기억에 미치는 대뇌변연계의 기능적 역할 : 에탄올 급성 투여 흰쥐의 행동 및 신경화학적 변화 Behavioral and Neurochemical Alterations Following Acute Administration of Ethanol in Rats

이순철,유관희,김응배 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

Behavioral and neurochemical effects of ethanol were assessed in rats after acute administration. Ethanol, 1-5g/㎏, inhibited the memory and rotarod performance, but significantly increased the spontaneous locomotor activity. Ethanol, 1-5g/㎏, did not affect the striatal dopaminergic neuronal activity and cortical noradrenergic neuronal activity. Ethanol, 1g/㎏, decreased the contents of DA(46.7%), DOPAC(66.7%) and HVA(79.2%) in frontal cortex, but increased the contents of DA(125%), DOPAC(116.7%) and HVA(l40%) in hippocampus. Ethanol, 2-5g/㎏, significantly increased the dopaminergic neuronal activity in frontal cortex, while it remarkably decreased the monoaminergic neuronal activity in hippocampus. These results suggest that the activity of cotical dopaminergic neuron play an important role in modulation of the motot activity induced by low does of ethanol, and that the activity of cotical and hippocampal catecholaminergic neurons could be responsible for the control of memory induced by higher does of ethanol.

Polyethylene glycol 용액(Colyte^(R))을 복용한 후 발생한 Boerhaave 증후군 1예

이관행,기승석,김인숙,김민정,박인호,장세중,하지수,김응수 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Spontaneous esophageal rupture (Boerhaave's syndrome) is a rare case that require early diagnosis and treatment because of its high mortality. The oral administration of osmotically balanced polyethylene-glycol-based electrolyte preparation is a commonly prescribed preparation for cleansing in patients undergoing colonoscopy. Nausea, vomiting and abdominal pain are frequently seen, but serious adverse reactions are rare. Esophageal rupture secondary to severe vomiting, which occurred during colonoscopy preparation using polyethylene gIycoI(PEG) electrolyte solution is extremely rare and only few cases have been published in the literature. We report a case of spontaneous esophageal rupture after routine administration of the PEG before colonoscopy. 대장 정결을목적으로 PEG 사용 후 아주 드물게 발생하는 Boerhaave 증후군 1예를 경험하였기에 보고하는 바이다.

