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Biological Approaches to Treating Intervertebral Disk Degeneration: Devising Stem Cell Therapies
Han, Inbo,Ropper, Alexander E.,Konya, Deniz,Kabatas, Serdar,Toktas, Zafer,Aljuboori, Zaid,Zeng, Xiang,Chi, John H.,Zafonte, Ross,Teng, Yang D. Cognizant Communication Corp. 2015 CELL TRANSPLANTATION Vol.24 No.11
Karaoz, Erdal,Tepekoy, Filiz,Yilmaz, Irem,Subasi, Cansu,Kabatas, Serdar The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.2
Objective : Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestin-positive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. Methods : rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, $S100{\beta}$, brain derived neurotrophic factor (BDNF), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor $[TGF]-{\beta}$, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors. Results : rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), ${\beta}3$-tubulin and nestin as well as anti-inflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined. Conclusion : Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.
Omer Ozdemir,Furkan Diren,Osman Boyali,Erdinc Civelek,Serdar Kabatas 대한척추신경외과학회 2021 Neurospine Vol.18 No.2
Objective: To evaluate the quality and reliability of carpal tunnel syndrome surgery videos on YouTube. Methods: A keyword set of “carpal tunnel syndrome surgery” was searched on YouTube. The DISCERN scoring system, Journal of the American Medical Association (JAMA) scoring system, and Health on the Net (HON) ranking systems were used to evaluate the quality and reliability of the first 50 videos appeared in the search results. The characteristics of each video, such as the number of likes, dislikes and views, upload days, video length, and the uploader, were collected retrospectively. The relationships between the video quality and these factors were investigated statistically. Results: All of the featured videos sorted were found to be of poor content (mean DISCERN score [n=1.71 of 5], mean JAMA score [n=1.76 of 4], mean HON score [n=5.65 of 16]). Yet, DISCERN scores of the videos uploaded by medical centers were higher than that of the others (p=0.022). No relationship was detected between the other variables and video quality. Conclusion: Healthcare professionals and organizations should be more cautious when recording and uploading a video to the online platforms. As those videos could reach a wide audience, their content should provide more information about possible complications of a treatment and other treatment modalities.
Kabataş Memiş Esra,Çakan Akkaş Büşra Nur 서울대학교 교육연구소 2020 Asia Pacific Education Review Vol.21 No.3
This study aimed to investigate the effects of the argumentation-based inquiry (ABI) approach on the critical thinking skills of fifth-grade students in a secondary school using a hybrid method. Using an experimental research model, the study had a semi-experimental design form with pre-test and post-test control groups. It was conducted in a middle school in Kastamonu with fifth-grade students from two classes during the fall semester of the 2016–2017 academic year. One of the groups was randomly assigned as the control group and the other as the experimental group. The science classes for the experimental group included activities fitting the ABI approach. In the control group, the lessons were carried out with frequently used teaching techniques such as lectures, question-and-answer and demonstrative experiments. The activities were implemented during the units “Measuring the Size of a Force” and “Matter and Change”. A Critical Thinking Test was used to measure the critical thinking skills of the groups at the beginning and the end of the study. T-test and ANCOVA analyses were applied to the quantitative data using the SPSS software. At the end of the study, semi-structured interviews were conducted with 12 students; six students from each group. The interviews were analysed using the Nvivo 11 software to obtain themes and codes. The evaluation of the quantitative and qualitative findings revealed that the ABI approach used in science lessons had improved the critical thinking skills of the experimental group students.
Esra KABATAŞ MEMİŞ,Esma KARAKUŞ 서울대학교 교육연구소 2021 Asia Pacific Education Review Vol.22 No.3
This mixed-method study aimed to compare the academic achievements of students to their use of argument maps and concept maps in learning environments designed for argument-based instruction (ABI). The study was conducted during the spring term of the academic year 2018–2019 with the students of three sections of grade six instructed by the same teacher at a secondary school in the province of Kastamonu. Before the study began, one of the participating sections was randomly designated as the control group, while the other two were assigned as the experimental group. The control group students undertook research interrogation-based activities during lessons and individually reported activities appropriate for the ABI student template for each activity. The experimental group students handled ABI applications. In addition, one section of the experimental group prepared concept maps, while the other section made argument maps. The 5-week study was accomplished during the instruction of the “sound and its properties” unit of the curriculum. The data were acquired via a pre- and post-administration of the unit-based success test to measure academic success. Further, semi-structured interviews were conducted to ascertain the opinions of students vis-à-vis the pedagogy. The obtained quantitative data were analyzed using the ANCOVA analysis via the SPSS software. The qualitative data collected through semi-structured interviews were examined by the creation of themes, codes, and frequencies. The experimental group using argument maps or concept maps in addition to ABI applications revealed signifcant outcomes in terms of academic achievements. Further, students expressed the belief that argument and concept maps helped them learn and remember the topic.
Kyoichi Ogawa,Tamon Kabata,Toru Maeda,Yoshitomo Kajino,Hiroyuki Tsuchiya 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.2
Background: Several studies have shown that better placement of the acetabular cup and femoral stem can be achieved in total hip arthroplasty (THA) by using the computer navigation system rather than the free-hand alignment methods. However, there have been no comparisons of the relevant clinical advantages in using the computer navigation as opposed to the manual intraoperative measurement devices. The purpose of this study is to determine whether the use of computer navigation can improve postoperative leg length discrepancy (LLD) compared to the use of the measurement device. Methods: We performed a retrospective study comparing 30 computer-assisted THAs with 40 THAs performed using a simple manual measurement device. Results: The postoperative LLD was 3.0 mm (range, 0 to 8 mm) in the computer-assisted group and 2.9 mm (range, 0 to 10 mm) in the device group. Statistically significant difference was not seen between the two groups. Conclusions: The results showed good equalization of the leg lengths using both computed tomography-based navigation and the simple manual measurement device.