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      • KCI등재

        Synthesis and application of 8-hydroxyquinoline modified magnetic mesoporous carbon for adsorption of multivariate metal ions from aqueous solutions

        Wenlu Guo,Xiangguo Meng,Yan Liu,Liang Ni,Zhaoyong Hu,Rui Chen,Minjia Meng,Yun Wang,Juan Han,Min Luo 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

        The new 8-hydroxyquinoline (8-HQ) modified magnetic mesoporous carbon (8-HQ-Ni-CMK-3) wasprepared and applied for adsorption of multivariate metal ions from aqueous solution. The preparedadsorbent was characterized by Fourier transform infrared, X-ray diffraction, scanning electronmicroscopy, transmission electron microscope, nitrogen adsorption-desorption isotherm, elementalanalysis, and vibrating sample magnetometer. The static adsorption behaviors toward multivariatemetal ions on graphite, the modified graphite by 8-HQ, magnetic mesoporous carbon, and 8-HQ-Ni-CMK-3 were compared, which showed that 8-HQ-Ni-CMK-3 had excellent adsorption capacity. Theremoval of multivariate metal ions using 8-HQ-Ni-CMK-3 by fixed-bed column was further investigated.

      • SCIESCOPUSKCI등재

        Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy

        Ni Wang,Junyan Yang,Ruijun Chen,Yunyun Liu,Shunjie Liu,Yining Pan,Qingfeng Lei,Yuzhou Wang,Lu He,Youqiang Song,Zhong Li The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3

        Background: Alzheimer's disease (AD) is a common form of dementia, and impaired mitophagy is a hallmark of AD. Mitophagy is mitochondrial-specific autophagy. Ginsenosides from Ginseng involve in autophagy in cancer. Ginsenoside Rg1 (Rg1 hereafter), a single compound of Ginseng, has neuroprotective effects on AD. However, few studies have reported whether Rg1 can ameliorate AD pathology by regulating mitophagy. Methods: Human SH-SY5Y cell and a 5XFAD mouse model were used to investigate the effects of Rg1. Rg1 (1µM) was added to β-amyloid oligomer (AβO)-induced or APPswe-overexpressed cell models for 24 hours. 5XFAD mouse models were intraperitoneally injected with Rg1 (10 mg/kg/d) for 30 days. Expression levels of mitophagy-related markers were analyzed by western blot and immunofluorescent staining. Cognitive function was assessed by Morris water maze. Mitophagic events were observed using transmission electron microscopy, western blot, and immunofluorescent staining from mouse hippocampus. The activation of the PINK1/Parkin pathway was examined using an immunoprecipitation assay. Results: Rg1 could restore mitophagy and ameliorate memory deficits in the AD cellular and/or mouse model through the PINK1-Parkin pathway. Moreover, Rg1 might induce microglial phagocytosis to reduce β-amyloid (Aβ) deposits in the hippocampus of AD mice. Conclusion: Our studies demonstrate the neuroprotective mechanism of ginsenoside Rg1 in AD models. Rg1 induces PINK-Parkin mediated mitophagy and ameliorates memory deficits in 5XFAD mouse models.

      • KCI등재

        Systolic Arrays for Lattice-Reduction-Aided MIMO Detection

        Ni-Chun Wang,Ezio Biglieri,Kung Yao 한국통신학회 2011 Journal of communications and networks Vol.13 No.5

        Multiple-inputmultiple-output (MIMO) technology provides high data rate and enhanced quality of service for wireless communications. Since the benefits from MIMO result in a heavy computational load in detectors, the design of low-complexity suboptimum receivers is currently an active area of research. Latticereduction-aided detection (LRAD) has been shown to be an effective low-complexity method with near-maximum-likelihood performance. In this paper, we advocate the use of systolic array architectures for MIMO receivers, and in particular we exhibit one of them based on LRAD. The “Lenstra-Lenstra-Lov´asz (LLL) lattice reduction algorithm” and the ensuing linear detections or successive spatial-interference cancellations can be located in the same array, which is considerably hardware-efficient. Since the conventional form of the LLL algorithm is not immediately suitable for parallel processing, two modified LLL algorithms are considered here for the systolic array. LLL algorithm with full-size reduction-LLL is one of the versions more suitable for parallel processing. Another variant is the all-swap lattice-reduction (ASLR) algorithm for complex-valued lattices, which processes all lattice basis vectors simultaneously within one iteration. Our novel systolic array can operate both algorithms with different external logic controls. In order to simplify the systolic array design, we replace the Lov´asz condition in the definition of LLL-reduced lattice with the looser Siegel condition. Simulation results show that for LR-aided linear detections, the bit-error-rate performance is still maintained with this relaxation. Comparisons between the two algorithms in terms of bit-error-rate performance, and average field-programmable gate array processing time in the systolic array are made, which shows that ASLR is a better choice for a systolic architecture, especially for systems with a large number of antennas.

