Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis : Pharmacokinetics of oltipraz in LCD rats

Ahn, CY,Bae, SK,Bae, SH,Kim, T,Jung, YS,Kim, YC,Lee, MG,Shin, WG Wiley (Blackwell Publishing) 2009 British journal of pharmacology Vol.156 No.6

<P>BACKGROUND AND PURPOSE: The incidence of diabetes mellitus is increased in patients with liver cirrhosis. Oltipraz is currently in trials to treat patients with liver fibrosis and cirrhosis induced by chronic hepatitis types B and C and is primarily metabolized via hepatic cytochrome P450 isozymes CYP1A1/2, 2B1/2, 2C11, 2D1 and 3A1/2 in rats. We have studied the influence of diabetes mellitus on pharmacokinetics of oltipraz and on expression of hepatic, CYP1A, 2B1/2, 2C11, 2D and 3A in rats with experimental liver cirrhosis. EXPERIMENTAL APPROACH: Oltipraz was given intravenously (10 mg x kg(-1)) or orally (30 mg x kg(-1)) to rats with liver cirrhosis induced by N-dimethylnitrosamine (LC rats) or with diabetes, induced by streptozotocin (DM rats) or to rats with both liver cirrhosis and diabetes (LCD rats) and to control rats, and pharmacokinetic variables measured. Protein expression of hepatic CYP1A, 2B1/2, 2C11, 2D and 3A was measured using Western blot analysis. KEY RESULTS: After i.v. or p.o. administration of oltipraz to LC and DM rats, the AUC was significantly greater and smaller, respectively, than that in control rats. In LCD rats, the AUC was that of LC and DM rats (partially restored towards control rats). Compared with control rats, the protein expression of hepatic CYP1A increased, that of CYP2C11 and 3A decreased, but that of CYP2B1/2 and 2D was not altered in LCD rats. CONCLUSIONS AND IMPLICATIONS: In rats with diabetes and liver cirrhosis, the AUC of oltipraz was partially restored towards that of control rats.</P>

조기 양수천자술과 중기 양수천자술의 안정성에 관한 비교연구

안현경,이환견,최수경,김은성,한호원,김문영,류현미,한정렬,송하균,김진미 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1

We sought to determine whether early amniocentesis is a safe and acceptable method of genetic evaluation in early pregnancy. During the 20-month period from February 1994 to September 1995, 80 consecutive early amniocentesis were performed transabdominally at 12+3-14+6 weeks of gestation and 305 consecutive mid- second-trimester transabdominal amniocenteses were performed at 16+0- 18+0 weeks of gestation. All amniotic fluid samples were cultured using flask method. There were no significant differences between the early and mid-second- trimester amniocenteses in failed sampling, ambiguous results, pregnancy loss within 4 weeks after the procedure, pregnancy loss from 4 weeks after procedure to 28 weeks of gestation, preterm birth, and perinatal death. We may conclude that early amniocentesis is a safe and acceptable method for prenatal diagnosis.

Synchronous Multiple Colonic Adenocarcinomas Arising in Patient with Neurofibromatosis Type 1

Kong SK,Ahn SH,Kwon HJ,Kim YW,Kim IY 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3

유착태반

박세교(SK Park),유한기(HK Yoo),신호영(HY Shin),안동원(DW Ahn) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.3

Seven cases of palcental adhesion which were treated at Severance Hospital during last 11 years were summarized clinically with review of references. 1) Incidence of placental adhesion was 1 : 1,925 deliveries. Six out of seven cases were placenta accreta and the rest one was placenta increta histopathologically. 2) All cases were multiparous, and one was a case of previous cesarean secion, one combined with placenta previa and one appeared in case of spontaneous abortion on mid trimester. 3) All cases were treated with total hysterectomy following failure of treatment with manual separation or curettage of placenta. Those placentas were attached to posterior wall of the uterus except for one to anterior wall. 4) Postoperative infection appeared in two cases as postoperative complication.

