Transcatheter Arterial Embolization of Renal VX-2 Carcinoma: Ethiodol-Ethanol Capillary Embolization Combined with Carboplatin

Andras Konya,최병길,Carolyn S. Van Pelt,Kenneth C. Wright 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.2

Objective: We wanted to determine whether transcatheter Ethiodol-based capillary embolization in combination with carboplatin could improve the efficiency of a 1:1 Ethiodol-ethanol mixture (EEM) to ablate kidneys that been inoculated with VX-2 carcinoma. Materials and Methods: The right kidney in 34 New Zealand white rabbits were inoculated with fresh VX-2 tumor fragments. One week later, the kidneys were subjected to transarterial treatment (4 5 rabbits/group): Saline infusion (Group 1); carboplatin infusion (5 or 10 mg, Groups 2A and 2B); carboplatin- Ethiodol (CE) alone (Group 3) and followed by main renal artery occlusion with ethanol (RAO) (Group 4); carboplatin-EEM (C-EEM) followed by RAO (Group 5); carboplatin infusion followed by EEM plus RAO (Group 6); and EEM followed by RAO (Group 7). The animals were followed for up to 3-weeks. The treated kidneys were evaluated angiographically and macroscopically. The kidneys that showed successful embolization macroscopically were entirely cut into serial sections, and these were examined microscopically. Histologically, the kidneys were evaluated on the basis of the residual tumor found in the serial sections. Results: The results obtained with carboplatin infusion alone (Groups 2A and 2B) and CE without RAO (Group 3) were similar to those of the control animals (Group 1). Kidneys from Groups 4 7 demonstrated macroscopically successful embolization with histologically proven complete renal parenchyma infarction; however, some residual tumor was evident in all but one animal. Conclusion: None of the Ethiodol-based modalities combined with locoregional carboplatin were more efficacious for tumor ablation than EEM alone.

Saving and Growth: Granger Causality Analysis with Bootstrapping On Panels of Countries

Laszlo Konya 한양대학교 경제연구소 2005 JOURNAL OF ECONOMIC RESEARCH Vol.10 No.2

Session 1 B TILLAGE & TERRAMECHANICS : Identification of Dynamic Parameters of the Rubber Cravles System for Farm Machinery

(E. Inoue),(H. Konya),(Y. Hirai),(R. Noguchi),(K. Hashiguchi),(C. J. Seod) 한국농업기계학회 2000 Agricultural Mechanization in Korea Vol.2 No.14

Evaluation and follow-up of pain, fatigue, and quality of life in COVID-19 patients

Sevda Adar,Petek Şarlak Konya,Ali İzzet Akçin,Ümit Dündar,Neşe Demirtürk 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.1

Objectives: We evaluated pain, fatigue, anxiety, depression, and quality of life in patients hospitalized for coronavirus disease 2019 (COVID-19) and observed them over a period of 3 months. We also investigated the relationship of these symptoms to age, sex, disease severity, and levels of anxiety and depression. Methods: The study included 100 confirmed COVID-19 patients (i.e., positive on a polymerase chain reaction test) between the ages of 18 and 75 years. Pain (visual analog scale [VAS]), fatigue (fatigue severity scale), anxiety, and depression (hospital anxiety and depression scales) were evaluated on the first day of hospitalization and at 1-month and 3-month follow-ups. The short form-12 questionnaire was used to measure quality of life at the 1-month and 3-month follow-ups. Results: No differences were found in pain, fatigue, anxiety levels, depression levels, and quality of life according to disease severity. High VAS scores at hospital admission were related to continued pain at the 3-month follow-up (odds ratio [OR], 1.067; p<0.001). High VAS (OR, 1.072; p=0.003) and anxiety levels (OR, 1.360; p=0.007) were related to severe fatigue at the 3-month evaluation. Conclusion: Pain, fatigue, anxiety, and depression appear to be long-term sequelae of COVID-19 and can affect quality of life. High VAS and anxiety levels were found to be associated with long-term fatigue.

The Influence of Mechanic Factors in Disc Degeneration Disease as a Determinant for Surgical Indication

Gulden Demirci Otluoğlu,Deniz Konya,Zafer Orkun Toktas 대한척추신경외과학회 2020 Neurospine Vol.17 No.1

Objective: Low back pain is the most common reason for physician visit in Western population. It’s one of the factors that affect health-related quality of life. Intervertebral disc degeneration is one of the leading factors for low back pain and disc degeneration needs serious attention. In this article, we try to summarize biomechanical factors on the degenerative process. Methods: Patients with low back pain in Neurosurgery Department between January 2012 and June 2019 are searched for this study. The patients were gathered under 2 groups; surgical intervention and conservative treatment groups. Intervertebral disc degeneration was assessed by Pfirrmann grading system. All spinopelvic parameters were measured by using standardized lateral plain standing lumbar radiographs. Results: There were 165 patients in the surgical group (60 females, 105 males) and 84 patients in the conservative group (57 females, 27 males) after randomization. One hundred fifty patients had microdiscectomy and 15 patients had spinal instrumentation with transforaminal lumbar interbody fusion. There was not a statistically significant difference between surgical intervention and conservative treatment groups when comparing disc degeneration status. There was a statistically significant difference in parameters lumbar lordosis (LL), L4–S1, and pelvic incidence-LL (PI–LL) between the 2 treatment groups. In the surgical group when we further analyze the spinopelvic parameters in between the 2 different surgical techniques; L4–S1, pelvic tilt, and PI–LL showed a statistically significant difference. Conclusion: Degenerative disc disease is related with multiple factors which can be detailed under the mechanic components and the genetic components. Of these factors, spinopelvic parameters seem highly penetrating to patients’ surgery needs with degenerative disc disease independently.

