우울증 환자 치료에 있어서 Tianeptine과 Sertraline의 효과와 안전성 비교

이민수,강성민,기백석,연병길,오병훈,이철,채정민,백인호 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 주요 우울증의 치료에 있어서 티아넵틴과 써트랄린의 임상적 효과와 안정성을 비교하기 위하여 연구를 시행하였다. 방법: DSM-IV 진단 기준에 의거하여 주요 우울증의 진단기준에 부합되고 17항목 해밀턴 우울척도 점수가 14점 이상인 환자를 대상으로 하였다. 총 40명의 환자를 무작위적 방식에 따라 티아넵틴 치료군과 써트랄린 치료군으로 분류하였다. 선탠된 환자에서 다른 항우울제를 복용하고 있는 경우 7일 이상의 약물 배설기간을 가진 후 티아넵틴과 써트랄린을 각각 6주간 투여하였으며, 기준점, 1주후, 2주 후, 4주 후, 6주 후에 HAM-D, MADRS, 그리고 CGI, COVI 등을 사용하여 평가하였다. 본 연구기간 중 발생된 모든 부작용은 부작용의 발생 및 소실 시기, 심한 정도, 발생 빈도, 관련 조치 및 결과에 대하여 증례기록서에 기록하도록 하였다. 결과: 30명(티아넵틴군 15명 ; 써트랄린군 15명)이 6주간의 연구를 완결하였고 티아넵틴 치료군에서는 1일 37.5mg을 투여하였으며 써트랄린군에서는 1일 평균 64.0±22.5mg을 투여하였다. 본 연구 결과 HAM-D, MADRS, CGI 상에서 두 군 모두에서 치료 1주 후부터 유의한 감소를 나타내었으며 이는 2주 후, 4주 후, 6주 후에도 지속적인 감소를 보였고 두 군간에 항우울 효과의 차이는 없었다. 활력징후, 일반 혈액학, 생화학, 심전도 검사 등에서는 두 군 모두 유의한 변화는 없었다. 티아넵틴과 관련된 부작용으로 흔히 보고한 증상은 오심(33.3%), 복부 불쾌감(26.7%), 구강 건조(20.0%), 두통(13.3%)등 이었고 써트랄린 치료군에서는 구강 건조(53.3%), 두통(46.7%), 오심(33.3%), 그리고 식욕 부진(33.3%)등으로 티아넵틴군에서 보다 적은 발현빈도를 보였다. 결론: 티아넵틴은 우울증의 치료에 있어서 효과적이고, 내약성이 우수한, 안전한 항우울제이다. Objective: This study was designed to evaluate the efficacy and safety of tianeptine and sertraline in the treatment of patients with depression. Method: The study was done on the patients with major depression diagnosed by DSM-IV, who had aHamilton Rating Scale for Depression(HAM-D) score ≥ 14 on the first 17 items of the HAM-D. A total of 40 patients were randomly assigned to tianeptine group and sertraline group. Tianeptine and sertraline were prescribed to each group. 6 weeks of each medication was carried out after 7 days of drug excretion period. Evaluation using 17 item HAM-D, Montgomery and Åsberg Depression Rating Scale(MADRS), Clinical Global Impression Scale (CGI), and Covi Scale was done on the baseline and after 1 week, 2 weeks, 4 weeks, and 6 weeks. Regrding all side effects that had occurred during the period of our study such as their developed/disappeaed time, severitien, incidences, managements and results have been recorded. Results: A total of 30 patients(tianeptine group 15 ; sertraline froup 15) finished the 6 weeks of research. 37.5mg of the daily dose was regularly prescribed to the tianeptine group, the average amount of 64.0±22.5mg of the final daily dose was prescribed to the sertraline group. Total 17 item HAM-D scores, total points of MADRS and CGI showed significant decrease after 1 week in each treatment froup and continous decrease after 2, 4 and 6 weeks ; and no difference was found between tianeptine group and sertaline group in the antidepressant efficacy. Also there were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The common reported side effects of tianeptine were nausea(33.3%), epigastic distress(26.7%), dry mouth(20.0%), headache(13.3%) and those of sertraline were dry mouth (53.3%), headache(46.7%), nausea(33.3%), anorexia(33.3%). Conclusion: According to the results, tianeptine was effective in improvement of depressive symptoms and was well tolerated and safe in patients with depression.