폐쇄성 수면 무호흡증 환자에 있어서 하악 재위치 장치 장착과 체위에 따른 상기도 구조와 근활성도의 변화에 관한 EMG 및 두부방사선학적 연구

박영철,배응권,이정권,이종석,김태관 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

폐쇄성 수면 무호흡증(obstructive sleep apnea, 이하 OSA로 표시)은 수면 도중 계속 반복 되어 일어나는 상기도 폐쇄로 인하여 무호흡증을 나타내는 장애(disorder)이다. 근래의 연구에 의하면 상기도 구조의 해부학적 요인뿐 아니라 생리적 요인도 무호흡 발생에 기여한다고 하였으며 또한 이설근이 상기도 유지에 중요한 역할을 한다고 하였다. OSA의 치료를 위해 다양한 술식이 시행되었으며 하악 재위치 장치를 통한 치료 역시 양호한 결과를 나타낸다고 하였다. 그러나 하악 재위치 장치 장착에 따른 구조적 생리적 작용기전에 대한 연구는 미비한 상태이다. 이에 본 저자는 연세대학교 치과대학병원 교정과에 내원한 OSA 환자 26명(남 17명, 여 9명)과 일반 정상 성인 20명(남 10명 여 10명)을 대상으로 앙와위에서 장치 장착 전후의 두부방사선사진을 채득하여 장치에 따른 상기도의 구조 변화를 연구하고 두군 사이의 장치 장착에 따른 효과를 비교하였으며, 또한 OSA 환자 14명(남자 10명 여 4명)을 대상으로 체위 변화와 장치장착에 따른 이설근 근전도 변화를 연구하여 다음과 같은 결론을 얻었다. 1. 상기도 구조에 대한 두부계측학적 측정치 중 연구개의 길이, 연구개 최대 두께와 SPAS, MAS, VAL, H-H1. MP-H에서 정상군과 OSA군 사이의 통계적 유의차를 보였으며, IAS와 EAS는 두 군간에 통계적 유의차를 보이지 않았다. 2. 정상군과 OSA군 모두에서 장치 장착에 따라 후두개가 전방 이동하면서 후두개 수준(epiglottis level)의 기도 폭경은 증가하였고 연구개의 최대 두께가 변하였으며 설골은 전방 이동하였으나 두 군 모두 IAS에서는 다양한 반응을 나타내었다. 장치 장착에 따른 상기도 구조에 대한 효과는 두 군 사이에 서로 차이을 나타내었다. 3. 체위 변화에 따라 앙와위에서 이설근 근전도가 증가하는 경향을 나타내었으나 통계적 유의차는 없었으며, 직립위와 앙와위 모두에서 하악 재위치 장치 장착시에 통계적으로 유의하게 이설근 근전도가 증가하였다. 하악 재위치 장치는 상기도의 해부학적 구조뿐 아니라 상기도 영향을 미치는 것으로 생각되며 장치에 대한 반응은 정상군과 OSA군 사이에 차이를 나타내었고, 두 군은 상기도 생리에 있어서도 서로 다르다고 사료된다. Obstructive sleep apnea (OSA)is a disorder characterized by repetitive episode of upper airway collapse during sleep. Recent studies showed that not only the anatomic factors but the physiologic factors of the upper airway also have effects on the occurrence of apnea and that the genioglossus muscle also plays in important role in the maintenance of the upper airway. A variety of therapies were performed to treat OSA, and among them the use of mandibular repositioning appliances showed reasonable results. But there is still a lack of research on the structural and physiological mechanism upon the use of mandibular repositioning appliances. The author selected 26(male 17, female 9) OSA patients that came to the Yonsei University Dental Hospital, Department of Orthodontics, and 20 normal adults (male 10, female 10) and took cephalometric radiographs of them in a supine position before and after the palcement of the mandibular repositioning appliance to see the structural changes of the upper airway and compare the therapeutic effects between the two groups. We also studied the waking genioglossus muscle activity in OSA patients and investigated the difference in the electromyogram of the genioglosssus muscle upon the change in body posture and the use of mandibular repositioning appliance. Following results were obtained. 1. Among the cephalometric measurements of the upper airway structure, the length of the soft palate, maximum thickness of the soft palate and SPAS, MAS, VAL, H-HI, MP-H showed statistically significant differences between the normal and OSA groups, but the IAS and EAS showed no statistically significant differences between the two groups. 2. In both the normal and OSA groups, as the epiglottis moved forward on wearing the mandibular repositioning appliance, the epiglottis level of the upper airway increased and the maximum thickness of the soft palate changed and the hyoid bone also moved forward, but the IAS in both groups showed various results and the effect of the mandibular repositioning appliance on the structure of the upper airway was different in the two groups. 3. Upon changing the position, the electromyogram of the genioglossus muscle showed a increasing tendency but there was no statistically significant differences, and when the mandibular repositioning appliance were worn there was a statistically significant increase in the electromyogram of the genioglossus muscle in both the upright and supine positions. The mandibular repositioning appliances not only have an effect on the anatomical structure of the upper airway but also on the physiology of the upper airway. There are different responses to the use of mandibular repositioning appliance between the normal and OSA groups therefore it could be considered to have the different physiology of the upper airway between the two groups.

Surface structures and magnetic anisotropies of a Fe/Pt (001) surface: An <i>ab initio</i> study

Lee, Eung-Kwan,Choi, Heechae,Hwang, Yubin,Chung, Yong-Chae American Institute of Physics 2011 JOURNAL OF APPLIED PHYSICS - Vol.109 No.7

성인에서의 선천성 심기형에 대한 개심술

김응수,유환국,유재현,이원용,나찬영,정윤섭,백완기,한재진,이영탁,박영관,홍승록,이영균 世宗醫學硏究所 1993 世宗醫學 Vol.10 No.1

慢性 B형 肝炎 患者의 라미부딘 1년 投與의 效果와 安全性에 關한 硏究

이승철,김응주,윤범,정은주,신원창,이진호,김관엽 인제대학교 2001 仁濟醫學 Vol.22 No.1

Objectives: There are increasing needs for the better treatments for chronic hepatitis B. Lamivudine, the (-)enantiomer, is a potent inhibitor of hepatitis B virus(HBV). This study investigated the effect and safety of one year lamivudine therapy in patients with chronic hepatitis B. Materials and Methods: We retrospectively analyzed 60 patients with chronic hepatitis B from March 1997 to August 2000. They received 100mg of lamivudine orally once daily for 12 months. HBV DNA, liver enzymes, creatinine, CBC, side effects were checked. Mean duration of thrapy was 12 months(range;10-14 months). Results: The suppression of serum HBV-DNA was sustained in 76% of the patients and the normalization of serum ALT in 75%. The proportion of patients with HBeAg seroconversion was 10%. During the treatment periods, adverse effects were few events. However, during follow-up, relapse rate of serum HBV-DNA was 84%. Conclusions: Lamivudine was well tolerated and induced sustained suppression of hepatitis B replication during treatment in all patients. But relapse rate was high even in responders. It is suggested that response to lamivudine is not durable in Korean patients with chronic hepatitis B.

