흡연력을 고려한 궤양성 대장염 발생과 충수 절제술 사이의 상관 관계

남승우,양석균,정훈용,심기남,조병동,김승용,박의련,홍원선,민영일 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.1

슬관절에 히야루론산 주입후 발생한 활막성 연골종증 : 증례 보고

최의성,김용민,김동수,손현철,박경진,조병기,배승환 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.18 No.2

활막성 연골종증은 비교적 드문 양성 종양으로 관절내 활액막 결체조직의 양성 반응성 이형성에 의해 여러 개의 연골성 결절을 형성하고 이것이 관절내로 유리되어 유리체를 형성하는 질환으로 주로 슬관절에 발생한다. 활막성 연골종증의 정확한 발생 기전은 아직 밝혀지지 않았으나 외상, 감염 등이 원인으로 제시되고 있다. 저자들은 슬관절 내 히야루론산 주입후 발생한 슬관절내 활막성 연골종증을 1 례 경험하였으며, 관절경적 제거술을 통해 만족스런 결과를 얻었다. As a relatively rare benign tumor, synovial chondromatosis forms several cartilaginous nodules by the benign reactive metaplasia of synovial connective tissues within joints, which are loosed into the joints and cause a disease forming loose body mainly in knee joint. Accurate mechanism of synovial chondromatosis has not been clarified yet; however, trauma, infections and others have been suggested as its possible causes. The authors of this study experienced an example of a patient with synovial chondromatosis in knee joint occurred after the injection of hyaluronic acid in the joints and had a satisfactory outcome through the arthroscopic resection.

백서에서 N-dimethylnitrosamine에 의한 간독성 작용에 L-ascorbic Acid가 미치는 영향에 관한 연구

송준민,양승하,변광의,강상균 순천향대학교 1994 논문집 Vol.17 No.2

Toxic effect of NDMA on liver is variable due to dose and duration of administration. Experimental studies showed hemorrhagic necrosis, liver cirrhosis and hepatoma development with NDMA administration. To observe the protective action of L-ascorbic acid on NDMA toxicity of the liver, experimental studies were carried out. Rats were divided into two groups' acute and chronic intoxication. Acute group was divided into three subgroups regarding to dose and duration of NDMA administration, AGI-1(NDMA 40㎎/㎏) and AGI-2(NDMA with L-ascorbic acid 720㎎/㎏), AGII-1(NDMA 20㎎/㎏ for 2 days) and AGII-2(same with AGII-1 with AGII-1 with L-ascorbic acid 360㎎/㎏ for first day, and 10㎎/㎏, 180㎎/㎏ for 2nd and third day). Serological study of liver function and histologic study were carried out 48 hours after NDMA administration. Animal were sacrified on 9th week, then serological and histological studies were carried out. Also ultrastructural observation were performed for the liver tissue. The results were following as : 1. Acute NDMA intoxication group reveals low level of serum protein and albumin while elevation of total bilirubin, alkaline phosphatase and marked elevation of SGOT and SGPT. Histologically, marked hemorrhagic necrosis was noted in the central zone of hepatic lobules. 2. In chronic NDMA intoxication, serological studies showed slight elevation of SGOT and SGPT, and normal levels of total protein, total bilirubin, and ALP. Histologically, swelling of hepatocyte, necrosis of individual cells, enlargement of nucleus with prominent nucleoli were evident. 3. Chronic intoxication of NDMA groups does not showed special difference between NDMA alone and combined L-ascorbic acid administration. 4. Both acute and chronic NDMA intoxication groups showed ultrastructural changes, such as nuclear irregularity, dilatation of cisternae of RER, partially obscured cisternae with increased density of mitochondira, and focal lipid droplet accumulation in the cytoplasm. The above results show that L-ascorbic acid may play a protective role in toxicity of NDMA.

씨큐리트 종사자의 직무스트레스에 관한 연구

김의영,임승혁,이재학,강민철 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.14 No.2

The purpose of this study was to determine the relationship of demographic characteristics to job stress among security guards. The subjects in this study were 474 people selected by random cluster sampling from a population that consisted of private bodyguards and security guards from Seoul, Gyeonggi province and Daejeon. They gave a faithful response when a survey was conducted, and incomplete answer sheets from the others of the population were excluded. For data analysis, SPSS/PC Windows V11.0 program was utilized, and frequency analysis, t-test, one-way ANOVA and Scheffe posttest were employed. The findings of this study were as follows: First, the gender of the security guards investigated made a significant difference to their job satisfaction(p<.05). Job characteristics, compensation and organizational characteristics put higher strain on the men than on the women, and the latter group was more stressed out about their roles and interpersonal relations. Second, their age, education, years of services and monthly income made a significant difference to their job stress subvariables related to job characteristics, roles, human relations, compensation and organizational characteristics(p<01). Third, their job stress was significantly different according to their position and status(p<01). Specifically, those who had no position were under heavier pressure due to job characteristics, roles, interpersonal relations, compensation and organizational characteristics.

