홍순에 발생한 출혈성 궤양 병소의 증례보고 및 감별진단

이경은,정원,조남표,서봉직,Lee, Kyung-Eun,Jung, Won,Cho, Nam-Phy,Suh, Bong-Jik 대한안면통증구강내과학회 2011 Journal of Oral Medicine and Pain Vol.36 No.2

The vermilion zone of the lips is mucocutaneous junction between the skin and the oral mucosa of lips. Diseases of the vermilion zone may be related to a local or systemic condition, and can be manifestation of a systemic disease. In this cases, we introduced patients with hemorrhagic, ulcerative lesions on the vermilion zone and reported plasma cell cheilitis and lesion of the vermilion zone related to Stevens-Johnson syndrome(SJS).

하악과두 흡수(Condylar Resorption)에 대한 고찰

이경은,Lee, Kyung-Eun 대한안면통증구강내과학회 2007 Journal of Oral Medicine and Pain Vol.32 No.1

Condylar resroption, or condylysis can be defined as progressive alteration of condylar shape and decrease in mass. Although the cause is unknown, condylar resorption has been assocated with rheumatoid arthritis, systemic sclerosis, systemic erythematous, steroid usage, orthodontic treatment and orthognathic surgery. In most case, however, there is no identifiable precipitating event. Hence the term is idiopathic condylar resorption. With condylar resorption, the bone loss is resulting in a loss of posterior support in the involved condyle and the mandible can then shift. As a result, the most patients exhibit occlusal change, openbite, retrognathism, and a decrease in posterior face height. This article reports cases of condylar resorption. And the author will review factors capable of changes of condyle, pathogensis and management of conylar resorption.

Osteomyelitis of Mandibular Condyle : A Case Report in 9-year-old Child

이경은,최순정,서봉직,Lee, Kyung-Eun,Choi, Soon-Jeong,Suh, Bong-Jik Korean Academy of Orofacial Pain and Oral Medicine 2009 Journal of Oral Medicine and Pain Vol.34 No.3

Osteomyelitis means inflammation of the bone marrow. It usually begins in the medullary cavity, involving the cancellous bone; then it extends and spreads to the cortical bone and eventually to the periosteum. The cause is usually thought to be microbiological. But there still are factors that predispose to produce a possible bone infection such as injuries, syphilis, actionomycosis, chronic kidney failure, alcoholism, malnutrition, radiotherapy, and chemotherapy. Treatment of modalities have been directed toward eradicating microbes and improving circulation in the early stage. In the case presented, surgical debridement and IV antibiotics were the treatment of choice. Osteomyelitis in children is mainly affected in the mandible. And in childhood, the mandibular condyle is regarded as an important center of mandibular growth. Therefore, in young patients, osteomyelitis involving this region may cause a restraint of mandibular development, resulting in facial asymmetry. So diagnosis in the early stage is important in child with osteomyelitis. Recently, we have encountered an interesting case of osteomyelitis of the mandibular condyle in 9-year-old boy. So we present the case and review the literature about osteomyelitis.

입원 암환자의 영적건강, 불안, 통증과의 관계

이경은,이영은,Lee, Kyoung Eun,Lee, Young Eun 한국호스피스완화의료학회 2015 한국호스피스.완화의료학회지 Vol.18 No.1

