Chemical Constituents from Rhizomes of Curculigo breviscapa

Cui-Cui Zhu,Kai-Jin Wang,Zhi-Yuan Wang,Ning Li 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.1

Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling

( Ning Ding ),( Yanzhu Lu ),( Hanmin Cui ),( Qinyu Ma ),( Dongxia Qiu ),( Xueting Wei ),( Ce Dou ),( Ning Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2020 BMB Reports Vol.53 No.3

We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor кB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKLevoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulindependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway. [BMB Reports 2020; 53(3): 154-159]

Chemical Constituents from Rhizomes of Curculigo breviscapa

Zhu, Cui-Cui,Wang, Kai-Jin,Wang, Zhi-Yuan,Li, Ning Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.1

Salt template-assisted construction of three-dimensional interconnected network in thermally conductive EP/PVDF/NiCo@GNP composites

Ning Jia,Bin Yang,Xiaohong Wang,Shishuang Cui,Peng Chen,Ru Xia,Zhengzhi Zheng,Jiasheng Qian,Yuchao Ke,Yang Pan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

In this study, graphene nanoplatelets (GNP) and nickel–cobalt (NiCo) alloy were adopted as reinforcingmaterials to prepare epoxy (EP) resin-based composites. NiCo particles were able to achieve uniformanchoring on GNPs’ surface under the electrostatic force due to the successful introduction of oxygendefects on GNPs. With the synergistic effect of adhesive PVDF and salt particles, the system with threedimensionally(3D) interconnected network was successfully constructed. Benefit from the formation ofmechanically stable and efficient heat conduction paths, the thermal conductivity (TC) of the EP/PVDF/NiCo@GNP composite reached 1.077 Wm1K1 at a filler volume fraction of 6.82 vol%, while the counterpart’sstoragemodulus (E’) was up to 3.22 GPa. In addition, a scaling formula was quantitatively proposed tocorrelate TC with E’, and the perfect agreement between the theoretical prediction and experimental dataclarified the underlying mechanism of the relationship between phonons transport and stress transferwithin a systemwith 3D ordered structures. The establishment of relationship between AHR (average heatingrate) and TC made it possible to further predict TC of composites based upon the infrared thermal imaging(ITI) data. The as-prepared GNP composites show good application prospects as thermal managementmaterials which need to experience thermally mechanical deformation.

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

Ning Hao,Zhaojun Wang,Sujuan Kuang,Guangyan Zhang,Chunyu Deng,Jue Ma,Jianxiu Cui 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol on human pulmonary arteries obtained from patients who had undergone surgery. Arterial rings were mounted in a Multi-Myograph system for measurement of isometric forces. U46619 was used to induce sustained contraction of the intrapulmonary arteries, and propofol was then applied (in increments from 10-300 μM). Arteries denuded of endothelium, preincubated or not with indomethacin, were used to investigate the effects of propofol on isolated arteries. Propofol exhibited a bifunctional effect on isolated human pulmonary arteries contracted by U46619, evoking constriction at low concentrations (10-100 μM) followed by secondary relaxation (at 100-300 μM). The extent of constriction induced by propofol was higher in an endothelium-denuded group than in an endothelium-intact group. Preincubation with indomethacin abolished constriction and potentiated relaxation. The maximal relaxation was greater in the endothelium-intact than the endothelium-denuded group. Propofol also suppressed CaCl₂-induced constriction in the 60 mM K⁺-containing Ca²⁺-free solution in a dose-dependent manner. Fluorescent imaging of Ca²⁺ using fluo-4 showed that a 10 min incubation with propofol (10-300 μM) inhibited the Ca²⁺ influx into human pulmonary arterial smooth muscle cells induced by a 60 mM K⁺-containing Ca²⁺-free solution. In conclusion, propofol-induced arterial constriction appears to involve prostaglandin production by cyclooxygenase in pulmonary artery smooth muscle cells and the relaxation depends in part on endothelial function, principally on the inhibition of calcium influx through L-type voltage-operated calcium channels.