만성 요통 환자의 심리사회적 특성

김용민,원중희,최의성,서중배,이호승,허윤무 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 만성 요통 환자의 많은 수가 직업 등 주변 환경과 심리 상태의 영향을 받는 것으로 추정되나 그 연관성은 아직 논란이 많다. 본 연구에서는 설문 조사를 통하여 만성 요통 환자의 심리사회적 특성을 알아보고자 하였다. 대상 및 방법. 1997년 7월부터 1998년 12월까지 6주 이상 지속된 만성 요통으로 본원 정형외과 외래를 내원한 환자들 중 기질적 원인이 불명확한 62명의 환자들에서 직업, 유발요인, 치료 등 요통 관련 요소 설문과 Minnesota Multiphasic Personal Inventory (MMPI)를 실시하였다. 요통 관련 사항에는 통증의 기간, 정도, 통증이 유발 또는 심해지는 자세, 그리고 본인이 생각하는 요통의 원인 등을 포함하였다. MMPI는 전체 평균을 이용한 방법과 two-code 방법을 이용하여 평가하였다. 결과: 만성 요통환자의 직업 상 실내에서 앉아 일하는 직업이 가장 맡았으며 일정한 자세를 오래 유지하며 앉거나 서 있는 경우 증상이 악화되는 것으로 기술되었다. MMPI에서는 건강 염려증, 우울증, 히스테리의 세 척도의 평균이 55이상으로 상승되어 있었다. Two-code 방법에서는 92% (46/50)의 환자에서 위 세 척도 중 적어도 하나 이상 상승되어 있었다. 결론: 만성 요통 환자들에서 일상 생활의 자세와 직업이 요통의 발생 및 악화에 영향이 있을 것으로 보여졌다. MMPI를 통한 심리 인성 검사 상 건강 염려증, 우울증, 히스테리의 성향이 증가되어 있어 요통의 발생과 만성화에 심리적 요소가 영향을 미치는 것으로 보여졌다. 사회경제학적, 정신심리학적 요인이 만성 요통에 미치는 영향의 규명을 위한 다양하고 심도 있는 연구가 필요하다고 생각된다. Purpose : Socioeconomic and psychologic factors seem to affect incidence, severity, and chronicity of low back pain. Purpose of this study is to survey socioeconomic factors and document psychoneurotic traits via MMPI in chronic low back pain patients. Materials and Methods : From July 1997 to December 1998, questionnaire about low back pain-related factors such as duration, severity, posture, occupation etc. and MMPI were given to patients who visited our department for chronic low back pain()6weeks). 62 patients completed, and 50 of them completed MMPI. The answers were analyzed. MMPI scores were evaluated in mean±SD method and two-code method. Results : Sedentary workers were the most common. And symptoms were told to be elicited by long sitting or standing posture(job) . Hs, D, Hy scales of MMPI, which are know as "neurotic triad by two-code method was observed in 92% (46/50) . Conclusion : It seemed that job and posture had Important role in chronic low back pain. And, it seemed that chronic low back pain patients had some psychoneurotic traits especially in hypochondriasis, depression, and hysteria. More investigations to document the influences of socioeconomic and psychoneurotic factors in chronic low back pain seems to be necessary.