목적: 본 연구의 목적은 입원 암환자의 영적건강, 불안과 통증과의 관계를 규명하여 입원 암환자의 통증감소를 위해 영적건강을 증진시키고 불안을 감소시키는 간호중재 프로그램을 개발하기 위한 기초자료를 제공하는 것이다. 방법: 대상자는 B광역시 소재 대학병원에서 입원 치료중인 암환자 167명이고, 자료수집기간은 2012년 4월 27일부터 동년 5월 11일까지였다. 연구도구로 영적건강은 Highfield(1992)의 SHI (Spiritual Health Inventory)를 이원희 등(2001)이 번안한 것을, 불안은 Spielberger(1975)의 STAI (State-Trait Anxiety Inventory)를 김정택과 신동균(1978)이 번안한 것을, 통증은 국가암정보센터(2010)의 VAS (Visual Analogue Scale) 척도를 사용하였다. 자료분석은 SPSS 20 프로그램을 이용하여 분석하였다. 결과: 본 연구의 결과는 다음과 같다. 1. 입원 암환자의 영적건강과 불안은 중간 정도, 통증은 약한 정도로 나타났다. 2. 입원 암환자의 일반적 특성에 따른 영적건강은 종교, 교육, 평균월수입, 질병상태, 건강상태, 전이, 일상생활, 지지정도에 따라 차이가 있었다. 3. 입원 암환자의 일반적 특성에 따른 상태불안은 종교, 교육, 질병상태, 건강상태, 전이, 일상생활, 지지정도, 진통제에 따라 차이가 있었다. 4. 입원 암환자의 일반적 특성에 따른 통증은 질병상태, 건강상태, 전이, 일상생활, 지지정도, 진통제에 따라 차이가 있었다. 5. 입원 암환자의 영적건강과 상태불안의 관계는 중간 정도의 역상관관계(r=-0.627, P<0.001), 영적건강과 통증의 관계는 약한 역상관관계(r=-0.255, P=0.001), 상태불안과 통증의 관계는 약한 순상관관계(r=0.306, P<0.001)로 나타났다. 결론: 입원한 암환자의 영적건강, 불안 및 통증을 관리하기 위해 본 연구에서 규명한 관련 요인을 고려한 프로그램 개발 및 효과검증 연구가 필요할 것으로 생각된다. Purpose: This study is to find relationship between cancer patient's spiritual health and the level of their anxiety and pain. Methods: From April 27 through May 11, 2012, a survey was conducted with 167 cancer patients hospitalized at a university hospital in Busan. Spiritual health was measured by the Spiritual Health Inventory developed by Highfield (1992). The instrument for anxiety measurement was the State-Trait Anxiety Inventory by Spielberger (1975) and that for pain was the Visual Analogue Scale (2009). The association between patients' characteristics and spiritual health, anxiety or pain degree were analyzed using the ANOVA test. The interrelationship between spiritual health, anxiety and pain was analyzed using Pearson's correlation coefficients. Results: The patients exhibited a moderate degree of spiritual health and anxiety and a mild level of pain. Patients' spiritual health significantly differed by their religion, education, monthly income of the family, illness conditions, physical conditions, metastasis, daily living and support. Their anxiety level was significantly different according to age, religion, education, illness conditions, physical conditions, metastasis, daily living, family/friends' support and use of analgesics. Significant differences were also found in the level of pain according to illness conditions, physical conditions, metastasis, daily living, family/friends' support and use of analgesics. We found a moderately negative correlation between spiritual health and anxiety. Anxiety and pain showed a positive correlation, and spiritual health and pain exhibited a negative correlation. Conclusion: To help cancer patients to manage their spiritual health, anxiety and pain, a program should be developed considering the primary factors discussed in this study.

