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Construction of amphiphilic networks in blend membranes for CO2 separation
Jiangnan Wang,Xia Lv,Lu Huang,Long Li,Xueqin Li,Jinli Zhang 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.1
Blend membranes have attracted great attention because they can combine the advantages of different polymers. To investigate the effect of amphiphilic polymer on the separation performance of blend membranes, a series of blend membranes were designed and fabricated by blending an amphiphilic polymer of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) into poly(ether-block-amide) (Pebax) polymer for CO2 separation. For the as-prepared Pebax/PEDOT:PSS blend membranes, the interconnected CO2-philic networks were constructed by hydrophilic anionic chains of PSS− for accelerating CO2 transport. Meanwhile, non-CO2-philic networks were constructed by the hydrophobic cationic chains of PEDOT+, which distributed around the PSS− chains to provide low friction diffusion for CO2. Therefore, the amphiphilic polymer of PEDOT:PSS was an excellent material for improving CO2 separation performance of blend membranes. The results showed that the Pebax/PEDOT:PSS blend membranes were endowed with excellent CO2 separation performance. Pebax/PEDOT:PSS blend membrane demonstrated the optimal separation performance with a CO2 permeability of 440.2±3.3 Barrer and a CO2/CH4 separation factor of 28±0.6. This study indicates that introducing the amphiphilic polymer into the blend membranes is an efficient strategy for gas separation.
Yuan Zhu,Miaomiao Wang,Jiajia Zhang,Wei Peng,Caleb Kesse Firempong,Wenwen Deng,Qilong Wang,Shicheng Wang,Feng Shi,Jiangnan Yu,Ximing Xu,Weiming Zhang 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study innovatively prepared an effectivecapsaicin-loaded liposome, a nanoformulation with fewerirritants, for oral administration. The in vitro and in vivoproperties of the liposomal encapsulation were investigatedand the potential possibility of oral administration evaluated. The liposomal agent composed of phospholipid, cholesterol,sodium cholate and isopropyl myristate was prepared usingfilm-dispersion method. A level A in vitro–in vivo correlation(IVIVC) was established for the first time, which demonstratedan excellent IVIVC of both formulated and freecapsaicin in oral administration. Physicochemical characterizationsincluding mean particle size, zeta (f) potentialand average encapsulation efficiency of capsaicin-loadedliposome were found to be 52.2 ± 1.3 nm, -41.5 ±2.71 mv and 81.9 ± 2.43 %, respectively. In vivo, liposomalencapsulation allowed a 3.34-fold increase in relativebioavailability compared to free capsaicin. The gastricmucosa irritation studies indicated that the liposomal systemwas a safe carrier for oral administration. These resultssupport the fact that capsaicin, an effective drug for thetreatment of neuropathic pain, could be encapsulated inliposome for improved oral bioavailability. The excellentIVIVC of capsaicin-loaded liposome could also be a promisingtool in liposomal formulation development with anadded advantage of reduced animal testing.
An Efficient Response Distribution Function for 3D MIMO Channel Modeling from a Scatterer View
Sheng Deng,Yuhao Wang,Jiangnan Yu,Henry Leung,Huilin Zhou,Bo Kong 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.10
A Radio Environment Map (REM) maps its geolocation information to the propagation characteristics as complementary information for an adaptive communication of cognitive radio (CR). In this paper we propose a novel theoretical three dimension (3D) Multiple Input Multiple Output (MIMO) channel model. The proposed model parameterizes the geolocation information of interacting obstacles referred as scatterers. An efficient response distribution function (ERDF) is developed to interpolate the array response for an arbitrary scatterer location. It is shown that the mutual information of the proposed model is consistent with a conventional geometry-based model with the lower simulation time. It allows us to generate channels with all possible scatterer distribution on the surface of a building effectively.
