Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography.

Lee, Changho,Kim, Kyungun,Han, Seunghoon,Kim, Sehui,Lee, Jun Hoon,Kim, Hong Kyun,Kim, Chulhong,Jung, Woonggyu,Kim, Jeehyun SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.3

<P>An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of the microscope. This improvement helps surgeons to focus on the operation without distraction to view OCT images on another separate display. Moreover, displaying the OCT live images on the eyepiece helps surgeon's depth perception during the surgeries. Finally, we successfully processed stimulated penetrating keratoplasty in live rabbits. We believe that these technical achievements are crucial to enhance the usability of the VISOCT system in a real surgical operating condition.</P>

주의력결핍 과잉행동장애 한국형 치료 권고안 개정안(Ⅲ)

김효원(Hyo-Won Kim),김은주(Eunjoo Kim),김지훈(Ji-Hoon Kim),박장호(Jangho Park),반건호(Geon Ho Bahn),이연정(Yeon Jung Lee),정경운(Kyungun Jhung),신동원(Dongwon Shin) 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.2

The objective of this review is the revision of the Korean practice parameters for the pharmacological treatment of attention-deficit hyperactivity disorder (ADHD) based on the change in the diagnostic system from DSM-IV-TR to DSM-5 and psychopharmacological developments. For the evidence-based approach, the authors conducted a review of the literature, including controlled clinical trials, studies of the side effects of drugs, toxicology and meta-analyses from the United States and Europe, as well as recent research conducted in Korea. The review committee composed of Korean experts on ADHD reviewed the revised parameters. This revised version reveals how to use central nervous system psychostimulants, non-stimulants such as atomoxetine and alpha2 agonists, and other medication for ADHD, and how to manage the adverse effects of such medication. At the end of this revised version, the authors propose recommendations for the pharmacotherapy of ADHD.

Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability

( Innsun Park ),( Heeyeon Kim ),( Kyungun Jhung ),( Dukyong Yoon ),( Jihoon Seo ),( Jin Young Park ),( Hee Young Cho ) 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-

Reduction of Hemispheric Asymmetry in Autism Spectrum Disorder

Keun-Ah Cheon,Kyungun Jhung,Sung-Yeon Park,Young-Shin Kim,Yun-Joo Koh,Bennett L. Leventhal,F. Xavier Castellanos 대한소아청소년정신의학회 2012 대한소아청소년정신의학회 학술대회논문집 Vol.2012 No.5

The Correlation between Maternal Ante- and Postpartum Depression and Mode of Delivery: Preliminary Study

( Hwa Seon Koo ),( Young Ran Kim ),( Jin Young Park ),( Kyungun Jhung ),( Kyungmi Chung ),( Hee Young Cho ) 대한주산의학회 2020 Perinatology Vol.31 No.4

Objective: To investigate the relationship of prenatal and postnatal depression and mode of delivery. Methods: The study population consisted of 35 pregnant women who underwent antenatal care in Bundang CHA Medical Center from October 2018 to September 2019. Among them, 20 women underwent cesarean section (c-sec) and 15 women underwent vaginal delivery (VD). The survey was conducted at 34 to 36 gestational weeks and at postpartum 4 weeks consecutively using Korean version of Edinburgh Perinatal/Postnatal Depression Scale (EPDS). To evaluate the association between maternal ante- and postpartum depression and mode of delivery, we analyzed the differences of EPDS according to mode of delivery and pre- and postpartum. Results: The mean scores of EPDS before delivery was 7.2±5.0 in C-sec group and 5.8±4.7 in VD group, but it was not statistically significant (P=0.390). The EPDS scores at postpartum was significantly higher in women who underwent C-sec compared to VD group (9.2±4.9 vs. 7.6±5.4, P=0.010; respectively). Also when comparing the mode of delivery in fourteen women with EPDS 9 or above at postpartum, C-sec rate (64.3%) was significantly higher than VD rate (35.7%) (P=0.010). In both groups, the scores of EPDS were increased after delivery with statistical significance (P=0.039). Conclusion: C-sec delivery could increase the EPDS at postpartum and delivery itself could result in maternal depressive symptoms during postpartum period regardless of mode of delivery.

