패혈증의 경과에 따른 혈중 스테로이드와 Nitric Oxide의 연관성

이규성 ( Keu Sung Lee ),김영선 ( Young Sun Kim ),이형노 ( Hyoung No Lee ),박주헌 ( Joo Hun Park ),오윤정 ( Yoon Jung Oh ),신승수 ( Seung Soo Sheen ),최영화 ( Young Hwa Choi ),박광주 ( Kwang Joo Park ),황성철 ( Sung Chul Hwang ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4

연구배경: 패혈증에서 Nitric oxide 스테로이드 호르몬은 혈역학적 변화와 염증반응에 관여하는데 이 두 인자는 서로 상관성이 있는 것으로 알려지고 있다. 하지만 실제 환자에서 서로의 상관성이나 임상적 의의는 연구가 부족한 실정이다. 방법: 패혈증 환자 26예와 대조군 14예를 대상으로 혈중 총 NO와 혈중 코티졸 농도를 측정하였고 이어서 제 3, 5, 7병일에도 연속적으로 측정을 하였다. 결과: 패혈증 환자군에서 초기 혈중 코티졸 및 총 NO 농도는 대조군에 비하여 유의하게 증가하였고 경증 패혈증에 비하여 중증 패혈증 환자군에서 유의하게 높았다. 초기 혈중 총 NO의 농도는 APACHE II 점수, 정맥혈 lactate 농도와 상관성이 있었다. 패혈증의 시간의 경과에 따라 혈중 NO 농도는 제 1병일, 제 5병일, 제 7병일에 혈중 코티졸의 농도와 유의한 상관성이 있었다. 결론: 패혈증 환자들에서 혈중 NO와 코티졸 농도는 증가되어 있었으며, 경과에 따라 서로 유의한 상관성이 지속되었다. 상호작용기전에 대하여는 추가적인 연구가 필요할 것이다. Background: The nitric oxide (NO) released by inducible NO synthase (iNOS) plays an important role in the pathophysiology of sepsis. Corticosteroids also play a role in the hemodynamic and inflammatory reactions in sepsis. Both have been shown to have a relationship theoretically, but their correlation and clinical impacts have rarely been evaluated. Methods: 26 patients with sepsis and 14 healthy controls were enrolled in this study. The initial random plasma total NO and the serum cortisol levels were measured. The same measurements were serially carried out on the 3rd, 5th, and 7th days. Results: The initial total plasma levels of NO and cortisol were higher in the patients with sepsis than in the healthy controls. The total NO levels were higher in patients with severe sepsis than in the those with mild sepsis. There was a correlation between the total NO and cortisol level throughout the study. Conclusion: In patients with sepsis, the levels of plasma NO and cortisol were well correlated during the first week of sepsis, which suggests an interrelationship. However, the clinical and pathogenetic implications await further evaluation. (Tuberc Respir Dis 2007; 62: 308-313)

미소균열 탐상을 위한 자기광학소자를 이용한 비파괴탐상법의 제안과 적용

이형노,박한주,庄子 哲雄 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2

항공기나 대형 플랜트 등의 경년구조물에 있어서 제조 및 설계 혹은 작업환경 등에 의해 발생하는 미소결함은 응력부식파괴로 이어지는 결정적인 원인으로 알려져 있다. 따라서 제조단계에서의 결함의 검출뿐만 아니라 운전개시 후에 있어서도 비파괴검사에 기초를 둔 정기적인 건전성평가가 요구된다. 특히 구조물내의 미소균열 평가는 구조 건전성 평가에 있어서 중요한 과제라 할 수 있다. 자기광학소자를 이용한 비파괴탐상법은 균열부근의 누설자속에 의한 자구 및 자벽의 변화를 이용하여 균열정보를 화상형태로 얻는다. 그러므로 빠른 탐상속도와 결과데이터 해석의 용이 그리고 실시간적으로 탐상결과를 획득할 수 있다는 장점을 지니고 있다. 본 논문은 자기광학소자를 이용한 새로운 비파괴적 탐상법을 제안하고, 본 탐상법을 이용하여 구조물에 존재하는 표면결함의 검출가능성 및 균열깊이의 평가를 실증하였다. 표면결함을 갖는 시험편과 파이프의 내면에 존재하는 피로균열을 대상으로 실험을 실시한 결과, 표면결함의 위치 및 2차원적 형상을 화상형식으로 얻을 수 있음을 증명하였다. 또한 피로시험중의 시험편을 대상으로 균열발생 및 균열진전과정을 평가를 통하여 원격탐상의 가능성을 제시하였다. Micro-defects induced by design and production failure or working environments are known as the cause of SCC(Stress Corrosion Cracking) in aged structures. Therefore, the evaluation of structural integrity based on micro-cracks is required not only a manufacturing step but also in-service term. So we introduce a new nondestructive inspection method using the magneto-optical film to detect micro-cracks. The method has some advantage such as high testing speed, real time data acquisition and the possibility of remote sensing by using of a magneto-optical film that takes advantages of the change of magnetic domains and domain walls. This paper introduces the concept of the new nondestructive inspection method using the magneto-optical film, also proves the possibility of this method as a remote testing system under oscillating load considering application on real fields by applying the method to four types of specimens.

