가감청영탕(加減淸營湯)에 효과를 보인 열성 아토피 피부염 환자 6례 증례 보고

서지혜,정창환,박선정,임소영,한수련,Seo, Ji-Hye,Jung, Chang?Hwan,Park, Seon-Jeong,Lim, So-Young,Han, Su-Ryun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

신경회로망을 이용한 이면비드 폭 예측에 관한 연구

정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results

자연발생 라돈가스의 실내축적 문제에 관한 연구

정지환 천안대학교 2001 천안외국어대학논문집 Vol.- No.1

A study on how to reduce in-door accumulation of naturally-born radon gas has been being carried out. The results of the primary stage are discussed in this paper. The legislation about in-door radon in public places was made because radon gas was found to be a carcinogen. The radon gas is naturally created from earth soil and flows upwards to penetrate into buildings. In order to reduce the accumulation of radon gas in an in-door environment the under-standings of radon gas flow are necessary. Radiological characteristics of radon are briefly reviewed and risk of radon is compared with other risks that people are exposed in everyday life. Seven leak paths to buildings are suggested and further research plans are introduced.

肺炎 誘發菌의 生育을 抑制하는 韓藥材 探索에 關한 硏究

정병운,서운교,정지천,한영환 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

韓藥材 중 肺炎의 치료효과가 기대되는 淸熱化痰, 止咳平喘藥을 중심으로 23種의 藥材를 사용하여 肺炎을 유발하는 K. pneumoniae, S. pyogenes 및 S. pneumoniae 세균의 생육을 억제하는 藥材를 탐색하고, 탐색된 藥材의 추출물에 대한 세균의 最小生育抑制濃度를 측정하였다. 韓藥材의 水溶性 추출물 중 黃連, 胡黃蓮, 敗醬, 黃芩이 K. pneumoniae에서, 黃連이 S. pyogenes에 대해서 생육억제 효과가 있었으며, S. pneumoniae에 대한 比較沮止環의 直徑은 黃連, 鳥梅, 五味子, 黃芩이 우수하였으나 黃連 추출물 사용시 병원균 모두에서 生育沮止環의 크기가 가장 크게 나타났으며 對照群로 사용된 大腸菌과 枯草菌에서도 어느 정도의 抗細菌 효과를 볼 수 있었다. 에탄올 추출물에서는 敗醬, 黃芩, 五味子, 鳥梅가 K. pneumoniae 세균의 생육을 억제하였으며, S. pyogenes 세균은 黃連, 五味子, 鳥梅, 馬兜鈴찾, 黃芩에 의하여 생육이 억제되어 黃連은 水溶性 및 에탄올 溶解性 주출물에서 모두 우수한 抗細菌 효과를 보여주고 있다. 각 세균에 대한 最小生育沮止濃度(MIC)는 K. pneumoniae 세균일 경우 黃連 및 黃芩의 水溶性 추출물과 鳥梅 및 敗醬의 에탄올 溶解性 추출물이 유의성을 보였으며, S. pyogenes 세균은 黃連의 水溶性 및 에탄올 溶解性 추출물과 鳥梅의 에탄올 溶解性 추출물, S. pneumoniae 세균은 黃連과 鳥梅의 水溶性 및 에탄올 溶解性 주출물에서 유의성이 나타났다. 이상의 결과를 통하여 黃連, 五味子, 鳥梅, 黃芩, 胡黃蓮, 敗醬의 水溶性 및 에탄올 溶解性 추출물이 肺炎 誘發菌f K. pneumoniae, S. pyogenes, S. pneumoniae에 對하여 우수한 生育抑制 作用을 나타냄을 알 수 있었다. The various oriental herbal medicines, which have usually been used for treatment of reducing fever, purging intense heat and detoxication, were screened to determine the antibacterial activity and the minimal inhibitory concentration against pulmonary disease-causing Klebsiella pneumoniae, Streptococcus pyogenes, and Streptococcus pneumoniae. The results obtained were as follows: 1. Among the 23 oriental medicines tested, the water-soluble extracts of Coptis japonica, Scutellaria baicalensis and Picrorrhiza kurroca showed the antibacterial activity against K. pneumoniae and that of C. japonica against S. pyogenes. The antibacterial activities of C. japonica, Prunus mume, Schizandra chinesis, Scutellaria baicalensis were also found against S. pyogenes. When C. japonica was used, the high antibacterial activity was shown against Bacillus subtilis and other extracts showed a little activity against B. subtilis and E. coli as a control. 2. The ethanol-soluble extracts of Patrinia scabriosaefolia, P. mume, S. baicalensis, S. chinensis showed the antibacterial activity against K. pneumoniae and those of S. baicalensis, C. japonica, S. chinensis P. mume against S. pyogenes and S. pneumoniae. However, those extract showed a little antibacterial activity against B. subttilis and E. coli except for that the extract of C. japonica showed comparatively high growth inhibition of B. subtilis. 3. Among the medicinal herbs tested, the water- and ethanol extracts of C. japonica showed very extcellent antibacterial activity against the pathogenic bacteria and controls. 4. When the water-soluble extracts of C. japonica and S. baicalensis, minimal inhibitory concentrations (MICs) against K. pneumoniae were 10 ㎎/㎖ and 22 ㎎/㎖, respectively. The MICs of the ethanol-soluble extracts of P. mume and P. scabriosaefolia were 5 ㎎/㎖ and 20 ㎎/㎖, respectively. 5. For the MICs against S. pyogenes, C. japonica showed 15 ㎎/㎖ with the water-soluble extract and P. mume and C. japonica with the ethanol-souble extract did 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. 6. For the MICs against S. pneumoniae, C. japonica and P. mume with the water- and ethanol-souble extract showed 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. As a result, the highest antibacterial activity was found in the water- and ethanol-soluble extracts of C. Japonica against pulmonary disease-causing bacteria, K. pneumoniae, S. pyogenes, and S. pneumoniae. Also, the water- and ethanol-soluble extracts of S, chinensis, P. mume, S. baicalensis and P. kurrooa showed high antibacterial activities.