주의력 결핍 과잉 행동 환자에서 OROS-Methylphenidate 투여 후 신경심리학적 변화에 대한 개방 연구

국소담(So-Dahm Kook),김주영(Joo-Young Kim),천근아(Keun-Ah Cheon),정경운(Kyungun Jhung),송동호(Dong-Ho Song) 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.3

Objectives:Previous studies reported that attention-deficit hyperactivity disorder (ADHD) resulted from a deficit of selective attention and sustained attention. In this study, we assessed the result of methylphenidate-induced changes of the cerebral frontal executive functions in patients with ADHD. Methods:The subjects in this study consisted of 16 ADHD patients whose age ranged from 7 to 12. We used ADHD Diagnostic System (ADS) for the attention improvement, and the Stroop Test for the executive function response to pharmacotherapy with MPH. Results:After pharmacotherapy with methylphenidate for 12 weeks, the study group showed improvement in the clinical aspects through Clinical Global Impression-Severity, ADHD-rating scale and Inattention/Overactivity With Aggression Conner’s Parents Rating Scale. In the ADS test, only in auditory task there was a decrease of both the response time and the standard deviation of the response time significantly. In the Stroop Test, there was a decrease in the word task, color task and color-word task significantly. Conclusion:Our results show that psychostimulant medication improves neuropsychological function, including the cerebral frontal executive function. This study implies that we have to consider the improvement of executive function, as well as attention when evaluating the efficacy of treatment.

Defining Subtypes in Children with Nail Biting: A Latent Profile Analysis of Personality

Oh Yunhye,Choi Jungwon,송열매,Jhung Kyungun,Lee Young-Ryeol,Yoo Nam-Hee,Kim Yeni 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.6

Objective This study aimed to examine personality profiles and behavioral problems of children with nail biting (NB) to gain insight into the developmental trajectory of pathological NB.Methods 681 elementary school students were divided into non NB (n=436), occasional NB (n=173) and frequent NB group (n=72) depending on the frequency of NB reported in Child Behavioral Checklist (CBCL). Children’s personality was assessed using the Junior Temperament and Character Inventory (JTCI), and behavioral problems were assessed using the CBCL. Latent Profile Analysis (LPA) was performed using JTCI profiles to classify personalities of the children with NB (belonging to frequent and occasional NB group, n=245).Results For subscale scores of CBCL, the total, internalizing, externalizing, anxious/depressed withdrawn/depressed, depression, thought, rule-breaking, and aggressive behavior problems, were most severe in the frequent NB group followed by occasional NB and non NB group. LPA of personality profile in children with NB revealed four classes (‘adaptiveness,’ ‘high reward dependence,’ ‘low self-directedness,’ and ‘maldaptiveness’). The four personality classes demonstrated significant group differences in all of the CBCL subscales. Children who showed low self-directedness and cooperativeness and high novelty seeking and harm avoidance personality profiles demonstrated highest tendency for problematic behavior irrespective of the frequency of NB.Conclusion Children with NB reported significantly more problematic behaviors compared to children without NB. Children with specific personality profile demonstrated higher tendency for problematic behavior irrespective of the frequency of NB. Therefore, accompanying personality profiles should be considered when assessing behavioral problems in children with NB.

성학대를 경험한 소아, 청소년에서 성학대가 외상 후 정신 증상에 미치는 영향

신은영(Eun-Young Shin),천근아(Keun-Ah Cheon),정경운(Kyungun Jhung),송동호(Dong-Ho Song),김소향(So-Hyang Kim) 대한소아청소년정신의학회 2015 소아청소년정신의학 Vol.26 No.1

Objectives:The purpose of this study is to examine the effects of the characteristics of victim and sexual abuse on posttraumatic psychiatric symptoms in children and adolescents with a history of sexual abuse. Methods:A total of 137 children and adolescents were recruited from the Seoul Sunflower Children Center, a nation-funded sexual violence victim protection center, from January 2009 to December 2013. We collected the demographic data of the victims and the Trauma Symptom Checklist for Children (TSCC) from victims. We hypothesized victims’ age, sex, and intelligence quotient, and the characteristics of sexual abuse as the affecting factors of posttraumatic psychiatric symptoms. Descriptive analysis and hierarchical regression analysis were performed for analysis of demographic data, TSCC scores, and psychiatric symptoms. Results:The victims’ age and the characteristics of sexual abuse were significantly related to the traumatic distress of sexual abuse. R-square was 23% for anxiety, 39% for depression, 21% for posttraumatic stress, and 37% for dissociation on TSCC. Conclusion:This study suggests that victims’ age, type, frequency and duration of exposure, and disclosure of sexual abuse are significant affecting factors on posttraumatic psychiatric symptoms in children and adolescents. Exploration of psychiatric symptoms other than posttraumatic symptoms, and relations between pretraumatic and posttraumatic psychiatric symptoms is needed through collection of larger samples.

