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A Fuzzy based Routing Protocol for Delay Tolerant Network
Neelam Malik,Shailender Gupta,Bharat Bhushan 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.1
Delay Tolerant Network (DTN) is a wireless ad hoc network that intends to provide communication between pair of nodes in spite of having intermittent connectivity and long delays. The nodes are buffer and energy constrained. To provide communication in such scenario, a sturdy routing mechanism is needed. In this paper we propose a new routing technique based on fuzzy logic for intermittently connected network. Also an effort has been made to evaluate the performance of the proposed routing strategy in realistic environment (having obstacles) in MATLAB. The simulation results show that the performance of the network is improved using fuzzy logic based routing strategy and the results of realistic environment are quite different from idealistic environment.
Shailesh Sharma,Neelam Sharma,Ghanshyam Das Gupta 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
The present research work was undertaken to optimize and formulate Promethazine Theoclate as a fast dissolving tablet using pore forming technology that disintegrates or dissolves rapidly and offer a suitable approach for the treatment of nausea and vomiting. Fast dissolving tablets of Promethazine Theoclate was prepared by increasing the solubility i.e. using β-cyclodextrin, crospovidone, and menthol. A 33 full factorial design was employed to investigate the combined influence of these three independent variables, i.e., amount of menthol, crospovidone and β-cyclodextrin on disintegration time, percentage friability and percentage drug release after 5 min. In the optimization study, multiple regression analysis has revealed that an optimum amount of menthol, crospovidone and β-cyclodextrin gives a rapidly disintegrating/dissolving tablet. In order to prove the validity of the evolved mathematical model a checkpoint batch was also prepared. Optimized tablets were prepared with an optimum amount of β-cyclodextrin, menthol and crospovidone which disintegrated in the 30 s, having friability 0.599% and released drug 89% after 5 min.
Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma
( Rashi Garg ),( Neelam Gupta ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.6
We report a rare case of vaginal amelanotic melanoma. Malignant melanomas are cutaneous and extracutaneous tumors that arise from embryological remnants of neural crest cells/melanocytes. Amelanotic melanomas at such rare locations can be misdiagnosed both clinically and radiologically. Therefore, histopathological examination and immunohistochemistry are mandatory for the diagnosis of these tumors. We diagnosed this case using histopathology and confirmed the diagnosis based on the presence of immunohistochemical markers human melanoma black 45 (HMB45) and S-100.
Sarcopenia is common in ulcerative colitis and correlates with disease activity
( Pardhu B Neelam ),( Rimesh Pal ),( Pankaj Gupta ),( Anupam K Singh ),( Jimil Shah ),( Harshal S Mandavdhare ),( Harjeet Singh ),( Aravind Sekar ),( Sanjay K Bhadada ),( Usha Dutta ),( Vishal Sharma 대한장연구학회 2024 Intestinal Research Vol.22 No.2
Background/Aims: Association of sarcopenia with disease severity in ulcerative colitis (UC) is not clearly defined. We planned to estimate the prevalence of sarcopenia in patients with UC as per the revised definition and its relation with the disease severity. Methods: A cross-sectional assessment of sarcopenia in patients with UC was performed. Disease activity was graded according to complete Mayo score. Hand grip strength was assessed with Jamar hand dynamometer, muscle mass using a dual energy X-ray absorptiometry scan, and physical performance with 4-m walk test. Sarcopenia was defined as a reduction of both muscle mass and strength. Severe sarcopenia was defined as reduced gait speed in presence of sarcopenia. Results: Of 114 patients (62 males, mean age: 36.49 ± 12.41 years), 32 (28%) were in remission, 46 (40.4%) had mild-moderate activity, and 36 (31.6%) had severe UC. Forty-three patients (37.7%) had probable sarcopenia, 25 (21.9%) had sarcopenia, and 14 (12.2%) had severe sarcopenia. Prevalence of sarcopenia was higher in active disease (2 in remission, 6 in active, and 17 in severe, P< 0.001). Of 14 with severe sarcopenia, 13 had severe UC while 1 had moderate UC. On multivariate analysis, lower body mass index and higher Mayo score were associated with sarcopenia. Of 37 patients with acute severe colitis, 16 had sarcopenia. Requirement of second-line therapy was similar between patients with and without sarcopenia. On follow-up (median: 18 months), there was a non-significant higher rate of major adverse events in those with sarcopenia (47.4% vs. 33.8%, P= 0.273). Conclusions: Sarcopenia and severe sarcopenia in UC correlate with the disease activity. (Intest Res 2024;22:162-171)
Behl, Rahul,Behl, Jyotsna,Gupta, Neelam,Gupta, S.C.,Ahlawat, S.P.S. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.1
The capability of microsatellite markers for individual identification and their potential for breed assignment of individuals was evaluated in two Indian horse breeds. The strength of these individual assignment methods was also evaluated by increasing the number of loci in increments of five. The probability of identity of two random horses from the two breeds at all twenty five studied loci was as low as $1.08{\times}10^{-32}$ showing their suitability to distinguish between individual horses and their products. In the phylogenetic approach for individual assignment using Nei's genetic distances, 10.81% of horses associated with breed other than the major cluster of the source breed horses when all twenty five microsatellite loci were implemented. Similar results were obtained when the maximum likelihood approach for individual assignment was used. Based on these results it is proposed that, although microsatellite markers may prove very useful for individual identification, their utility for breed assignment of horses needs further evaluation.
Vijay G Goni,Rajesh Chhabra,Ashok Gupta,Neelam Marwaha,Mandeep S Dhillon,Sudesh Pebam,Nirmal Raj Gopinathan,Shashidhar Bangalore Kantharajanna 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.4
Study Design: Prospective case series. Purpose: To study the safety and feasibility of cotransplantation of bone marrow stem cells and autologous olfactory mucosa in chronic spinal cord injury. Overview of Literature: Stem cell therapies are a novel method in the attempt to restitute heavily damaged tissues. We discuss our experience with this modality in postspinal cord injury paraplegics. Methods: The study includes 9 dorsal spine injury patients with American Spinal Injury Association (ASIA) Impairment Scale (AIS) A neurological impairment who underwent de-tethering of the spinal cord followed by cotransplantation with bone marrow stem cells and an olfactory mucosal graft. Participants were evaluated at the baseline and at 6 monthly intervals. Safety and tolerability were evaluated through the monitoring for adverse events and magnetic resonance imaging evaluation. Efficacy assessment was done through neurological and functional outcome measures. Results: Surgery was tolerated well by all participants. No significant difference in the ASIA score was observed, although differences in the Functional Independence Measure and Modified Ashworth Scale were statistically significant. No significant complication was observed in any of our patients, except for neurogenic pain in one participant. The follow-up magnetic resonance imaging evaluation revealed an increase in the length of myelomalacia in seven participants. Conclusions: The cotransplantation of bone marrow stem cells and olfactory mucosa is a safe, feasible and viable procedure in AIS A participants with thoracic level injuries, as assessed at the 24-month follow-up. No efficacy could be demonstrated. For application, further large-scale multicenter studies are needed.
Genetic Variability and Bottleneck Analysis of Jakhrana Goats by Microsatellite DNA Fingerprinting
Dinesh Kumar,A. K. Pandey,S. P. S. Ahlawat,Geetu Malik,Rekha Sharma,Digpal Singh Gour,S. P. Dixit,N. K. Verma,R. A. K. Aggarwal,Neelam Gupta,B. N. Shahi,S. C. Gupta 한국유전학회 2005 Genes & Genomics Vol.27 No.3