불량행위 청소년을 중심으로 한 학교폭력 가해자의 사회인구학적 특성 및 정신병리(V)

박지도,최현경,장우성,조동환,김정기 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 이 연구는 불량행위 청소년군과 학생군을 대상으로 학교내외에서 행하는 폭력행동의 특징을 알아보고 특히 가해자의 정신병리와 청소년의 폭력행동과의 관계를 알아봄으로써 학교폭력의 이해와 대처방법 그리고 예방프로그램의 수립에 도움이 되고자 한다. 방 법 : 불량행위 청소년(청소년 선도프로그램인 BBS참석자) 남자 331명과 남자 중고등학교생 394명을 폭력의 유형을 괴롭힘, 금품갈취, 신체적 폭력, 언어적 폭력, 위협 등의 5가지 유형으로 나눈 설문문항을 바탕으로 각 경우의 경험빈도를 5점 척도로 하여 각 문항에서 3점 이상을 가해자군으로 분류하였으며 설문지를 통한 조사와 정신병리의 측정도구로서 한국판 아동-청소년 문제행동 평가 척도표(CBCL : Child Behavior Checklist, 청소년용)및 청소년의 자기개념을 알아보기 위해 한국판 피어스-해리스 소아 자기 개념척도(Piers-Harris Children's Self-Concept Scale, Piers, 1984, 이하 자기개념척도)를 적용하였으며 Chi-square test, T-test, 그리고 Two-way ANOVA를 사용하여 비교하였다. 결 과 : 사회 인구학적 특성에서는 대부분의 요인에서 불량행위군과 학생군 그리고 가해자군과 비가해군간에 차이는 보이지 않았으나 흡연과 음주하는 비율이 불량행위군과 학생군 두 군 모두 가해자군이 비가해자군보다 의미있게 높게 나타났다. 부모의 부부싸움 빈도는 불량행위군에서는 가해자와 비가해자군간에 차이를 보이지 않았으나 학생군에서는 가해자군에서 종종 싸운다는 비율이 의미있게 높게 나타났다. 학교생활에서는 성적이나 교우관계에서는 두 군 사이와 가해여부에 따라 유의한 차이를 보이지는 않았으며 성적은 불량행위군이 학생군에 비해 낮은 반면 가해여부에 따라서는 차이가 없었다. 하지만 학생군에서는 가해자군이 비가해자군보다 성적이 낮았으며 만화방을 이용하는 빈도도 가해자군에서 높게 나타났다. 폭력물 시청 시 느낌은 불량행위군과 학생군 모두에게서 가해자군이 비가해자군에 비해 흥분된다는 비율이 높게 나타났다. CBCL(Child Behavior Checklist)척도는 불량행위군의 경우 비행, 공격성, 외현화, 사회성 척도가 학생군에 비해 유의하게 높았고 위축, 사회적 미성숙, 사고문제, 주의집중, 내재화 척도는 학생군에서 불량행위군에 비해 유의하게 높았다. 전체 대상군을 가해자군과 비가해자군으로 나누어 비교하였을 때 신체증상, 사고문제, 주의집중, 비행, 공격성, 내재화, 외현화척도에서 가해자군이 비가해자군에 비해 유의하게 높았으며 군과 가해여부의 상호작용효과 검증결과에서는 유의한 상호작용을 보이는 척도는 없었으나 각 집단의 모든 척도에서 가해자군이 비가해자군보다 높은 점수를 보여주었으며 불량행위군의 경우 가해자군일수록 비행, 공격성, 외현화 척도가 높아지는 경향을 보였으며 학생군의 경우에서도 마찬가지로 비행, 공격성, 외현화 척도에서 가해자군이 비가해자군보다 높게 나타났다. 자기개념 척도는 불량행위군의 경우 행동, 지적학업척도에서 학생군에 비해 유의하게 낮게 나타났으며 불안, 인기척도는 학생군에서 불량행위군보다 유의하게 낮게 나타났다. 전체 대상군을 가해자군과 비가해자군으로 나누어 비교하였을 때 행동, 지적학업척도는 가해자군이 비가해자군에 비해 유의하게 낮은 점수를 보여주었으며 각 군과 가해여부의 상호작용검증결과에서는 유의한 상호작용효과를 보인 것은 없었으나 두 군 모두 행동척도가 가해자군이 비가해자군에 비해 낮은 경향을 보여주었다. 결 론 : 불량행위군과 학생군에서의 폭력가해자는 사회인구학적 변인에서는 비가해자와 유사한 특징을 가지나 각자의 내재된 심리상태와 정신병리에 따라 폭력 영상물과 음주 흡연의 가능성증가 그리고 가정에서의 폭력의 학습 등 주변의 위해 요인에 가해자군이 비가해자군에 비해 영향을 많이 받는 것으로 생각된다. 이에 학교폭력에 대한 대책수립 시 결과에만 초점을 맞춘 처벌 위주의 방식에서 벗어나 이들이 가진 심리적 특징과 정신병리를 이해하고 그에 따른 예방적인 대책수립이 필요할 것으로 생각된다. Objective : The purpose of this study was to identify the characteristics of school violence, self concept, psychopathology and psychosocial characteristics of male aldolescent delinquency doing school violence. And we hoped to use this result as basic material for prevention of school violence through comparison of those of students group. Method : We surveyed 725 male adolescents including 331 deliquents from educational program called "Big Brothers and Sister" in Pusan. We used self-reporting questionnaire composed of demographic data and attitude to violence. In order to investigate the psychopathology and self-concept, we used Child Behavior Check List, Youth edit, Korean version(CBCL) and the Piers-Harris Children's Self-Concept Scale. Statistical