Effect of Angiotensin II Type I Receptor A1166C Polymorphism on Benazepril Action in Hypertensive Patients: A Family-based Association Test Study

Ning Zhang,Huadong Cui,Lili Yang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10

Background: Few studies have examined the effect of the angiotensin II type I receptor (AT1R) A1166C polymorphism on the antihypertensive effect of the angiotensin-converting-enzyme inhibitor benazepril in patients with hypertension, and no such studies have performed analysis using the Family-Based Association Test (FBAT), The aim of our study was to examine the association between AT1R A1166C gene polymorphism and the antihypertensive effect of benazepril using the FBAT. Methods and Results: A total of 864 patients (aged, 26-62 years) with essential hypertension were identified in an epidemiological survey and enrolled in this study. Blood pressure (BP) was measured before and after 16 days of treatment with benazepril (10 mg/day). The association between the A1166C gene polymorphism and the antihypertensive effect of benazepril was assessed by FBAT. The frequencies of alleles A and C were 95.1% and 4.9%, respectively. FBAT analysis revealed that the C allele was significantly associated with high baseline diastolic BP (Z = 2.041, p = 0.041), decreased systolic BP after treatment (Z = 2.549, p = 0.011), and decreased diastolic BP after treatment (Z = 2.320, p = 0.020). Conclusion: Our results, determined using the FBAT, are the first evidence that the AT1R A1166C polymorphism may increase the antihypertensive effect of benazepril in patients with hypertension.

Study on the coupling relationship between wear and dynamics under steady uniform temperature field of planetary gear system

Ning Dong,Jianxing Zhou,Ruiting Tong,Quanwei Cui,Yiyi Kong,Junshang Feng,Shichen Xiao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

Wear of tooth profiles and thermal deformation caused by temperature changes are difficult to avoid in gear systems and have important effects on the performance, even to failure. In this paper, a dynamic wear prediction model with coupled thermal deformation and wear is proposed to study the interaction between wear and dynamics of planetary gear system under temperature field, accounting for the effect of temperature on material properties. The system's performance under different wear cycles and temperatures is analyzed. The results show that the difference in the structure makes the curve shape of the thermal deformation error for the external and internal gear pairs completely different, which in turn affects the dynamic response. The distribution and the degree of fluctuation of tooth profile wear depth change as the mesh cycle increases. The early wear is beneficial to the system's uniform load performance and vibration, and the performance decreases as the wear increases, but the external and internal gear pairs are affected by wear to a different extent. The thermal deformation and wear errors have competing or facilitating mechanisms depending on the temperature difference and the degree of wear.

Case studies on the probabilistic characteristics of ultimate strength of stiffened panels with uniform and non-uniform localized corrosion subjected to uniaxial and biaxial thrust

Cui, Jinju,Wang, Deyu,Ma, Ning The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1

Based on Nonlinear Finite Element Analysis (NFEA), this paper focuses on the bi-axial ultimate strength of typical bottom structures under corrosion. On one hand, uniform and not simultaneous corrosion across different structures is introduced, and surrogate models by Gaussian Process (GP) are built for both longitudinal and transverse cases individually, and corresponding probabilistic characteristics are investigated; meanwhile, corrosion effects on interaction between bi-axial stresses at ultimate state are studied. On the other hand, non-uniform localized pitting corrosion of normally distributed circular shapes is introduced, and different pitting corrosion densities are considered; structural bi-axial ultimate strengths under pitting corrosion are studied, and the results are compared with that from equivalent uniform corrosion; the probabilistic characteristics of structural ultimate strength in life cycle are studied; finally, the ultimate strength under randomly distributed pitting corrosion is compared with results from normally distributed pitting and uniform corrosion under various boundary conditions.

