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중증 허혈성 지체질환 환자에서 시행된 vascular endothelial growth factor의 혈관신생 유전자치료 1예
김현중,장신이,김종묵,김선영,김병문,김원배,김덕경 대한내과학회 2003 대한내과학회지 Vol.64 No.1
저자 등은 기존의 치료에 반응하지 않은 중증 허혈성 지체질환 환자를 대상으로 하여 vascular endothelial growth factor를 이용한 혈관신생 유전자 치료를 시행하였다. 치료 후 환자의 허혈에 의한 하지 통증이 현격하게 감소하고 상처의 진행이 측부혈관이 많이 증가됨이 관찰되어 이에 문헌고찰과 함께 보고하는 바이다. We report VEGF-induced angiogenic gene therapy in a patient with critical limb ischemia, who did not respond to conventional treatment. This patient was the first case in a dose-escalating series of phase I clinical trial. The patient had severe resting pain, gangrene and diffuse ulcer in his left foot. Total 1,000㎍ of naked DNA encoding human VEGF165 was administered intramuscularly to 8 sites of the loft lower extremity. Four weeks after the first 1,000㎛ was administered to the same sites (total dose: 2,000㎛). After gene therapy, resting pain gradually reduced and the amount of analgesics taken by the patient decreased. The ischemic wound of lower extremity slightly improved. However, there was no complete wound healing at 12 weeks of treatment. Digital subtraction angiography at 12 weeks after gene therapy showed an increase in collateral vessels at the mid-tibial, ankle and foot arch levels. Immediately and up to 12 weeks, there was no complication related to gene therapy. These findings may be cautiously interpreted to indicate that intramuscular injection of naked plasmid DNA of VEGF_165 may induce therapeutic angiogencsis in a patient with critical limb ischemia. Further clinical evaluation of VEGF-induced gene therapy is needed to evaluate the safety and efficiency of this treatment.(Korean J Med 64:85-90, 2003)
석탄회로 합성한 제올라이트에 대한 암모니아성 질소 흡착특성 조사
류완호,이원묵,백일현,배장순 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.4
국내 석탄화력 발전소에서 폐기되는 석탄회를 이용하여 폐수 중 암모니아성 질소 제거용 흡착제를 제조하고자 NaOH를 반응물로 한 수열합성 반응을 이용, 제올라이트를 합성하였으며 제조된 제올라이트를 실제공정에 활용하기 위하여 흡착실험 및 공정모사를 수행하였다. 또한 흡착제를 구형으로 제조하여 암모니아성 질소의 등온 흡착 공정에 이용하였으며 이 결과 Langmuir식에 잘 일치함을 알 수 있었다. 고정층에서의 흡착 거동은 축 방향 분산흐름, 입자 내부에서의 표면 확산 및 Sips 흡착 등온식을 바탕으로 한 고정층 흡착모델의 주요 공정 변수에 대한 파과곡선을 잘 모사할 수 있음을 확인할 수 있었다. Zeolite was synthesized from coal fly ash produced by a domestic power plant and applied for the removal of ammonia from waste water. Zeolite was synthesized using a hydrothermal method involving an akaline reaction with NaOH, and adsorption experiments and simulations were conducted. Adsorption experiments with the pelletized spherical zeolite were carried out. The experimental data obtained from adsorption isotherms agreed well with the Langmuir equation. Also, most of the correlated results for the fixed bed model based on surface diffusion and Sips adsorption isotherms equation were consistent with the experimental data.
PLASTICIZATION OF CHITOSAN MEMBRANE FOR PERVAPORATION OF AQUEOUS ETHANOL SOLUTION
Won, Jang Mook,Bae, Seong Youl,Ha, Baik Hyun,Kim, Hee Taik,Kumazawa, Hidehiro 한국화학공학회 1996 Korean Journal of Chemical Engineering Vol.13 No.3
The process of pervaporation in which two components diffuse through a nonporous polymer membrane was modelled when one of the penetrants can exert a plasticization action to the membrane material. Thereat a phenomenological model was employed for describing the plasticization effect on the diffusivities for penetrants in the membrane. The sorption equilibria and permeation fluxes for aqueous ethanol soletions in a chitosan membrane were measured, and the permeation fluxes for water were compared with those predicted by the proposed model. The concentration of sorbed water was linear with its weight fraction (x_A) in the feed solution, whereas the permeation flux of water was affected by the plasticization action of sorbed water to the polymer. This plasticization effect on the diffusion process can be simulated in terms of the proposed phenomenological model.
