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Kim, Jae Il,Lee, Sang Hyo,Kang, Hwi Ju,Kwon, Doo Yeon,Kim, Da Yeon,Kang, Won Seok,Kim, Jae Ho,Kim, Moon Suk Royal Society of Chemistry 2011 SOFT MATTER Vol.7 No.18
<P>Thermogelling block copolymers are central to a variety of biomedical applications. Here, we examined the thermal phase transition behavior of the MPEG-<I>b</I>-PCL diblock copolymer (MC) with carboxyl (MC–COOH) and amine (MC–NH<SUB>2</SUB>) groups, and their salt forms (MC–COO<SUP>−</SUP>Na<SUP>+</SUP> and MC–NH<SUB>3</SUB><SUP>+</SUP>Cl<SUP>−</SUP>) at the chain ends of the PCL segment. All MC copolymers formed an opaque emulsion sol at room temperature when prepared as 20 wt% aqueous solutions. As the temperature increased from room temperature, a sol-to-gel transition was observed for MC, MC–COOH, and MC–NH<SUB>2</SUB> copolymers, although not for their salt forms (MC–COO<SUP>−</SUP>Na<SUP>+</SUP> and MC–NH<SUB>3</SUB><SUP>+</SUP>Cl<SUP>−</SUP>). Introduction of a carboxyl and an amine group into the PCL segment decreased the crystallinity and hydrophobicity of the PCL block domains, which altered the onset temperature of gelation (the gel temperature range) and the maximum viscosity. We confirmed that the sol-to-gel phase transition behavior, which indicated the formation and destruction of a structured gel network of MC copolymers, depended on the crystallinity and hydrophobicity of the PCL domains in aqueous media.</P> <P>Graphic Abstract</P><P>In this work, we showed that the formation and destruction of a structured gel network of thermogelling block copolymers (MC, MC–COOH and MC–COO<SUP>−</SUP>Na<SUP>+</SUP>) depended on the crystallinity and hydrophobicity of the hydrophobic domains in aqueous media. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1sm05977g'> </P>
Kim, Ju-Hwi,Jang, Woo-Youl,Jung, Tae-Young,Kim, In-Young,Lee, Kyung-Hwa,Kang, Woo Dae,Kim, Seul-Kee,Moon, Kyung-Sub,Jung, Shin Williams & Wilkins Co 2017 Medicine Vol.96 No.15
<P><B>Abstract</B></P><P>Despite the advances in the microsurgical technique and anatomical understanding of the anterior and middle skull base, anterior clinoidal meningiomas are still challenging lesions to resect completely and safely due to their intimate relationship with vital neurovascular structures. We report predictive factors for tumor recurrence and postoperative complications based on surgical outcome of patients with anterior clinoidal meningiomas treated at our institution.</P><P>Fifty-nine consecutive patients with anterior clinoidal meningioma who were surgically treated between March, 1993, and July, 2015, were reviewed retrospectively. For microsurgical tumor removal, orbitocranial or orbitozygomatic (78.0%), extended pterional (15.3%) and subfrontal approach (6.8%) were performed.</P><P>The median follow-up duration was 54.1 months. Gross total resection (GTR, Simpson's grade I or II) was achieved in 38 patients (64.4%). The overall recurrence rate (new lesion in GTR cases and re-growth in non-GTR cases) was 18.6%. GTR (Hazard ratio [HR] 0.014, 95% confidence interval [CI] 0.001–0.256; <I>P</I> = .004), absence of internal feeder (HR 0.058, 95% CI 0.004–0.759; <I>P</I> = .030) and benign pathology (WHO grade I, HR 0.056, 95% CI 0.005–0.674; <I>P</I> = .023) were independent prognostic factors for recurrence-free. Fourteen patients (23.7%) developed permanent complications. The most common complication was cranial nerve injury (n = 6; 10.2%), followed by postoperative hemorrhage/infarction, hydrocephalus and infection. Larger size (≥ 40 mm) was significant as an independent predictive factor for permanent complication (HR 0.139, 95% CI 0.030–0.653; <I>P</I> = .012). Old age (≥60 years, <I>P</I> = .056) and peritumoral edema (thickness ≥ 5 mm, <I>P</I> = .303) did not reach statistical significance in multivariate analysis.</P><P>In surgical resection of anterior clinoidal meningiomas, various clinicoradiological factors were related with resection degree, complication, and progression rate. Although our results showed acceptable resection degree and morbidity, mortality, and recurrence rate, compared to the results of past, anterior clinoidal meningioma remain as neurosurgical challenges because of their close contact to critical vascular and neural structures.</P>