Study on wear evolution of spur gears considering dynamic meshing stiffness

Ning Dong,Quanwei Cui,Jianxing Zhou,Ruiting Tong,Haiwei Wang,Feng-xia Lu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7

Wear is an inevitable phenomenon in gear systems and has a great impact on performance and longevity. In view of the fact that the actual variation of meshing stiffness in the double teeth contact region and the nonlinear relationship between meshing stiffness and force are ignored in previous wear prediction studies, a new method with loss-of-lubrication is proposed in this study. A translational-torsional dynamic model is developed for the coupling effect between wear and dynamic characteristics of external spur gears. To obtain more precise dynamic responses, the meshing stiffness and force are coupled with tooth wear, taking into account the structural coupling effect and nonlinear contact. The tooth surface is then discretized, and a wear model is developed based on Archard wear equation, in which the average pressure is used for the engaging point. Experiments and numerical simulations are carried out to analyze the wear pattern and the interaction between wear and dynamic responses. The results show that the progressive wear process is self-adaptive. Meanwhile, the area with the largest wear depth moves slightly from the dedendum and addendum to the pitch line as the wear cycle increases. When the wear depth is at the level of the tooth profile deviation, the influence of wear on meshing stiffness is very small within the single tooth contact region. However, there is a significant decrease in the stiffness of the double teeth contact, and this decrease is related to the wear cycle and torque. At the initial wear phase, as the load increases, the fluctuation of the wear depth within the engaging-in region intensifies and the overall wear depth increases. With the increment of rotate speed, the engaging-in impact makes the fluctuant area of wear depth become larger.

중일 양국의 해양 패턴 조형 비교연구

녕우안 (Ning,YuAn),최문천 (Cui,WenQian),우철위 (Yu,TieWei) 한국해양디자인학회 2024 JMDR 해양디자인학연구 Vol.2 No.1

As an important cultural symbol, Chinese ocean pattern plays an important role in the traditional culture of China and Japan. This paper discusses their historical background, characteristics, influence and inheritance in cultural exchange through the comparative study of Chinese and Japanese Marine patterns. Firstly, this paper analyzes the importance of Marine patterns in cultural exchanges, and introduces the current situation of the study of Marine patterns in China and Japan. Secondly, the paper makes a detailed comparative study on the historical background and characteristics of Chinese and Japanese Marine patterns, including the origin and development of ancient Marine patterns, patterns and meanings. Then, by comparing the patterns and meanings of Chinese and Japanese ocean patterns, we find the similarities and differences between them. Then, it discusses the influence of ocean patterns in cultural exchanges, including the mutual influence of ocean patterns between China and Japan and the significance of ocean patterns to cultural inheritance. Finally, the application of Marine pattern in design and art is analyzed, and the development direction of Marine pattern research in the future is prospected. The purpose of this study is to deepen the understanding of the Marine patterns of China and Japan and promote the cultural exchanges and cooperation between the two countries. 본 연구 중국 해양 중요한 문화 기호로서 중국과 일본의 전통 문화에서 중요한 역할을 한다. 이 연구는 중국과 일본의 해양 패턴에 대한 비교 연구를 통해 역사적 배경과 특징 문화교류에서의 영향과 계승에 대해 논의한다. 먼저 문화교류에서 해양문양의 중요성을 분석하고 중국과 일본의 해양문양 연구 현황을 소개했다. 다음으로 고대 해양 문양의 기원과 발전 문양과 의미 등 중국과 일본해양 문양의 역사적 배경과 특성에 대한 상세한 비교 연구를 수행하였다. 그런 다음 중국과 일본의 해양 문양의 양식과 의미를 비교하여 유사성과 차이점을 발견했다. 이어 중국과 일본의 해양문양 상호 영향과 해양문양이 문화유산에 미치는 의미 등 문화교류에서 해양문양이 미치는 영향에 대해 논의했다. 마지막으로 디자인과 예술에서 해양 패턴의 적용을 분석하고 향후 해양 패턴 연구의 발전 방향을 전망한다. 본 연구의 목적은 중일 양국의 해양 패턴에 대한 인식을 높이고 중일 양국의 문화교류와 협력을 촉진하는 것이다.