자궁경부암 환자에서 광범위 자궁적출술 전후의 방광과 요도의 해부학적 형태에 대한 연구 - 금속성 염주상 연쇄 요도방광 조영술을 이용한 분석-

송승규,박태철,김수평,김은중,김사진,이귀세라,이형근,허수영,김진범,공기환,안상복 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

This present study was undertaken to evaluate the chacteristic anatomic configuration of bladder and urethra in parients with cervical cancer before and after radical hysterectomy. From July 1994 to December 1996, metallic beaded chain urethrocystography was conducted in 33 patients with cervical cancer before and after radical hysterectomy at Holy Family hospital. The results were as follows. 1. After radical hysterectomy, posterior urethrovesical angles at rest and strain were significantly increased(P = 0.0004 at rest, P = 0.0016 at strain) and posterior urethrovesical junction at rest and strai were significantly descended(P = 0.004 at rest, P = 0.0024 at strain). 2. Postoperative urethral inclination angle at rest was greater than before radical hysterectomy(P = 0.002), but postoperative urethral inclination angle at strain was not increased statistically(P > 0.05). From these results, we concluded that stress urinary incontinence after radical hysterectomy is the results of anatomically defective supports of urethrovesical junction and urethra. We must consider a proper surgical method to prevent stress urinary incontinnce and anatomical defect of urethrovesical junction.

전신성 홍반성 낭창과 동반된 임신 1례

정승균(SK Chung),한치동(CD Han),신수제(SJ Shin),김승도(SD Kim),안재영(JY Ahn) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.10

저자들은 고려병원 산부인과에서 임상적, 이학적 소견이 전신성홍잔성낭창과 일치하고 안면 피부조직거마상, L.E.세포, A.N.A.검사에서 확진된 28세의 다산부의 임신과정을 관찰할 수 있었다. Systemic lupus erythematosus (S.L.E) is an autoimmune disease occuring most frequently in woman during the reproductive age and it has been known that this disease is often complicated by renal disease up to 75% of cases. Recently we encountered a case of S.L.E. associated with pregnancy which was confirmed by skin biopsy, positive L.E. cell, and A.N.A. test. Authors report clinical course, therapy on the patient with brief review of concerned literatures.

복강경 불임술에 대한 정신의학적 연구

민성길(SK Min),김경희(KH Kim),안동원(DW Ahn),곽현모(HM Kwak) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.2

피임 목적으로 복강경 난관 결찰술을 받은 102명의 여성을 대상으로 수술 전에 비하여 수술 후 6개월만에 어떤 정신과적 후유증이 발생하는가를 조사 연구하여 다음과 같은 결과를 얻었다. 여성의 불임술은 전체적으로 보아 어느 정도 우울, 불안, 건강염려증 등 정신증상과 그에 수반되는 신체증상들 즉 성욕감퇴, 소화장애, 월경장애, 요통, 심계항진, 두통, 피로 등을 유발시켰다고 생각되나, 그 정도는 병적 상태가 아닌 매우 경미한 상태였고, 또한 대부분 수술에 대해 만족하는 등 정신과적으로 비교적 안전한 방법임이 입증되었다. 예후가 나쁜 악화군을 따로 구별하여 호전군과 비교해 보았을 때, 나쁜 예후는 개인력과 가족력에 있어 이에 정신과적 문제가 존재하고 있음과 관련되었다. 즉 너무 일찍 수술하였을 때, 과거 다른 피임법을 사용해 본 경험이 없었을 때 수술동기에 있어 자원이 아닌 타의에 의했을 때 및 결혼과 성생활에 문제가 있었을 때 예후가 나빴다. 그러나 학력, 직업, 종교, 자녀수 및 유산회수 등도 유의한 정도는 아니나 영향을 주고 있었다. 수술을 후회하는 경우가 약 20%에 달했는데, 그 정도는 심하지 않았고, 더구나 복원수술을 고려하는 사람은 전무하였다. 후회하는 이유는 아들이 없거나 하나 뿐이어서 이제 더 이상 아들을 못가지리라는 점과, 불임술이 곧 여성으로서의 기능상실을 의미한다고 믿거나, 수술에 대한 비상식적인 기대가 충족되지 않은 것 등이었다. 이는 남아선호 경향과 의학적 무지 때문으로 생각된다. 이에 저자들은 이러한 후유증을 극소화 또는 예방하기 위해서는 지원자에 대해 수술전에 적절한 정신과적 평가가 선행되어야 할 필요가 있음을 결론 지었으며 그 기준에 대해 논의하였다. A psychiatric study was conducted on the female sterilization with randomly selected 102 women who had been given the laparoscopic tubal ligation for contraceptive reason at Yonsei University, Medical Center from April to September in 1977. Each patient was interviewed evaluated her emotional state by two psychiatrists twice, before and six months after the operation. Results indicated that the contraceptive laparoscopic tubal ligation was a relatively safe procedure in psychiatric aspects and that most patients were satisfied with the result of operation. However, some patients complained that various psychiatric symptoms had developed or aggravated after the operation as sequele. Those were depression, anxiety, hypochondria, fear, impaired intellectual functioning, irritability and associated psychosomatic disturbances such as decreased libido, indigestion, menstrual disturbance, headache, palpitation, backache and fatigability. But those symptoms were not of neurotic severity but of very mild one. It was also revealed that the poor outcome were associated with patient` already existing psychiatric problems in their personal life, premorbid personality and their motivation for the operation. Among them the most significant factors were too early operation in young age, involuntary operation, less experience with other contraceptive methods, neurotic personality and various difficulties in their marital and sexual life. Other factors such as religion, number of children and occupation were also discussed. About 20% of the patients regretted for the operation but no one considered the repairing operation. The main reason of regret for the operation were that they had no son or would never have son any more in the future, and that the tubal ligation would mean the loss of feminity and sexual function. These seemed to reflect the boy-preferring tendency in korean society and their poor medical knowledge. So we concluded that, to minimize or prevent these sequele, preoperative psychiatric evaluation is