Fe/Co/Cu/Co 스핀밸브 박막의 자기 및 자기저항 특성

송민석,김택기 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.2

Fe(60Å≤x≤240Å)/Co(0Å≤y≤60Å)/Cu(25Å)/Co(90Å) spin valve thin films were prepared on oxidized Si(100) substrate, and the effects of as a function of Fe layer thickness and inserted Co layer thickness magnetic properties and magnetoresistance characteristics of the spin valve thin films were investigated. magnetoresistance ratio and coercivity of the Fe(60Å≤x≤240Å)/Co(30Å)/Cu(25Å)/Co(90Å) spin valve thin films show the maximum at the Fe layer thickness of x=60Å and decreases with increasing of the Fe layer thickness. As the Co layer was inserted into the Fe/Cu interface of Fe(120Å)/Co(y=0, 15, 30, 45, 60, 90Å)/Cu(25Å)/Co(90Å) spin valves, magnetoresistance ratio increased from 0.2 to 1.5 % However, the magnetoresistance ratio and coercivity of thin film were nearly constant as a function of Coinserted layer thickness.

시스템 부하를 고려한 전력제어 방식에 관한 연구

장민석,홍인기 경희-다반 ASIC 설계교육센터 2006 경희-다반 ASIC센터 논문집 Vol.7 No.-

기존 DS-CDMA 시스템에서의 전력제어는, 내부루프의 목표값을 외부루프에서 FER 을 고려하여 조절하였다. 그러나 이러한 방법은 간섭의 영향을 고려하지 못 하는 단점이 있다. 본 논문에서는 전력제어의 목표 SINR값이 시스템 부하에 의해 결정되는 새로운 방식을 제안하고, 목표 SINR 간과 시스템 부하값에 따른 Outage 확률을 분석하였다. 시스템의 부하가 적을 때는, 높은 목표 SINR 값에서 낮은 Outage를 보이는 반면에, 시스템의 부하가 많을 때는 목표 SINR 값을 낮게 설정함으로써 더 많은 시스템 용량을 얻을 수 있었다.

풍동시험에서 사용하는 시험지지부의 동특성 해석용 툴에 관한 연구

박태민,이기석,홍준희 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper is described the program algorithm which can easily estimate dynamics of test support system by using mathematica tool based on the finite element method. We can determine the geometry, dimensions of the test support system, through tool stated in this paper for a certain test conditions. As a result of computer simulation and manufactured test support system's experiment in oder to verify suggested program, the dynamics of the test support system was well correspondent each other.

산업용 이차전지의 열화진단에 관한 연구

장대경,황호석,박민기 서울産業大學校 2005 논문집 Vol.54 No.3

This paper proposes a new degradation diagnosis method of secondary battery in order to improve a battery economy. In the proposed method, a bad cell is detected by the measurement of DC internal resistance and the battery capacity is estimated by the electric discharge test in a short period of time, which can be used to determine the time to replace the battery. Through the computer simulation and actual experimentation, the proposed method's validity is confirmed by comparing and analyzing the performance. As a result, we show that it is possible to estimate the accurate capacity of secondary battery in a short space of time.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

폐성 고혈압환자에서 Amrinone 과 Dobutamine 이 전신 및 폐순환에 미치는 영향

민상기,김민석,유은숙,방서욱,홍용우,남상범,곽영란,김명옥 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.5

Background : Dobutamine and amrinone, phosphodiesterase-III inhibitor, are known to have both inotropic and vasodilatory properties. We evaluated the effects of both drugs on systemic and pulmonary hemodynamics in patients with pulmonary hypertension(PH). Methods : With Institutional Review Board approval, 45 patients whose mean pulmonary arterial pressure was greater than 30 mmHg were studied. After sternotomy under the steady state of anesthesia and controlled ventilation(30 mmHg<PaCO2<40 mmHg), patients recieved one of following drugs for 30minutes(min); dobutamine 5.0ug/kg/min(Group I), low dose amrinone(loading dose 1.0 mg/kg, followed by infusion 7.5 g/kg/min, Group II) or high dose amrinone (loading dose 2.0 mg/kg, followed by infusion 10 g/kg/min, Group III). Hemodynamic variables were measured at 10 min and 30 min after start of infusion. Results : Dobutamine didn't decrease pulmonary arterial pressure(PAP) and cause no hemodynamic change while low and high dose amrinone reduced PAP and especcial decrease of PAP in low dose amrinone group was statistically significnat. High dose amrinone increased cardiac index(CI) and decreased both systemic vascular resistance index(SVRI) and central venous pressure(CVP) more significantly than control value. Conclusions : In patients with chronic right ventricular failure associated with PH, amrinone may decrease the PAP and improve cardiac performance more effectively than dobutamin does. Increment of dosage of amrinone may not result in significant reduction of PAP. (Korean J Anesthesiol 1997; 33: 928∼936)

