급성백혈병의 화학요법에서 조혈간세포 보충요법

이규보,배선근,손상균,이재태,이건수,이경혜,서장수 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

1. 목적 급성백혈병의 화학요법에 있어서 관해유도 요법시에 보다 더 강력한 항암화학요법을 시행하고 골수억제의 회복을 위하여 말초혈액에서 채취한 조혈모세포의 투여로 그 효과를 증대시키고자 시도하였다. 2. 방법 관해유도 화학요법후에 골수억제시기로부터 회복단계로서 백혈구감소증이 호전도면서 단핵세포가 증가될 때에 말초혈액에서 조혈간세포(stem cell)로 인정되고 있는 CD34+세포의 함유량이 1% 이상되는 시기를 찾아내고 그 때부터 평균 4차례의 단핵구를 분리채집을 하여 -74。C에 냉동보관하였다가 제2차 화학요법후에 해동시켜서 정맥주입하였다. 3. 결과 대상 급성백혈병환자는 6명에 23회의 조혈간세포를 함유한 단핵구 채집을 시행하였고 유효한 단핵구의 채집은 4례에서 가능하였고 2례에서는 유효한 채집이 못되었다. 채집효율은 39.0-74.5%로서 평균 49.8%였다. 채집 후에 혈액학적 변화는 혈색소의 약간 감소 (평균 1.34g/dl)와 혈소판의 감소 (평균20.25%)를 나타내었다. 해동 단핵구를 투여할시에 일과성인 불쾌감, 기침, 흉부압박감, 호흡곤란 등이 있었다. 4. 결론 자가골수이식에서 자기말초혈액조혈간세포이식으로 관심이 이행되는 현시점에 자가조혈간세포를 채집하여 수혈하는 기술이 확립되는 기초를 이루었다고 본다. 이번 대상들은 재발된 금성백혈병들에 시행하였으나, 향후에는 초발시에 제일차 관해유도 화학요법 과정에 시도해야할 것으로 생각한다. Object: Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy. Method: Collection of mononuclear cells (MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 time in each patient of total 6 cases. The collected MNCs were stored in - 750C and reinfused after thawing in the water bath at 370C Results: Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticed transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells. Conclusion: The basic process for the peripheral blood stem cell transplantation (PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high does chemotherapy. (Korean J Blood Transfus 6(2) : 41~47,1995)

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

Gene pyramiding effect of two major bakanae disease resistance gene using qBK1 and qBKWD

Sais-Beul Lee,Tae-Heon Kim,Su-Min Jo,Jun-Hyun Cho,Ji-Yoon Lee,Jong-Hee Lee2,Dongjin Shin,You-Chun Song,Myung-Kyu Oh,Dong-Soo Park 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-

림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

Multi-media and multi-pathway aggregate exposure assessment for polycyclic aromatic hydrocarbons to the inhabitant in Tae-an county after Hebei-spirit oil spill

Kim Chan-Kook(김찬국),Woo-Chul Jeong,Jonil Hur,Pan-Soo Park,Tae-Woo Lee,Hwi-Soo Seol,Jung-hyeon Park,Jong-Heop Lee,Jong-Ho Kim,Byeong-Kyu Kwak,Jong-Hyeon Lee 대한직업환경의학회 2010 대한직업환경의학회 학술대회 논문집 Vol.45 No.-

인터넷 광고효과에 관한 조사연구

이태로,최만규,임국환 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.1

As internet becomes very important communication means for numerous people, a variety of advertisement are beginning to appear on the internet. People can get information about various things and do shopping via internet. This study was carried out to investigate the effect of internet advertisement on various groups. For this study, 200 people were surveyed. The results obtained were as follows: 1. Among the various advertisement types, since most people use e-mail and check e-mail very often, the advertisement through e-mail turned out the most effective advertisement means. 2. The type of advertisement using animation and moving pictures were preferred for most consumers. 3. As for the age groups, young people had the preference for the banner style and old age groups were interested in advertisements including free gift or discount events. 4. As for the favorite hours, the people in the twenties and the thirties preferred evening time(18:00 to 24:00) and people in the forties and fifties afternoon(12:00-18:00). 5. Male consumers showed preference (or the advertisement including free service programs and female consumers preferred the advertisement including discount programs or gifts.

상부위장관 출혈을 일으킨 Warfarin Sodium에 의한 위점막내 혈종 1예

이봉규,김태원,박찬국,김만우 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

A case of warfarin sodium-induced intramural hematoma and upper gastrointestinal bleeding is described, and the literature on this adverse effect is reviewed. A 83-year-old woman who has been receiving warfarin came to a emergency room because of hematemesis. She had a history of cerebral infarction. Physical examination was anemic conjunctiva, no abdominal mass and melena. The emergency gastroscopic finding was submucosal mass. Her hemoglobin and hematocrit concentration had falled to 6.7g/㎗ and 20%, Her prothrombin time (PT) was 130 sec and partial prothrombin time (aPTT) was 133 sec. The patient underwent an emergency exploratory laparotomy. The name of operation was hemigastrectomy with gastrojejunostomy(Billorth-Ⅱ). The pathology report indicated the presence of submucosal hematoma formation with mucosal ischemic necrosis and mucosal ulceration and regenerating epithelium.

한글ㆍ영문 겸용 Word Processor System 개발에 관한 연구

이상인,강석건,서창렬,신태민,박규태,여재준,장이한 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

The design theory and implementation of a word processor system with more efficient processing of Korean and English text are studied. A screen editing method is implemented which is more flexible to handle the texts. Convinient control of the keyboards, cursors moving, texts editing, line marking and block operations are considered. The codes to avoid the complexity and inefficiency which are caused by difference of the code length between the Korean and English characters are reconstructed. File management systems and algorithms for executing the control commands are also studied. As a result, a successful word processor system is designed and implemental which performs a complete screen editing system. The performance of the system includes flexible cursor movement, margin setting, block operations of insertion, deletion and copying any sizes of the line and blocks; and also, the printout routines for size variation of the characters are worked out.

초미세 마이크로 소성성형 가공시스템 기술 개발

이낙규,최태훈,이혜진,최석우,박훈재,나원기 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In this paper Research development about a micro metal forming manufacturing system has been developed. A micro forming system has been achieved in Japan and it's developed micro press is limited to single forming process. To coincide with the purpose to be more practical, research and development is necessary about the press which the multi forming process is possible. We set the development of the equipment including micro deep drawing, micro punching and micro restriking process to the goal. To achieve this goal, Research about micro forming process to be related to multi process forming must be preceded first. Material selection and analysis about micro forming process are accomplished in this paper. And the basis research to make actual system is accomplished.

JMF를 이용한 화상회의 설계 및 구현

이규대,양선모 공주대학교 생산기술연구소 2001 論文集 Vol.9 No.-

As the network continues remarkable growth, the need of the method for efficient and favorable human-to-human communication increase. To meet the need, applications like e-mail, news and others have been developed in various network. Videoconferencing has known as a kind of these applications to communicate with one another without face-to-face meeting. The existing videoconferencing system has a drawback that is dependent on specific platform. So, there's a increase in a need of system independent platform in these days. JMF, as one of Java API, was created for the purpose of the play, transmission, reception and obtainment of time based media. Also, JMF has a platform independent quality. In this paper, a simple platform independent system was developed by using JMF.