상피성난소암 환자에서 CA 125의 임상적 의의

송승규,이헌영,한구택,김세일,유기성,윤중한,안광순,홍경선 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.1

상피성난소암 환자에서 방사 면역측정법에 의하여 환자의 혈청으로부터 CA 125 측정값을 임상적경과, 병기별 및 조직학적 분류에 따라 다음과 같은 결론을 얻었다. 1. 상피성난소암 환자에서 병기가 증가할수록 CA 125 측정값이 유의하게 상승(P$lt;0.01)하였다. 2. 상피성난소암중 CA 125가 35U/ml이상으로 양성을 보이는 경우는 75.9%였으며 장액성의 경우 83.7%, 점액성에서는 50.0%로 장액성일때 CA 125가 양성인 경우가 더 많았다. 특히 장액성암의 경우 Ia기를 제외하면 94.7%의 높은 양성율을 보였다. 3. 1차 종양축소수술 및 화학요법을 시행한 후 3개월이내에 CA 125치가 35U/ml이하인 경우는 74.0%가 경쾌되었으나 반면에 CA125치가 35U/ml이상을 보인 군에서는 10.3%만이 경쾌되었다. 즉, CA 125치가 치료시작후 3개월이내에 정상범위를 보이지 않는 경우는 예후가 매우 불량하였다(P$lt;0.001). 4. 2차개복수술을 시행한 23예에서 수술직전 CA 125치가 양성을 보인 5예는 모두 조직학적으로 병변양성을 보였으며 모두 진행되었으며, CA 125가 음성을 보인 18예중 병변 양성을 보인 경우는 9예였으며, 4예(44.4%)는 진행, 4예(44.4%)는 지속, 1예(22.2%)는 경쾌판정을 받았다. CA 125치가 음성이고 병변음성인 9예는 모두 경쾌판정을 받았다. 이상의 결과로 볼 때 CA 125는 상피성난소암의 조기진단에 임상적으로 유용하며 난소암의 치료후 진행, 경쾌, 재발 및 지속되는 상태에 따라 일치하여 감소 및 증가하였다. 따라서 상피성난소암 환자에서 CA 125농도는 암의 파급효과와 연관성이 있으며 예후판정에 유용하게 이용될 수 있다고 생각된다. Ca 125 is an antigenic determinant that can be demonstrated in the majority of epithelial ovary carcinomas. It can be measured in the serum with a radioimmunoassay by means of a monoclonal antibody. It was reported that CA 125 was thighly positive in epithelial ovarian cancer and rising or faling level of CA 125 was correlated with progression or regression of disease. From Jan. 1986 to Dec. 1990, 79 cases of epithelial ovarian carcinoma were assessed and followed propectively using a murine monoclonal antibody OC 125 which detects the antigen CA 125. The results as follows ; 1. The histology of the ovarian carcinomas consisted of 43 serous, 24 mucinous, 4 endometriod, 1 clear cell and 7 undifferentiated. 2. Using 35 U/ml as a cutoff, the positive rates of CA 125 in serous epithelial and mucinous epithelial carcinomas were 36/43(83.7%) and 12/24(50.0%) respectively. 3. In serous ovarian carcinoma CA 125 levels were less than 35 U/ml in 5 cases of stage Ia and 36 out of 38 cases excluding stage Ia showed CA 125 level of more than 35 U/ml. 4. Three months after cytoreductive surgery and chemotherapy, 50 of 79 patients had less than 35 U/ml of CA 125. Among 50 patients, 10 patients (20.0%) had progression, 3 patients (6.0%) were stable, 37 patients (74.0%) had regression. 29 patients had more than 35 U/ml of CA 125, 25 of 29 patients (86.2%) had progression. 5. 2nd look operation was performed in 23 patients. 5 of 23 patients had preoperatively more than 35 U/ml of CA 125, had disease evidence pathologically and had progression of disease. Meanwhile, among 18 patients who had preoperatively less than 36 U/ml of CA 125, 9 patients had disease evidence, 3 patients(44.4%) had progression, 4 patients(44.4%) were stable, 1 patients (22.2%) had regression. 6. All the values of CA 125 in the 9 patients who had pathologically negative findings in the 2nd look operation were below 35 U/ml, had regression. CA 125 may be useful in monitoring the response to treatment, longterm follow-up and early diagnosis of the ovarian car