methods employed were Chi-square, t-test, two-way ANOVA. Result : The results show that in most demographic and psychosocial factor including age, education, socio-economic condition, religion and relationship with friends, there was no significant difference between delinquent and student group. And there was no significant difference between bully and non-bully in both group. The frequency of alcohol drinking and smoking were higher in bullying groups. For the feeling of watching violent mass-media, bullying delinquents reported more excited state than non-bullying delinquents in both group. On results of CBCL, subscales of delinquent behavior, aggressive behavior, externalizing problem, social scale in delinquent group were higher than those in student group. Subscale of somatic complaints, thought problem, attention problem, delinquent behavior, aggressive behavior, internalizing problem, and externalizing problem in bullying group were higher than those in nonbullying group. In both delinquent and student group, subscale of delinquent behavior, aggressive behavior, and externalizing problem in bullying group were significantly higher than those in nonbully group. In the results of self-concept scale, subscales of behavior, intellectual and school status in delinquent group were lower than those in student group. Subscale of somatic complaints, thought problem, attention problem, delinquent behavior, aggressive behavior, internalizing problem, and externalizing problem in bullying group were higher than those in nonbully group Conclusion : In both delinquent and student groups, most psychosocial factors in bully group were not significantly different with those in nonbully group. Bully group was more influenced by internal psychic state, psychopathology and environmental factor than nonbully group.

디지탈 멀티비젼 ASIC의 설계

류지구,최혁환,차영호,김정헌,조경연 釜慶大學校 1997 釜慶大學校 論文集 Vol.2 No.2

The wide spread of multimedia sysrem deands a large viewing display device which can inform a message to many peoples in open area. This paper is about the design and simulating of a large viewing digital multi-wision control ASIC(Application Specific Integrated Circuit). In this paper. the digital multi-vision ASIC has one channel of imput cideo signal wihich is compliance with CCIR-656 specification and four channels of output video signal which are compliance with CCIR-601 specificarion. It has 2 operating mode. The one is the pass-thro;ugh mode. input vido signal goes to output video signal without any change, and the another one is the expension mode, input video signal is expended by from 2 to 16 times into output video signal. In expension mode. awindow could be programmed and only the input video signal in the window is expended. The 0.6 micron CMOS sEA OF Gate is used to design the ASIC in amount of about 23,000 gates, and it is simulated at 48MHz.