      • SCIESCOPUSKCI등재

        Theoretic Analysis on the Manufacture of Blended Yarn by One Spinneret

        Wang, Ni,Zhang, Jianchun,Lai, Kan,Sun, Run-Jun The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.3

        The possibility of producing blended yam by using one spinneret is analyzed theoretically, especially the formation of differences in linear density and shrinkage between the monofils. Under the same spinning pressure, the die-spinning nozzles with different diameters are used to produce the differences in the flow of the melt. According to the hagen-poseuille equation for streamline flow in cylinder pipe, the volumetric flow rate and the mean melt speed of die-spinning nozzles increase with the increase of diameters. Under the conditions that the winding speeds are the same, so that the effective draw ratios decrease with the increase of the die-spinning nozzles diameters. Then, the filament formed through the die-spinning nozzle with large diameter is coarse and have a low birefringence. On the contrary, the filament formed through the die-spinning nozzle with small diameter is fine and have a high birefringence. The differences between the filament in structure and property could be acquired by one spinneret.

      • SCIESCOPUSKCI등재

        Harmonic Analysis of the Effects of Inverter Nonlinearity on the Offline Inductance Identification of PMSMs Using High Frequency Signal Injection

        Wang, Gaolin,Wang, Ying,Ding, Li,Yang, Lei,Ni, Ronggang,Xu, Dianguo The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6

        Offline inductance identification of a permanent magnet synchronous motor (PMSM) is essential for the design of the closed-loop controller and position observer in sensorless vector controlled drives. On the base of the offline inductance identification method combining direct current (DC) offset and high frequency (HF) voltage injection which is fulfilled at standstill, this paper investigates the inverter nonlinearity effects on the inductance identification while considering harmonics in the induced HF current. The negative effects on d-q axis inductance identifications using HF signal injection are analyzed after self-learning of the inverter nonlinearity characteristics. Then, both the voltage error and the harmonic current can be described. In addition, different cases of voltage error distribution with different injection conditions are classified. The effects of inverter nonlinearities on the offline inductance identification using HF injection are validated on a 2.2 kW interior PMSM drive.

      • SCIESCOPUSKCI등재

        Systolic Arrays for Lattice-Reduction-Aided MIMO Detection

        Wang, Ni-Chun,Biglieri, Ezio,Yao, Kung The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.5

        Multiple-input multiple-output (MIMO) technology provides high data rate and enhanced quality of service for wireless communications. Since the benefits from MIMO result in a heavy computational load in detectors, the design of low-complexity suboptimum receivers is currently an active area of research. Lattice-reduction-aided detection (LRAD) has been shown to be an effective low-complexity method with near-maximum-likelihood performance. In this paper, we advocate the use of systolic array architectures for MIMO receivers, and in particular we exhibit one of them based on LRAD. The "Lenstra-Lenstra-Lov$\acute{a}$sz (LLL) lattice reduction algorithm" and the ensuing linear detections or successive spatial-interference cancellations can be located in the same array, which is considerably hardware-efficient. Since the conventional form of the LLL algorithm is not immediately suitable for parallel processing, two modified LLL algorithms are considered here for the systolic array. LLL algorithm with full-size reduction-LLL is one of the versions more suitable for parallel processing. Another variant is the all-swap lattice-reduction (ASLR) algorithm for complex-valued lattices, which processes all lattice basis vectors simultaneously within one iteration. Our novel systolic array can operate both algorithms with different external logic controls. In order to simplify the systolic array design, we replace the Lov$\acute{a}$sz condition in the definition of LLL-reduced lattice with the looser Siegel condition. Simulation results show that for LR-aided linear detections, the bit-error-rate performance is still maintained with this relaxation. Comparisons between the two algorithms in terms of bit-error-rate performance, and average field-programmable gate array processing time in the systolic array are made, which shows that ASLR is a better choice for a systolic architecture, especially for systems with a large number of antennas.

