but CGI-I of augmentation group was better than monotherapy group (1.8 vs 2.8, p<0.001) at first month. Augmentation group showed higher MPR than monotherapy group but statistically not sig-nificant (0.950 vs 0.908, p=0.351). Conclusion:Our results suggest olanzapine augmentation would be able to increase treatment adherence and effectiveness.

입원 환자의 후향적 전자의무기록 분석을 통한 수혈과 관련된 급성 이상 반응의 발생 빈도와 임상 양상

김용현 ( Yong-hyun Kim ),서장호 ( Jang-ho Seo ),안경민 ( Kyung-min Ahn ),양민석 ( Min-suk Yang ),김세훈 ( Sae-hoon Kim ),조상헌 ( Sang-heon Cho ),장윤석 ( Yoon-seok Chang ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4

Purpose: Adverse transfusion reactions (ATRs) are unfavorable reactions to the transfused unit, and the severity may be different among individuals, depending upon the type of reactions and the patient’s susceptibility. It is necessary to operate and manage a systematic monitoring system to minimize these ATRs and increase the safety. This study was conducted to evaluate clinical features of transfusion-related adverse events and morbidities. Methods: We retrospectively analyzed transfusion data from electronic medical records during the recent 3 years (April 2017 to April 2020) at Seoul National University Bundang Hospital. The electronic search strategy was applied to search for the type of blood prod-ucts prescribed and identify symptoms that occurred during transfusion as recorded in the nursing chart which is based on the In-ternational Classification for Nursing Practice. Results: A total of 18,772 people were transfused during the study period. A total of 524 people were reported as suspected ATRs, of whom 466 were finally confirmed. Red blood cell was the most frequent culprit blood product (59.9%), followed by apheresis plate-let (25.1%), fresh frozen plasma (10.1%), and platelet (4.9%). Clinical symptoms included fever (54.9%), urticaria and itching (34.7%), chillness and shivering (21.9%), and chest discomfort (6.0%), dyspnea (5.3%), cold sweating (3.8%), hypotension (2.1%), and palpita-tions (1.9%). The severity of ATRs were mild (91.8%), moderate (7.1%), and severe (1.1%). Conclusion: ATRs are mostly mild, but life-threatening reactions may occur. Physicians should be aware of various features of ATRs to appropriately recognize and treat such patients. (Allergy Asthma Respir Dis 2021;9:225-230)

Screening with the Korean Version of the Mood Disorder Questionnaire for Bipolar Disorders in Adolescents: Korean Validity and Reliability Study

Se-Hoon Shim,Jong-Hun Lee,Jye-Heon Song,Beomwoo Nam,Bo-Hyun Yoon,Ha-young Jin,Hyung-Mo Sung,Jong Hyun Jeong,Sae-Heon Jang,Duk-In Jon,Young Sup Woo,Won-Myong Bahk 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3

Objective: This study aimed to evaluate the validity and reliability of a Korean version of the Mood Disorder Questionnaire-Adolescent version (K-MDQ-A) as a screening instrument for bipolar disorders in adolescents. Methods: One hundred two adolescents with bipolar disorders and their parents were recruited from November 2014 to November 2016 at 7 training hospitals. One hundred six controls were recruited from each middle school in two cities of South Korea. The parent version of the original MDQ-A was translated into Korean. The parents of all participants completed the K-MDQ-A. The diagnoses of bipolar disorders were determined based on the Korean version of K-SADS-PL. The test-retest reliability with a 10-month interval was investigated in 33 bipolar adolescents. Results: K-MDQ-A yielded a sensitivity of 0.90 and a specificity of 0.92 when using a cut-off score of endorsement of 5 items, indicating that symptoms occurred in the same time period and caused moderate or serious problems. The internal consistency of the K-MDQ-A was good. The correlations between each item and the total score ranged from 0.40 to 0.76 and were all statistically significant. Factor analysis revealed 3 factors that explained 61.25% of the total variance. The mean total score was significantly higher in bipolar adolescents (7.29) than in controls (1.32). The Pearson correlation coefficient for the total test-retest score was 0.59 (p<0.001). Conclusion: The K-MDQ-A completed by parents showed the excellent validity and reliability and may be a useful screening tool for adolescents with bipolar disorders attending in- and outpatient psychiatric clinics.