Caffeic Acid의 ONOO^(-) 제거활성

이지영,성도유,노재경,김유정,제정환,김민선,최재수,정해영,이경희 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.3

편측 협응훈련에 의한 운동신경망의 재조직 및 교차훈련의 효과

박지원,김종만,서정환,김연희 한국전문물리치료학회 2002 한국전문물리치료학회지 Vol.9 No.3

We report the reorganization of motor network resulted from intensive unilateral coordination training and the effect of cross education on the untrained side in patient with traumatic brain injury using functional magnetic resonance imaging (fMRI). A 22 year-old male patient who had suffered from diffuse axonal injury for 58 months showed coordination deficit in the left hand at initial examination. Intensive motor training including complex finger movements and coordination activities using a metronome was introduced to the patient 4 hours per day for a week. FMRI was performed on a 3T ISOL Forte scanner. All functional images were analyzed using SPM-99 software. Hand function was improved after training not only in the trained lefr hand, but also in the untrained right hand. There was no activation in the right primary motor area (M1) during left hand movement before training whereas robust activation of left M1 was demonstrated by the right hand movement. Profuse activation of bilateral prefrontal lobes was seen during both hand movements before training. After training of left hand, right M1 became prominently activated during the left hand motion. The activation of bilateral prefrontal lobes disappeared after training not only for the left hand movement but also for the right, which clearly demonstrated the effect of cross education. This case report demonstrated the learning-dependent reorganization of the M1 and the effect of cross education.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

중소규모 사업장 근로자의 직무스트레스로 인한 결근, 조퇴 현황과 한국형직무스트레스 하부요인과의 관련성

김정훈,박신구,김동현,김환철,임종한,이의철,이동훈,이지영 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2

목적: 중소규모 사업장 근로자들의 직무 스트레스로 인한 결근, 조퇴의 현황과 한국형 직무 스트레스 하부 요인과의 관련성을 알아보고자 하였다. 방법: 중소규모 사업장 83곳 근로자들에 대해 한국형 직무스트레스요인 평가도구-단축형(KOSS-SF)과 사회 일반적 특성, 직업적 특정 및 직무스트레스로 인한 결근이나 조퇴 경험여부 등을 묻는 구조화된 자가 기입식 설문을 실시하였고, 응답한 4,350명에 대해 최종 분석을 시행하였다. 직무스트레스로 인한 결근, 조퇴와 한국형 직무스트레스 하부 요인들과의 관련성을 확인하기 위하여 로지스틱 회귀분석을 시행 하였다. 결과: 직무 스트레스로 인한 결근, 조퇴를 한 근로자는 남자에서 7%(196명), 여자에서 8%(113명) 로 조사되었고 한국형 직무 스트레스 하부요인과의 관련성에서는 남, 여 모두 직무요구, 관계갈등, 조직체계, 보상부적절, 직장문화 영역의 스트레스가 높은 군에서 통계적으로 의미있게 직무스트레스로 인한 결근, 조퇴율이 증가하였다. 결론: 중소규모 사업장 근로자들의 직무 스트레스로 인한 결근, 조퇴와 한국형 직무 스트레스 하부요인과의 관련성은 남자에서는 조직체계 영역이 가장 높았고, 여자는 직장문화 영역에서 가장 높은 관련성을 보였다. Objective: The aim of this study was to examine the actual conditions of absence and early leave due to job stress of 4,350 workers in 83 small and medium scale industries, and its relationship to job stress factors using Korean Occupational Stress Scale-Short Form (KOSS-SF). Methods: A structured self-reported questionnaire was used to assess each respondent's Sociodemographics, job stress, experience of absence and early leave due to job stress. Seven KOSS-SF domains of job stress were used. We estimated the relation of absence and early leave due to job stress and job stress factors using logistic regression analyses. Results: Absence or early leave due to job stress occurred in 7% of male workers and 8% of female workers. Multiple regression analysis revealed a significantly positive association job stress-related absence/early leave and job demand, interpersonal conflict, organizational system, lack of rewards and occupational climate. Conclusions: Absence and early leave due to job stress is significantly attributed to organizational System and lack of reward for men, and occupational climate and organizational system for women.