Ephedrine이 뇌내 Biogenic Amine 함량에 미치는 영향

이경은,Lee, Kyung-Eun 대한약리학회 1995 대한약리학잡지 Vol.31 No.2

Sympathomimetic amines, especially ephedrine, are a major ingredient in proprietary medications for symptomatic treatment of upper respiratory infections. Their frequent uses can lead to occasional instances of abuse and habituation. The clinical symptoms of ephedrine abuse are similar to that of amphetamine psychosis and resemble closely that of schizophrenia. Because both amphetamine psychosis and schizophrenia are thought to be mediated primarily through the action on catecholamines, ephedrine-induced changes of the biogenic amines can be suspected. However, there were few studies about the central effects of ephedrine because of the milder central action than peripheral. Therefore, the present investigation was undertaken to elucidate the relations between the effects of single or repeated administration of ephedrine on the regional levels of biogenic amines in rat brain and ephedrine-induced CNS stimulation. The male Sprague-Dawley rats weighing $100{\sim}200\;g$ were used. After single or repeated administrations of ephedrine, blocks of tissue were obtained from frontal cortex, corpus striatum, hippocampus, thalamus, hypothalamus, substantia nigra and cerebellum. The concentration of biogenic amines(norepinephrine, epinephrine, dopamine, 5-hydroxytryptamine(5-HT)) and their metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid(HVA), 5-hydroxyindoleacetic acid(5-HIAA)) were measured by means of high performance liquid chromatography-electrochemical detector(HPLC-ECD). The results obtained were as follows: 1) In the normal rat, the concentration of norepinephrine was the highest in hypothalamus. Dopamine, DOPAC and HVA were highest in corpus striatum, and 5-HT and 5-HIAA were highest in substantia nigra. Epinephrine was not detectable in any part of the brain tissue. 2) In a single administration of ephedrine, the concentration of DOPAC was decreased in corpus striatum. However, the other biogenic amines and their metabolites were not changed. 3) In repeated administration of ephedrine, the concentration of norepinephrine was decreased in all brain region checked. Dopamine was decreased in corpus striatum and substantia nigra and, increased in hypothalamus, and HVA was decreased in corpus striatum. 5-HT was decreased in all brain region except cerebellum and, 5-HIAA was decreased only in frontal cortex. The ratio of 5-HIAA/5-HT was increased in corpus striatum, thalamus, hypothalamus and substantia nigra. These data indicated that, although a single administration of ephedrine did not change the central neurotransmitters, repeated administration of ephedrine caused the decreases of norepinephrine and 5-HT in the most regions of brain, which may be responsible for the emergence of abnormal behavioral effect after ephedrine abuse.

코로나-19 환자의 후유증 한약 치료에 대한 고찰

이경은,정선형,정민정,최유민,송미덕,장인수,Lee, Kyoungeun,Jeong, Seonhyung,Jeong, Minjeong,Choi, Yoomin,Song, Mideok,Jang, Insoo 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.1

Objective: The purpose of this study was to collect and evaluate evidence of herbal medicine treatments for the residual effects of COVID-19. Methods: Nine electronic databases, namely PubMed, Science Direct, CINAHL, CNKI, Wanfang, J-STAGE, CiNii, OASIS, and Science ON, were searched with the following keywords: 'COVID-19'; 'sequelae'; 'Convalescence' for 'P (Population)' and 'Medicine, Chinese Traditional'; 'Korean medicine'; 'Herbal medicine' for 'I (Intervention)'. For the selected studies, various clinical data were extracted including patient symptoms, pattern identification, herbal medicines prescribed, and treatment results. Results: A total of nine clinical studies were identified (two case control trials; one case series; and six case reports). Various residual symptoms had been detected in the recovery stage of COVID-19 with the most commonly used pattern identifications being deficiency in both lung and spleen and in both qi and yin. Any herbal medicine prescriptions were written using these patterns. We found several reports of the positive effect of herbal medicines in that it improved symptoms, lung function, and lung inflammation. No adverse events were reported. Conclusions: The results indicate that treatment with herbal medicines has a possible therapeutic effect on the residual symptoms of COVID-19. Large-scale studies are necessary to confirm the effectiveness of these approaches.

주조방식에 따른 티타늄 주조체의 내부결함 비교

이경은,김부섭,정인성,Lee, Kyung-Eun,Kim, Bu-Sob,Chung, In-Sung 대한치과기공학회 2007 대한치과기공학회지 Vol.29 No.2

The purpose of this study was to evaluate the titanium castability (internal porosity) between pressure type casting machine & centrifugal casting machine with air-vent or not. Internal porosity is a well-known problem in dental titanium casting, resulting in inferior mechanical properties of dental restorations. To evaluate the castability, the square plate was chosen. 40 plate patterns($20{\times}20{\times}1.8mm$)were attached to funnel-shaped sprue. Then 20 plate patterns were attached air-vent. They were invested in titanium investment material and cast in a pressure type casting machine(20castings) and centrifugal casting machine(20castings). Each group were divided with air-vent(10castings) or not(10castings). The titanium castings were evaluated by radiographic photograph for the location of the internal porosities. The percentage porosity of each specimen was determined using standardized digital radiographs. The results were analyzed with analysis of variance and t-test for paired comparison between two groups.