Acute generalized exanthematous pustulosis induced by Rhus (Lacquer) (초)

( Min Seok Cheon ),( Jeong Ah Min ),( Jung Eun Kim ),( Jun Young Lee ),( Baik Kee Cho ),( Hyun Jeong Park ) 대한피부과학회 2009 초록집 Vol.47 No.10

Acute generalized exanthematous pustulosis induced by Rhus (Lacquer)

Min Seok Cheon,Jeong Ah Min,Jung Eun Kim,Jun Young Lee,Baik Kee Cho,Hyun Jeong Park 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.1

피부 활성을 갖는 Phytosphingosine Ascorbate의 합성

민석기 ( Seok Kee Min ),진용훈 ( Yong Hoon Jin ),박우정 ( Woo Jung Park ),엄상용 ( Sang Yong Eom ),김종헌 ( Jong Heon Kim ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.2

피부 활성 물질로 넓이 알려져 있는 vitamin C (L-Ascorbic acid)는 콜라겐 생합성 촉진과 강한 항산화 작용으로 피부 항노화 및 주름 개선 효과 있을 뿐만 아니라 멜라닌 세포 활성 억제, 자외선 차단, 상처치유 등의 효능을 갖고 있다. 그러나 물성 면에서 피부 자극과 수분 및 공기, 빛에 불안정하여 쉽게 산화된다는 단점을 갖고 있다 이러한 문제점을 해결하기 위해 많은 연구가 진행되어 왔고, 그 결과 다양한 vitamin C 유도체가 개발되었다. 그러나 아직까지도 vitamin C의 불안정한 물성을 해결하면서 그 자체의 효능을 피부에 적용시키기에는 미흡한 점이 많다는 평을 받고 있다. 본 연구에서는 이러한 vitamin C의 불안정한 물성을 개선시키고 그 효능을 피부에 적용시킬 수 있는 vitamin C 유도체를 개발하기 위해, 피부 친화성이 우수한 스핑고지질류 중 하나인 phytosphingosine을 이용하여 산염기 반응에 의한 vitamin C의 OH기와 phytosphingosine의 -NH₂이온 결합시킨 새로운 vitamin C 유도체인 phytosphingosine ascorbate (SP-VC)를 합성하였다. 이렇게 합성된 phytosphingosine ascorbate (SP-VE)는 원소 분석(C58.3 : H9.3 : N2.8 : 029.5) 및 mass spectrosocopy (Maldi TOF-MS), UV/vis spectra (268.5 nm), ¹H NMR, FT-IR, 열분석 (m.p=154°C), HPLC 등을 통하여 구조 및 물성을 확인하였다 또한 효능면에서는 우선적으로 phytosphingosine ascorbate(SP-VC)의 항균 및 항산화 효과를 확인하였다. 이러한 결과를 토대로 vitamin C와 phytosphingosine의 효능을 동시에 갖으며 불안정한 물성과 자극을 개선시킬 것이라 예상되는 새로운 소재를 합성하였다. In the human skin, vitamin C (L -ascorbic acid) that is well known as the activated materials has effects that is skin anti-aging and wrinkle repair by giving impetus to collagen biosynthesis and anti-oxidation, and that is the sun screen, a wound recovering, inhibition melanogenesis and so on. In spite of its effects, vitamin C has the defects of the skin stimulation and easily oxidized instability by water, air, heat and light. For solving their matters, many investigation is advanced and its results are synthesized the various vitamin C derivatives. And yet they have not solved the unstable property of vitamin C and were still insufficient for the comparing with the effect of the pure vitamin C itself. In this study, in order to prepare vitamin C derivative of being improved the stability and to apply vitamin C effect in the skin, we prepared new vitamin C derivative, phytosphingosine ascorbate, by using phytosphingosine, one of sphingolipids, which have a distinguished skin affinity. Phytosphingosine ascorbate can be prepared as the ionic bond between amine group (-NH₂) of phytosphingosine and hydroxy group (-OH) of vitamin C by way of the relatively simple reaction. So the structure and properties of the synthesized phytosphingosine ascorbate was confirmed the use of elemental analysis (C 58.3 : H 9.3 : N 2.8 : O 29.5), MALDI TOF-MS (Mw=492.58), Ultraviolet spectra (268.5 nm), 1H NMR, FT-IR spectra, thermal analysis (m.p=l54°C), HPLC and so on. And we could confirm the anti-bacterial and anti-oxidation effects. Based on these results, we could confirm to prepare a new material that was expected of both effects of vitamin C and phytosphingosine and that is improved properties of vitamin C.