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( Subeen Lee ),( Juyeon Kang ),( Hyun Jung Lee ),( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Yoon Soon Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: We evaluated the clinical significance of clinical factors and hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). Methods: We retrospectively analyzed 125 patients with LACC (FIGO stage IIB to IIIB) who received definitive CCRT. Clinical factors and hematological parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed pre- and post-CCRT. Neutrophil-to-lymphocyte ratio (NLR) was calculated by dividing absolute neutrophil counts by absolute lymphocyte counts. Tumor size was determined by measuring the largest tumor diameter in MRI or CT images. Univariate and multivariate analysis for disease-free survival (DFS) and overall survival (OS) were performed using clinical factors and hematological parameters. Results: Disease recurred in 46 (36.8%) patients, and 24 patients (19.2%) died. On multivariate analysis, tumor size, paraaortic lymph node metastasis, post-treatment NLR, NLR (pre-treatment NLR/post-treatment NLR) and PLR (platelet-to-lymphocyte ratio) (pretreatment PLR /posttreatment PLR) were significant prognostic factors for DFS. Among them, only post-treatment NLR and tumor size were a significant prognostic factor for OS (p<0.001). Combination of tumor size and post-treatment NLR were significant prognostic factor for DFS and OS. Patients with large tumor size and elevated post-treatment elevated NLR were shown poor prognosis. Conclusion: Combination of tumor size and post-treatment NLR may serve as a prognostic indicator in patients with LACC who received definitive CCRT.
이주희(Lee, JuHee),이태화(Lee, Taewha),이현경(Lee, Hyunkyeong),김상희(Kim, Sanghee),배주연(Bae, Juyeon),한지희(Han, Jeehee),이경은(Lee, Kyongeun) 한국간호교육학회 2015 한국간호교육학회지 Vol.21 No.4
Purpose: The purpose of this study was to develop an integrated nursing practicum education matrix based on the learning outcomes of each stage. Methods: In this Delphi technique study, 10 experts, consisting of six professors and four nurses, participated in the development of the matrix. The first step was an in-depth review for the composition of the questionnaire and the second step was the Delphi technique. The Delphi survey was conducted two times in order to complete the components of the matrix. The survey data was analyzed for statistical averages and standard deviations to decide the order of priority. Results: According to each stage (i.e. fundamental stage, competent stage, and proficient stage), the matrix was composed of education contents, methods, evaluation methods, and curriculum outcomes. Conclusion: The integrated nursing practicum education matrix of Y University was completed. The developed matrix will result in a reduction in the gap between nursing education and clinical practice and an improvement in nursing competency.
유비쿼터스 환경에서 다양한 개인화 서비스에 적용하기 위한 사용자 모델링의 일반화 방법론
이주연(Juyeon Lee),이성진(Seongjin Lee),이수원(Soowon Lee) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.2B
최근 연구가 활발히 진행되고 있는 ‘유비쿼터스’라는 새로운 패러다임은 기존보다 더욱 많은 컴퓨팅 자원을 이용하여 사용자의 편의를 지원하는 것을 그 목표로 하고 있다. 유비쿼터스 컴퓨팅 환경에서 사용자를 지원하기 위한 대표적인 예로 개인화 서비스를 들 수 있으며, 개인화 서비스는 사용자에 대한 모델링이 필수 요소가 된다. 개개인의 행동 패턴 혹은 선호도 정보로 구성된 사용자 모델은 다양한 개인화 서비스의 원활한 지원을 위해 지금까지 유용하게 사용되고 있지만, 기존의 사용자 모델은 각 서비스가 개발될 때, 그 서비스에 적합한 형태로 매번 설계되어야 하는 문제점을 지닌다. 본 논문에서는 이러한 문제점을 해결하고자, 사용자 모델을 구성하는 정보들을 분석하여, 모델 설계에 필요한 일반화된 입력 패턴들을 도출하고, 도출된 패턴들을 바탕으로 더욱 쉽고 빠르게 사용자 모델을 생성할 수 있는 방법을 제안한다.
Juyeon Lee,문창종,Jihoon Kim,Chanwoo Jung,이근화,주홍구,안미정,신태균 대한수의학회 2009 JOURNAL OF VETERINARY SCIENCE Vol.10 No.3
The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne’s disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl- Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.