다양한 절삭이송속도로 가공한 A1 7075-T6 소재의 쇼트피닝 전후 피로수명에 관한 연구

김형태,이재헌,신기훈,노승남,서성원 서울産業大學校 2005 논문집 Vol.54 No.1

Aluminum alloy 7075-T6 is ideally used for highly stressed parts such as aircraft components because of its excellent strength to weight ratio. This paper presents a study on the effect of feedrate changes on the fatigue life of A1 7075-T6 specimens before and after shotpeening. For this purpose, five groups of specimens, each of which consists of eight specimens, were first machined at five different feedrates (0.05, 0.10, 0.15, 0.20 0.25mm/rev). Half of eight specimens in each group were then peened and the others remained un-peened. Finally, the fatigue life of each specimen was measured by using 4-point rotatry bending machine. In this paper, comparison of fatigue life among ten sets of specimens is presented. One observation is that the fatigue life of unpeened specimens are inversely proportional to the feedrates. On the other hand, the fatigue life of peened specimens are similarly improved regardless of feedrates except 0.05. Based on the results, it is concluded that shotpeening may improve the fatigue life of Aluminium alloy regardless of feedrates. Therefore, machining productivity may also be increased by choosing higher feedrates for structural conponents that need to be strain-hardened by shotpeening after machining

Development of 3-axis Nano Stage for High Precision Positioning System

Hyoung Gil Choi(최형길),Moon Gu Lee(이문구),Suk-Won Lee(이석원),Dong-Ju Lee(이동주),Kang-Nyung Lee(이강녕),No-Cheol Park(박노철) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11

The precision positioning system requires robust structural design to obtain enough bandwidth and efficient magnetic circuit to have fast access time. In this paper, the 3-axis nano stage was proposed and dynamic characteristics was improved by design of experiments (DOE) based on specifications of our precision positioning device. Finally, it was checked that the designed actuator had the proper dynamic characteristics through dynamic experiments.

반자동 필드 기반 모핑

이형진(Hyoung-Jin Lee),김형민(Hyoung-Min Kim),서정구(Jeong-Gu Seo),곽노윤(No-Yoon Kwak) 한국통신학회 2004 한국통신학회 학술대회논문집 Vol.2004 No.7

다각형 기반 정점 탐색에 의한 필드 기반 모핑의 제어선 자동 생성

이형진(Hyoung-Jin Lee),김형민(Hyoung-Min Kim),곽노윤(No-Yoon Kwak) 한국콘텐츠학회 2004 한국콘텐츠학회 종합학술대회 논문집 Vol.2 No.1

필드 기반 영상 모핑은 제어선을 지정하는 과정의 대부분을 사용자의 수작업에 의존하기 때문에 작업 시간이 많이 소요될 뿐만 아니라 양질의 결과를 얻기 위해서는 숙련을 요하는 불편함이 있다. 본 논문은 소스 영상과 목표 영상에서 모핑 대상체 쌍의 형상 정보를 획득한 상태에서 사용자가 수동으로 최소한의 특징점 쌍만을 지정하면 이렇게 지정된 특징점 쌍을 기준 삼아 다각형 기반 정점 탐색에 의해 소스 영상과 목표 영상에 상호 대응되는 제어선들을 자동적으로 설정한 후, 제어선 길이의 비율과 제어선으로부터의 이격 거리를 이용하여 영상 모핑을 수행함으로써 영상 모핑의 반자동화를 실현할 수 있는 방법을 제안한다. 제안된 방법에 따르면, 사용자가 제어선을 설정하는 시간을 단축할 수 있고 비숙련자도 최소의 제어선만을 지정하여 자연스러운 모핑 결과를 획득할 수 있는 이점이 있다. The field based morping requires the user to set most of the control lines manually which requires much time and skill to get satisfactory results. This thesis proposes a method to acquire semi-automation of image morphing through first acquiring shape information from the source image and the target image, then after the user manually designates the least amount of a pair of feature points, these are used as standards for polygon based vertex search to set 1he appropriate control line to the source image and target image, and then using the ratio of control line lengths and space. Using the proposed method, the user can reduce the time setting the control line and unskilled persons can get natural image morphing results while designating the least amount of control line.