IL-17 Imbalance Promotes the Pyroptosis in Immune-Mediated Liver Injury Through STAT3-IFI16 Axis
Wenfang Xu,Yanan Wang,Changzhong Jin,Weiyang Zhang,Jiangnan Chen,Xuefang Chen,Junli Gao,Junshun Gao,Hong Wang 대한면역학회 2023 Immune Network Vol.23 No.6
Autoimmune hepatitis (AIH) affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with cell bursting and release of proinflammatory cytokines. A deeper understanding of AIH pathogenesis will contribute to novel therapy for AIH patients. Here, we aimed to investigate the role of IL-17 in immune-mediated liver injury. The levels of cytokines were measured by ELISA, and mRNA levels of STAT3 and IFN gammainducible protein 16 (IFI16) were detected by PCR. Expressions of STAT3, IFI16, gasdermin D and cleaved caspase-1 were measured by western-blotting. Immunohistochemical staining and transmission electron microscopy were applied to evaluate liver histopathological changes of the treated mice. Our results showed that the levels of IFI16 was increased in hepatocytes treated with IL-17 protein, and further elevated after STAT3-overexpressed (STAT3-OE) lentivirus treatment. The levels of IFI16 were reduced in hepatocytes treated with IL-17 neutralizing Ab (nAb), but were significantly increased after STAT3-OE treatment. Pyroptosis was observed in hepatocytes treated with IL-17 protein, and further cell damage was observed after STAT3-OE lentivirus treatment. Liver damage was alleviated in mice treated with IL-17 nAb, however sever damage was experienced after STAT3-OE lentivirus treatment. A binding interaction between IFI16 and STAT3 was detected in IL-17 treated hepatocytes. Glutathione transaminase activity was enhanced in concanavalin A-induced AIH mice compared to the control group (p<0.01). IL-17 plays an important role in activating STAT3 and up-regulating IFI16, which may promote the pyroptosis in AIH-related liver injury through STAT3-IFI16 axis.
Yuan Zhu,Shanshan Tong,Li Wang,Min Peng,Xia Cao,Ximing Xu,Jiangnan Yu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
Mixed micelles made of polyvinylpyrrolidone (PVP), sodium cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs. Sylibin, a drug used in treating liver diseases, was incorporated into the mixed micelles. The formulation of sylibin containing PVP-sodium cholate-phospholipid mixed micelles with an optimized composition (PVP/sodium cholate/phospholipid/silybin = 3:3:4:1~2 by weight) was obtained based on the study of pseudoternary phase diagrams. The critical micelle concentration was used to evaluate the micellar stability towards dilution. The results showed that addition of PVP to sodium-cholate-phospholipid mixed micelles increased stability. The solubility of sylibin in PVP-sodium cholate-phospholipid mixed micelles was higher than that in pure water or in sodium cholate-phospholipid mixed micelles. In a stability study, we found that PVP-sodium cholate-phospholipid mixed micelles showed good stability. After 3 months storage at 40oC, just 2.6% sylibin was lost with only minor changes of the particle size when compared to a reference formulation containing sodium cholate and phospholipid mixed micelles. In addition, the developed formulation significantly improved in vitro drug release. The time required to release 50% sylibin (t50%) from sodium cholate and phospholipid mixed micelles was 326 h, while the t50% from PVP-sodium cholate-phospholipid mixed micelles was only 51.1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field.
Pure Ultraviolet Emission from ZnO Quantum Dots-Based/GaN Heterojunction Diodes by MgO Interlayer
Cheng Chen,Renli Liang,Jingwen Chen,Jun Zhang,Shuai Wang,Chong Zhao,Wei Zhang,Jiangnan Dai,Changqing Chen 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.4
We demonstrate the fabrication and characterization of ZnO/GaNbasedheterojunction light-emitting diodes (LEDs) by using air-stableand solution-processable ZnO quantum dots (QDs) with a thin MgOinterlayer acting as an electron blocking layer (EBL). The ZnO QDs/MgO/p-GaN heterojunction can only display electroluminescence(EL) characteristic in reverse bias regime. Under sufficient reversebias, a fairly pure ultraviolet EL emission located at 370 nm derivingfrom near band edge of ZnO with a full width at half maximum(FWHM) of 8.3 nm had been obtained, while the deep-level emissionhad been almost totally suppressed. The EL origination andcorresponding carrier transport mechanisms were investigatedqualitatively in terms of photoluminescence (PL) results and energyband diagram.