Lee, SuMin,Lee, JuYeon,Yu, HyonPil,Lim, JongChoo Elsevier 2018 Colloids and surfaces. A, Physicochemical and engi Vol.536 No.-
<P><B>Abstract</B></P> <P>In this study, 2 types of zwitterionic phospholipid biosurfactants LP(A) and LP(O) were prepared using 2 different raw materials such as rapeseed oil and rapeseed acid respectively. The structure of the resulting products was elucidated by FT-IR, <SUP>1</SUP>H NMR, and <SUP>13</SUP>C NMR spectroscopies and the interfacial properties of LP(A) and LP(O) have been examined such as CMC, static and dynamic surface tensions, interfacial tension, wetting property, emulsion stability, and foam property. Detergency test evaluated by using a Terg-o-tometer showed moderately good detergency compared with conventional nonionic and anionic surfactants used in detergent formulations. Biodegradability, acute oral toxicity, acute dermal irritation and acute eye irritation tests revealed that LP(O) surfactant possesses excellent mildness and superior environmental compatibility, indicating the potential applicability in cosmetic and household products formulations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2 types of zwitterionic phospholipid biosurfactants LP(A) and LP(O) were prepared using rapeseed oil and rapeseed acid respectively and characterized by 1H NMR, 13C NMR, and FT-IR. </LI> <LI> Interfacial properties of synthesized surfactants were measured and environmental compatibility of the new surfactants such as biodegradability and acute oral toxicity was evaluated. </LI> <LI> Detergency, eye irritation and skin irritation tests have been performed in order to test the potential applicability in cosmetic and household products formulations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Synthetic routes of LP(O) where plant oil corresponds to rapeseed oil; (a) intermediate 1, (b) intermediate 2, (c) LP(O).</P> <P>[DISPLAY OMISSION]</P>
Language Choice in Note-Taking - The Case of Korean and English
Juyeon Lee 한국통역번역학회 2017 통역과 번역 Vol.19 No.3
The choice of language in note-taking for consecutive interpreting has been a focus of interest for many researchers. Regarding what factors may influence the interpreter’s choice of language, several variables have been suggested in the literature, including the source language (SL) vs. target language (TL) distinction, the A and B language distinction, characteristics of the languages involved, and levels of expertise. The present study examined how these factors may be related to language choices in note-taking for consecutive interpreting that involve Korean and English. Ten first-year students, ten second-year students, and three professional interpreters participated in the study to produce notes in both directions. The analysis of the notes suggests that the participants preferred to take notes in the source language (also A language) when interpreting from Korean to English. In the other direction, less experienced interpreters tended to fluctuate between taking notes in SL and TL (A language), but more experienced interpreters were found to prefer to take notes in SL (B language). Detailed findings and their implications are discussed.
mySyntenyPortal: an application package to construct websites for synteny block analysis
Lee, Jongin,Lee, Daehwan,Sim, Mikang,Kwon, Daehong,Kim, Juyeon,Ko, Younhee,Kim, Jaebum BioMed Central 2018 BMC bioinformatics Vol.19 No.-
<P><B>Background</B></P><P>Advances in sequencing technologies have facilitated large-scale comparative genomics based on whole genome sequencing. Constructing and investigating conserved genomic regions among multiple species (called synteny blocks) are essential in the comparative genomics. However, they require significant amounts of computational resources and time in addition to bioinformatics skills. Many web interfaces have been developed to make such tasks easier. However, these web interfaces cannot be customized for users who want to use their own set of genome sequences or definition of synteny blocks.</P><P><B>Results</B></P><P>To resolve this limitation, we present mySyntenyPortal, a stand-alone application package to construct websites for synteny block analyses by using users’ own genome data. mySyntenyPortal provides both command line and web-based interfaces to build and manage websites for large-scale comparative genomic analyses. The websites can be also easily published and accessed by other users. To demonstrate the usability of mySyntenyPortal, we present an example study for building websites to compare genomes of three mammalian species (human, mouse, and cow) and show how they can be easily utilized to identify potential genes affected by genome rearrangements.</P><P><B>Conclusions</B></P><P>mySyntenyPortal will contribute for extended comparative genomic analyses based on large-scale whole genome sequences by providing unique functionality to support the easy creation of interactive websites for synteny block analyses from user’s own genome data.</P>