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이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1
In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.
만성 골수성 백혈병(Chronic Myelogenous Leukemia) 치료 중 인터페론-알파(Interferon-α)에 의한 용혈성 요독 증후군 1예
장재원,김유미,서장원,최귀숙,유수진,지현숙,유종우,박수길 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2
Interferon-alpha is an established therapy for the patients with myeloproliferative disease. Unusual immune- mediated side effects have been reported during treatment. Among them, renal and cardiac toxicities are rare complications. Recently we experienced a case of hemolytic uremic syndome found in a 40-year old male undergoing interferon-alpha therapy for chronic myelogenous leukemia, chronic phase. On admission, his chief complaints were generalized edema and azotemia. Bone marrow biopsy revealed transformation into accelerated phase. bcl/abl gene was positive. Peripheral blood smear showed hemolytic anemia. Despite prompt diagnosis, institution of plasmapheresis, and steroid, his renal function did not recover, as expected. Hemolytic uremic syndrome was a chronic form of renal toxicity due to interferon- alpha. In this case, renal function did not recovered to normal level. However, early detection of renal toxicity such as proteinuria or acute tubular necrosis, and the discontinuation of interferon-alpha could achieve the recovery of normal renal function. Therefore, periodic examination of renal function should be performed in the patients with the use of long-term interferon-alpha. (Korean J Nephrol 2002; 21(2):341-347)
Confocal Laser Endomicroscopy and Molecular Imaging in Barrett Esophagus and Stomach
Kwi-Sook Choi,Hwoon-Yong Jung 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.1
Detection of premalignant lesions in the upper gastrointestinal tract may facilitate endoscopic treatment and improve survival. Despite technological advances in white light endoscopy, its ability to detect premalignant lesions remains limited. Early detection could be improved by using advanced endoscopic imaging techniques, such as magnification endoscopy, narrow band imaging, i-scanning, flexible spectral imaging color enhancement, autofluorescence imaging, and confocal laser endomicroscopy (CLE), as these techniques may increase the rate of detection of mucosal abnormalities and allow optical diagnosis. The present review focuses on advanced endoscopic imaging techniques based on the use of CLE for diagnosing premalignant lesions in Barrett esophagus and stomach.
( Kwi-Sook Choi ),( Segyeong Joo ),( Hwoon-Yong Jung ),( Seung-Jae Myung ),( Kee Wook Jung ),( Ho June Song ),( Seon-Ok Kim ),( Hye Ok Kim ),( So Young Seo ),( Jae Seung Kim ),( Ji Yong Ahn ),( Jeong 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: High-resolution Impedance Manometry (HRIM) is used to detect complete versus incomplete bolus transit. Three-Dimensional Volume of Inverted Impedance (VII) was developed to measure the remnant impedance volume between each swallow. However, its clinical usefulness and meaning were not fully evaluated. Radionuclide esophageal transit scintigraphy (RETS) has been used to determine bolus transit in esophageal motor disorders. Here we aimed to investigate the absolute measurement of bolus transit based on the 3-D volume of impedance and its clinical meaning by assessing its relationship with RETS. Methods: Thirty-one patients who underwent both HRIM and RETS were enrolled in this study. Twenty-nine of these patients were diagnosed with achalasia and two patients were normal. Each patient underwent HRIM using a catheter with 32 circumferential pressure and 16 impedance sensors. The impedance profi les were converted to ASCII fi les and analyzed with the MATLAB program. VII was plotted after transforming the data to a cubic spline interpolation followed by resampling the manometry position at 0.2-cm intervals. The VII between swallows was categorized into four different 5-second frames. RETS was performed by using 99mTc-DTPA, and remnant radionuclide in the lumen of esophageal body was measured at 1,5,10,15,and 20 minutes ofinterval after swallowing. Results: A total of 40 HRIM and RETS procedures were analyzed (nine patients with achalasia underwent both tests twice before and after treatment). The mean VII value of the later 15 second frames from each swallow showed a signifi cant positive correlation to the 20-minute RETS (r=0.31, P=0.04). Moreover, the mean VII value of the later 10-second frames also showed a signifi cant positive correlation to 20-minute RETS (r=0.32, P=0.04). Conclusions: The newly developed VII method may have a close relationship with the currently using RETS despite different protocols.
최귀숙 ( Kwi Sook Choi ),변정식 ( Jeong Sik Byeon ),윤순만 ( Soon Man Yoon ),김경조 ( Kyung Jo Kim ),예병덕 ( Byong Duk Ye ),명승재 ( Seung Jae Myung ),양석균 ( Suk Kyun Yang ),김진호 ( Jin Ho Kim ) 대한장연구학회 2008 Intestinal Research Vol.6 No.1
Background/Aims: There are a limited number of studies concerning the outcomes of diverticulitis in the Oriental population. We sought to evaluate the clinical features and the long-term outcomes of diverticulitis in Korean patients. Methods: We retrospectively reviewed the clinical courses of 104 patients (59 men, 45 women; median age 48.5 years [range: 24-83 years]) hospitalized for their first episode of diverticulitis between 1989 and 2005. Results: Right-sided diverticulitis was more common (71/104, 68%). However, the proportion of left-sided diverticulitis increased as age increased. Thirty-two patients underwent operations: 30 because of complications and 2 because of presumed appendicitis. Left-sided diverticulitis was an independent risk factor for complications (OR=7.6, p< 0.001), and it required surgical treatment more often than right-sided diverticulitis did (61% vs. 17%, p<0.001). Eighty-five patients were followed for a median of 36 months. Four of the 62 medically treated patients developed recurrence of diverticulitis, with a 3-year cumulative recurrence rate of 4.8%. None of the 4 recurrences showed complications, and all were successfully managed using conservative treatment. No predictive factors for the recurrence of diverticulitis could be determined. Conclusions: The recurrence rate and risk of complications associated with recurrence are low in patients treated conservatively for the first episode of diverticulitis. Therefore, elective surgery to prevent recurrence and complications should be utilized sparingly in patients with diverticulitis. (Intest Res 2008;6:37-44)
Antiviral Activity of Yogurt against Enterovirus 71 in Vero Cells
Choi, Hwa-Jung,Song, Jae-Hyoung,Park, Kwi-Sung,Baek, Seung-Hwa,Lee, Eun-Sook,Kwon, Dur-Han 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.2
Five yogurts were fermented with each bacteria strain. The viability and pH of each yogurt during fermentation or storage were evaluated, and then the cytotoxicity and antiviral activity against enterovirus (EV) 71 of cell-free supernatants (CFS) of the metabolites of each yogurt were compared with those of de Man, Rogosa, and Sharpe (MRS) broth fermented with the same bacteria. As the results, the number of viable bacteria for each yogurt after fermentation or during storage always remained higher than 5 log CFU/mL and the pH of those ranged from 4 to 6. The CFS of all yogurts showed antiviral activity over 45% against EV71, while it didn't exhibit cytotoxicity in Vero cells. Specially, the CFS of yogurt fermented with Lactobacillus plantarum and Bifidobacterium bifidum exhibited high anti-EV71 activity of 92.74 and 90.44%, respectively. In contrast, the CFS of each MRS broth fermented with the same bacteria showed low antiviral activity of less than 30%.