Multiple Oral Lipomas of the Tongue: Case Report

이경은,고승오,변진석,서봉직,Lee, Kyung-Eun,Ko, Seung-O,Byun, Jin-seok,Suh, Bong-Jik The Korean Academy of Orofacial Pain and Oral Medi 2012 Journal of Oral Medicine and Pain Vol.37 No.3

지방종은 성숙한 지방세포로 이루어진 흔한 연조직 양성 종양이다. 그러나, 구강에서는 드물게 발생하며, 일반적으로 단독으로 발생하기 때문에 구강내에서 다발성으로 발생한 지방종을 경험하기는 매우 어렵다. 이에 저자는 아주 드물게 발생하는 혀의 다발성 지방종을 경험하여서 이를 보고하며 구강 지방종에 대해 고찰하고자 한다. Lipoma is a benign tumor composed of mature adipocytes and the most common soft tissue mesenchymal neoplasm but relatively rare in the oral cavity. Lipoma of the tongue is uncommon and especially multiple lipomas are quite rare and only several cases of those were reported. We describe an unusual case of multiple lipomas of the tongue.

초고차원 다범주분류를 위한 변수선별 방법 비교 연구

이경은,김경희,신승준,Lee, Kyungeun,Kim, Kyoung Hee,Shin, Seung Jun 한국통계학회 2017 응용통계연구 Vol.30 No.5

We compare various variable screening methods on multiclass classification problems when the data is ultrahigh-dimensional. Two different approaches were considered: (1) pairwise extension from binary classification via one versus one or one versus rest comparisons and (2) direct classification of multiclass responses. We conducted extensive simulation studies under different conditions: heavy tailed explanatory variables, correlated signal and noise variables, correlated joint distributions but uncorrelated marginals, and unbalanced response variables. We then analyzed real data to examine the performance of the methods. The results showed that model-free methods perform better for multiclass classification problems as well as binary ones. 본 논문에서는 초고차원 자료의 다항분류를 위한 변수선별 방법에 대해 비교 연구를 진행하였다. 다항분류를 위한 변수선별 방법에는 일대일 혹은 일대다 비교를 통해 이항분류를 위한 방법을 확장시켜 적용하는 방법과 다항 반응 변수에 직접 적용할 수 있는 방법이 있다. 다항분류를 위한 변수선별 성능을 확인하기 위하여 여러가지 상황-설명변수의 꼬리가 두꺼운 경우, 신호변수와 잡음변수가 서로 연관된 경우, 결합분포상으로 연관되어 있지만 주변분포 상으로는 연관되어 있지 않은 경우, 다범주 반응변수의 분포가 불균형인 경우-을 가정하고 모의실험을 진행하였고, 실제 자료에도 적용해 보았다. 그 결과, 모형 가정을 필요로 하지 않는 방법들이 안정적인 성능을 보이는 것을 확인하였다.

삼릉추출물이 항산화와 멜라노제네시스에 미치는 영향

이경은,심관섭,김진화,박성민,이범천,윤여표,표형배,Lee, Kyung-Eun,Sim, Gwan-Sub,Kim, Jin-Hwa,Park, Sung-Min,Lee, Bum-Chun,Yun, Yeo-Pyo,Zhang, Yong He,Pyo, Hyeong-Bae 대한약학회 2004 약학회지 Vol.48 No.6

Whitening effect, which decreases the skin pigmentation, is the one of important targets in cosmetics. This study was investigated the effects of Scirpi rhizoma on ant ioxidation and melanogenesis. S.rhizoma is a rhizome of Scirpus fluviatilis G. a perennial Cyperaceae species of wide occurrence in Asia, Europe, Africa and North America. S.rhizoma shown scavenging activities of free radicals and reactive oxygen species (ROS) with the IC50 of 638${\mu}g/ml$ against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 21.7${\mu}g/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. S.rhizoma treatment (48 h) suppressed the biosynthesis of melanin up to 27% and reduced tyrosinase activity up to 31% at 100${\mu}g/ml$ in B16 melanoma cells. S.rhizoma was also able to significantly inhibit tyrosinase and TRP-1 expres- sion in protein level. These results suggest that S.rhizoma inhibited melanin biosynthesis by regulating tyrosinase activity and expression in B16 melanoma cells. Therefore S.rhizoma may be useful as new whitening agent due to the antioxidant effect and the inhibitory effect against melanogenesis.