각종 피부종양에서 p53과 bcl-2 발현양상

정용민,양승하,이성열,김대중,김의한 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Background : The function of p53 protein was known to accelerate the apoptosis, but bcl-2 protein was known to suppress the apoptosis. The overexpression of p53 and bcl-2 proteins has been reported in many malignant tumors. Although the mechanism of tumorgenesis of the p53 and bcl-2 protein took hasnot been proved, bcl-2 positive tumors contrast to p53, appeared to have good prognosis. The expression pattern of p53 and bcl-2 in epidermal tumors has not been well known. The author analyzed immunohistochemical expression of p53 and bcl-2 protein and investigated the role of p53 and bcl-2 protein in the developing tumors of epidermal origin. Method : 15 cases of squamous cell carcinoma, 20 cases of basal cell carcinoma, 10 cases of keratoacanthoma and 6 cases of Bowen's disease were stained immunohistochemically stain with anti p53 and anti bcl-2 monoclonal antibody. Results : 1. In squamous cell carcinoma, the reaction of p53 was positive in 13 cases(86%) and the stain pattern showed more intensive reaction in poorly differentiated cells in the same tumor. bcl-2 showed negative in all cases of squamous cell carcinoma(0%). 2. In basal cell carcinoma, the reaction of p53 was positive in 10 cases (50%). The positive cells were mainly observed in squamous metaplastic portion, but the reaction was weak. bcl-2 showed positive in all cases of basal cell carcinoma (100%) and the reaction was strong. 3. In keratoacanthoma, p53 was positive in 7 cases (70%). The positive cells were mainly observed in the cells around the basement membrane. This finding suggested that p53 positive basal cells were programmed to become keratoacanthoma. bcl-2 was negative in all 10 cases of keratoacanthoma. (0%) In some cases, bcl-2 positive cells were observed around the basement membrane in some cases., which were negative to p53 This finding suggested that the existence of these bcl-2 positive cells were related to the prognosis of keratoacanthoma. 4. In Bowen's disease, p53 was positive in 5 cases ( 83% ) and the reaction was strong, so the tumor cells in Bowen's disease appeared to be poorly differentiated type. bcl-2 was negative in all 6 cases ( 0% ) of Bowen's disease, but bcl-2 positive cells were observed in the basement membrane in some cases.

제7차 환경교육과정 특성에 대한 미학적 고찰

이민부,박승규,장의선 한국지리환경교육학회 2001 한국지리환경교육학회지 Vol.9 No.1

제 7차 환경과 교육과정에서는 초등학교와 중·고등학교에서의 환경교육이 균형있는 환경인식을 형성할 수 있도록 가치관, 지식, 기능, 태도, 참여 등 다양한 영역에 걸쳐서 목표를 제시하고 있다. 내용영역에서도‘인간과 환경’, ‘환경문제’, ‘환경보전’이라는 세 영역을 초등학교와 중·고등학교에서 계속적으로 다루면서 심화·확대시키고 있다. 특히 고등학교에서는 이들 세 영역 이외에‘환경과 사회’의 영역 등을 추가하여 학습자들이 자연과학적인 측면에서의 이해에서 벗어나 인문·사회과학적인 측면에서의 접근을 통해 우리의 삶과 환경과의 밀접한 관련성을 인식하고, 환경문제해결에 참여할 수 있도록 하고 있다. 그러나 제 7차 환경과 교육과정에서도 학습자들의 일상적인 삶의 영역과의 관련성을 염두에 두고 있으면서도 대부분의 내용들이 환경파괴나 환경오염, 그리고 그에 대한 대책 등과 관련된 것들이 대부분이어서 학습자들로 하여금 환경적 감수성이나 환경에 대한 아름다움을 통한 환경교육의 가능성이 그만큼 제한되어 있다. 따라서 본 연구에서는 경관을 매개로 한 미학적인 관점에서 제 7차 학교급별 환경교육의 특성을 비판적으로 살펴보고자 한다. The 7th national curriculum for environmental education in elementary and secondary school focuses on consideration of learner’s ability, learner’s activities, and learner’s region of everyday life. The contents of environmental education are scattered subjects in elementary schools and an independent subject as ‘Environment’ in middle school and ‘Environment and Ecology’ in high school of the secondary school. With upgrading of schools, the aims and activities of environmental learning move up from valuecentered, through activity-oriented and to cognition-centered. The esthetic considerations, such as landscape sensitivity, are required for better environmental education curriculum focusing on value and attitudes in everyday life space or region.

CoMFA 법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석

김의기,민선영,정병호,천승훈,최보길,조원제 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-

We have performed a 3D-QSAR/ CoMFA analysis of the cytotoxiv activities of thirty-five 3-arylisoquinoline derivative against SK-OV-3 tumor cell line. The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinoline were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.841) was obtained through CoMFA.

잠김 금속판을 이용한 대퇴골 전자하 골절의 치료 : 압박 고 나사와 비교

손현철, 김용민, 김동수, 최의성, 박경진, 조병기, 박지강, 배승환 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

-본문참고-

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.