소아에 있어 통원수술과 입원수술의 비교

박관현,최진호,오세권,전성수,이규성,이성원,최한용,채수응 大韓泌尿器科學會 1997 Korean Journal of Urology Vol.38 No.12

Studies on the Bituminization Process of Radioactive Liquid Waste[I]

Lee, Sang-Hoon,Chun, Kwan-Sik,Lim, Eung-Keuk Korean Nuclear Society 1975 Nuclear Engineering and Technology Vol.7 No.3

알카리로 처리한 국산 blown asphalt를 사용해서 방사성 폐액을 180-20$0^{\circ}C$ 범위 내에서 고화처리한 것이 산처리 한것보다 좋은 결과를 얻었으며, 방사선 조사선량이 4.0$\times$$10^{7}$ rad까지도 안정된 고화체로 존재하고 있다. 한편 40wt%의 고형분이 함유되어 있는 $^{137}$Cs-asphalt 고화체의 증류수에 의한 $^{137}$Cs의 용출율이 8.27$\times$$10^{-4}$ g/$\textrm{cm}^2$-day 인데 반하여 $^{90}$ Sr은 낮았으며, 일반적으로 증류수보다 해수때가 또한 pH가 증가함에 따라 용출율은 낮아진다. Immobilization of the second-cycle radioactive liquid wastes from a Purex process was developed with the blown asphalt (manufactured by Kukdong Shell Oil Company Ltd) to eliminate the possibility that the radioactive materials will be redispersed into the environment. Attempts to incorporate these wastes directly into the asphalt martrices without any pretreatment were not successful, as it was observed that the sulphuric acid in the waste oxidised the asphalt. Hence, the waste was treated with caustic soda and made alkaline prior to bituminization, so that it was found that this pretreatment made the waste compatible to the asphalt matrices. The pure blown asphalt samples irradiated with doses of 4.0$\times$10$^{7}$ rad showed no evidence of volume increase. The suitable temperature for incorporation of the alkaline wastes into blown asphalt was 180-20$0^{\circ}C$. The Products containing 50 wt% salts represented the following good properties viz., volume reduction (about 1.4), homogeneity, teachability etc. During the period of 131 day $s^{l37}$Cs from products containing 40wt% salts was leached at rates ranging from 2.70$\times$10-4 to 8.27$\times$10-4g/cm2_day but the rate for $^{90}$ Sr was lower by one to two orders of magnitude by distilled water. The leaching rates for $^{137}$ Cs and $^{90}$ Sr by sea water were slightly lower than by distilled water. Both of the leaching rates decreased with increasing pH.H.

Studies on the Bituminization Process of Radioactive Liquid Waste[I]

Lee, Sang-Hoon,Chun, Kwan-Sik,Lim, Eung-Keuk Korean Nuclear Society 1975 Journal of The Korean Nuclear Society Vol.7 No.3

알카리로 처리한 국산 blown asphalt를 사용해서 방사성 폐액을 180-20$0^{\circ}C$ 범위 내에서 고화처리한 것이 산처리 한것보다 좋은 결과를 얻었으며, 방사선 조사선량이 4.0$\times$$10^{7}$ rad까지도 안정된 고화체로 존재하고 있다. 한편 40wt%의 고형분이 함유되어 있는 $^{137}$Cs-asphalt 고화체의 증류수에 의한 $^{137}$Cs의 용출율이 8.27$\times$$10^{-4}$ g/$\textrm{cm}^2$-day 인데 반하여 $^{90}$ Sr은 낮았으며, 일반적으로 증류수보다 해수때가 또한 pH가 증가함에 따라 용출율은 낮아진다.

발포 프라스틱의 착화특성 및 연소가스 분석

이근원,김관응 한국산업안전학회 2001 한국안전학회지 Vol.16 No.1

This study was undertaken to investigate fire risk characteristics of the plastics foam that is used an insulating materials in workplaces. The ignition characteristics and combustion gas of the plastics foam were carried out using the ISO self-Ignition tester, the Cone Calorimeter, and NES combustion analyzer. The experimental materials used were commercial samples and their composition is not disclosed by the manufacturer. As the experimental results, the self-ignition temperature of the plastics foam ranges from 410℃ 560℃, and the flash-ignition temperature of plastics foam ranges from 370℃ to 450℃. The difference of ignition temperature on density with plastics foam type was smaller since the amount of combustible gas to ignite is not caused enough. The time to ignition of the polyethylene foam in samples of the plastics foam was shorter, and its of polyethylene foam was longer. The concentration of carbon dioxide of the polyethylene foam shows higher in samples of the plastics foam. It is found that the concentration values of carbon monoxide of the plastics foam show very fatality on people during exposure of 30 minutes in fire.