김시영,김태형,이동호,이상목,김정훈,조경삼,장영운,윤휘중,박용구,이주희,김명임 대한내과학회 2001 대한내과학회지 Vol.60 No.3
$quot;Primary non-Hodgkin's lymphoma of the liver, an organ normally devoid of a native lymphoid tissue, is very rare. We report a case of primary hepatic T-cell lymphoma in a 18-year-old girl, with review of literature. The pateint admitted with fever for 5 months. The ultrasonography revealed a 10 × 7 cm sized mass in the left lobe of the liver. On abdominal CT, the mass was poorly enhancing and low attenuated. On MRI, the signal intensity of the mass was low in T1 weighted image, heterogeneously high in T2 weighted image, and peripherally enhanced in contrast enhancing T1 weighted image. The biopsy specimen obtained by laparatomy showed anaplastic tumor. The malignant cells were positive for T-cell lineage (CD3, CD44, CD45RO). There was no evidence of the lymphoma in other regions. The patient was treated with CHOP (cyclophosphamide, adriamycin, vincristine and prednisolone) chemotherapy without objective response. The patient died of sudden cardiogenic shock.(Korean J Med 60:260-265, 2001)$quot;
( Hwi Young Kim ),( Jeong-hoon Lee ),( Dong Hyeon Lee ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Sorafenib is the standard therapy for patients with advanced hepatocellular carcinoma (HCC). However, validated biomarkers for prediction of outcome with sorafenib therapy are lacking. The aims were to develop and validate a biomarker-based model for predicting sorafenib response and overall survival (OS). Methods: This prospective cohort study included 124 consecutive patients (44 achieving disease control and 80 experiencing progression) with Child-Pugh class A liver function who received sorafenib for advanced HCC. Potential serum biomarkers (i.e, hepatocyte growth factor [HGF], fibroblast growth factor [FGF], vascular endothelial growth factor receptor-1, CD117, and angiopoietin-2) were tested. After identification of independent predictors of the tumor response, a risk scoring system for predicting OS was developed and 3-fold internal validation was conducted. Results: A risk scoring system was developed using six covariates: etiology of underlying liver disease, fibrosis index score, and serum levels of PIVKA-II, HGF, and FGF (Table 1). When we stratified patients into group A (risk score <9), B (9≤risk score<10), and C (risk score ≥10), this model provided good discriminant functions on tumor response (c-index=0.869) and 12-month survival (AUC=0.825). Median OS times were 17.2 mo in group A, 11.2 mo in group B, and 6.6 mo in group C, respectively (P<0.001, Figure 1). In internal validation, the model maintained good discriminant functions on tumor response (c-index=0.855), 12-month survival (AUC=0.828) and good calibration functions (all P>0.05 between expected and observed values). Conclusions: This new model including serum FGF and HGF showed good performance in the prediction of response to sorafenib as well as survival in patients with advanced HCC. Value of those serum markers in risk stratification and decision of therapeutic agents needs further studies.
Kim, Seong-Yeon,Na, Yeon-Joo,Kim, Dong-Ju,Kim, Yeong-Seok,Kim, Hyeong-Min,Hwang, Sung-Ha,Kwak, Ji-Yeon,Kuh, Hyo-Jeong,Lee, Jae-Hwi The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3
The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion ($Fe^{3+}$) and xylenol orange, often called FOX assay and subsequent monitoring of absorbance values of the reactant at 540 nm. The reaction was to some extent pH-dependent and detection sensitivity was greatest at pH 1.75. Genistein liposomal gel demonstrated better anti-oxidative effect with regard to lowering hydrogen peroxide levels elevated by UVB irradiation compared to genistein-suspended gel. A linear relationship has been observed between anti-oxidative effect of genistein and drug deposition in the skin tissue. Genistein liposomal gel resulting in the localization of the drug in the deeper skin led to improved anti-oxidative effect compared to genistein gel. The suggested method for evaluation of oxidation of the skin can be used as a tool to screen effective anti-oxidative agents and their delivery systems acting on the skin.