      • Treatment of Human Thyroid Carcinoma Cells with the G47delta Oncolytic Herpes Simplex Virus

        Wang, Jia-Ni,Xu, Li-Hua,Zeng, Wei-Gen,Hu, Pan,Rabkin, Samuel D.,Liu, Ren-Rin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

        Background: Thyroid carcinoma is the most common malignancy of the endocrine organs. Although the majority of thyroid cancer patients experience positive outcomes, anaplastic thyroid carcinoma is considered one of the most aggressive malignancies. Current therapeutic regimens do not confer a significant survival benefit, and new therapies are urgently needed. Oncolytic herpes simplex virus (oHSV) may represent a promising therapy for cancer. In the present study, we investigated the therapeutic effects of a third-generation HSV vector, $G47{\Delta}$, on various human thyroid carcinoma cell lines in vitro. Two subcutaneous (s.c.) models of anaplastic thyroid carcinoma were also established to evaluate the in vivo anti-tumor efficacy of $G47{\Delta}$. Materials and Methods: The human thyroid carcinoma cell line ARO, FRO, WRO, and KAT-5, were infected with $G47{\Delta}$ at different multiplicities of infection (MOIs) in vitro. The survival rates of infected cells were calculated each day. Two s.c. tumor models were established using ARO and FRO cells in Balb/c nude mice, which were intratumorally (i.t.) treated with either $G47{\Delta}$ or mock. Tumor volumes and mouse survival times were documented. Results: $G47{\Delta}$ was highly cytotoxic to different types of thyroid carcinomas. For ARO, FRO, and KAT-5, greater than 30% and 80% of cells were killed at MOI=0.01 and MOI=0.1, respectively on day 5. WRO cells displayed modest sensitivity to $G47{\Delta}$, with only 21% and 38% of cells killed. In the s.c. tumor model, both of the anaplastic thyroid carcinoma cell lines (ARO and FRO) were highly sensitive to $G47{\Delta}$; $G47{\Delta}$ significantly inhibited tumor growth and prolonged the survival of mice bearing s.c. ARO and FRO tumors. Conclusions: The oHSV $G47{\Delta}$ can effectively kill different types of human thyroid carcinomas in vitro. $G47{\Delta}$ significantly inhibited growth of anaplastic thyroid carcinoma in vivo and prolonged animal survival. Therefore, $G47{\Delta}$ may hold great promise for thyroid cancer patients.

      • KCI등재

        Metal-Doped In2O3 Nanosphere Arrays with Enhanced Gas-Sensing Property

        Xuanji Zhang,Ni Deng,Xianjia Chen,Yanting Yang,Jing Li,BO HONG,DINGFENG JIN,Xiaoling Peng,XINQING WANG,Hongliang Ge,HONGXIAO JIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3

        In2O3 and metal-doped (Ni or Ce) In2O3 mesoporous three-dimensional (3D) nanospheres arrays were synthesized via nanocasting using mesoporous silica as hard templates. Effects of Ni or Ce doping on the structure, optical and gas-sensing properties of the In2O3 nanospheres were investigated. Both the undoped and the doped In2O3 nanospheres showed single-phase structure without any impurity. The nanospheres were about 20 nm in size and they stacked closely to formrigid 3D mesoporous structure. Achange in the value of optical band gap was observed upon metal doping. The room temperature photo luminescence behavior also showed some differences between pure and doped In2O3. Compared with pure In2O3 nanospheres, the metal-doped In2O3 exhibited superior response, fast recovery and good selectivity to ethanol. The enhanced gas-sensing properties might be related to the doping of metal ion and its effective contribution towards the oxygen vacancies, conductivity and crystallite size of the grains.

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