반자동 필드 기반 영상 워핑 및 모핑에 관한 연구

이형진(Hyoung-Jin Lee),김형민(Hyoung-Min Kim),곽노윤(No-Yoon Kwak) 한국멀티미디어학회 2004 한국멀티미디어학회 학술발표논문집 Vol.2004 No.1

원자력발전소 안전등급 대형유도전동기의 기기검증

이형우(Hyoung Woo Lee),고우식(Woo Sik Ko),류정현(Jeong Hyeon Ryu),박노길(No Gill Park) Korean Society for Precision Engineering 2007 한국정밀공학회지 Vol.24 No.6

A safety-related equipment for the nuclear power plant should be needed an equipment qualification. In this paper, the approach, methods, philosophies, and procedures for qualifying the large squirrel-cage induction electric pumpmotors for use in ULCHIN 5, 6 Nuclear Power Plants were presented. The method of qualification is a combination of experimental test and analytic method, which is composed of radiation exposure test, seismic simulation test, thermal aging analysis for non-metallic materials, and seismic analysis. The results showed that the motor performed its safety function with no failure mechanism under postulated service conditions.

로터-베어링 시스템의 잔류불평형량을 결정하는 방법에 대한 연구

이형우(Hyoung Woo Lee),이동환(Dong Han Lee),박노길(No Gill Park),김인환(In Hwan Kim) Korean Society for Precision Engineering 2004 한국정밀공학회지 Vol.21 No.9

A new method to measure residual unbalance of rotor - bearing system was proposed. The method which determine residual unbalance based on polar plot and an analytical method which calculates the residual unbalance of the rotor from the vibration response of the Jeffcott rotor are proposed in this study with respect to a real rotor system of which the residual unbalance is unknown. The unbalance eccentricity of the produced experimental model is 3.78 mil, developing the measurement method of the residual unbalance more convenient than the proposed method of ISO and API standard. The proposed method was experimentally compared with the ISO standard, and the two methods were exactly correspondent to each other within an error of 1%.

정자의 운동특성이 인공수정 수태율에 미치는 영향

이성수,김덕임,박노형,원유석,Lee, Seoung-soo,Kim, Duk-im,Park, No-hyoung,Won, You-seog 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.1

The ejaculates from 67 HanWoo prove bull, bred in Livestock Improvement Main center of NLCF, were used to determine the correlation between the sperm motional characteristics and the pregnancy rate of artificial insemination(AI). The motional characteristics of sperm were analysed by Computer-assisted sperm analyser(CASA), thereafter inseminated equally 1,256 heads of cow regarding to parity, age, and live weight. There were no significant difference(p>0.05) in the pregnancy rate according to year from 1996 to 1998, but the LIN, ALH, STR, BCF, MAD and WOB of sperm in the year 1997, were highest pregnancy rate, were higher than those of sperm in the year 1998, were lowest pregnancy rate(p<0.05). The semen had no significant effect on pregnancy rate according to season(p>0.05). However spring, had a little higher pregnancy rate than that of autumn, were higher than autumn in VSL, VAP, LIN, ALH, BCF, MAD and WOB, but in DNM. The pregnancy rates of spring in the year 1996 and 1997 were higher than that of autumn in the year 1998(p<0.05). The spring in the year 1997, highest in pregnancy rate, were higher than the autumn in the year 1998 in VSL, VAP, LIN, STR, BCF, MAD and WOB, but in DNM(p<0.05). There were no the motion characteristic of sperm that was significant correlate with pregnancy rate of AI as the semen were analysed before artificial insemination and those, had some degree characteristics in motility, viability and abnormality, were used to AI. However there were a tendency that the higher the VSL, VAP, ALH, LIN, STR, BCF, MAD and WOB and the lower the DNM were, the higher the pregnancy rate of AI were.