쌍태아간 수혈증후군 1 례

박신근,신경재,안철영,김태국,전영식,박경원,강영제 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.6

본 병원 산부인과에서는 반복 양수천자로 임신을 지속시킨 쌍태아간 수혈증후군 1례를 경험 하였기에 문헌고찰과 함께 보고하는 바이다. TWIN-TWIN Transfusion Syndrome(TTTS) is a serious complication of monochorionic gestaions and is associated with high rates of perinatal morbidity and mortality resulting from shunting of blood from one twin(donor) to the other(recipient) through placental vascular anastomoses. We experienced a case of TTTS at 27 wks in which amniocentesis was attempted serially for therapeutic purpose. Therefore, we present this case with a brief review of the literatures.

Candida성 질염에 대한 Fluconazole의 임상적 치료 효과

오병찬,안진섭,김종덕,황수경,이희섭,차경연,양재이 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.11

저자 등은 1991년 2월 1일부터 9월 30일까지 대하, 음부소양증 및 작열감을 주소로 전북대학교병원 산부인과 외래에 내원한 환자중 질분비물 직접도말검사와 배양검사에 의해 candida가 확인된 비임신 여성 33명을 대상으로 fluconazole 1회 경구요법을 사용하여 다음과 같은 결과를 얻었다. 1. 환자의 연령분포는 28∼60세이며, 평균연령은 37.7세였고 분만횟수는 2회 군이 21례로 63.6%를 차지했다. 2. 치료후 자각증상의 소실은 작열감이 100%, 대하증이 81.5% 음부소양증이 76.9%였으며 질경소견상의 호전은 외음 및 질의 표피박라기 91.7%, 홍반이 85.0%, 분비물이 73.3%였다. 3. 진균성 질염의 원인균은 candida albicans가 29례로 88%차지하였다. 4. Sabouraud dextrose배지를 이용한 배양법에 의해 치료판정한 결과 치료 1주후의 추적검사에서 90.0%의 치료성적을 보였으며 4주후의 추적검사에서 93.1%의 치료 지속효과를 나타냈다. 5. 약제의 부작용은 자각적 증상이나 검사학적인 면에서 발견할 수 없었다. A clinical study about effectiveness of single dose Fluconazole (Diflucan) therapy in vaginal candidiasis has been carried out in 33 patients who visited Department of Obstetrics and Gynecology, Chonbuk National University Hospital form February 1st, 1991 to September 30th, 1991. Ages ranged from 28 years to 60 years with a mean of 37.7 years and the mean height was 157.1 cm and the mean body weight was 53.0kg. The majority of contanception methods (69.7%) were IUD and surgically sterilized methods. The most offending organism was Candida albicans (88%). The subjective symptoms such as discharge, pruritus, burning were ameliorated after treatment in 81.5%, 76.9% and 100%, respectively. The clinical signs such as erythema, excoriation, erosion and discharge were ameliorated after treatment in 85.0%, 91.7%, 71.4% and 73.3%, respectively. Ninety-one percent(30/33) of patients treated with the single dose were found to be cured at the 1-week follow-up, and this persisted in 93.1%(27/29) of patients to the 4-week follow up. There were no undesirable side effects in all patients during and after treatment. Fluconzole may become the orally active antifungal agents capable of treating vaginal candidiasis with single dose therapy.