흰쥐 시상에서 Epidermal growth factor receptor면역반응 신경세포의 생후 발달에 관한 연구

박영란,정윤영,김종중,문정석,오재욱,정영욱,김주수 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Epidermal growth factor receptor (EGFR), a 170-kDa transmembrane glycoprotein, appears to mediate epidermal growth factor (EGF) activity. Transforming growth factor-α and EGF produce their biological effects in numerous systems by stimulating the EGFR In this study, we examine the postnatal development of EGFR immunoreactivity in the different regions of the thalamus of the rat Materials and Methods : The present study is based on 28 postnatal cases of rat thalamus ranging from the day of birth, postnatal day 0 (P0) to 30 days (P3, P5, P10, P15, P20, P30), and these cases were compared with adult rat thalamus. Cryostat sections were processed free-floating with monoclonal antibody by immunohistochemistry Results : EGFR immunoreactivity in the thalamus of the rat showed very different patterns according to postnatal ages and thalamic areas. EGFR-immunoreactive cells appeared in the first two postnatal weeks, except the ventral posterior thalamic nuclei. In the early postnatal days, EGFR-immunoreactive cells appeared thalamic midline structures, increased progressively in the first two postnatal weeks, and followed mediolateral gradient. The mature patterns of EGFR-immunoreactive cells were achieved at P20 Conclusion : These data indicate that the maturation of EGFR-immunoreactive cells requires a relatively prolonged period of time to achieve an adult configuration. Many growth factors probably play protective or neurotrophic roles at EGFR-immunoreactive neurons of thalamus both young and adult rats In addition to difference in time of appearance in thalamic nuclei and developing pattern with mediolateral gradient suggest that EGFR-immunoreactivities are correlated with the appearance of the related functional.

高層아파트 團地의 形狀要素에 관한 硏究(Ⅰ) : 小規模 高層아파트 團地의 駐車空間을 中心으로 Centering on the parking place in small-scale high-rise apartment building complex

朴文瑀,姜大奎,趙容準 조선대학교 동력자원연구소 1991 動力資源硏究所誌 Vol.13 No.1

All dwelling complex should be plan with the consideration on the cars. this is because the car is no only a necessary tool for the man's various wants, but also a checking cause for the dwelling complex's comforts. this study focuses on the apartment complex of the dwelling scale taking a large percentage in Kwangju, and the various matters and the remedy about the parking space. the results are following. 1. The parking space is affected by the dwelling bwelling's arrangement, the open space and the incidental facilities. therefore the apartment complex plan of the future must apply the view of mass space. 2. Recently, the environs of the dwelling building are used as a parking space. It affects a bad effect on the complex's comfort. So the laws enacted to establish the underground parking place are required. 3. For the great comforts and closeness, the complex's plan has to consider the closeness of the complex entrance, the dwelling building entrance and the parking space.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

도시공원 내 인공습지 도입을 위한 소생태계 사계 연구

鄭龍文,朴眞英 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

This study is presented the improvement techniques of artificial wetland, one of micro-ecosystem developed to promote bio-diversity in urban areas, through studies of problem in cases. To this end, based on instances found in broad and importance which is development method of ecological park, wetland and micro-ecosystem at cases was proved the effect of techniques. There was no monitoring result and biological lacking about biological form in urban areas in korea. But this study selected the subject which it built up until the present time and it was presumes development possibility site. So this study showed techniques to promote bio-diversity. Key result of this study are as follows. (1) There is the problem of the living environment for creatures. The artificial embankment is necessary to various water depths and considering of the living of aquatic life. It is an important factor for the ability of activity place and prevention of soil erosion for activities of aquatic insects and young fish as well as the growth of aquatic plants. Therefore, as create of the embankment must considering that form of embankment, various grade, soil stability, food-plant and as well as the plant by water to clean . (2) It is necessary for making observation way to protection. Recently, this problem must consider because of ecological park stand out in bold relief. As a result, the ecological park must accept many people to use. Therefore, nature get damaged. Until now, cases are developed deck and way for observation too accessible. So a soil environment has been change for the worse and caused soil compaction. It was menaced the living environment for creature. Therefore, suitable pattern of observation way and areas for protection through the control should be consider to protect of living environment for creatures. (3) Cases presented is lack model of living environment for creature. In such a case of a forward nation, there is studying about ecological model to promote bio-diversity even detailed part. To example, stone-constructed, to placement a log, to built of a grass-roofed house(a small cottage), it is induce a micro-living thing by create porous environment. Therefore, we must continually study for allurement a living thing at the place-constructed in urban areas. (4) Environment education program's development are more earnest are urgent. It is most important works. Therefore, study have to going afterward. The present state of artificial wetland and eco-pond were not development of program. So it is raise the problem. Environment education by placement of guide map or book and a volunteer in the field is a practice way of a narrow means. Also development program is urgent to aware important of environment and development program and training for environmental specialist have to preceding. As a result of development method groping should be sponsored education of special and efficacious.