불안, 기분장애로 치료 중 보행장애 외에 서동과 강직을 동반한 정상뇌압수두증 증례

장세헌,제영묘,최진혁,배정훈,성상윤,조세훈,김영훈,Jang, Sae Heon,Jae, Young Myo,Choi, Jin Hyuk,Bae, Jung Hoon,Seong, Sang Yoon,Cho, Se Hoon,Kim, Young Hoon 한국정신신체의학회 2015 정신신체의학 Vol.23 No.1

정상뇌압수두증은 보행장애, 요실금 및 치매 등의 전형적인 세 가지 증상 외에도 추체외로 증상과 다양한 신경심리 증상이 동반될 수 있다. 이 사례는 불안과 정동증상으로 치료 중 보행장애와 요실금 증상을 보였던 46세 여자 환자에서 항파킨슨 약물의 사용과 기존 정신과 치료 약물의 중단에도 불구하고 증상의 호전이 없었으나, 뇌 컴퓨터 단층 촬영상 뇌실의 확장 소견이 보였고 시험적 뇌척수액 배액에 의해서 수일 내에 증상들이 극적으로 호전되어 정상뇌압수두증을 감별해야 했던 경우이다. 뚜렷한 대뇌 실질의 위축 소견이 없으나 뇌실이 확장되어 있을 경우 추체외로 증상과 신경심리 증상이 있을 경우 정상뇌압수두증의 전형적 세 가지 증상을 보이지 않는다 하더라도 정상뇌압수두증의 가능성을 고려해서 시험적 뇌척수액 배액 등의 시술이 진단과 치료에 도움이 될 수 있음을 보여주는 사례라고 생각된다. In addition to classical triad such as gait disturbance, urinary incontinence and dementia, parkinsonian extrapyramidal motor signs and neuropsychiatric symptoms can be observed in patients with normal pressure hydrocephalus (NPH). In our case, a 46 year old female patient showed extrapyramidal symptoms such as bradykinesia, rigidity and neuropsychiatric symptoms such as agitation, anxiety, restlessness and regressed behavior beside two(gait disturbance & urinary incontinence) symptoms of three classical triad. It was difficult to diagnose this patient as NPH from the beginning because of her relatively young age and previous psychiatric mediation history for controlling advanced anxiety and affective disorder. Antiparkinsonian agents and discontinuation of psychiatric medications did not work for this patient. Patient's brain computed tomographic finding showed enlarged ventricles. We suspected NPH and did empirical drainage of 30mL CSF. Finally, patient's pyramidal and neuropsychiatric symptoms as well as two of three classical triad of NPH were improved dramatically within several days. It is important to consider NPH as one of the differential diagnosis in patient with parkinsonian symptoms and various neuropsychiatric symptoms who did not respond to usual clinical management especially in case of ventricular enlargement in neuroimaging because of its treatable property by CSF shunt operation.

Yield Prediction of Chinese Cabbage (Brassicaceae) Using Broadband Multispectral Imagery Mounted Unmanned Aerial System in the Air and Narrowband Hyperspectral Imagery on the Ground

( Ye Seong Kang ),( Chan Seok Ryu ),( Seong Heon Kim ),( Sae Rom Jun ),( Si Hyeong Jang ),( Jun Woo Park ),( Tapash Kumar Sarkar ),( Hye Young Song ) 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.2

Purpose: A narrowband hyperspectral imaging sensor of high-dimensional spectral bands is advantageous for identifying the reflectance by selecting the significant spectral bands for predicting crop yield over the broadband multispectral imaging sensor for each wavelength range of the crop canopy. The images acquired by each imaging sensor were used to develop the models for predicting the Chinese cabbage yield. Methods: The models for predicting the Chinese cabbage (Brassica campestris L.) yield, with multispectral images based on unmanned aerial vehicle (UAV), were developed by simple linear regression (SLR) using vegetation indices, and forward stepwise multiple linear regression (MLR) using four spectral bands. The model with hyperspectral images based on the ground were developed using forward stepwise MLR from the significant spectral bands selected by dimension reduction methods based on a partial least squares regression (PLSR) model of high precision and accuracy. Results: The SLR model by the multispectral image cannot predict the yield well because of its low sensitivity in high fresh weight. Despite improved sensitivity in high fresh weight of the MLR model, its precision and accuracy was unsuitable for predicting the yield as its R² is 0.697, root-mean-square error (RMSE) is 1170 g/plant, relative error (RE) is 67.1%. When selecting the significant spectral bands for predicting the yield using hyperspectral images, the MLR model using four spectral bands show high precision and accuracy, with 0.891 for R2, 616 g/plant for the RMSE, and 35.3% for the RE. Conclusions: Little difference was observed in the precision and accuracy of the PLSR model of 0.896 for R², 576.7 g/plant for the RMSE, and 33.1% for the RE, compared with the MLR model. I f the multispectral imaging sensor composed of the significant spectral bands is produced, the crop yield of a wide area can be predicted using a UAV.