국내 초등학생 및 중학생의 성별에 따른 직접적 공격성과 관계적 공격성의 차이

정다운,김지웅,홍현주,김승준,이나현,양지선,안송이,임우영,정경운,Jeong, Da-un,Kim, Ji-Woong,Hong, Hyun-ju,Kim, Seung-Jun,Lee, Na-Hyun,Yang, Ji-sun,Ahn, Song-ii,Im, Woo-Young,Jhung, Kyungun 한국정신신체의학회 2015 정신신체의학 Vol.23 No.2

연구 목적 본 연구는 국내 초등학생 및 중학생을 대상으로 직접적 공격성과 관계적 공격성의 성별간 차이를 알아보고자 하였다. 연구 방법 946명의 초등학생($9.54{\pm}1.72$세, 남아 485명, 여아 461명)의 경우 부모 보고를 통해 K-CBCL를 시행하였다. 중학생의 경우 603명의 대상자가($13.98{\pm}0.93$세, 남아 301명, 여아 302명) 자가보고를 통해 K-YSR를 시행하였다. 성별간 공격성 차이를 확인하기 위해 독립표본 t 검정 및 교차 분석(chi-square test or Fisher's exact)을 시행하였다. 연구 결과 초등학생의 경우 남학생이 여학생에 비해 유의미하게 직접 공격성의 T-score가 높았으며(p<0.001) 관계 공격성에서는 유의미한 차이가 나타나지 않았다(p=0.235). 중학생의 경우 직접적 공격성과 관계적 공격성 모두에서 유의미한 차이가 관찰되었는데, 직접 공격성의 경우 남학생이 여학생보다 유의미하게 높았고(p=0.00 ; p<0.000), 관계 공격성의 경우 여학생이 남학생보다 유의미하게 높게 나타났다(p=0.017 ; p<0.001). 결 론 본 연구는 한국의 초등학생 및 중학생에서 성별 간 공격성 하위 요인의 차이가 존재함을 시사하고 있다. 이러한 성별 간 차이가 향후 아동 청소년 공격성의 예방 및 개입 방향 수립에 고려되어야 할 것으로 생각된다. Objectives : The aim of this study was to investigate the gender differences of direct aggression and relational aggression in Korean elementary and middle school students. Methods : Parents of 946 elementary school students(age $9.54{\pm}1.72$ years, 485 boys, 461 girls) completed the Child Behavior Checklist(CBCL). Six-hundred-and-three middle school students(age $13.98{\pm}0.93$ years, 301 boys, 302 girls) completed the Youth Self-Report(YSR). Independent t-test, chi-square test, and Fisher's exact test were used. Results : Boys had significantly higher direct aggression scores than girls in elementary school students(p<0.001). There was no significance gender difference of relational aggression in elementary school students(p=0.235). In middle school students, boys had significantly higher direct aggression than girls(p=0.017), and girls had significantly higher relational aggression compared to the boys(p<0.001). Conclusions : Our results suggest the presence of gender differences in manifestation of aggression subtypes in Korean elementary and middle school students. These gender differences should be taken into account in prevention and intervention approaches of aggression in children and adolescents.

The Association between Maternal Folate Status and Childhood Obesity-Systematic Review and Meta-Analysis

김준철,Bo-Eun Yoon,박진호,Eun Hye Kwon,Kyungun Kim,Suk-Ho Lee 한국운동생리학회 2022 운동과학 Vol.31 No.2

PURPOSE: Maternal nutrition plays a crucial role in fetal growth and lifelong health outcomes. Folate is an essential methyl donor in the epigenetic programming of offspring. This review and meta-analysis was conducted to compile the evidence reported thus far to identify associations between maternal folate status and childhood obesity. METHODS: A keyword/reference search was performed in EBSCOhost and Web of Science databases. A CMA program was used for a meta-analysis to estimate the pooled effect of maternal folate status on childhood obesity in offspring and to examine the influence of moderating variables on the overall effect. RESULTS: Better maternal folate intake was associated with a lower risk of childhood obesity: the overall effect size (ES; Hedges’ g) was 0.168 (95% CI=0.075 to 0.260, p<.001; small effects; cf., Cohen’s criteria). Moderator analysis revealed that the ≥Q statistic for the age group was statistically significant (Qb=4.730, df=1. p=.030; heterogeneity of ES). In offspring <7 years and >7 years, the ES was 0.277 (95% CI=0.151, 0.404) and 0.089 (95% CI=-0.025, 0.202), respectively. The study design was a statistically significant variable (Qb=4.310, df=1. p=.038; heterogeneity of ES). In cohort studies, ES was 0.251 (95% CI=0.135, 0.367), whereas in randomized controlled trial group, ES was 0.062 (95% CI=-0.073, 0.197). CONCLUSIONS: Maternal folate intake significantly affects childhood obesity, and the effect of maternal folate status is stronger in children younger than 7 years.