Biological Approaches to Treating Intervertebral Disk Degeneration: Devising Stem Cell Therapies

Han, Inbo,Ropper, Alexander E.,Konya, Deniz,Kabatas, Serdar,Toktas, Zafer,Aljuboori, Zaid,Zeng, Xiang,Chi, John H.,Zafonte, Ross,Teng, Yang D. Cognizant Communication Corp. 2015 CELL TRANSPLANTATION Vol.24 No.11

Application of carbon nanotubes to silicon nitride matrix reinforcements

Cs. Bal?zsi,F. Weber,Zs. Kover,Z. Shen,Z. Konya,Zs Kasztovszky,Z. Vertesy,L.P. Biro,I. Kiricsi,P. Arato 한국물리학회 2006 Current Applied Physics Vol.6 No.2

tiwall carbon nanotube (MWNT) reinforced silicon nitride composites. Morphological, structural, compositional investigations, aswell as mechanical characterization have been performed. The rst results show that carbon nanotubes have been preserved in com-posite structure during these two high-temperature processes. Carbon nanotubes have been found to have good adherence to thesilicon nitride grains as observed for both processing methods. Moreover, carbon nanotubes may serve as crystallization sitesand seeds for silicon nitride grain growth. Signicant dierences have been found between composites prepared by these two sin-obtained by spark plasma sintering. The conventional sintering resulted in partially densied composites with coarser grainstructure

Tubular inorganic nanostructures

I. Kiricsi,D. Fudala,D. Mehn,A. Kukovecz,Z. Konya,M. Hodos,E. Horvath,M. Urban,T. Kanyo,E. Molnar,R. Smajda 한국물리학회 2006 Current Applied Physics Vol.6 No.2

Tubular inorganic nanostructures are high aspect ratio nanomaterials possessing few nanometer wide inner channels. We reporton our studies about engineering the chemical composition, morphology and pore size of carbon, silica and titania nanotubes as wellas of mesoporous silicate MCM-41. The former three systems represent three dierent classes of inorganic nanotubes, since theyexhibit superior catalyst support properties as well.

Migration of Rod into Retroperitoneal Region: A Case Report and Review of the Literature

Yaşar Bayri,Murat Sakir Eksi,Ramazan Doğrul,Demet Yalçinkaya Koç,Deniz Konya 대한척추신경외과학회 2014 Neurospine Vol.11 No.4

Spinal stabilization with fusion is the widely used method for traumatic or pathologic fracture of spine, spinal stenosis, and spondylolisthesis. Complications may emerge during or after the operations. Infection, hematoma and neurological deficits are early noticed findings. Screw and/or rod fractures present in long-term after surgery. Rod migration in out of the spinal column is a rare entity. A 67-year-old woman was visited our clinic for right leg pain. She had a previous spinal instrumentation surgery for spondylolisthesis in another center 6 years before. After radiological work-up, a distally migrated rod piece was observed in the retroperitoneal portion. The patient was operated for degenerative change; old instruments were replaced and extended to the L2 level with posterior spinal fusion. After the operation, her right leg pain improved. The asymptomatic migrated rod piece has regularly been followed clinically and radiologically, since then. Although it has rarely been reported, migration of the instrumentation material should be kept in mind. Spinal fixation without fusion makes the mechanical system vulnerable to motion effects of spine, especially in a degenerative and osteoporotic background. Long-term, even life-long follow-up is necessary for late term complications.

Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Ahmed B. Bayoumi,Oyku Ikizgul,Ceren Nur Karaali,Selma Bozkurt,Deniz Konya,Zafer Orkun Toktas 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.6

Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs as a part of the medical management of diseases of the spine. Our review article describes a systematic method using the PubMed/Medline database with a specific set of keywords to identify such benefits and drawbacks based on 17 original relevant articles published between January 2000 and February 2018; this provides the community of spine surgeons with available cumulative evidence contained within two tables illustrating both observational (10 studies; three cross-sectional, three case-control, and four cohort studies) and interventional (seven randomized clinical trials) studies. While tricyclic antidepressants (e.g., amitriptyline) and duloxetine can be effective in the treatment of neuropathic pain caused by root compression, venlafaxine may be more appropriate for patients with spinal cord injury presenting with depression and/or nociceptive pain. Despite the potential associated consequences of a prolonged hospital stay, higher cost, and controversial reports regarding the lowering of bone mineral density in the elderly, antidepressants may improve patient satisfaction and quality of life following surgery, and reduce postoperative pain and risk of delirium. The preoperative treatment of preexisting psychiatric diseases, such as anxiety and depression, can improve outcomes for patients with spinal cord injury-related disabilities; however, a preoperative platelet function assay is advocated prior to major spine surgical procedures to protect against significant intraoperative blood loss, as serotonergic antidepressants (e.g., selective serotonin reuptake inhibitors) and bupropion can increase the likelihood of bleeding intraoperatively due to drug-induced platelet dysfunction. This comprehensive review of this evolving topic can assist spine surgeons in better understanding the benefits and risks of antidepressant drugs to optimize outcomes and avoid potential hazards in a spine surgical setting.