장하은 ( Ha-eun Jang ),장지민 ( Ji-min Jang ),허민희 ( Min-hee Heo ),노진원 ( Jin-won Noh ),김장묵 ( Jang-mook Kim ) 대한보건협회 2021 대한보건연구 Vol.47 No.3
목적 : 본 연구에서는 인구사회학적 요인을 통제하여 안전벨트 착용에 따른 음주운전 경험 여부의 관계를 파악하고, 연구대상자의 인구사회학적 특성에 따른 음주운전 경험 여부의 영향요인을 확인하고자 하였다. 방법 : 제7기 국민건강영양조사 3차 년도 자료를 활용하여, 만 19세 이상인 설문응답자 중 음주운전과 안전벨트 관련 문항에 응답한 3,312명을 최종 분석 대상으로 선정하였다. 결과 : 평상시 안전벨트 착용 여부와 최근 1년 내 음주운전 여부는 통계적으로 유의한 관련성을 보였으며, 평상시에 안전벨트를 항상 착용하는 사람에 비해 그렇지 않은 사람의 음주운전 경험률이 더 높은 것으로 나타났다. 자동차 음주운전의 영향요인은 성별, 결혼상태, 교육수준, 경제활동 상태, 거주지역으로 나타났다. 결론 : 안전벨트의 착용이 자동차 음주운전과 유의한 관계를 지녔음을 알 수 있으며, 본 연구 결과가 차량 운전자의 안전의식 향상 및 교통안전 정책 수립의 기초자료로 활용되기를 기대한다. Objective : The purpose of this study is to investigate the correlation between the experience of drunk driving and seatbelt usage controlling socio-demographic factors. Methods : A cross-sectional analysis was performed with 3,312 participants among those who answered the data of the third year of the 7th National Health Nutrition Survey. Results : It was identified participants with lower seatbelt usage were more likely to have a drunk driving experience compared to those higher seatbelt usage. Conclusion : We revealed that seatbelt usage has a significant relationship with drunk driving. These results are expected to be utilized for improving safety consciousness of drivers and establishing traffic safety policies.
Ocular MALT Lymphoma : Report of Two Cases
윤영묵,장효찬,김동석,김상원,박미옥,박재복 대구효성가톨릭대학교 1998 연구논문집 Vol.57 No.2
Lymphoma arising in mucosa-associated lymphoid tissue(MALT) is extranodal marginal zone lymphoma displaying a proliferation of follicle marginal zone-type cells(centrocyte-like cells or monocytoid B-cells), often with surrounding reactive germinal centers and lympoepithelial lesions. This typically expresses pan-B-cell markers and monotypic immunoglobulin but not CD5 or CD10. Ocular MALT consists of the lacrimal gland, lcular soft tissue, orbit, conjunctiva and cornea. Lymphoma arising in thses sites is of very rare occurrence in up to 1.5% of all patients with non-Hodgkin's lymphoma. Herein we report two cases of ocular MALT lymphoma which was very rare in the dermatologic field. Case 1, 73-year-old man, developed the right upper conjunctival swelling measuring about 2.0×2.5cm for about 1 year. Histologically, the excised lesion showed follicular centers and infiltration of centrocyte-like cells of B-cell lineage in the stroma but no lymphoepithelial lesions, consistent with low-grade B-cell lymphoma. Case 2, a 66-year-old female, had a rapid course of about 1.2×1.0cm-sized, soft, wellow mass arising from lacrimal gland of the right upper eyelid for about 1 month. Hostologically, the lesion showed diffuse patterend features admixed with centrocyte-like cells and large cells such as centroblast, compatible with high-grade lymphoma. Case 2 received combined chemotherapy of m-BACOD, with a somewhat improvement.
Atypical Polypoid Dermatofibroma
김장오 ( Jang Oh Kim ),김종우 ( Jong Woo Kim ),윤영묵 ( Young Mook Yoon ),김상원 ( Sang Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
Atypical polypoid dermatofibroma(APDF) represents a distinctive clinicopathologic variant of dermatofibroma. We des~<.,ribe an unusual case of APDF occuring on the right butt~ack in a 27-year old female. The lesion was a reddish-hued, rounded, hard protuberant tumor with short pedicle, measuring 2,7 x 2.7 x 1.5cm. Excised tumor showed a well circumscribed dermal le~sion loca- lized in the protruded ar~ea, and dense proliferation of fibrobl~asts and capillaries reminiseent of fi- brous or scle~rosing hema~ngioma type, with prominent focal cellular atypia. The tumor cells were vimentin-positive, but di~rl not express CD34. There was no evidence of recurrence after 18 months postoperative foll~ow-up. (Kor J Dermatol 1996;34(5): 818-822)