초등학생 입학 후 발생한 두통의 유병률과 임상적 특성

노영일,김은영,양은석,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Purpose : The purpose of the study was to determine prevalence and clinical features of the occurrence of childhood headache after the start of elementary school. Method : The survey was performed by a special questionnaire on 552 children in grade 1 (195 children) and grade 6 (357 children) at the three elementary schools from 1 to 31 August, 2002 in Gwangju city. We have analyzed the prevalence and the clinical features of headache of them. Result: The prevalence of headache in grade 6(49.0%) was statistically higher than grade 1(22.6%). The onset time of headache within 6 months in grade 1 (88.2%) was significantly higher than grade 6 (64.1 %). The frequency of headache is more often in grade 6. As for the timing of occurrence of headache, grade 1 student suffered from it after school (36.4%), grade 6 student suffered from it at school (30.9%). Children who suffered from severe headache can't live in the routine life were grade 1 20.5 % and grade 6 21.1 %, respectively. According to the duration of headache, there were within 1 hour grade 1 90.9%, grade 6 81.8%, respectively. Risk factors of headache were, in grade 1, fatigue (34.0%), stress (25.0%), weather change (18.2%), anxiety (11.4%), and others (11.4%). In grade 6, there were fatigue(44.3%), stress (34.0%), weather change(10.9%), others (5.7%) and anxiety (5.1%). Conclusion : Starting school represents a remarkable life event for children. Starting school results in significantly increasing prevalence of overall headache. 목적 : 입학 전에 비해 입학 후 두통의 증가률을 알아보고, 1학년의 두통의 임상적 특징을 알아보고자 하였다. 방법 : 2002년 8월 1일부터 31일까지 광주시내 3개 초등학교 1학년과 6학년 학생 612명에게 설문지 (두통 에 대한 주요 설문지 내용 :부록)를 배부하여 그 중 작성이 불량한 60명을 제외한 552명 (1학년 195명, 6학년 357명)을 대상으로 두통의 유병률을 알아보았으며, 임상적 특징은 두통이 있는 학생 219명 (1학년 44명, 6학년 175명)을 대상으로 분석하였다. 결과 : 두통의 빈도는 1학년 44명 (22.6%), 6학년 175명 (49.0%)로 6학년에서 의의 있게 높았다(0.001). 두통의 초발 시기가 6개월 이상인 경우 1학년 11.8%, 6학년 35.9%이였으며, 6개월 미만인 경우는 1학년 88.2%, 6학년 64.1%로 입학 전보다 입학 후에 더 높았으며 6개월 미만의 초발 두통이 1학년에서 의의 있게 높았다(p=o. 03). 두통의 발생빈도는 6학년에서 통계학적으로 의의 있게 높았다(P=0. 03). 두통이 가장 자주 발생하는 시기는 1학년에서 학교 수업 후 (36.4%)이었고, 6학년에서는 학교 수업 중(30.9%)이었다. 학교나 일상 생활을 하기 힘들 정도의 두통은 각각 1학년에서 20.5%, 6학년에서 21.1%이었다. 두통의 지속시간은 1시간 이내인 경우가 각각 1학년 90.9%,6학년 81.8%이었다. 두통의 유별인자는 1학년에서 피로, 수면 부족이 34.0%로 가장 많았으며, 스트레스, 기후 변화, 불안, 기타 순이었고, 6학년은 피로 수면 부족 44.3%로 가장 많았으며, 스트레스 34.0%, 기후 변화, 기타, 불안 순이었다.

남매에서 발생한 심한 용혈성 빈혈과 간경변증을 동반한 Wilson 병 2례

노영일,박동호,서우철,문경래,박상기,박영봉,이미숙,전호종 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

We experienced two case of Wilson's disease in female and male sibling. The first case was a 10 year-old female who showed jaundice. pancytopenia and cirrhotic change in liver biopsy. She died 10 days after diagnosis. The second case of 7 year-old male showed specific symptoms and revealed increased AST/ALT, low serun copper level and increased 24 hour urinary copper excretion level He is being treated with D-penicillamine and follow up examinations.

모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향

김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

노인 위암의 임상 병리학적 특징 및 Helicobacter pylori 감염

김혜랑,문영수,박영숙 凡石學術奬學財團 1999 凡石學術論文集 Vol.3 No.-